Details of the Target

General Information of Target

Target ID LDTP05793
Target Name Methanethiol oxidase (SELENBP1)
Gene Name SELENBP1
Gene ID 8991
Synonyms
SBP; Methanethiol oxidase; MTO; EC 1.8.3.4; 56 kDa selenium-binding protein; SBP56; SP56; Selenium-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVI
HRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHK
VIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERP
GGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPADVEAGLYGSHLYVWDWQRHEIVQ
TLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKNEGGTWSVEKVIQVPPKKVKG
WLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGP
VQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIRE
GSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI
Target Bioclass
Enzyme
Family
Selenium-binding protein family
Subcellular location
Nucleus
Function
Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
Uniprot ID
Q13228
Ensemble ID
ENST00000368868.10
HGNC ID
HGNC:10719

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P Deletion: p.D445TfsTer? .
Ishikawa (Heraklio) 02 ER SNV: p.M1? .
RPMI7951 SNV: p.A40D .
SKOV3 SNV: p.S354R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		3.00  LDD0390  [1]
IPM
 Probe Info  		C31(4.94)  LDD1701  [2]
Acrolein
 Probe Info  		C268(0.00); C31(0.00)  LDD0221  [3]
DBIA
 Probe Info  		C5(2.76); C8(2.20)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [5]
NAIA_5
 Probe Info  		C31(0.00); C268(0.00); C57(0.00); C466(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C5(1.32)  LDD1509  [7]
 LDCM0278  AC19 HEK-293T C5(1.13)  LDD1517  [7]
 LDCM0287  AC27 HEK-293T C5(1.31)  LDD1526  [7]
 LDCM0290  AC3 HEK-293T C5(1.18)  LDD1529  [7]
 LDCM0296  AC35 HEK-293T C5(1.33)  LDD1535  [7]
 LDCM0305  AC43 HEK-293T C5(1.32)  LDD1544  [7]
 LDCM0314  AC51 HEK-293T C5(1.46)  LDD1553  [7]
 LDCM0322  AC59 HEK-293T C5(1.30)  LDD1561  [7]
 LDCM0108  Chloroacetamide HeLa C268(0.00); C31(0.00); C57(0.00)  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C5(0.57)  LDD2227  [6]
 LDCM0406  CL19 HEK-293T C5(1.29)  LDD1610  [7]
 LDCM0420  CL31 HEK-293T C5(1.39)  LDD1624  [7]
 LDCM0433  CL43 HEK-293T C5(1.24)  LDD1637  [7]
 LDCM0446  CL55 HEK-293T C5(1.36)  LDD1649  [7]
 LDCM0459  CL67 HEK-293T C5(1.22)  LDD1662  [7]
 LDCM0462  CL7 HEK-293T C5(1.26)  LDD1665  [7]
 LDCM0472  CL79 HEK-293T C5(1.24)  LDD1675  [7]
 LDCM0486  CL91 HEK-293T C5(1.19)  LDD1689  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C31(2.04)  LDD1702  [2]
 LDCM0107  IAA HeLa C268(0.00); C31(0.00)  LDD0221  [3]
 LDCM0022  KB02 HCT 116 C5(2.76); C8(2.20)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C5(1.11); C8(1.17)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C5(2.09); C8(1.73)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0390  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Mitochondrial peptide methionine sulfoxide reductase (MSRA) MsrA Met sulfoxide reductase family Q9UJ68
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
52 kDa repressor of the inhibitor of the protein kinase (THAP12) . O43422

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402