Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	C421			Probe Info
Probe concentration	Probe:50uM; negative probe:50uM
Criteria	Quantification: AfBPP Probe vs Negative Probe
Quantitative Method	TMT
*In Vivo* Experiment Model**	Model Type		Living cell
	Derived Tissue		Peripheral blood
	Disease Model	Normal
	Model Name	Human normal cells (HEK-293T)
Note	Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme

Click to Show/Hide to Show 3 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP05758	S-methyl-5'-thioadenosine phosphorylase (MTAP)	17.8
LDTP08728	Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1)	15.1
LDTP05862	NAD(P) transhydrogenase, mitochondrial (NNT)	6.5

Transporter and channel

Click to Show/Hide to Show 7 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP11813	Solute carrier family 25 member 32 (SLC25A32)	48.2
LDTP03277	ER lumen protein-retaining receptor 1 (KDELR1)	46.2
LDTP02215	Prosaposin (PSAP)	13.1
LDTP10913	Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)	12.9
LDTP07885	Mitochondrial S-adenosylmethionine carrier protein (SLC25A26)	11.6
LDTP06426	Translocating chain-associated membrane protein 1 (TRAM1)	9.2
LDTP06365	Transmembrane emp24 domain-containing protein 2 (TMED2)	7.8

Other

Click to Show/Hide to Show 2 Protein Related to This Bioclass

Target ID	Target Name					Binding Ratio
LDTP03678	ER lumen protein-retaining receptor 2 (KDELR2)					31.1
LDTP12565	Mitochondrial import receptor subunit TOM22 homolog (TOMM22)					29.4

References

1	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587