Details of the Target

General Information of Target

Target ID LDTP00310
Target Name Syntenin-1 (SDCBP)
Gene Name SDCBP
Gene ID 6386
Synonyms
MDA9; SYCL; Syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLS
LNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKD
QDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQ
AFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICE
INGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV
Target Bioclass
Transporter and channel
Subcellular location
Cell junction, focal adhesion
Function
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Uniprot ID
O00560
Ensemble ID
ENST00000260130.9
HGNC ID
HGNC:10662
ChEMBL ID
CHEMBL4739667

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.I136M .
SKMEL3 SNV: p.M1? .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBPP2
 Probe Info  		2.03  LDD0324  [2]
STPyne
 Probe Info  		K109(9.84); K124(1.35); K176(4.96); K179(6.38)  LDD0277  [3]
ONAyne
 Probe Info  		K109(0.83)  LDD0275  [3]
OPA-S-S-alkyne
 Probe Info  		K124(1.60); K223(2.46); K109(5.45)  LDD3494  [4]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0392  [5]
BTD
 Probe Info  		C239(0.23)  LDD2096  [6]
Jackson_14
 Probe Info  		2.04  LDD0123  [7]
AHL-Pu-1
 Probe Info  		C118(2.98)  LDD0169  [8]
HHS-475
 Probe Info  		Y50(0.82); Y46(1.34)  LDD0264  [9]
DBIA
 Probe Info  		C166(0.96)  LDD0531  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C166(0.00); C239(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C166(0.00); C239(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C118(0.00); C166(0.00); C239(0.00)  LDD0037  [12]
IPM
 Probe Info  		N.A.  LDD0025  [14]
NHS
 Probe Info  		N.A.  LDD0010  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
MPP-AC
 Probe Info  		N.A.  LDD0428  [18]
NAIA_5
 Probe Info  		C118(0.00); C166(0.00); C239(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		N.A.  LDD2240  [20]
PAL-AfBPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.62  LDD1714  [21]
C134
 Probe Info  		22.32  LDD1816  [21]
C135
 Probe Info  		10.34  LDD1817  [21]
C140
 Probe Info  		8.28  LDD1822  [21]
C170
 Probe Info  		15.67  LDD1850  [21]
C208
 Probe Info  		10.20  LDD1883  [21]
C210
 Probe Info  		47.84  LDD1884  [21]
C211
 Probe Info  		12.73  LDD1885  [21]
C212
 Probe Info  		5.50  LDD1886  [21]
C213
 Probe Info  		24.25  LDD1887  [21]
C293
 Probe Info  		23.92  LDD1963  [21]
C296
 Probe Info  		16.00  LDD1966  [21]
C310
 Probe Info  		14.52  LDD1977  [21]
FFF probe11
 Probe Info  		15.18  LDD0471  [22]
FFF probe12
 Probe Info  		20.00  LDD0473  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe15
 Probe Info  		11.63  LDD0478  [22]
FFF probe2
 Probe Info  		12.39  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe9
 Probe Info  		19.27  LDD0470  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
OEA-DA
 Probe Info  		20.00  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C118(2.98)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C166(0.96)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C166(0.71)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C166(1.45)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C166(1.12)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C166(1.14)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C166(1.13)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C166(0.98)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C166(1.33)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C166(1.21)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C166(1.18)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C166(1.22)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C166(1.33)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C166(0.83)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C166(1.09)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C166(0.95)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C166(0.93)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C166(0.93)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C166(0.77)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C166(0.71)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C166(0.91)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C166(0.81)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C166(0.84)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C166(0.73)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C166(0.86)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C166(0.79)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C166(0.94)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C166(0.77)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C166(0.89)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C166(0.98)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C166(0.77)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C166(0.93)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C166(0.83)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C166(1.07)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C166(1.23)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C166(1.11)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C166(1.14)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C166(1.13)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C166(0.90)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C166(0.91)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C166(1.07)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C166(0.96)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C166(0.94)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C166(0.82)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C166(0.95)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C166(0.77)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C166(0.86)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C166(0.95)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C166(0.96)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C166(1.05)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C166(0.91)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C166(0.85)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C166(0.89)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C166(0.65)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C166(0.96)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C166(0.84)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C166(0.84)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C166(0.99)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C166(0.78)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C166(0.65)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C166(0.86)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C166(0.72)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C166(0.87)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C166(1.33)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C166(1.11)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C166(1.15)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C166(1.08)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C166(1.07)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C166(0.83)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C166(1.04)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C166(1.09)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C166(0.95)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C166(0.94)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C166(1.18)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C166(0.83)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C166(0.69)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C166(0.93)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C166(1.01)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C166(0.66)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C166(0.84)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C166(1.14)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C166(0.76)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C166(0.65)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C166(0.78)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C166(0.72)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C166(1.20)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C166(0.89)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C166(0.96)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C166(0.98)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C166(1.01)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C166(0.95)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C166(0.88)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C166(0.76)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C166(0.84)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C166(0.76)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C166(0.80)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C166(0.76)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C166(0.96)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C166(0.86)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C166(0.90)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C166(0.78)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C166(0.87)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C166(0.76)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C166(0.98)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C166(0.94)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C166(0.86)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C166(0.82)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C166(0.82)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C166(0.76)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C166(0.74)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C166(0.82)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C166(0.69)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C166(0.70)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C166(0.60)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C166(0.82)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C166(0.63)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C166(0.65)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C166(0.55)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C166(0.63)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C166(0.77)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C166(0.58)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C166(0.83)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C166(0.85)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C166(0.78)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C166(0.81)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C166(0.96)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C166(0.88)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C166(0.81)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C166(0.85)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C166(0.79)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C166(1.00)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C166(0.90)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C166(0.97)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C166(0.95)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C166(0.76)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C166(1.00)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C166(1.01)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C166(0.76)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C166(0.90)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C166(0.79)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C166(0.88)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C166(1.10)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C166(1.29)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C166(1.19)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C166(0.98)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C166(1.85)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C166(0.97)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C166(0.87)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C166(0.90)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C166(1.05)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C166(1.05)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C166(1.12)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C166(0.87)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C166(1.04)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C166(1.12)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C166(0.97)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C166(0.83)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C166(0.70)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 13.11  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C118(8.60)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C166(0.97)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C166(0.84)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C166(0.93)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C166(0.77)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C166(0.84)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C166(1.03)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C166(1.01)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C166(1.23)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C166(1.46)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C166(1.09)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C166(1.23)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C166(1.06)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C166(0.80)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C166(1.29)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C166(0.97)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C166(1.01)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C166(0.72)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C166(0.64)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C166(0.68)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C166(0.76)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C166(1.02)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C166(0.94)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C166(0.85)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C166(1.01)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C166(0.79)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C166(0.69)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C166(0.80)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C166(1.06)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C166(0.83)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C166(0.99)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C166(0.69)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C166(0.72)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C166(0.80)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C166(0.86)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C166(0.79)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C166(0.94)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C166(0.79)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C166(0.71)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C166(0.74)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C166(0.74)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C166(0.71)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C166(0.72)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C166(0.86)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C166(0.69)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C166(0.70)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C166(0.75)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C166(0.75)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C166(0.66)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C166(0.80)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C166(0.67)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C166(0.84)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C166(0.74)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C166(0.85)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C166(0.92)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C166(0.70)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C166(1.00)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C166(0.67)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C166(0.71)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C166(0.78)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C166(0.74)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C166(0.87)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C166(1.05)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C166(0.76)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C166(0.76)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C166(0.73)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C166(0.69)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C166(0.75)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C166(0.75)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C166(0.99)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C166(0.79)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C166(1.04)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C166(1.38)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C166(0.90)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C166(1.27)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C166(1.25)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C166(1.04)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C166(1.00)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C166(1.68)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C166(1.21)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C166(0.95)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C166(0.91)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C166(1.06)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C166(1.12)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C166(0.66)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C166(1.26)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C166(0.67)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C166(0.80)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C166(0.64)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C166(0.79)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C166(0.87)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C166(0.59)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C166(0.99)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C166(0.64)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C166(0.69)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C166(0.88)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C166(0.59)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C166(0.59)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C166(0.63)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C166(0.66)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C166(0.69)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C166(0.90)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C166(0.77)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C166(0.82)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C166(1.01)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C166(0.82)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C166(1.25)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C166(1.00)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C166(1.11)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C166(0.75)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C166(0.80)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C166(0.73)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C166(0.71)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C166(0.81)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C166(0.77)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C166(1.06)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C166(0.88)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C166(0.83)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C166(0.84)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C166(1.00)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C166(1.15)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C166(1.03)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C166(0.89)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C166(1.01)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C166(0.83)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C166(0.76)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C166(0.79)  LDD0811  [10]
 LDCM0185  Compound 17 HEK-293T 6.62  LDD0512  [22]
 LDCM0184  Compound 20 HEK-293T 12.82  LDD0503  [22]
 LDCM0191  Compound 21 HEK-293T 9.43  LDD0508  [22]
 LDCM0186  Compound 31 HEK-293T 8.58  LDD0506  [22]
 LDCM0188  Compound 33 HEK-293T 5.10  LDD0505  [22]
 LDCM0190  Compound 34 HEK-293T 9.39  LDD0510  [22]
 LDCM0192  Compound 35 HEK-293T 9.71  LDD0509  [22]
 LDCM0193  Compound 36 HEK-293T 12.12  LDD0511  [22]
 LDCM0468  Fragment33 HCT 116 C166(0.65)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C166(0.78)  LDD0744  [10]
 LDCM0116  HHS-0101 DM93 Y50(0.82); Y46(1.34)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y46(0.98); Y50(1.43)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y46(1.10); Y50(1.20)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y46(0.83); Y50(1.21)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y50(1.36); Y46(1.64)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C166(0.83)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C166(1.02)  LDD1497  [24]
 LDCM0024  KB05 MKN45 C166(2.67)  LDD3332  [25]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C239(0.23)  LDD2096  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C239(1.12)  LDD2099  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C239(0.41)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C239(1.11)  LDD2107  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C239(0.45)  LDD2118  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C239(0.58)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C239(0.97)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C239(0.40)  LDD2124  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C239(1.00)  LDD2143  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C239(0.51)  LDD2145  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C118(3.59)  LDD2149  [6]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0392  [5]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.04  LDD0123  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 59 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytosolic purine 5'-nucleotidase (NT5C2) 5'(3')-deoxyribonucleotidase family P49902
26S proteasome regulatory subunit 10B (PSMC6) AAA ATPase family P62333
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Methylthioribulose-1-phosphate dehydratase (APIP) Aldolase class II family Q96GX9
DNA-directed RNA polymerase II subunit RPB11-a (POLR2J) Archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family P52435
DNA-directed RNA polymerase III subunit RPC10 (POLR3K) Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family Q9Y2Y1
Poly [ADP-ribose] polymerase tankyrase-1 (TNKS) ARTD/PARP family O95271
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Cytidine deaminase (CDA) Cytidine and deoxycytidylate deaminase family P32320
Deoxycytidylate deaminase (DCTD) Cytidine and deoxycytidylate deaminase family P32321
Choline-phosphate cytidylyltransferase A (PCYT1A) Cytidylyltransferase family P49585
Spliceosome RNA helicase DDX39B (DDX39B) DEAD box helicase family Q13838
Triokinase/FMN cyclase (TKFC) Dihydroxyacetone kinase (DAK) family Q3LXA3
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) ENOX family Q8TC92
N-acetyl-D-glucosamine kinase (NAGK) Eukaryotic-type N-acetylglucosamine kinase family Q9UJ70
Geranylgeranyl pyrophosphate synthase (GGPS1) FPP/GGPP synthase family O95749
Vesicle transport protein GOT1B (GOLT1B) GOT1 family Q9Y3E0
Glutaredoxin domain-containing cysteine-rich protein 1 (GRXCR1) GRXCR1 family A8MXD5
L-lactate dehydrogenase B chain (LDHB) LDH family P07195
Protein-cysteine N-palmitoyltransferase HHAT (HHAT) Membrane-bound acyltransferase family Q5VTY9
Ubiquitin carboxyl-terminal hydrolase MINDY-3 (MINDY3) MINDY deubiquitinase family Q9H8M7
FAD synthase (FLAD1) MoaB/Mog family; PAPS reductase family Q8NFF5
NAD kinase (NADK) NAD kinase family O95544
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Proteasome subunit beta type-3 (PSMB3) Peptidase T1B family P49720
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) Pterin-4-alpha-carbinolamine dehydratase family P61457
6-pyruvoyl tetrahydrobiopterin synthase (PTS) PTPS family Q03393
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) Purine/pyrimidine phosphoribosyltransferase family P00492
Pyrroline-5-carboxylate reductase 3 (PYCR3) Pyrroline-5-carboxylate reductase family Q53H96
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) Ribonucleoside diphosphate reductase small chain family P31350
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
Exosome complex component RRP41 (EXOSC4) RNase PH family Q9NPD3
Carbonyl reductase [NADPH] 3 (CBR3) Short-chain dehydrogenases/reductases (SDR) family O75828
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Probable global transcription activator SNF2L2 (SMARCA2) SNF2/RAD54 helicase family P51531
Sulfotransferase 1B1 (SULT1B1) Sulfotransferase 1 family O43704
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570
Neuronal-specific septin-3 (SEPTIN3) Septin GTPase family Q9UH03
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
Translin (TSN) Translin family Q15631
E3 ubiquitin-protein ligase TRIM32 (TRIM32) TRIM/RBCC family Q13049
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Probable tRNA(His) guanylyltransferase (THG1L) TRNA(His) guanylyltransferase family Q9NWX6
Tryptophan 2,3-dioxygenase (TDO2) Tryptophan 2,3-dioxygenase family P48775
Ubiquitin-conjugating enzyme E2 A (UBE2A) Ubiquitin-conjugating enzyme family P49459
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Ubiquitin-conjugating enzyme E2 R1 (CDC34) Ubiquitin-conjugating enzyme family P49427
Ubiquitin-conjugating enzyme E2 R2 (UBE2R2) Ubiquitin-conjugating enzyme family Q712K3
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
dCTP pyrophosphatase 1 (DCTPP1) . Q9H773
E3 ubiquitin-protein ligase makorin-1 (MKRN1) . Q9UHC7
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
E3 ubiquitin-protein ligase TRIM38 (TRIM38) . O00635
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (SSC5D) . A1L4H1
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-2 (CAV2) Caveolin family P51636
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Copper homeostasis protein cutC homolog (CUTC) CutC family Q9NTM9
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) Cytochrome c oxidase IV family P13073
Derlin-3 (DERL3) Derlin family Q96Q80
Receptor expression-enhancing protein 6 (REEP6) DP1 family Q96HR9
Eukaryotic translation initiation factor 5A-1 (EIF5A) EIF-5A family P63241
Eukaryotic translation initiation factor 5A-2 (EIF5A2) EIF-5A family Q9GZV4
Huntingtin (HTT) Huntingtin family P42858
Inward rectifier potassium channel 2 (KCNJ2) Inward rectifier-type potassium channel family P63252
Potassium voltage-gated channel subfamily H member 1 (KCNH1) Potassium channel family O95259
Protein S100-B (S100B) S-100 family P04271
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Sugar transporter SWEET1 (SLC50A1) SWEET sugar transporter family Q9BRV3
Alpha-synuclein (SNCA) Synuclein family P37840
Transmembrane protein 17 (TMEM17) TMEM17 family Q86X19
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Kelch-like protein 2 (KLHL2) . O95198
Optineurin (OPTN) . Q96CV9
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Syntenin-1 (SDCBP) . O00560
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A7 (HOXA7) Antp homeobox family P31268
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
High mobility group protein B3 (HMGB3) HMGB family O15347
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) Krueppel C2H2-type zinc-finger protein family Q3MJ62
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 485 (ZNF485) Krueppel C2H2-type zinc-finger protein family Q8NCK3
Zinc finger protein 660 (ZNF660) Krueppel C2H2-type zinc-finger protein family Q6AZW8
Zinc finger protein 768 (ZNF768) Krueppel C2H2-type zinc-finger protein family Q9H5H4
Leucine zipper transcription factor-like protein 1 (LZTFL1) LZTFL1 family Q9NQ48
Dr1-associated corepressor (DRAP1) NC2 alpha/DRAP1 family Q14919
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
DNA-binding protein inhibitor ID-3 (ID3) . Q02535
Forkhead box protein P2 (FOXP2) . O15409
Homeobox protein MOX-1 (MEOX1) . P50221
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 21 (TCF21) . O43680
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nectin-1 (NECTIN1) Nectin family Q15223
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Interleukin-5 receptor subunit alpha (IL5RA) Type I cytokine receptor family Q01344
Other
Click To Hide/Show 136 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) ANP32 family Q92688
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Ataxin-1 (ATXN1) ATXN1 family P54253
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Cancer/testis antigen family 45 member A1 (CT45A1) CT45 family Q5HYN5
Cancer/testis antigen family 45 member A10 (CT45A10) CT45 family P0DMU9
Cancer/testis antigen family 45 member A3 (CT45A3) CT45 family Q8NHU0
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172
Dysbindin (DTNBP1) Dysbindin family Q96EV8
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Large ribosomal subunit protein eL22 (RPL22) Eukaryotic ribosomal protein eL22 family P35268
Small ribosomal subunit protein eS26 (RPS26) Eukaryotic ribosomal protein eS26 family P62854
Protein FAM118A (FAM118A) FAM118 family Q9NWS6
Protein FAM118B (FAM118B) FAM118 family Q9BPY3
Retrotransposon Gag-like protein 8B (RTL8B) FAM127 family Q17RB0
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Ferritin light chain (FTL) Ferritin family P02792
Golgi to ER traffic protein 4 homolog (GET4) GET4 family Q7L5D6
G kinase-anchoring protein 1 (GKAP1) GKAP1 family Q5VSY0
G patch domain-containing protein 11 (GPATCH11) GPATCH11 family Q8N954
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Heat shock factor-binding protein 1 (HSBP1) HSBP1 family O75506
Checkpoint protein HUS1 (HUS1) HUS1 family O60921
Keratin, type I cytoskeletal 14 (KRT14) Intermediate filament family P02533
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 1-5 (KRTAP1-5) KRTAP type 1 family Q9BYS1
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
LIM domain-binding protein 2 (LDB2) LDB family O43679
Protein LDOC1 (LDOC1) LDOC1 family O95751
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) MAD2 family Q13257
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NEDD4-binding protein 3 (N4BP3) N4BP3 family O15049
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Protein SET (SET) Nucleosome assembly protein (NAP) family Q01105
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Odontogenic ameloblast-associated protein (ODAM) ODAM family A1E959
Proteasome activator complex subunit 2 (PSME2) PA28 family Q9UL46
Oncomodulin-1 (OCM) Parvalbumin family P0CE72
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Pre-mRNA-splicing factor 38A (PRPF38A) PRP38 family Q8NAV1
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
Protein reprimo (RPRM) Reprimo family Q9NS64
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
ELAV-like protein 1 (ELAVL1) RRM elav family Q15717
Poly(U)-binding-splicing factor PUF60 (PUF60) RRM half pint family Q9UHX1
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Ribosome biogenesis regulatory protein homolog (RRS1) RRS1 family Q15050
RUN domain-containing protein 3A (RUNDC3A) RUNDC3 family Q59EK9
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Charged multivesicular body protein 1a (CHMP1A) SNF7 family Q9HD42
U6 snRNA-associated Sm-like protein LSm6 (LSM6) SnRNP Sm proteins family P62312
Sperm protein associated with the nucleus on the X chromosome N3 (SPANXN3) SPAN-X family Q5MJ09
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Serine/arginine-rich splicing factor 11 (SRSF11) Splicing factor SR family Q05519
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Serine/arginine-rich splicing factor 7 (SRSF7) Splicing factor SR family Q16629
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
Synaptophysin-like protein 1 (SYPL1) Synaptophysin/synaptobrevin family Q16563
Protein SYS1 homolog (SYS1) SYS1 family Q8N2H4
Tektin-1 (TEKT1) Tektin family Q969V4
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) TNFAIP8 family O95379
Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNFAIP8L3) TNFAIP8 family Q5GJ75
Activated RNA polymerase II transcriptional coactivator p15 (SUB1) Transcriptional coactivator PC4 family P53999
Polyubiquitin-B (UBB) Ubiquitin family P0CG47
UPF0696 protein C11orf68 (C11orf68) UPF0696 family Q9H3H3
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Protein YIF1A (YIF1A) YIF1 family O95070
Actin nucleation-promoting factor WASL (WASL) . O00401
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Ankyrin repeat domain-containing protein 40 (ANKRD40) . Q6AI12
Arfaptin-2 (ARFIP2) . P53365
Bcl-2-like protein 15 (BCL2L15) . Q5TBC7
BTB/POZ domain-containing protein KCTD1 (KCTD1) . Q719H9
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Calcium-binding protein 5 (CABP5) . Q9NP86
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 106 (CCDC106) . Q9BWC9
CUB domain-containing protein 1 (CDCP1) . Q9H5V8
Ectodysplasin-A receptor-associated adapter protein (EDARADD) . Q8WWZ3
EMILIN-3 (EMILIN3) . Q9NT22
FAS-associated death domain protein (FADD) . Q13158
Four and a half LIM domains protein 3 (FHL3) . Q13643
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Galectin-2 (LGALS2) . P05162
Glutamate-rich protein 2 (ERICH2) . A1L162
Heat shock factor 2-binding protein (HSF2BP) . O75031
INO80 complex subunit E (INO80E) . Q8NBZ0
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
KATNB1-like protein 1 (KATNBL1) . Q9H079
Kelch-like protein 12 (KLHL12) . Q53G59
Leucine rich adaptor protein 1-like (LURAP1L) . Q8IV03
Methyl-CpG-binding domain protein 3 (MBD3) . O95983
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Myomegalin (PDE4DIP) . Q5VU43
Osteoclast-stimulating factor 1 (OSTF1) . Q92882
PDZ and LIM domain protein 4 (PDLIM4) . P50479
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
PHD finger protein 11 (PHF11) . Q9UIL8
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Proline-rich protein 13 (PRR13) . Q9NZ81
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Protein SREK1IP1 (SREK1IP1) . Q8N9Q2
Retinitis pigmentosa 9 protein (RP9) . Q8TA86
Ribonuclease inhibitor (RNH1) . P13489
RING finger protein 11 (RNF11) . Q9Y3C5
Secretogranin-3 (SCG3) . Q8WXD2
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Transmembrane and coiled-coil domain-containing protein 2 (TMCO2) . Q7Z6W1
Transmembrane protein 239 (TMEM239) . Q8WW34
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6
Zinc finger CCHC domain-containing protein 17 (ZCCHC17) . Q9NP64
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840