Details of the Target

General Information of Target

Target ID LDTP06210
Target Name Golgin subfamily B member 1 (GOLGB1)
Gene Name GOLGB1
Gene ID 2804
Synonyms
Golgin subfamily B member 1; 372 kDa Golgi complex-associated protein; GCP372; Giantin; Macrogolgin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQL
VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT
VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST
EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL
VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME
AEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE
SRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI
QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL
ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA
EESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ
MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE
LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN
LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQR
RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL
QNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKD
QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK
QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK
DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL
EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL
VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH
LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST
PGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE
LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ
IAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALH
TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK
SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL
ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ
SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK
FAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSK
KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ
DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK
EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKD
DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT
KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER
TVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK
LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG
EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ
SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD
TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG
IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA
ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD
SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD
DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE
EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE
VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET
AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK
YDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHL
SSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK
KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ
ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP
LKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE
EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGV
HRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR
LEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLA
AIYFLMIHVLLILCFTGHL
Target Bioclass
Other
Subcellular location
Golgi apparatus membrane
Function May participate in forming intercisternal cross-bridges of the Golgi complex.
Uniprot ID
Q14789
Ensemble ID
ENST00000340645.10
HGNC ID
HGNC:4429

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.70  LDD0402  [1]
STPyne
 Probe Info  		K103(1.40); K1179(8.33); K1478(9.38); K1484(6.13)  LDD0277  [2]
Probe 1
 Probe Info  		Y110(45.57); Y707(20.05); Y963(11.26); Y1410(15.95)  LDD3495  [3]
Alkylaryl probe 2
 Probe Info  		11.00  LDD0392  [4]
DBIA
 Probe Info  		C980(1.48)  LDD3311  [5]
BTD
 Probe Info  		C2233(0.71)  LDD2099  [6]
AHL-Pu-1
 Probe Info  		C681(3.19); C1713(2.64); C1462(2.84); C3197(2.24)  LDD0168  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K103(0.00); K994(0.00)  LDD0199  [9]
1d-yne
 Probe Info  		N.A.  LDD0358  [10]
CY-1
 Probe Info  		D2472(0.00); Q2470(0.00)  LDD0246  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1055(0.00); C681(0.00); C2279(0.00); C1569(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C1055(0.00); C1964(0.00); C2279(0.00); C3070(0.00)  LDD0037  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
IPM
 Probe Info  		C1055(0.00); C681(0.00)  LDD0005  [14]
TFBX
 Probe Info  		C395(0.00); C2279(0.00); C3090(0.00); C3070(0.00)  LDD0148  [16]
VSF
 Probe Info  		C3144(0.00); C3213(0.00)  LDD0007  [14]
Acrolein
 Probe Info  		C3090(0.00); C1569(0.00); C681(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C681(0.00); C3070(0.00)  LDD0218  [17]
W1
 Probe Info  		C2279(0.00); C681(0.00)  LDD0236  [18]
AOyne
 Probe Info  		5.80  LDD0443  [19]
NAIA_5
 Probe Info  		C2664(0.00); C395(0.00); C3197(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		10.48  LDD1782  [21]
C231
 Probe Info  		14.52  LDD1904  [21]
C326
 Probe Info  		7.57  LDD1990  [21]
C350
 Probe Info  		25.81  LDD2011  [21]
C362
 Probe Info  		26.54  LDD2023  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C2233(1.06)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C2233(1.18)  LDD2152  [6]
 LDCM0025  4SU-RNA HEK-293T C681(3.19); C1713(2.64); C1462(2.84); C3197(2.24)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C681(3.84); C1713(2.66); C1462(5.73); C3213(2.07)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C2233(0.85); C3144(1.07); C395(1.08); C681(0.99)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C2233(1.01); C3144(1.19); C395(1.08); C681(0.95)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C2233(1.03); C3090(1.16); C3144(1.16); C395(1.05)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C2233(1.02); C3144(1.01); C395(1.10); C681(0.94)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C2233(1.05); C3090(1.05); C3144(1.04); C395(1.00)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C2233(0.96); C3144(1.05); C395(1.06); C681(0.98)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C2233(0.99); C3144(1.15); C395(0.98); C681(0.85)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C2233(1.04); C3144(1.03); C395(1.11); C681(0.98)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C2233(1.47); C3090(1.03); C3144(1.76); C395(1.07)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C2233(1.01); C3144(1.12); C395(1.01); C681(0.97)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C2233(0.97); C3144(1.15); C395(1.04); C681(1.04)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C2233(0.96); C3090(1.03); C3144(1.06); C395(1.01)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C2233(0.99); C3090(1.12); C3144(0.82); C395(1.33)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C2233(0.94); C3144(0.97); C395(1.01); C681(1.07)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C2233(1.00); C3144(1.06); C681(1.10); C3070(0.95)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C2233(0.92); C3144(1.20); C395(1.03); C681(0.91)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C2233(1.06); C3144(1.17); C395(1.10); C681(1.01)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C2233(1.01); C3090(1.06); C3144(1.04); C395(1.07)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C2233(1.00); C3144(1.11); C395(1.02); C681(1.04)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C2233(0.98); C3090(1.03); C3144(1.12); C395(1.02)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C2233(1.02); C3090(1.07); C3144(1.08); C395(0.99)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C2233(1.00); C3090(1.03); C3144(0.93); C395(1.26)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C2233(0.95); C3144(0.97); C395(0.86); C681(0.99)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C2233(0.97); C3144(0.87); C681(0.91); C3070(1.00)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C2233(0.94); C3144(1.27); C395(1.07); C681(0.94)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C2233(1.01); C3144(1.27); C395(1.03); C681(1.03)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C2233(0.99); C3090(1.11); C3144(1.12); C395(1.09)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C2233(0.93); C3144(1.15); C395(1.04); C681(1.04)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C2233(1.08); C3090(1.07); C3144(1.17); C395(0.98)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C2233(1.03); C3090(1.13); C3144(0.81); C395(0.96)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C2233(0.96); C3144(1.02); C395(0.97); C681(1.07)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C2233(0.98); C3144(1.09); C395(0.94); C681(0.98)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C2233(1.06); C3144(0.92); C681(1.05); C3070(1.01)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C2233(0.85); C3144(1.21); C395(1.16); C681(0.99)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C2233(1.01); C3144(1.22); C395(1.25); C681(0.95)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C2233(0.99); C3090(1.02); C3144(1.08); C395(1.11)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C2233(0.98); C3144(1.13); C395(0.99); C681(0.96)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C2233(1.05); C3090(1.07); C3144(1.18); C395(1.04)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C2233(1.01); C3090(1.14); C3144(0.80); C395(1.05)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C2233(0.99); C3144(0.87); C395(1.21); C681(1.13)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C2233(0.97); C3144(0.92); C681(1.00); C3070(1.02)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C2233(0.98); C3144(1.21); C395(1.18); C681(0.96)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C2233(1.07); C3090(0.98); C3144(1.23); C395(1.11)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C2233(1.03); C3144(1.07); C395(1.08); C681(0.94)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C2233(0.98); C3090(1.04); C3144(1.06); C395(1.04)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C2233(0.97); C3144(1.15); C395(1.22); C681(1.02)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C2233(1.07); C3090(1.04); C3144(1.19); C395(1.04)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C2233(1.05); C3090(1.09); C3144(1.03); C395(1.31)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C2233(0.95); C3144(1.04); C395(1.26); C681(0.98)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C2233(1.04); C3144(1.01); C681(1.18); C3070(1.05)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C2233(0.99); C3144(1.07); C395(1.08); C681(0.93)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C2233(1.02); C3144(1.05); C395(1.05); C681(0.99)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C2233(1.00); C3090(1.06); C3144(1.15); C395(1.08)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C2233(1.07); C3090(1.07); C3144(1.04); C395(1.14)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C2233(0.94); C3144(1.13); C395(1.21); C681(0.99)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C2233(1.01); C3090(0.95); C3144(1.26); C395(1.09)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C2233(0.99); C3090(0.91); C3144(1.08); C395(1.11)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C2233(0.93); C3144(1.07); C395(1.03); C681(1.11)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C2233(1.01); C3144(1.15); C681(1.22); C3070(1.01)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C2233(0.98); C3144(0.97); C395(1.18); C681(0.94)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C2233(1.08); C3144(1.08); C681(1.04); C3070(0.94)  LDD1569  [22]
 LDCM0520  AKOS000195272 MDA-MB-231 C2233(0.79)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C2233(1.04); C3090(1.00); C3144(1.09); C395(1.04)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C2233(0.90); C3144(1.10); C395(1.06); C681(0.95)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C2233(1.05); C3144(1.01); C681(1.03); C3070(0.96)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 11.62  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C681(0.00); C3070(0.00); H1634(0.00); C1569(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C2664(1.50); C3070(1.38); C1713(0.70); C1964(0.67)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C2233(0.94); C3090(1.06); C3144(1.01); C395(1.03)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C2233(0.99); C3090(1.18); C3144(1.15); C395(0.88)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C2233(0.91); C3144(1.06); C681(1.02); C3070(0.99)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C2233(0.93); C3090(1.04); C3144(1.06); C395(0.99)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C2233(0.94); C3144(1.05); C395(0.93); C681(0.97)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C2233(1.00); C681(1.02); C3070(0.91); C1811(1.13)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C2233(0.94); C3144(1.00); C681(1.03); C3070(0.93)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C2233(0.90); C3090(0.99); C3144(0.95); C395(1.05)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C2233(0.94); C3144(0.94); C395(0.98); C681(0.96)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C2233(1.05); C681(0.92); C3070(0.88); C1811(1.11)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C2233(0.96); C3144(1.11); C681(1.10); C3070(1.14)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C2233(0.94); C3090(1.00); C3144(0.97); C395(1.12)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C2233(1.04); C3144(0.85); C395(0.97); C681(0.94)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C2233(0.92); C3144(1.06); C395(0.96); C681(0.93)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C2233(1.10); C681(0.99); C3070(0.95); C1811(1.11)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C2233(0.96); C3144(1.17); C681(1.03); C3070(1.05)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C2233(0.99); C3090(1.08); C3144(1.01); C395(1.02)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C2233(0.94); C3144(1.00); C395(0.94); C681(0.97)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C2233(0.99); C681(0.97); C3070(0.95); C1811(1.18)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C2233(0.92); C3144(1.11); C681(0.98); C3070(1.04)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C2233(0.98); C3090(1.12); C3144(1.17); C395(1.20)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C2233(0.96); C3144(1.67); C395(1.03); C681(1.05)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C2233(1.08); C681(1.00); C3070(0.94); C1811(1.05)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C2233(1.02); C3144(1.20); C681(1.19); C3070(1.07)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C2233(0.97); C3144(1.16); C681(1.12); C3070(1.07)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C2233(0.93); C3090(1.05); C3144(0.99); C395(1.05)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C2233(0.96); C3144(1.12); C395(1.06); C681(0.95)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C2233(0.93); C681(0.96); C3070(0.86); C1811(1.08)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C2233(0.91); C3144(1.08); C681(1.02); C3070(1.01)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C2233(0.92); C3090(0.96); C3144(1.05); C395(1.11)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C2233(0.96); C3144(1.05); C395(1.14); C681(1.08)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C2233(0.96); C681(1.02); C3070(0.91); C1811(0.92)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C2233(0.97); C3144(1.04); C681(1.05); C3070(0.99)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C2233(0.99); C3090(0.93); C3144(1.03); C395(1.06)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C2233(1.02); C3144(1.36); C395(1.09); C681(0.95)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C2233(1.03); C681(1.05); C3070(0.97); C1811(1.42)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C2233(0.99); C3144(1.15); C681(1.10); C3070(1.01)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C2233(0.85); C3144(1.05); C395(0.97); C681(0.93)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C2233(1.00); C3144(1.13); C395(1.00); C681(1.02)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C2233(1.05); C3090(1.38); C3144(1.11); C395(1.15)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C2233(1.06); C3144(1.04); C395(0.99); C681(0.95)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C2233(1.04); C3144(1.08); C395(1.04); C681(0.94)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C2233(1.11); C3090(1.31); C3144(0.83); C395(0.95)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C2233(1.13); C3090(1.40); C3144(1.03); C395(1.34)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C2233(1.19); C3144(0.88); C395(1.33); C681(1.17)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C2233(1.25); C3144(1.04); C681(1.13); C3070(0.99)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C2233(0.91); C3090(1.04); C3144(0.89); C395(0.84)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C2233(1.07); C3144(1.07); C395(1.13); C681(1.00)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C2233(1.03); C681(1.02); C3070(0.91); C1811(1.20)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C2233(0.92); C3144(1.12); C681(1.07); C3070(0.98)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C2233(1.11); C3144(1.05); C395(1.17); C681(1.05)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C2233(1.04); C681(0.88); C3070(0.89); C1811(1.27)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C2233(1.06); C3144(1.17); C395(1.03); C681(0.94)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C2233(1.01); C3090(1.24); C3144(1.00); C395(1.06)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C2233(1.04); C3144(0.99); C395(1.04); C681(0.93)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C2233(1.00); C3090(1.30); C3144(0.64); C395(0.98)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C2233(1.05); C3090(1.29); C3144(1.06); C395(1.03)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C2233(1.21); C3144(0.85); C395(1.07); C681(1.08)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C2233(1.10); C3144(1.08); C681(1.20); C3070(1.04)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C2233(0.94); C3090(1.04); C3144(1.02); C395(1.21)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C2233(1.05); C681(0.99); C3070(0.83); C1811(1.11)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C2233(0.91); C3144(1.14); C681(0.97); C3070(1.01)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C2233(1.00); C3144(0.92); C681(1.02); C3070(1.08)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C2233(0.98); C3144(1.18); C395(1.03); C681(1.09)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C2233(1.07); C3144(0.95); C395(1.11); C681(1.03)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C2233(1.02); C3090(1.31); C3144(0.93); C395(1.01)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C2233(1.11); C3144(0.97); C395(1.14); C681(1.05)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C2233(1.04); C3090(1.24); C3144(0.75); C395(1.04)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C2233(1.13); C3090(1.38); C3144(1.05); C395(1.19)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C2233(1.24); C3144(0.82); C395(0.97); C681(1.12)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C2233(1.40); C3144(1.28); C681(1.14); C3070(1.00)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C2233(0.97); C3090(1.06); C3144(1.10); C395(1.18)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C2233(0.92); C3144(1.11); C395(1.08); C681(0.96)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C2233(1.04); C3144(1.36); C395(1.07); C681(1.01)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C2233(0.83); C3144(1.01); C681(1.09); C3070(1.09)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C2233(0.94); C3144(1.16); C395(1.09); C681(1.04)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C2233(0.94); C3144(1.06); C395(1.10); C681(0.91)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C2233(1.07); C3090(1.31); C3144(1.03); C395(1.09)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C2233(1.02); C3144(1.04); C395(0.96); C681(1.04)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C2233(1.11); C3090(1.18); C3144(0.83); C395(1.04)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C2233(1.13); C3090(1.26); C3144(0.99); C395(1.17)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C2233(1.18); C3144(0.85); C395(1.19); C681(1.13)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C2233(1.02); C3144(1.28); C395(0.95); C681(0.91)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C2233(1.31); C3144(1.11); C681(1.15); C3070(0.93)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C2233(1.01); C3090(1.07); C3144(0.98); C395(0.94)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C2233(1.03); C3144(1.32); C395(1.10); C681(0.96)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C2233(0.97); C681(1.00); C3070(0.97); C1811(1.15)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C2233(0.91); C3144(1.11); C681(0.97); C3070(1.02)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C2233(1.12); C3144(1.22); C395(1.11); C681(0.94)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C2233(0.97); C3144(1.17); C395(1.09); C681(0.95)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C2233(1.06); C3090(1.23); C3144(0.99); C395(1.10)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C2233(1.06); C3144(0.90); C395(0.91); C681(1.00)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C2233(1.10); C3090(1.31); C3144(0.71); C395(1.04)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C2233(1.12); C3090(1.25); C3144(1.06); C395(1.02)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C2233(1.11); C3090(1.32); C3144(1.07); C395(1.06)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C2233(1.21); C3144(0.77); C395(0.97); C681(0.98)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C2233(1.19); C3144(1.09); C681(1.06); C3070(1.05)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C2233(0.96); C3090(0.91); C3144(1.02); C395(0.91)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C2233(1.07); C3144(1.14); C395(1.06); C681(0.99)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C2233(0.95); C3144(1.05); C681(0.96); C3070(0.91)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C2233(0.98); C3144(0.98); C395(1.04); C681(0.93)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C2233(1.04); C3144(1.13); C395(1.14); C681(1.05)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C2233(1.05); C3090(1.29); C3144(1.06); C395(1.07)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C2233(0.87); C3144(1.12); C395(0.85); C681(0.97)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C2233(1.08); C3144(1.03); C395(1.01); C681(1.04)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C2233(1.11); C3090(1.22); C3144(0.81); C395(1.18)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C2233(1.06); C3090(1.19); C3144(1.00); C395(1.11)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C2233(1.11); C3144(0.80); C395(0.80); C681(1.03)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C2233(1.11); C3144(0.94); C681(0.98); C3070(1.05)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C2233(0.98); C3090(1.05); C3144(1.04); C395(1.11)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C2233(1.03); C3144(1.26); C395(1.03); C681(0.96)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C2233(1.05); C681(0.90); C3070(0.86); C1811(0.94)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C2233(0.91); C3144(1.10); C681(1.09); C3070(1.03)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C2233(0.95); C3144(1.01); C395(1.23); C681(0.90)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C2233(1.20); C3090(1.24); C3144(0.81); C395(1.04)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C2233(0.89); C3144(1.06); C395(0.75); C681(1.01)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C2233(1.08); C3090(1.25); C3144(1.09); C395(1.05)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C2233(0.95); C3144(1.00); C395(0.94); C681(1.04)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C2233(1.06); C3090(1.17); C3144(0.87); C395(1.07)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C2233(1.06); C3090(1.28); C3144(1.02); C395(1.22)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C2233(0.92); C3144(0.82); C395(1.02); C681(0.92)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C2233(1.06); C3144(0.93); C681(1.01); C3070(1.00)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C2233(0.93); C3090(0.90); C3144(1.13); C395(0.93)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C2233(0.93); C3144(1.14); C395(0.98); C681(0.98)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C2233(1.02); C681(1.05); C3070(0.89); C1811(0.94)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C2233(1.10); C681(0.99); C3070(0.88); C1811(1.12)  LDD1698  [22]
 LDCM0203  EV-96 T cell C3197, C3213(20.00)  LDD0523  [23]
 LDCM0204  EV-97 T cell C3197, C3213(4.79)  LDD0525  [23]
 LDCM0468  Fragment33 HEK-293T C2233(1.05); C681(0.90); C3070(0.85); C1811(1.09)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C2233(1.01); C3144(1.15); C395(1.08); C681(1.02)  LDD1631  [22]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C1811(0.80); C2233(0.96); C2279(1.04); C395(0.94)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C1811(1.09); C2233(0.97); C2279(0.99); C395(0.97)  LDD1497  [22]
 LDCM0024  KB05 G361 C980(1.48)  LDD3311  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C2233(0.71)  LDD2099  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C2233(0.38)  LDD2104  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C2233(0.87)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2233(0.67)  LDD2140  [6]
 LDCM0099  Phenelzine MDA-MB-231 11.00  LDD0392  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Profilin-2 (PFN2) Profilin family P35080

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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