Details of the Target

General Information of Target

Target ID LDTP04289
Target Name Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)
Gene Name ACADVL
Gene ID 37
Synonyms
VLCAD; Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; VLCAD; EC 1.3.8.9
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL
TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA
KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA
HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY
YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM
GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV
DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI
FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK
GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL
EQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEK
MLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF
Target Bioclass
Enzyme
Family
Acyl-CoA dehydrogenase family
Subcellular location
Mitochondrion inner membrane
Function
Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.
Uniprot ID
P49748
Ensemble ID
ENST00000350303.9
HGNC ID
HGNC:92
ChEMBL ID
CHEMBL4105892

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ICC10 Deletion: p.F471YfsTer84 DBIA    Probe Info 
ICC106 Deletion: p.F471YfsTer84 DBIA    Probe Info 
ICC108 Deletion: p.F471YfsTer84 DBIA    Probe Info 
IGR37 SNV: p.I457T DBIA    Probe Info 
IGR39 SNV: p.I457T DBIA    Probe Info 
JURKAT SNV: p.S235T; p.T242A Compound 10    Probe Info 
MFE319 Insertion: p.M440YfsTer23 DBIA    Probe Info 
MOLT4 Deletion: p.K195RfsTer22 IA-alkyne    Probe Info 
NCIH661 SNV: p.V400M .
RKO SNV: p.Q86R DBIA    Probe Info 
SAOS2 SNV: p.G314Ter DBIA    Probe Info 
SNU5 SNV: p.L524H DBIA    Probe Info 
SUPT1 SNV: p.T280A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.10  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		5.00  LDD0391  [2]
A-EBA
 Probe Info  		5.73  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		K51(5.56)  LDD0274  [6]
BTD
 Probe Info  		C237(2.14)  LDD1699  [7]
DBIA
 Probe Info  		C179(1.14); C500(1.78)  LDD3310  [8]
AHL-Pu-1
 Probe Info  		C156(2.25)  LDD0168  [9]
5E-2FA
 Probe Info  		H293(0.00); H55(0.00); H593(0.00); H335(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C156(0.00); C215(0.00); C477(0.00); C433(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C156(0.00); C215(0.00); C477(0.00); C237(0.00)  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		C156(0.00); C215(0.00); C237(0.00); C477(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
TFBX
 Probe Info  		C215(0.00); C237(0.00)  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		N.A.  LDD0010  [15]
PF-06672131
 Probe Info  		N.A.  LDD0152  [17]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Ox-W18
 Probe Info  		N.A.  LDD2175  [19]
Acrolein
 Probe Info  		C477(0.00); C237(0.00); H55(0.00); H374(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		H598(0.00); C477(0.00); C237(0.00); H593(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
NAIA_5
 Probe Info  		C156(0.00); C477(0.00); C237(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		5.78  LDD1733  [22]
C064
 Probe Info  		9.00  LDD1761  [22]
C094
 Probe Info  		40.79  LDD1785  [22]
C131
 Probe Info  		7.57  LDD1813  [22]
C135
 Probe Info  		12.13  LDD1817  [22]
C147
 Probe Info  		8.63  LDD1829  [22]
C173
 Probe Info  		12.47  LDD1853  [22]
C275
 Probe Info  		9.71  LDD1945  [22]
C283
 Probe Info  		6.19  LDD1953  [22]
C326
 Probe Info  		15.35  LDD1990  [22]
C366
 Probe Info  		8.88  LDD2027  [22]
C367
 Probe Info  		7.26  LDD2028  [22]
C407
 Probe Info  		18.90  LDD2064  [22]
C426
 Probe Info  		12.73  LDD2081  [22]
FFF probe11
 Probe Info  		20.00  LDD0471  [23]
FFF probe13
 Probe Info  		20.00  LDD0475  [23]
FFF probe14
 Probe Info  		20.00  LDD0477  [23]
FFF probe3
 Probe Info  		9.89  LDD0465  [23]
JN0003
 Probe Info  		16.36  LDD0469  [23]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [24]
DA-2
 Probe Info  		N.A.  LDD0071  [25]
OEA-DA
 Probe Info  		20.00  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C477(0.40)  LDD2142  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C237(0.68); C215(0.63)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C237(0.97)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C237(0.92); C215(1.29); C477(0.79)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C477(1.21)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C237(0.70)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C237(0.90)  LDD2131  [7]
 LDCM0025  4SU-RNA HEK-293T C156(2.25)  LDD0168  [9]
 LDCM0214  AC1 HEK-293T C237(1.09); C477(0.91); C156(0.98); C215(1.00)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C237(0.98); C477(1.01); C156(1.14); C215(0.99)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C237(0.93); C477(0.95); C156(1.14); C215(1.06)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C237(0.89); C477(0.95); C156(1.22); C215(0.89)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C237(0.92); C477(1.01); C156(0.95)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C237(1.05); C477(1.06); C156(0.92); C215(1.10)  LDD1513  [27]
 LDCM0276  AC17 HEK-293T C237(1.02); C477(0.84); C156(0.94); C215(1.11)  LDD1515  [27]
 LDCM0277  AC18 HEK-293T C237(1.07); C477(0.95); C156(0.93); C215(1.15)  LDD1516  [27]
 LDCM0278  AC19 HEK-293T C237(0.89); C477(0.89); C156(1.03); C215(0.85)  LDD1517  [27]
 LDCM0279  AC2 HEK-293T C237(0.99); C477(0.92); C156(1.06); C215(1.09)  LDD1518  [27]
 LDCM0280  AC20 HEK-293T C237(0.96); C477(0.94); C156(0.91); C215(0.97)  LDD1519  [27]
 LDCM0281  AC21 HEK-293T C237(0.96); C477(1.00); C156(0.97)  LDD1520  [27]
 LDCM0282  AC22 HEK-293T C237(0.97); C477(1.07); C156(0.97)  LDD1521  [27]
 LDCM0283  AC23 HEK-293T C237(1.07); C477(0.94); C156(0.90); C215(1.22)  LDD1522  [27]
 LDCM0284  AC24 HEK-293T C237(1.00); C477(0.99); C156(0.99); C433(1.03)  LDD1523  [27]
 LDCM0285  AC25 HEK-293T C237(1.12); C477(0.92); C156(1.07); C215(1.22)  LDD1524  [27]
 LDCM0286  AC26 HEK-293T C237(1.06); C477(0.99); C156(0.97); C215(1.07)  LDD1525  [27]
 LDCM0287  AC27 HEK-293T C237(1.04); C477(1.06); C156(1.20); C215(1.00)  LDD1526  [27]
 LDCM0288  AC28 HEK-293T C237(0.94); C477(1.08); C156(1.01); C215(1.11)  LDD1527  [27]
 LDCM0289  AC29 HEK-293T C237(1.00); C477(1.00); C156(1.06)  LDD1528  [27]
 LDCM0290  AC3 HEK-293T C237(0.90); C477(0.99); C156(1.04); C215(1.25)  LDD1529  [27]
 LDCM0291  AC30 HEK-293T C237(0.98); C477(1.00); C156(1.00)  LDD1530  [27]
 LDCM0292  AC31 HEK-293T C237(1.19); C477(1.05); C156(0.99); C215(1.16)  LDD1531  [27]
 LDCM0293  AC32 HEK-293T C237(1.09); C477(0.97); C156(1.07); C433(1.03)  LDD1532  [27]
 LDCM0294  AC33 HEK-293T C237(0.92); C477(0.85); C156(1.17); C215(1.40)  LDD1533  [27]
 LDCM0295  AC34 HEK-293T C237(0.91); C477(0.97); C156(1.03); C215(1.10)  LDD1534  [27]
 LDCM0296  AC35 HEK-293T C237(0.88); C477(0.93); C156(0.97); C215(0.85)  LDD1535  [27]
 LDCM0297  AC36 HEK-293T C237(0.88); C477(1.16); C156(1.16); C215(0.98)  LDD1536  [27]
 LDCM0298  AC37 HEK-293T C237(0.94); C477(0.96); C156(0.93)  LDD1537  [27]
 LDCM0299  AC38 HEK-293T C237(0.89); C477(0.97); C156(0.87)  LDD1538  [27]
 LDCM0300  AC39 HEK-293T C237(1.11); C477(1.21); C156(1.13); C215(1.12)  LDD1539  [27]
 LDCM0301  AC4 HEK-293T C237(0.89); C477(0.86); C156(1.11); C215(1.15)  LDD1540  [27]
 LDCM0302  AC40 HEK-293T C237(0.95); C477(0.92); C156(1.10); C433(1.16)  LDD1541  [27]
 LDCM0303  AC41 HEK-293T C237(0.99); C477(0.77); C156(1.16); C215(1.13)  LDD1542  [27]
 LDCM0304  AC42 HEK-293T C237(0.95); C477(0.97); C156(1.21); C215(1.09)  LDD1543  [27]
 LDCM0305  AC43 HEK-293T C237(0.88); C477(0.96); C156(1.11); C215(1.09)  LDD1544  [27]
 LDCM0306  AC44 HEK-293T C237(0.85); C477(1.10); C156(1.13); C215(1.07)  LDD1545  [27]
 LDCM0307  AC45 HEK-293T C237(0.92); C477(0.96); C156(0.89)  LDD1546  [27]
 LDCM0308  AC46 HEK-293T C237(0.89); C477(0.94); C156(1.04)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C237(1.06); C477(1.10); C156(1.14); C215(1.13)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C237(0.91); C477(0.99); C156(0.96); C433(1.01)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C237(1.17); C477(1.03); C156(0.85); C215(1.53)  LDD1550  [27]
 LDCM0312  AC5 HEK-293T C237(0.95); C477(1.06); C156(0.95)  LDD1551  [27]
 LDCM0313  AC50 HEK-293T C237(0.93); C477(0.96); C156(1.00); C215(1.06)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C237(0.85); C477(1.00); C156(1.03); C215(1.01)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C237(0.89); C477(0.99); C156(1.06); C215(0.92)  LDD1554  [27]
 LDCM0316  AC53 HEK-293T C237(0.98); C477(1.01); C156(1.01)  LDD1555  [27]
 LDCM0317  AC54 HEK-293T C237(0.88); C477(1.02); C156(1.09)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C237(1.11); C477(0.98); C156(0.92); C215(1.01)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C237(1.10); C477(0.99); C156(0.92); C433(1.08)  LDD1558  [27]
 LDCM0320  AC57 HEK-293T C237(1.05); C477(1.07); C156(0.86); C215(1.25)  LDD1559  [27]
 LDCM0321  AC58 HEK-293T C237(0.98); C477(1.00); C156(0.95); C215(0.98)  LDD1560  [27]
 LDCM0322  AC59 HEK-293T C237(0.94); C477(0.96); C156(1.09); C215(1.00)  LDD1561  [27]
 LDCM0323  AC6 HEK-293T C237(0.89); C477(1.05); C156(1.07)  LDD1562  [27]
 LDCM0324  AC60 HEK-293T C237(0.83); C477(1.03); C156(1.07); C215(1.13)  LDD1563  [27]
 LDCM0325  AC61 HEK-293T C237(0.90); C477(1.02); C156(1.02)  LDD1564  [27]
 LDCM0326  AC62 HEK-293T C237(0.93); C477(1.07); C156(1.11)  LDD1565  [27]
 LDCM0327  AC63 HEK-293T C237(1.03); C477(0.99); C156(1.09); C215(1.04)  LDD1566  [27]
 LDCM0328  AC64 HEK-293T C237(1.03); C477(1.00); C156(1.04); C433(1.03)  LDD1567  [27]
 LDCM0334  AC7 HEK-293T C237(1.20); C477(0.91); C156(1.07); C215(1.05)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C237(0.99); C477(1.05); C156(1.04); C433(0.94)  LDD1569  [27]
 LDCM0545  Acetamide MDA-MB-231 C237(0.43)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C477(0.76)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C237(0.94); C477(1.07); C156(0.91)  LDD1511  [27]
 LDCM0356  AKOS034007680 HEK-293T C237(1.06); C477(0.89); C156(0.80); C215(1.19)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C237(1.04); C477(0.93); C156(1.04); C433(0.98)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0498  BS-3668 MDA-MB-231 C237(0.60)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C433(0.00); C477(0.00); C237(0.00); H598(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C237(0.84); C477(0.96); C156(1.09)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C237(0.75); C477(1.01); C156(1.13)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C237(0.89); C477(1.02); C156(1.16); C215(1.25)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C237(0.97); C477(0.98); C156(0.95)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C237(0.89); C477(1.04); C156(1.19)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C237(0.88); C477(0.98); C156(1.02)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C237(0.92); C477(1.04); C156(1.02); C215(1.18)  LDD1577  [27]
 LDCM0374  CL105 HEK-293T C237(0.91); C477(1.03); C156(1.10)  LDD1578  [27]
 LDCM0375  CL106 HEK-293T C237(1.00); C477(0.89); C156(1.21)  LDD1579  [27]
 LDCM0376  CL107 HEK-293T C237(0.95); C477(1.01); C156(0.85)  LDD1580  [27]
 LDCM0377  CL108 HEK-293T C237(1.02); C477(1.09); C156(1.04); C215(1.14)  LDD1581  [27]
 LDCM0378  CL109 HEK-293T C237(0.97); C477(1.03); C156(0.98)  LDD1582  [27]
 LDCM0379  CL11 HEK-293T C237(0.75); C477(1.14); C156(0.76); C215(1.05)  LDD1583  [27]
 LDCM0380  CL110 HEK-293T C237(0.91); C477(0.92); C156(1.10)  LDD1584  [27]
 LDCM0381  CL111 HEK-293T C237(0.93); C477(1.02); C156(0.92)  LDD1585  [27]
 LDCM0382  CL112 HEK-293T C237(1.01); C477(1.03); C156(0.91); C215(1.10)  LDD1586  [27]
 LDCM0383  CL113 HEK-293T C237(0.92); C477(1.00); C156(1.00)  LDD1587  [27]
 LDCM0384  CL114 HEK-293T C237(0.89); C477(0.80); C156(1.21)  LDD1588  [27]
 LDCM0385  CL115 HEK-293T C237(0.87); C477(0.97); C156(1.15)  LDD1589  [27]
 LDCM0386  CL116 HEK-293T C237(0.90); C477(0.97); C156(0.95); C215(1.32)  LDD1590  [27]
 LDCM0387  CL117 HEK-293T C237(0.89); C477(0.94); C156(0.98)  LDD1591  [27]
 LDCM0388  CL118 HEK-293T C237(0.91); C477(0.81); C156(1.02)  LDD1592  [27]
 LDCM0389  CL119 HEK-293T C237(0.89); C477(1.01); C156(0.83)  LDD1593  [27]
 LDCM0390  CL12 HEK-293T C237(0.90); C477(1.12); C156(1.01); C433(1.02)  LDD1594  [27]
 LDCM0391  CL120 HEK-293T C237(0.96); C477(1.01); C156(1.08); C215(1.67)  LDD1595  [27]
 LDCM0392  CL121 HEK-293T C237(0.93); C477(1.02); C156(0.93)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C237(0.97); C477(0.98); C156(1.17)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C237(0.81); C477(0.92); C156(1.01)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C237(0.91); C477(0.98); C156(1.05); C215(1.17)  LDD1599  [27]
 LDCM0396  CL125 HEK-293T C237(0.89); C477(1.01); C156(0.95)  LDD1600  [27]
 LDCM0397  CL126 HEK-293T C237(0.93); C477(0.96); C156(0.94)  LDD1601  [27]
 LDCM0398  CL127 HEK-293T C237(0.85); C477(1.04); C156(0.90)  LDD1602  [27]
 LDCM0399  CL128 HEK-293T C237(0.94); C477(1.01); C156(1.26); C215(1.47)  LDD1603  [27]
 LDCM0400  CL13 HEK-293T C237(0.95); C477(0.95); C156(1.06)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C237(0.95); C477(1.09); C156(0.85)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C237(0.81); C477(0.95); C156(0.94)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C237(1.00); C477(1.07); C156(1.04); C215(1.22)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C237(0.89); C477(1.12); C156(1.16); C215(1.24)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C237(0.95); C477(1.04); C156(1.03); C215(1.08)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C237(0.86); C477(0.97); C156(1.12); C215(0.89)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C237(1.06); C477(1.00); C156(1.12)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C237(0.90); C477(1.06); C156(1.05); C215(1.19)  LDD1612  [27]
 LDCM0409  CL21 HEK-293T C237(0.83); C477(0.90); C156(0.95)  LDD1613  [27]
 LDCM0410  CL22 HEK-293T C237(0.89); C477(1.07); C156(1.05)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C237(1.13); C477(1.26); C156(1.30); C215(0.76)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C237(1.02); C477(1.04); C156(0.98); C433(1.01)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C237(0.91); C477(1.05); C156(0.93)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C237(1.04); C477(0.81); C156(0.99)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C237(0.97); C477(1.05); C156(1.05)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C237(1.01); C477(1.02); C156(1.01); C215(1.01)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C237(0.97); C477(1.34); C156(1.13); C215(1.10)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C237(0.87); C477(1.06); C156(1.03)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C237(1.06); C477(1.07); C156(1.05); C215(1.10)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C237(1.01); C477(0.94); C156(1.14); C215(0.75)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C237(0.96); C477(1.02); C156(1.20); C215(0.99)  LDD1625  [27]
 LDCM0422  CL33 HEK-293T C237(0.85); C477(0.91); C156(1.16)  LDD1626  [27]
 LDCM0423  CL34 HEK-293T C237(0.97); C477(1.07); C156(1.39)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C237(0.98); C477(1.00); C156(1.02); C215(0.77)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C237(0.99); C477(1.06); C156(0.96); C433(0.98)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C237(0.98); C477(0.92); C156(0.96)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C237(0.88); C477(0.97); C156(0.88)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C237(0.88); C477(1.04); C156(1.02); C215(1.25)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C237(1.04); C477(0.98); C156(1.00); C215(1.18)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C237(1.08); C477(0.91); C156(1.06); C215(1.36)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C237(1.03); C477(0.95); C156(0.97); C215(0.89)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C237(1.04); C477(1.00); C156(1.00); C215(1.10)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C237(0.94); C477(0.98); C156(1.06); C215(0.83)  LDD1638  [27]
 LDCM0435  CL45 HEK-293T C237(0.89); C477(1.05); C156(1.01)  LDD1639  [27]
 LDCM0436  CL46 HEK-293T C237(0.98); C477(1.02); C156(0.95)  LDD1640  [27]
 LDCM0437  CL47 HEK-293T C237(0.91); C477(1.07); C156(1.01); C215(0.87)  LDD1641  [27]
 LDCM0438  CL48 HEK-293T C237(1.01); C477(0.97); C156(0.92); C433(1.16)  LDD1642  [27]
 LDCM0439  CL49 HEK-293T C237(0.80); C477(1.00); C156(1.02)  LDD1643  [27]
 LDCM0440  CL5 HEK-293T C237(0.91); C477(0.88); C156(0.97); C215(1.23)  LDD1644  [27]
 LDCM0441  CL50 HEK-293T C237(0.87); C477(0.93); C156(0.87)  LDD1645  [27]
 LDCM0443  CL52 HEK-293T C237(0.91); C477(1.02); C156(1.11); C215(1.30)  LDD1646  [27]
 LDCM0444  CL53 HEK-293T C237(0.98); C477(0.65); C156(0.91); C215(1.30)  LDD1647  [27]
 LDCM0445  CL54 HEK-293T C237(0.89); C477(1.00); C156(0.99); C215(1.03)  LDD1648  [27]
 LDCM0446  CL55 HEK-293T C237(0.92); C477(1.01); C156(1.05); C215(0.82)  LDD1649  [27]
 LDCM0447  CL56 HEK-293T C237(0.88); C477(1.30); C156(1.12); C215(1.01)  LDD1650  [27]
 LDCM0448  CL57 HEK-293T C237(0.83); C477(0.82); C156(0.96)  LDD1651  [27]
 LDCM0449  CL58 HEK-293T C237(0.89); C477(1.06); C156(1.10)  LDD1652  [27]
 LDCM0450  CL59 HEK-293T C237(0.88); C477(1.09); C156(1.03); C215(0.95)  LDD1653  [27]
 LDCM0451  CL6 HEK-293T C237(0.86); C477(1.05); C156(1.00); C215(1.01)  LDD1654  [27]
 LDCM0452  CL60 HEK-293T C237(0.97); C477(1.06); C156(0.96); C433(1.15)  LDD1655  [27]
 LDCM0453  CL61 HEK-293T C237(0.93); C477(1.12); C156(0.97)  LDD1656  [27]
 LDCM0454  CL62 HEK-293T C237(0.95); C477(1.00); C156(0.94)  LDD1657  [27]
 LDCM0455  CL63 HEK-293T C237(0.89); C477(0.99); C156(1.03)  LDD1658  [27]
 LDCM0456  CL64 HEK-293T C237(1.02); C477(0.92); C156(1.18); C215(1.34)  LDD1659  [27]
 LDCM0457  CL65 HEK-293T C237(1.05); C477(1.01); C156(1.00); C215(1.37)  LDD1660  [27]
 LDCM0458  CL66 HEK-293T C237(0.92); C477(1.01); C156(1.08); C215(1.08)  LDD1661  [27]
 LDCM0459  CL67 HEK-293T C237(0.85); C477(0.99); C156(1.14); C215(1.01)  LDD1662  [27]
 LDCM0460  CL68 HEK-293T C237(0.90); C477(1.17); C156(0.98); C215(0.94)  LDD1663  [27]
 LDCM0461  CL69 HEK-293T C237(0.89); C477(0.91); C156(1.05)  LDD1664  [27]
 LDCM0462  CL7 HEK-293T C237(0.82); C477(1.03); C156(1.13); C215(0.83)  LDD1665  [27]
 LDCM0463  CL70 HEK-293T C237(0.89); C477(0.98); C156(1.03)  LDD1666  [27]
 LDCM0464  CL71 HEK-293T C237(0.95); C477(0.99); C156(0.88); C215(0.85)  LDD1667  [27]
 LDCM0465  CL72 HEK-293T C237(1.04); C477(0.89); C156(1.00); C433(1.15)  LDD1668  [27]
 LDCM0466  CL73 HEK-293T C237(0.88); C477(0.94); C156(1.00)  LDD1669  [27]
 LDCM0467  CL74 HEK-293T C237(0.94); C477(0.92); C156(0.99)  LDD1670  [27]
 LDCM0469  CL76 HEK-293T C237(0.99); C477(0.99); C156(0.92); C215(1.06)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C237(0.87); C477(0.89); C156(0.84); C215(1.06)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C237(1.01); C477(0.99); C156(0.89); C215(1.03)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C237(0.90); C477(1.01); C156(1.06); C215(0.92)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C237(0.66); C477(1.49); C156(1.22); C215(0.76)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C237(0.94); C477(1.05); C156(0.98); C215(0.82)  LDD1677  [27]
 LDCM0475  CL81 HEK-293T C237(0.99); C477(0.98); C156(0.95)  LDD1678  [27]
 LDCM0476  CL82 HEK-293T C237(0.97); C477(1.11); C156(1.05)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C237(0.89); C477(1.03); C156(0.96); C215(0.92)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C237(0.96); C477(0.93); C156(0.99); C433(1.00)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C237(0.90); C477(1.02); C156(1.01)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C237(0.97); C477(1.09); C156(1.04)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C237(0.86); C477(1.00); C156(0.89)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C237(0.96); C477(1.00); C156(0.91); C215(1.32)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C237(0.99); C477(0.92); C156(0.88); C215(1.23)  LDD1686  [27]
 LDCM0484  CL9 HEK-293T C237(0.94); C477(1.04); C156(0.95)  LDD1687  [27]
 LDCM0485  CL90 HEK-293T C237(0.71); C477(0.93); C156(1.09); C215(0.99)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C237(0.90); C477(0.97); C156(0.99); C215(1.04)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C237(0.82); C477(0.89); C156(1.09); C215(0.91)  LDD1690  [27]
 LDCM0488  CL93 HEK-293T C237(0.86); C477(0.97); C156(0.94)  LDD1691  [27]
 LDCM0489  CL94 HEK-293T C237(0.94); C477(0.99); C156(1.05)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C237(1.00); C477(1.08); C156(1.00); C215(0.72)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C237(0.86); C477(1.03); C156(1.01); C433(1.05)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C237(0.97); C477(1.00); C156(0.95)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C237(0.97); C477(0.95); C156(1.05)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C237(0.91); C477(0.97); C156(0.90)  LDD1697  [27]
 LDCM0495  E2913 HEK-293T C237(0.82); C477(1.06); C156(1.08)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C477(2.16); C237(0.91)  LDD1702  [7]
 LDCM0625  F8 Ramos C237(1.62)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C237(0.26)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C237(0.11)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C237(0.30)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C237(0.75)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C237(0.93)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C237(0.24)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C237(0.65)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C237(0.34)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C237(0.64)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C237(0.88)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C237(0.51)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C237(0.37)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C237(0.39)  LDD2201  [28]
 LDCM0468  Fragment33 HEK-293T C237(0.91); C477(0.90); C156(1.27)  LDD1671  [27]
 LDCM0596  Fragment38 Ramos C237(0.58)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C237(0.93)  LDD2184  [28]
 LDCM0427  Fragment51 HEK-293T C237(0.99); C477(0.93); C156(1.14)  LDD1631  [27]
 LDCM0610  Fragment52 Ramos C237(0.79)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C237(0.56)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C237(0.76)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C237(0.27)  LDD2188  [28]
 LDCM0107  IAA HeLa C477(0.00); H598(0.00); H593(0.00); H55(0.00)  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C237(0.96); C215(0.96); C477(0.93); C156(1.11)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C237(0.93); C215(1.03); C477(0.88); C156(1.10)  LDD1497  [27]
 LDCM0024  KB05 COLO792 C179(1.14); C500(1.78)  LDD3310  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C237(0.59)  LDD2089  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C477(0.73)  LDD2097  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C237(0.66); C477(1.66)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C477(0.71)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C477(0.83)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C215(0.45); C477(0.36)  LDD2104  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C477(0.41)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C237(0.86); C477(0.98)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C477(0.44)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C237(0.77); C215(0.74)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C215(0.41); C477(0.59)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C237(0.75); C477(1.47)  LDD2111  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C477(0.51)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C237(0.35)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C237(1.57); C477(1.15)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C477(0.95)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C237(0.75)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C237(0.80); C477(0.95)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C237(0.56)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C237(0.69); C477(1.16)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C237(0.18)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C237(0.89); C477(1.03)  LDD2127  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C477(0.55)  LDD2133  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C237(1.00)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C237(0.86); C215(1.17); C477(1.09)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C237(0.94); C477(1.16)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C237(0.99)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C237(0.71); C477(0.91)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C215(0.67); C477(0.59)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C477(0.62)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C237(2.34)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C477(1.09)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C237(0.72); C477(0.96)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C477(1.18)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C237(0.86); C477(0.51)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C237(0.36)  LDD2150  [7]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0392  [2]
 LDCM0131  RA190 MM1.R C156(1.31); C215(1.14)  LDD0304  [29]
 LDCM0110  W12 Hep-G2 C477(0.83)  LDD0237  [21]
 LDCM0111  W14 Hep-G2 C237(18.46)  LDD0238  [21]
 LDCM0112  W16 Hep-G2 C237(0.67)  LDD0239  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TATA box-binding protein-associated factor RNA polymerase I subunit B (TAF1B) RRN7/TAF1B family Q53T94

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
25 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.