Details of the Target

General Information of Target

Target ID LDTP02215
Target Name Prosaposin (PSAP)
Gene Name PSAP
Gene ID 5660
Synonyms
GLBA; SAP1; Prosaposin; Proactivator polypeptide) [Cleaved into: Saposin-A; Protein A; Saposin-B-Val; Saposin-B; Cerebroside sulfate activator; CSAct; Dispersin; Sphingolipid activator protein 1; SAP-1; Sulfatide/GM1 activator; Saposin-C; A1 activator; Co-beta-glucosidase; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin-D; Component C; Protein C)]
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKS
LPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDI
IKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLY
PQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADI
CKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVE
PIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEV
VDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLD
RNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIG
ACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Target Bioclass
Transporter and channel
Subcellular location
Lysosome; Secreted
Function
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
Uniprot ID
P07602
Ensemble ID
ENST00000394936.8
HGNC ID
HGNC:9498
ChEMBL ID
CHEMBL3580523

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.G195V DBIA    Probe Info 
COLO320 SNV: p.P98S .
NCIH1155 SNV: p.P294H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.41  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		5.00  LDD0391  [2]
FBPP2
 Probe Info  		1,782.93  LDD0318  [3]
Jackson_1
 Probe Info  		13.12  LDD0122  [4]
TH211
 Probe Info  		Y113(20.00); Y418(20.00); Y447(20.00)  LDD0260  [5]
TH216
 Probe Info  		Y113(20.00); Y418(20.00); Y447(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
ONAyne
 Probe Info  		K414(0.93)  LDD0274  [7]
STPyne
 Probe Info  		K290(8.08); K303(9.52); K304(9.03); K37(6.56)  LDD0277  [7]
IPM
 Probe Info  		N.A.  LDD0241  [8]
Probe 1
 Probe Info  		Y418(14.85)  LDD3495  [9]
P11
 Probe Info  		20.00  LDD0201  [10]
Alkylaryl probe 1
 Probe Info  		3.00  LDD0386  [2]
Alkylaryl probe 3
 Probe Info  		4.04  LDD0384  [2]
DBIA
 Probe Info  		C33(5.73); C241(2.90); C42(5.31)  LDD3310  [11]
BTD
 Probe Info  		C412(1.02); C42(0.92); C482(0.93)  LDD2097  [12]
Jackson_14
 Probe Info  		4.35  LDD0123  [4]
HHS-475
 Probe Info  		Y447(0.66); Y113(2.73)  LDD0264  [13]
Acrolein
 Probe Info  		N.A.  LDD0221  [14]
5E-2FA
 Probe Info  		H486(0.00); H399(0.00); H305(0.00)  LDD2235  [15]
CY-1
 Probe Info  		K55(0.00); W53(0.00)  LDD0246  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C440(0.00); C33(0.00); C48(0.00); C482(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C440(0.00); C33(0.00); C48(0.00); C482(0.00)  LDD0036  [17]
Lodoacetamide azide
 Probe Info  		C440(0.00); C33(0.00); C48(0.00); C482(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
SF
 Probe Info  		N.A.  LDD0028  [20]
TFBX
 Probe Info  		N.A.  LDD0148  [21]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		C409(0.00); C271(0.00); C346(0.00); C48(0.00)  LDD2223  [23]
HHS-482
 Probe Info  		Y447(0.78)  LDD2239  [24]
PAL-AfBPP Probe
Click To Hide/Show 153 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		7.31  LDD1711  [25]
C004
 Probe Info  		15.14  LDD1714  [25]
C007
 Probe Info  		5.50  LDD1716  [25]
C022
 Probe Info  		35.51  LDD1728  [25]
C026
 Probe Info  		7.52  LDD1732  [25]
C041
 Probe Info  		6.36  LDD1741  [25]
C045
 Probe Info  		9.45  LDD1744  [25]
C053
 Probe Info  		8.22  LDD1751  [25]
C055
 Probe Info  		12.47  LDD1752  [25]
C056
 Probe Info  		25.81  LDD1753  [25]
C063
 Probe Info  		23.43  LDD1760  [25]
C064
 Probe Info  		8.11  LDD1761  [25]
C067
 Probe Info  		6.82  LDD1763  [25]
C070
 Probe Info  		30.91  LDD1766  [25]
C072
 Probe Info  		10.63  LDD1768  [25]
C073
 Probe Info  		6.45  LDD1769  [25]
C082
 Probe Info  		7.01  LDD1774  [25]
C085
 Probe Info  		5.98  LDD1777  [25]
C087
 Probe Info  		30.70  LDD1779  [25]
C091
 Probe Info  		24.76  LDD1782  [25]
C092
 Probe Info  		36.76  LDD1783  [25]
C100
 Probe Info  		8.06  LDD1789  [25]
C106
 Probe Info  		47.50  LDD1793  [25]
C107
 Probe Info  		11.31  LDD1794  [25]
C108
 Probe Info  		21.41  LDD1795  [25]
C112
 Probe Info  		91.14  LDD1799  [25]
C115
 Probe Info  		12.13  LDD1802  [25]
C117
 Probe Info  		13.93  LDD1804  [25]
C130
 Probe Info  		20.82  LDD1812  [25]
C134
 Probe Info  		45.57  LDD1816  [25]
C135
 Probe Info  		18.64  LDD1817  [25]
C139
 Probe Info  		18.64  LDD1821  [25]
C140
 Probe Info  		14.32  LDD1822  [25]
C141
 Probe Info  		25.99  LDD1823  [25]
C143
 Probe Info  		48.50  LDD1825  [25]
C147
 Probe Info  		8.57  LDD1829  [25]
C149
 Probe Info  		10.06  LDD1830  [25]
C153
 Probe Info  		15.89  LDD1834  [25]
C159
 Probe Info  		14.62  LDD1839  [25]
C160
 Probe Info  		15.03  LDD1840  [25]
C161
 Probe Info  		25.11  LDD1841  [25]
C163
 Probe Info  		11.79  LDD1843  [25]
C164
 Probe Info  		10.20  LDD1844  [25]
C165
 Probe Info  		14.93  LDD1845  [25]
C166
 Probe Info  		7.94  LDD1846  [25]
C169
 Probe Info  		27.67  LDD1849  [25]
C170
 Probe Info  		37.79  LDD1850  [25]
C171
 Probe Info  		13.93  LDD1851  [25]
C177
 Probe Info  		8.11  LDD1856  [25]
C178
 Probe Info  		31.56  LDD1857  [25]
C183
 Probe Info  		5.03  LDD1861  [25]
C186
 Probe Info  		22.16  LDD1864  [25]
C187
 Probe Info  		59.30  LDD1865  [25]
C193
 Probe Info  		5.10  LDD1869  [25]
C194
 Probe Info  		22.32  LDD1870  [25]
C197
 Probe Info  		16.68  LDD1873  [25]
C198
 Probe Info  		15.89  LDD1874  [25]
C201
 Probe Info  		99.73  LDD1877  [25]
C205
 Probe Info  		7.67  LDD1880  [25]
C206
 Probe Info  		42.81  LDD1881  [25]
C208
 Probe Info  		30.70  LDD1883  [25]
C210
 Probe Info  		56.49  LDD1884  [25]
C211
 Probe Info  		25.28  LDD1885  [25]
C212
 Probe Info  		9.51  LDD1886  [25]
C213
 Probe Info  		43.11  LDD1887  [25]
C218
 Probe Info  		15.89  LDD1892  [25]
C219
 Probe Info  		8.28  LDD1893  [25]
C220
 Probe Info  		46.53  LDD1894  [25]
C221
 Probe Info  		15.14  LDD1895  [25]
C223
 Probe Info  		22.63  LDD1897  [25]
C225
 Probe Info  		12.91  LDD1898  [25]
C226
 Probe Info  		11.71  LDD1899  [25]
C228
 Probe Info  		37.53  LDD1901  [25]
C229
 Probe Info  		15.67  LDD1902  [25]
C231
 Probe Info  		31.12  LDD1904  [25]
C232
 Probe Info  		78.79  LDD1905  [25]
C233
 Probe Info  		24.08  LDD1906  [25]
C234
 Probe Info  		5.78  LDD1907  [25]
C235
 Probe Info  		30.70  LDD1908  [25]
C237
 Probe Info  		15.45  LDD1910  [25]
C240
 Probe Info  		9.58  LDD1913  [25]
C243
 Probe Info  		20.25  LDD1916  [25]
C245
 Probe Info  		5.03  LDD1918  [25]
C246
 Probe Info  		22.32  LDD1919  [25]
C249
 Probe Info  		27.47  LDD1922  [25]
C258
 Probe Info  		5.66  LDD1931  [25]
C264
 Probe Info  		38.32  LDD1935  [25]
C265
 Probe Info  		21.41  LDD1936  [25]
C270
 Probe Info  		7.11  LDD1940  [25]
C277
 Probe Info  		10.06  LDD1947  [25]
C281
 Probe Info  		14.03  LDD1951  [25]
C282
 Probe Info  		16.00  LDD1952  [25]
C284
 Probe Info  		29.24  LDD1954  [25]
C286
 Probe Info  		5.82  LDD1956  [25]
C287
 Probe Info  		19.56  LDD1957  [25]
C288
 Probe Info  		14.52  LDD1958  [25]
C289
 Probe Info  		40.50  LDD1959  [25]
C293
 Probe Info  		20.11  LDD1963  [25]
C296
 Probe Info  		18.51  LDD1966  [25]
C299
 Probe Info  		13.55  LDD1968  [25]
C302
 Probe Info  		21.26  LDD1971  [25]
C303
 Probe Info  		5.66  LDD1972  [25]
C305
 Probe Info  		28.64  LDD1974  [25]
C307
 Probe Info  		5.35  LDD1975  [25]
C310
 Probe Info  		36.76  LDD1977  [25]
C313
 Probe Info  		18.25  LDD1980  [25]
C314
 Probe Info  		31.78  LDD1981  [25]
C318
 Probe Info  		5.24  LDD1984  [25]
C326
 Probe Info  		20.53  LDD1990  [25]
C343
 Probe Info  		28.44  LDD2005  [25]
C346
 Probe Info  		19.03  LDD2007  [25]
C350
 Probe Info  		56.10  LDD2011  [25]
C355
 Probe Info  		88.03  LDD2016  [25]
C356
 Probe Info  		29.86  LDD2017  [25]
C357
 Probe Info  		14.52  LDD2018  [25]
C362
 Probe Info  		82.71  LDD2023  [25]
C363
 Probe Info  		54.95  LDD2024  [25]
C364
 Probe Info  		50.21  LDD2025  [25]
C376
 Probe Info  		19.97  LDD2036  [25]
C378
 Probe Info  		10.27  LDD2037  [25]
C380
 Probe Info  		7.11  LDD2039  [25]
C382
 Probe Info  		12.82  LDD2041  [25]
C383
 Probe Info  		31.12  LDD2042  [25]
C386
 Probe Info  		10.85  LDD2045  [25]
C387
 Probe Info  		4.96  LDD2046  [25]
C388
 Probe Info  		61.82  LDD2047  [25]
C405
 Probe Info  		6.28  LDD2063  [25]
C407
 Probe Info  		30.48  LDD2064  [25]
C413
 Probe Info  		73.52  LDD2069  [25]
C419
 Probe Info  		45.89  LDD2074  [25]
C420
 Probe Info  		64.89  LDD2075  [25]
C421
 Probe Info  		13.09  LDD2076  [25]
C422
 Probe Info  		17.88  LDD2077  [25]
C423
 Probe Info  		11.00  LDD2078  [25]
C425
 Probe Info  		20.11  LDD2080  [25]
C426
 Probe Info  		14.03  LDD2081  [25]
C429
 Probe Info  		34.78  LDD2084  [25]
C431
 Probe Info  		68.59  LDD2086  [25]
C433
 Probe Info  		13.93  LDD2088  [25]
FFF probe11
 Probe Info  		20.00  LDD0471  [26]
FFF probe12
 Probe Info  		20.00  LDD0473  [26]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe14
 Probe Info  		20.00  LDD0477  [26]
FFF probe15
 Probe Info  		20.00  LDD0478  [26]
FFF probe2
 Probe Info  		20.00  LDD0463  [26]
FFF probe3
 Probe Info  		20.00  LDD0464  [26]
FFF probe4
 Probe Info  		20.00  LDD0466  [26]
FFF probe6
 Probe Info  		10.71  LDD0467  [26]
FFF probe7
 Probe Info  		20.00  LDD0483  [26]
FFF probe9
 Probe Info  		20.00  LDD0470  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]
A-DA
 Probe Info  		2.34  LDD0144  [27]
OEA-DA
 Probe Info  		20.00  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C412(0.34)  LDD2142  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C42(0.84)  LDD2117  [12]
 LDCM0025  4SU-RNA HEK-293T C48(10.54)  LDD0371  [29]
 LDCM0026  4SU-RNA+native RNA HEK-293T C48(10.33)  LDD0372  [29]
 LDCM0214  AC1 HEK-293T C482(0.90); C33(1.15); C42(1.13); C48(1.17)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C482(1.02); C33(0.98); C42(1.07); C48(1.05)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C482(0.99); C33(1.04); C42(1.15); C48(1.09)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C33(0.99); C42(1.03); C409(1.03); C138(1.45)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C482(1.06); C33(0.97); C440(0.95); C409(1.12)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C482(1.04); C409(1.07); C138(1.26); C63(1.26)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C482(1.11); C33(1.13); C42(1.18); C48(1.25)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C482(0.93); C33(1.06); C42(1.10); C48(1.22)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C482(1.17); C33(1.47); C42(1.88); C48(2.31)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C482(0.94); C33(0.89); C42(1.02); C48(1.05)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C33(1.12); C42(1.05); C409(0.97); C138(1.39)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C482(1.00); C33(0.99); C42(1.11); C409(1.07)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C482(1.05); C33(1.08); C440(0.96); C409(1.13)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C482(1.05); C409(1.09); C138(1.25); C63(1.29)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C482(1.07); C33(0.96); C48(0.95); C440(1.13)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C482(1.15); C33(1.14); C42(1.05); C48(1.22)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C482(0.96); C33(0.99); C42(1.07); C48(1.02)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C482(0.97); C33(1.09); C42(1.03); C48(1.13)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C33(1.07); C42(1.01); C409(0.95); C138(1.31)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C482(1.01); C33(0.98); C42(0.92); C409(1.07)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C482(0.92); C33(1.08); C42(1.01); C48(1.32)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C482(1.07); C33(0.95); C440(0.89); C409(1.12)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C482(1.05); C409(1.13); C138(1.47); C63(1.31)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C482(1.08); C33(1.06); C48(0.93); C440(1.01)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C482(1.03); C33(1.47); C42(1.26); C48(1.42)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C482(1.09); C33(0.96); C42(1.10); C48(1.18)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C482(1.09); C33(1.05); C42(1.14); C48(1.17)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C33(1.01); C42(0.99); C409(0.99); C138(1.41)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C482(1.02); C33(0.81); C42(1.01); C409(1.02)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C482(1.13); C33(0.94); C440(1.11); C409(1.16)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C482(1.06); C409(1.09); C138(1.42); C63(1.40)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C33(0.97); C42(0.92); C409(0.86); C138(1.24)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C482(1.09); C33(0.97); C48(0.99); C440(1.05)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C482(1.12); C33(1.27); C42(1.26); C48(1.15)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C482(1.05); C33(1.00); C42(1.10); C48(1.01)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C482(1.00); C33(1.19); C42(1.15); C48(1.00)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C33(1.05); C42(1.08); C409(0.94); C138(1.56)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C482(1.01); C33(0.93); C42(1.19); C409(1.14)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C482(1.12); C33(1.00); C440(1.09); C409(1.15)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C482(1.02); C409(0.89); C138(1.37); C63(1.38)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C482(0.95); C33(1.04); C48(0.99); C440(1.15)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C482(0.91); C33(1.15); C42(1.21); C48(1.25)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C482(0.98); C33(0.91); C42(1.04); C409(0.98)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C482(0.94); C33(0.95); C42(1.05); C48(1.09)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C482(1.04); C33(1.01); C42(1.07); C48(1.06)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C33(1.06); C42(1.05); C409(0.98); C138(1.42)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C482(0.97); C33(0.93); C42(1.04); C409(0.98)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C482(1.00); C33(1.02); C440(1.12); C409(0.96)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C482(1.04); C409(1.02); C138(1.51); C63(1.35)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C482(0.99); C33(1.04); C48(1.10); C440(1.15)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C482(0.95); C33(1.21); C42(1.29); C48(1.20)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C482(0.92); C33(0.96); C42(1.08); C48(1.07)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C482(0.94); C33(1.10); C42(1.11); C48(1.04)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C482(1.09); C33(1.01); C440(1.07); C409(1.16)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C33(1.07); C42(1.01); C409(1.06); C138(1.45)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C482(0.91); C33(0.96); C42(1.03); C409(1.08)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C482(0.97); C33(1.08); C440(1.12); C409(1.11)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C482(0.96); C409(0.99); C138(1.78); C63(1.63)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C482(0.96); C33(0.96); C48(0.94); C440(1.10)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C482(1.02); C409(0.94); C138(1.22); C63(1.22)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C482(1.10); C33(1.03); C48(0.96); C440(1.07)  LDD1569  [30]
 LDCM0520  AKOS000195272 MDA-MB-231 C42(1.12); C482(0.98)  LDD2113  [12]
 LDCM0248  AKOS034007472 HEK-293T C482(0.92); C33(0.89); C42(0.99); C409(1.02)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C482(0.98); C33(1.09); C42(1.17); C48(1.17)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C482(1.02); C33(0.96); C48(0.98); C440(1.08)  LDD1514  [30]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [10]
 LDCM0108  Chloroacetamide HeLa C241(0.00); C318(0.00); C66(0.00); H144(0.00)  LDD0222  [14]
 LDCM0367  CL1 HEK-293T C482(0.98); C33(0.89); C42(0.98); C409(1.23)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C482(1.72); C33(1.22); C440(1.00); C409(1.36)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C33(1.10); C48(1.01); C409(1.04); C138(1.20)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C482(0.97); C33(1.01); C42(1.05); C409(1.11)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C482(1.10); C33(1.08); C42(1.25); C48(1.11)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C33(1.22); C42(1.11); C48(1.15); C409(1.03)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C33(1.03); C48(0.98); C409(1.08); C138(1.37)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C482(0.98); C33(1.15); C42(1.10); C409(1.22)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C482(1.06); C33(1.09); C42(1.37); C48(1.04)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C33(1.12); C42(1.19); C48(1.07); C409(1.03)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C33(1.07); C48(1.07); C409(1.10); C138(1.36)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C482(0.93); C33(0.97); C42(0.99); C409(1.16)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C482(1.27); C409(1.15); C138(1.08); C63(1.20)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C482(1.04); C33(1.12); C42(1.30); C48(1.21)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C33(1.08); C42(1.04); C48(1.08); C409(0.94)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C33(1.08); C48(0.97); C409(1.16); C138(1.18)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C482(0.97); C33(0.99); C42(1.07); C409(1.07)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C482(1.11); C33(1.21); C42(1.36); C48(1.20)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C33(1.05); C42(1.21); C48(1.09); C409(1.06)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C33(1.17); C48(0.98); C409(1.22); C138(1.47)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C482(0.99); C33(0.99); C42(0.96); C409(1.09)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C482(1.07); C33(1.43); C42(1.35); C48(1.38)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C33(1.10); C42(1.20); C48(1.01); C409(0.98)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C482(1.36); C33(1.10); C48(1.27); C440(1.13)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C33(1.18); C48(0.98); C409(0.93); C138(1.44)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C482(0.86); C33(1.07); C42(1.07); C409(1.09)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C482(0.95); C33(1.14); C42(1.14); C48(1.15)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C33(1.09); C42(1.26); C48(1.23); C409(1.14)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C33(1.12); C48(0.97); C409(0.83); C138(1.35)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C482(0.84); C33(0.98); C42(1.04); C409(1.05)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C482(0.98); C33(1.13); C42(1.24); C48(1.21)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C33(1.12); C42(1.11); C48(1.13); C409(1.03)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C33(1.17); C48(1.06); C409(1.12); C138(1.62)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C482(0.69); C33(1.06); C42(1.26); C409(1.10)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C482(1.05); C33(1.05); C42(1.23); C48(1.20)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C33(1.25); C42(1.83); C48(1.26); C409(1.15)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C33(1.01); C48(1.07); C409(1.20); C138(1.66)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C482(1.09); C33(1.16); C42(1.54); C48(1.47)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C482(1.09); C33(0.92); C42(1.04); C48(0.94)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C482(1.12); C33(0.99); C42(1.39); C48(1.14)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C482(0.88); C33(1.02); C42(1.33); C48(1.10)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C33(1.00); C42(1.07); C409(1.02); C138(1.00)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C482(1.54); C33(0.95); C42(1.45); C409(1.21)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C482(1.51); C33(0.88); C440(1.17); C409(1.02)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C482(1.55); C409(1.08); C138(1.12); C63(1.18)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C482(1.37); C33(0.91); C48(1.22); C440(1.08)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C482(0.83); C33(0.92); C42(1.00); C409(1.03)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C482(1.00); C33(1.03); C42(1.09); C48(1.09)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C33(1.08); C42(1.01); C48(0.97); C409(1.09)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C33(1.04); C48(0.97); C409(1.14); C138(1.27)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C482(1.09); C33(1.11); C42(1.15); C48(1.10)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C33(0.93); C42(1.31); C48(1.01); C409(1.06)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C482(1.00); C33(0.88); C42(1.02); C48(0.96)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C482(0.94); C33(1.05); C42(1.14); C48(1.09)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C33(0.98); C42(1.01); C409(1.02); C138(1.10)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C482(1.26); C33(1.15); C42(1.36); C409(1.19)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C482(1.49); C33(1.00); C440(0.88); C409(1.17)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C482(1.66); C409(1.19); C138(1.16); C63(1.33)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C482(1.45); C33(0.95); C48(1.06); C440(1.05)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C482(0.82); C33(0.91); C42(1.04); C409(1.04)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C33(1.26); C42(1.14); C48(1.04); C409(1.15)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C33(0.95); C48(1.07); C409(0.99); C138(1.54)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C33(1.03); C48(0.99); C409(1.10); C138(1.41)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C482(1.07); C33(0.98); C42(1.12); C48(0.98)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C482(1.00); C33(0.97); C42(1.07); C48(0.87)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C482(1.08); C33(1.13); C42(1.07); C48(1.09)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C33(1.04); C42(1.07); C409(1.09); C138(1.33)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C482(1.19); C33(1.00); C42(1.08); C409(1.14)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C482(1.44); C33(1.03); C440(0.96); C409(1.14)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C482(1.45); C409(1.12); C138(1.28); C63(1.48)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C482(1.62); C33(0.97); C48(1.24); C440(0.94)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C482(0.85); C33(0.92); C42(0.96); C409(1.13)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C482(0.94); C33(1.08); C42(1.18); C48(1.11)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C482(0.97); C33(1.10); C42(1.48); C48(1.25)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C33(1.09); C48(1.03); C409(1.09); C138(1.31)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C482(1.06); C33(1.08); C42(1.45); C48(1.33)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C482(1.08); C33(0.89); C42(1.21); C48(1.33)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C482(1.13); C33(0.98); C42(1.12); C48(1.04)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C33(0.94); C42(1.00); C409(1.09); C138(1.23)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C482(1.24); C33(1.22); C42(1.32); C409(1.25)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C482(1.34); C33(0.95); C440(0.92); C409(1.26)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C482(1.45); C409(1.07); C138(1.17); C63(1.56)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C482(0.96); C33(0.93); C42(1.15); C48(1.08)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C482(1.58); C33(1.11); C48(1.31); C440(1.13)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C482(0.93); C33(0.89); C42(1.01); C409(1.00)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C482(1.03); C33(1.18); C42(1.22); C48(1.14)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C33(1.07); C42(1.08); C48(1.02); C409(1.11)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C33(1.05); C48(1.05); C409(1.50); C138(1.24)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C482(1.07); C33(1.15); C42(1.28); C48(1.17)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C482(1.08); C33(0.89); C42(1.06); C48(0.97)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C482(0.99); C33(0.88); C42(1.11); C48(0.93)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C33(0.96); C42(0.98); C409(1.16); C138(1.31)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C482(1.14); C33(0.95); C42(1.09); C409(1.18)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C482(1.07); C33(0.99); C42(1.36); C48(1.15)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C482(1.43); C33(1.07); C440(0.89); C409(1.17)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C482(1.37); C409(1.08); C138(1.26); C63(1.41)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C482(1.37); C33(1.10); C48(1.24); C440(1.13)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C482(0.93); C33(0.91); C42(0.98); C409(0.90)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C482(0.90); C33(1.13); C42(1.03); C48(0.89)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C33(1.09); C48(1.00); C409(1.11); C138(1.12)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C482(0.98); C33(1.16); C42(1.23); C48(1.24)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C482(0.96); C33(0.87); C42(0.98); C48(1.09)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C482(1.01); C33(0.96); C42(1.07); C48(1.03)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C33(1.67); C42(2.44); C409(1.24); C138(1.96)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C33(0.91); C42(0.93); C409(1.06); C138(1.07)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C482(1.17); C33(0.87); C42(1.18); C409(1.11)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C482(1.34); C33(0.86); C440(0.95); C409(1.28)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C482(1.41); C409(1.14); C138(1.24); C63(1.39)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C482(1.15); C33(0.93); C48(1.10); C440(1.10)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C482(0.70); C33(1.01); C42(0.98); C409(1.05)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C482(0.86); C33(1.12); C42(1.15); C48(1.29)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C33(1.08); C42(1.13); C48(1.12); C409(1.06)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C33(1.15); C48(0.99); C409(1.11); C138(1.46)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C482(0.76); C33(1.16); C42(1.16); C48(1.08)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C482(1.26); C33(0.84); C42(1.05); C409(1.16)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C482(0.99); C33(1.10); C42(1.74); C48(1.38)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C482(0.90); C33(0.98); C42(1.11); C48(0.97)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C33(1.01); C42(1.06); C409(1.06); C138(1.32)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C482(0.97); C33(0.90); C42(1.18); C409(1.10)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C482(1.25); C33(1.10); C440(0.98); C409(1.13)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C482(1.18); C409(1.03); C138(1.34); C63(1.45)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C482(0.87); C33(0.94); C48(1.11); C440(1.10)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C482(0.94); C33(1.00); C42(1.18); C409(1.18)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C482(0.99); C33(1.07); C42(1.13); C48(1.10)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C33(1.12); C42(0.99); C48(1.10); C409(1.02)  LDD1697  [30]
 LDCM0189  Compound 16 HEK-293T 18.87  LDD0492  [26]
 LDCM0185  Compound 17 HEK-293T 5.65  LDD0504  [26]
 LDCM0184  Compound 20 HEK-293T 15.75  LDD0503  [26]
 LDCM0191  Compound 21 HEK-293T 12.50  LDD0493  [26]
 LDCM0186  Compound 31 HEK-293T 9.43  LDD0506  [26]
 LDCM0187  Compound 32 HEK-293T 55.56  LDD0507  [26]
 LDCM0188  Compound 33 HEK-293T 8.10  LDD0505  [26]
 LDCM0190  Compound 34 HEK-293T 17.09  LDD0497  [26]
 LDCM0192  Compound 35 HEK-293T 12.27  LDD0491  [26]
 LDCM0193  Compound 36 HEK-293T 8.44  LDD0494  [26]
 LDCM0194  Compound 37 HEK-293T 18.52  LDD0498  [26]
 LDCM0195  Compound 38 HEK-293T 20.62  LDD0499  [26]
 LDCM0196  Compound 39 HEK-293T 9.80  LDD0496  [26]
 LDCM0495  E2913 HEK-293T C33(1.11); C42(1.35); C48(1.13); C409(1.00)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C33(1.78)  LDD1702  [12]
 LDCM0468  Fragment33 HEK-293T C33(1.02); C42(1.17); C48(1.06); C409(1.11)  LDD1671  [30]
 LDCM0427  Fragment51 HEK-293T C482(1.15); C33(1.07); C42(1.10); C48(1.26)  LDD1631  [30]
 LDCM0116  HHS-0101 DM93 Y447(0.66); Y113(2.73)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y113(0.64); Y447(2.11)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y447(0.60)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y113(0.27); Y447(1.12)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y447(0.81); Y113(1.50)  LDD0268  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 HEK-293T C42(0.88); C33(1.02); C440(0.89)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C42(0.90); C33(1.01); C440(0.79)  LDD1497  [30]
 LDCM0024  KB05 COLO792 C33(5.73); C241(2.90); C42(5.31)  LDD3310  [11]
 LDCM0109  NEM HeLa N.A.  LDD0227  [14]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C412(1.02); C42(0.92); C482(0.93)  LDD2097  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C42(1.08)  LDD2099  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C412(0.36); C42(0.45)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C412(0.31); C482(2.09)  LDD2101  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C412(0.26)  LDD2104  [12]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C412(1.21)  LDD2105  [12]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C412(0.17)  LDD2106  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C42(1.22)  LDD2107  [12]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C412(0.47)  LDD2108  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C412(0.31)  LDD2110  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C412(0.27); C482(0.98)  LDD2115  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C42(0.48)  LDD2123  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C42(0.77)  LDD2125  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C42(0.73)  LDD2127  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C482(1.15)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C412(0.40); C42(0.60); C482(0.76)  LDD2134  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C42(0.92)  LDD2136  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C412(0.75); C42(0.78)  LDD2141  [12]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C412(6.35)  LDD2145  [12]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C412(0.29); C42(0.83); C482(0.82)  LDD2148  [12]
 LDCM0099  Phenelzine MDA-MB-231 4.04  LDD0384  [2]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 4.35  LDD0123  [4]
 LDCM0084  Ro 48-8071 A-549 2.34  LDD0144  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Caspase-14 (CASP14) Peptidase C14A family P31944
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Amyloid protein-binding protein 2 (APPBP2) . Q92624

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Di-stearoyl-3-sn-phosphatidylethanolamine . DB01966

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
28 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
29 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402