Details of the Target

General Information of Target

Target ID	LDTP02505
Target Name	Lysosomal protective protein (CTSA)
Gene Name	CTSA
Gene ID	5476
Synonyms	PPGB; Lysosomal protective protein; EC 3.4.16.5; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Target Type	Clinical trial
Target Bioclass	Enzyme
Family	Peptidase S10 family
Subcellular location	Lysosome
Function	Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
TTD ID	T37154
Uniprot ID	P10619
DrugMap ID	TT5NILS
Ensemble ID	ENST00000191018.9
HGNC ID	HGNC:9251
ChEMBL ID	CHEMBL6115

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 24 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	12.42	LDD0402	[1]
Alkylaryl probe 2 Probe Info	9.00	LDD0391	[2]
FBPP2 Probe Info	29.57	LDD0318	[3]
SAA-alkyne Probe Info	1.15	LDD0252	[4]
TH211 Probe Info	Y249(20.00)	LDD0260	[5]
STPyne Probe Info	K43(10.00)	LDD0277	[6]
Probe 1 Probe Info	Y430(94.90)	LDD3495	[7]
P11 Probe Info	20.00	LDD0201	[8]
Alkylaryl probe 1 Probe Info	4.00	LDD0388	[2]
Alkylaryl probe 3 Probe Info	3.17	LDD0384	[2]
HHS-482 Probe Info	Y249(1.18)	LDD0285	[9]
DBIA Probe Info	C281(1.11)	LDD0531	[10]
5E-2FA Probe Info	N.A.	LDD2235	[11]
4-Iodoacetamidophenylacetylene Probe Info	C246(0.00); C256(0.00)	LDD0038	[12]
IA-alkyne Probe Info	C362(0.00); C246(0.00); C256(0.00)	LDD0036	[12]
Lodoacetamide azide Probe Info	C362(0.00); C246(0.00); C256(0.00)	LDD0037	[12]
IPM Probe Info	N.A.	LDD0147	[13]
Acrolein Probe Info	C256(0.00); C241(0.00)	LDD0217	[14]
Methacrolein Probe Info	C256(0.00); C240(0.00); C241(0.00)	LDD0218	[14]
AOyne Probe Info	11.80	LDD0443	[15]
MPP-AC Probe Info	N.A.	LDD0428	[16]
NAIA_5 Probe Info	N.A.	LDD2223	[17]
TER-AC Probe Info	N.A.	LDD0426	[16]
TPP-AC Probe Info	N.A.	LDD0427	[16]

PAL-AfBPP Probe

Click To Hide/Show 123 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C001 Probe Info	9.45	LDD1711	[18]
C004 Probe Info	6.15	LDD1714	[18]
C010 Probe Info	7.84	LDD1719	[18]
C011 Probe Info	8.94	LDD1720	[18]
C022 Probe Info	15.89	LDD1728	[18]
C026 Probe Info	5.10	LDD1732	[18]
C041 Probe Info	13.09	LDD1741	[18]
C045 Probe Info	5.50	LDD1744	[18]
C055 Probe Info	31.12	LDD1752	[18]
C063 Probe Info	19.97	LDD1760	[18]
C064 Probe Info	12.04	LDD1761	[18]
C070 Probe Info	21.26	LDD1766	[18]
C071 Probe Info	8.69	LDD1767	[18]
C087 Probe Info	8.69	LDD1779	[18]
C091 Probe Info	10.34	LDD1782	[18]
C092 Probe Info	23.43	LDD1783	[18]
C106 Probe Info	37.27	LDD1793	[18]
C107 Probe Info	9.38	LDD1794	[18]
C108 Probe Info	19.97	LDD1795	[18]
C112 Probe Info	19.03	LDD1799	[18]
C115 Probe Info	5.31	LDD1802	[18]
C130 Probe Info	19.16	LDD1812	[18]
C134 Probe Info	23.10	LDD1816	[18]
C135 Probe Info	13.83	LDD1817	[18]
C139 Probe Info	22.16	LDD1821	[18]
C140 Probe Info	11.31	LDD1822	[18]
C141 Probe Info	25.46	LDD1823	[18]
C143 Probe Info	19.97	LDD1825	[18]
C145 Probe Info	8.63	LDD1827	[18]
C147 Probe Info	10.20	LDD1829	[18]
C149 Probe Info	7.21	LDD1830	[18]
C153 Probe Info	28.64	LDD1834	[18]
C159 Probe Info	25.46	LDD1839	[18]
C160 Probe Info	20.39	LDD1840	[18]
C161 Probe Info	31.34	LDD1841	[18]
C163 Probe Info	13.83	LDD1843	[18]
C164 Probe Info	8.46	LDD1844	[18]
C165 Probe Info	12.82	LDD1845	[18]
C170 Probe Info	27.67	LDD1850	[18]
C171 Probe Info	6.77	LDD1851	[18]
C178 Probe Info	17.15	LDD1857	[18]
C183 Probe Info	11.39	LDD1861	[18]
C186 Probe Info	32.22	LDD1864	[18]
C187 Probe Info	36.50	LDD1865	[18]
C193 Probe Info	7.62	LDD1869	[18]
C194 Probe Info	24.08	LDD1870	[18]
C197 Probe Info	8.51	LDD1873	[18]
C198 Probe Info	16.34	LDD1874	[18]
C201 Probe Info	42.22	LDD1877	[18]
C206 Probe Info	37.53	LDD1881	[18]
C208 Probe Info	9.06	LDD1883	[18]
C211 Probe Info	18.25	LDD1885	[18]
C213 Probe Info	22.16	LDD1887	[18]
C219 Probe Info	15.03	LDD1893	[18]
C220 Probe Info	30.48	LDD1894	[18]
C221 Probe Info	9.06	LDD1895	[18]
C223 Probe Info	8.46	LDD1897	[18]
C225 Probe Info	7.21	LDD1898	[18]
C226 Probe Info	10.41	LDD1899	[18]
C229 Probe Info	13.55	LDD1902	[18]
C231 Probe Info	13.45	LDD1904	[18]
C232 Probe Info	74.03	LDD1905	[18]
C233 Probe Info	29.86	LDD1906	[18]
C234 Probe Info	6.36	LDD1907	[18]
C237 Probe Info	6.19	LDD1910	[18]
C239 Probe Info	5.78	LDD1912	[18]
C240 Probe Info	14.93	LDD1913	[18]
C243 Probe Info	34.78	LDD1916	[18]
C246 Probe Info	16.22	LDD1919	[18]
C249 Probe Info	29.45	LDD1922	[18]
C255 Probe Info	7.52	LDD1928	[18]
C264 Probe Info	18.90	LDD1935	[18]
C265 Probe Info	16.80	LDD1936	[18]
C277 Probe Info	15.14	LDD1947	[18]
C280 Probe Info	11.55	LDD1950	[18]
C281 Probe Info	5.98	LDD1951	[18]
C282 Probe Info	31.56	LDD1952	[18]
C284 Probe Info	53.82	LDD1954	[18]
C288 Probe Info	22.94	LDD1958	[18]
C293 Probe Info	36.76	LDD1963	[18]
C296 Probe Info	18.64	LDD1966	[18]
C299 Probe Info	8.51	LDD1968	[18]
C302 Probe Info	6.54	LDD1971	[18]
C305 Probe Info	15.78	LDD1974	[18]
C310 Probe Info	16.45	LDD1977	[18]
C314 Probe Info	17.27	LDD1981	[18]
C326 Probe Info	12.13	LDD1990	[18]
C338 Probe Info	11.31	LDD2001	[18]
C343 Probe Info	22.63	LDD2005	[18]
C346 Probe Info	21.26	LDD2007	[18]
C348 Probe Info	13.93	LDD2009	[18]
C349 Probe Info	23.59	LDD2010	[18]
C350 Probe Info	35.75	LDD2011	[18]
C355 Probe Info	27.86	LDD2016	[18]
C356 Probe Info	10.06	LDD2017	[18]
C363 Probe Info	32.00	LDD2024	[18]
C376 Probe Info	16.68	LDD2036	[18]
C378 Probe Info	6.02	LDD2037	[18]
C380 Probe Info	6.50	LDD2039	[18]
C382 Probe Info	9.85	LDD2041	[18]
C383 Probe Info	18.13	LDD2042	[18]
C386 Probe Info	8.75	LDD2045	[18]
C387 Probe Info	10.06	LDD2046	[18]
C390 Probe Info	57.28	LDD2049	[18]
C399 Probe Info	13.64	LDD2058	[18]
C403 Probe Info	22.94	LDD2061	[18]
C405 Probe Info	7.16	LDD2063	[18]
C408 Probe Info	5.13	LDD2065	[18]
C413 Probe Info	21.71	LDD2069	[18]
C419 Probe Info	16.91	LDD2074	[18]
C420 Probe Info	26.72	LDD2075	[18]
C425 Probe Info	11.08	LDD2080	[18]
C428 Probe Info	5.06	LDD2083	[18]
C429 Probe Info	54.19	LDD2084	[18]
C431 Probe Info	71.01	LDD2086	[18]
C433 Probe Info	6.23	LDD2088	[18]
FFF probe12 Probe Info	18.35	LDD0473	[19]
FFF probe13 Probe Info	20.00	LDD0475	[19]
FFF probe14 Probe Info	20.00	LDD0477	[19]
FFF probe15 Probe Info	20.00	LDD0478	[19]
FFF probe4 Probe Info	20.00	LDD0466	[19]
JN0003 Probe Info	20.00	LDD0469	[19]
OEA-DA Probe Info	11.84	LDD0046	[20]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HCT 116	C281(1.11)	LDD0531	[10]
LDCM0215	AC10	HEK-293T	C403(1.07)	LDD1508	[21]
LDCM0216	AC100	HCT 116	C281(0.60)	LDD0533	[10]
LDCM0217	AC101	HCT 116	C281(0.68)	LDD0534	[10]
LDCM0218	AC102	HCT 116	C281(0.82)	LDD0535	[10]
LDCM0219	AC103	HCT 116	C281(0.81)	LDD0536	[10]
LDCM0220	AC104	HCT 116	C281(0.64)	LDD0537	[10]
LDCM0221	AC105	HCT 116	C281(0.85)	LDD0538	[10]
LDCM0222	AC106	HCT 116	C281(0.71)	LDD0539	[10]
LDCM0223	AC107	HCT 116	C281(0.86)	LDD0540	[10]
LDCM0224	AC108	HCT 116	C281(0.69)	LDD0541	[10]
LDCM0225	AC109	HCT 116	C281(0.67)	LDD0542	[10]
LDCM0226	AC11	HEK-293T	C403(0.85)	LDD1509	[21]
LDCM0227	AC110	HCT 116	C281(0.75)	LDD0544	[10]
LDCM0228	AC111	HCT 116	C281(0.76)	LDD0545	[10]
LDCM0229	AC112	HCT 116	C281(0.68)	LDD0546	[10]
LDCM0237	AC12	HEK-293T	C403(0.90); C362(1.08)	LDD1510	[21]
LDCM0259	AC14	HEK-293T	C403(0.94); C362(1.16)	LDD1512	[21]
LDCM0270	AC15	HEK-293T	C403(1.08); C362(1.01); C256(1.25); C331(0.99)	LDD1513	[21]
LDCM0276	AC17	HCT 116	C281(1.11)	LDD0593	[10]
LDCM0277	AC18	HCT 116	C281(1.47)	LDD0594	[10]
LDCM0278	AC19	HCT 116	C281(0.93)	LDD0595	[10]
LDCM0279	AC2	HCT 116	C281(1.27)	LDD0596	[10]
LDCM0280	AC20	HCT 116	C281(1.29)	LDD0597	[10]
LDCM0281	AC21	HCT 116	C281(1.07)	LDD0598	[10]
LDCM0282	AC22	HCT 116	C281(0.75)	LDD0599	[10]
LDCM0283	AC23	HCT 116	C281(1.09)	LDD0600	[10]
LDCM0284	AC24	HCT 116	C281(1.04)	LDD0601	[10]
LDCM0285	AC25	HCT 116	C281(0.77)	LDD0602	[10]
LDCM0286	AC26	HCT 116	C281(0.75)	LDD0603	[10]
LDCM0287	AC27	HCT 116	C281(1.05)	LDD0604	[10]
LDCM0288	AC28	HCT 116	C281(0.97)	LDD0605	[10]
LDCM0289	AC29	HCT 116	C281(0.96)	LDD0606	[10]
LDCM0290	AC3	HCT 116	C281(1.34)	LDD0607	[10]
LDCM0291	AC30	HCT 116	C281(0.96)	LDD0608	[10]
LDCM0292	AC31	HCT 116	C281(0.90)	LDD0609	[10]
LDCM0293	AC32	HCT 116	C281(0.95)	LDD0610	[10]
LDCM0294	AC33	HCT 116	C281(0.99)	LDD0611	[10]
LDCM0295	AC34	HCT 116	C281(1.14)	LDD0612	[10]
LDCM0296	AC35	HCT 116	C281(0.63)	LDD0613	[10]
LDCM0297	AC36	HCT 116	C281(0.51)	LDD0614	[10]
LDCM0298	AC37	HCT 116	C281(0.55)	LDD0615	[10]
LDCM0299	AC38	HCT 116	C281(0.52)	LDD0616	[10]
LDCM0300	AC39	HCT 116	C281(0.48)	LDD0617	[10]
LDCM0301	AC4	HCT 116	C281(1.41)	LDD0618	[10]
LDCM0302	AC40	HCT 116	C281(0.76)	LDD0619	[10]
LDCM0303	AC41	HCT 116	C281(0.58)	LDD0620	[10]
LDCM0304	AC42	HCT 116	C281(0.44)	LDD0621	[10]
LDCM0305	AC43	HCT 116	C281(0.69)	LDD0622	[10]
LDCM0306	AC44	HCT 116	C281(0.65)	LDD0623	[10]
LDCM0307	AC45	HCT 116	C281(0.47)	LDD0624	[10]
LDCM0308	AC46	HEK-293T	C403(0.95); C362(0.97)	LDD1547	[21]
LDCM0309	AC47	HEK-293T	C403(0.97); C362(0.87); C256(1.13); C331(1.12)	LDD1548	[21]
LDCM0310	AC48	HEK-293T	C362(0.99)	LDD1549	[21]
LDCM0311	AC49	HEK-293T	C403(0.90); C281(1.15)	LDD1550	[21]
LDCM0312	AC5	HCT 116	C281(1.40)	LDD0629	[10]
LDCM0313	AC50	HEK-293T	C403(1.13)	LDD1552	[21]
LDCM0314	AC51	HEK-293T	C403(1.18)	LDD1553	[21]
LDCM0315	AC52	HEK-293T	C403(0.89); C362(0.93)	LDD1554	[21]
LDCM0316	AC53	HEK-293T	C403(1.15); C362(0.94)	LDD1555	[21]
LDCM0317	AC54	HEK-293T	C403(0.97); C362(1.17)	LDD1556	[21]
LDCM0318	AC55	HEK-293T	C403(0.98); C362(0.93); C256(1.11); C331(0.97)	LDD1557	[21]
LDCM0319	AC56	HEK-293T	C362(1.12)	LDD1558	[21]
LDCM0320	AC57	HEK-293T	C403(1.10); C281(0.99)	LDD1559	[21]
LDCM0321	AC58	HEK-293T	C403(1.00)	LDD1560	[21]
LDCM0322	AC59	HEK-293T	C403(0.96)	LDD1561	[21]
LDCM0323	AC6	HEK-293T	C403(0.96); C362(0.95)	LDD1562	[21]
LDCM0324	AC60	HEK-293T	C403(0.94); C362(1.24)	LDD1563	[21]
LDCM0325	AC61	HEK-293T	C403(1.03); C362(0.90)	LDD1564	[21]
LDCM0326	AC62	HEK-293T	C403(0.99); C362(1.13)	LDD1565	[21]
LDCM0327	AC63	HEK-293T	C403(0.97); C362(0.90); C256(1.09); C331(1.08)	LDD1566	[21]
LDCM0328	AC64	HEK-293T	C362(1.15)	LDD1567	[21]
LDCM0334	AC7	HEK-293T	C403(1.19); C362(1.06); C256(1.00); C331(0.97)	LDD1568	[21]
LDCM0345	AC8	HEK-293T	C362(1.09)	LDD1569	[21]
LDCM0365	AC98	HCT 116	C281(0.76)	LDD0682	[10]
LDCM0366	AC99	HCT 116	C281(0.56)	LDD0683	[10]
LDCM0248	AKOS034007472	HEK-293T	C403(1.08); C362(0.97)	LDD1511	[21]
LDCM0356	AKOS034007680	HEK-293T	C403(0.98); C281(0.89)	LDD1570	[21]
LDCM0275	AKOS034007705	HEK-293T	C362(1.03)	LDD1514	[21]
LDCM0156	Aniline	NCI-H1299	13.11	LDD0403	[1]
LDCM0088	C45	HEK-293T	20.00	LDD0201	[8]
LDCM0108	Chloroacetamide	HeLa	C240(0.00); C256(0.00)	LDD0222	[14]
LDCM0367	CL1	HEK-293T	C403(0.96); C362(1.31)	LDD1571	[21]
LDCM0368	CL10	HEK-293T	C403(0.82); C362(1.36)	LDD1572	[21]
LDCM0369	CL100	HCT 116	C281(1.46)	LDD0686	[10]
LDCM0370	CL101	HEK-293T	C403(0.91); C362(1.07)	LDD1574	[21]
LDCM0371	CL102	HEK-293T	C403(0.77); C256(0.75)	LDD1575	[21]
LDCM0372	CL103	HEK-293T	C403(1.02); C362(0.87)	LDD1576	[21]
LDCM0373	CL104	HEK-293T	C403(1.05); C362(1.02)	LDD1577	[21]
LDCM0374	CL105	HCT 116	C281(0.89)	LDD0691	[10]
LDCM0375	CL106	HCT 116	C281(1.00)	LDD0692	[10]
LDCM0376	CL107	HCT 116	C281(0.93)	LDD0693	[10]
LDCM0377	CL108	HCT 116	C281(1.05)	LDD0694	[10]
LDCM0378	CL109	HCT 116	C281(1.18)	LDD0695	[10]
LDCM0379	CL11	HEK-293T	C403(1.04); C362(0.86); C256(1.37); C331(1.06)	LDD1583	[21]
LDCM0380	CL110	HCT 116	C281(1.08)	LDD0697	[10]
LDCM0381	CL111	HCT 116	C281(1.01)	LDD0698	[10]
LDCM0382	CL112	HCT 116	C281(0.65)	LDD0699	[10]
LDCM0383	CL113	HCT 116	C281(0.98)	LDD0700	[10]
LDCM0384	CL114	HCT 116	C281(1.02)	LDD0701	[10]
LDCM0385	CL115	HCT 116	C281(1.05)	LDD0702	[10]
LDCM0386	CL116	HCT 116	C281(0.93)	LDD0703	[10]
LDCM0387	CL117	HCT 116	C281(0.96)	LDD0704	[10]
LDCM0388	CL118	HCT 116	C281(0.60)	LDD0705	[10]
LDCM0389	CL119	HCT 116	C281(0.44)	LDD0706	[10]
LDCM0390	CL12	HEK-293T	C362(0.94)	LDD1594	[21]
LDCM0391	CL120	HCT 116	C281(0.57)	LDD0708	[10]
LDCM0392	CL121	HEK-293T	C403(0.89); C362(1.07)	LDD1596	[21]
LDCM0393	CL122	HEK-293T	C403(0.86); C256(0.86)	LDD1597	[21]
LDCM0394	CL123	HEK-293T	C403(0.82); C362(0.98)	LDD1598	[21]
LDCM0395	CL124	HEK-293T	C403(1.06); C362(1.00)	LDD1599	[21]
LDCM0396	CL125	HEK-293T	C403(1.14); C362(1.46)	LDD1600	[21]
LDCM0397	CL126	HEK-293T	C403(1.11); C256(0.98)	LDD1601	[21]
LDCM0398	CL127	HEK-293T	C403(1.02); C362(1.05)	LDD1602	[21]
LDCM0399	CL128	HEK-293T	C403(1.12); C362(1.13)	LDD1603	[21]
LDCM0400	CL13	HEK-293T	C403(0.99); C362(0.98)	LDD1604	[21]
LDCM0401	CL14	HEK-293T	C403(1.02); C256(0.92)	LDD1605	[21]
LDCM0402	CL15	HEK-293T	C403(0.98); C362(0.99)	LDD1606	[21]
LDCM0403	CL16	HCT 116	C281(1.08)	LDD0720	[10]
LDCM0404	CL17	HCT 116	C281(0.99)	LDD0721	[10]
LDCM0405	CL18	HCT 116	C281(1.62)	LDD0722	[10]
LDCM0406	CL19	HCT 116	C281(1.18)	LDD0723	[10]
LDCM0407	CL2	HEK-293T	C403(0.90); C256(0.88)	LDD1611	[21]
LDCM0408	CL20	HCT 116	C281(1.12)	LDD0725	[10]
LDCM0409	CL21	HCT 116	C281(1.39)	LDD0726	[10]
LDCM0410	CL22	HCT 116	C281(1.12)	LDD0727	[10]
LDCM0411	CL23	HCT 116	C281(1.07)	LDD0728	[10]
LDCM0412	CL24	HCT 116	C281(1.53)	LDD0729	[10]
LDCM0413	CL25	HCT 116	C281(0.90)	LDD0730	[10]
LDCM0414	CL26	HCT 116	C281(1.15)	LDD0731	[10]
LDCM0415	CL27	HCT 116	C281(0.94)	LDD0732	[10]
LDCM0416	CL28	HCT 116	C281(1.59)	LDD0733	[10]
LDCM0417	CL29	HCT 116	C281(1.63)	LDD0734	[10]
LDCM0418	CL3	HEK-293T	C403(1.13); C362(1.15)	LDD1622	[21]
LDCM0419	CL30	HCT 116	C281(1.39)	LDD0736	[10]
LDCM0420	CL31	HCT 116	C281(0.85)	LDD0737	[10]
LDCM0421	CL32	HCT 116	C281(1.13)	LDD0738	[10]
LDCM0422	CL33	HCT 116	C281(0.83)	LDD0739	[10]
LDCM0423	CL34	HCT 116	C281(1.05)	LDD0740	[10]
LDCM0424	CL35	HCT 116	C281(1.26)	LDD0741	[10]
LDCM0425	CL36	HCT 116	C281(1.36)	LDD0742	[10]
LDCM0426	CL37	HCT 116	C281(1.07)	LDD0743	[10]
LDCM0428	CL39	HCT 116	C281(1.14)	LDD0745	[10]
LDCM0429	CL4	HEK-293T	C403(1.04); C362(0.88)	LDD1633	[21]
LDCM0430	CL40	HCT 116	C281(1.01)	LDD0747	[10]
LDCM0431	CL41	HCT 116	C281(1.26)	LDD0748	[10]
LDCM0432	CL42	HCT 116	C281(0.94)	LDD0749	[10]
LDCM0433	CL43	HCT 116	C281(1.07)	LDD0750	[10]
LDCM0434	CL44	HCT 116	C281(1.03)	LDD0751	[10]
LDCM0435	CL45	HCT 116	C281(1.31)	LDD0752	[10]
LDCM0436	CL46	HCT 116	C281(0.79)	LDD0753	[10]
LDCM0437	CL47	HCT 116	C281(0.67)	LDD0754	[10]
LDCM0438	CL48	HCT 116	C281(0.82)	LDD0755	[10]
LDCM0439	CL49	HCT 116	C281(1.73)	LDD0756	[10]
LDCM0440	CL5	HEK-293T	C403(0.98); C281(0.84)	LDD1644	[21]
LDCM0441	CL50	HCT 116	C281(1.02)	LDD0758	[10]
LDCM0442	CL51	HCT 116	C281(0.75)	LDD0759	[10]
LDCM0443	CL52	HCT 116	C281(0.84)	LDD0760	[10]
LDCM0444	CL53	HCT 116	C281(1.03)	LDD0761	[10]
LDCM0445	CL54	HCT 116	C281(0.72)	LDD0762	[10]
LDCM0446	CL55	HCT 116	C281(1.36)	LDD0763	[10]
LDCM0447	CL56	HCT 116	C281(1.22)	LDD0764	[10]
LDCM0448	CL57	HCT 116	C281(0.80)	LDD0765	[10]
LDCM0449	CL58	HCT 116	C281(1.20)	LDD0766	[10]
LDCM0450	CL59	HCT 116	C281(1.02)	LDD0767	[10]
LDCM0451	CL6	HEK-293T	C403(0.90)	LDD1654	[21]
LDCM0452	CL60	HCT 116	C281(1.24)	LDD0769	[10]
LDCM0453	CL61	HCT 116	C281(0.97)	LDD0770	[10]
LDCM0454	CL62	HCT 116	C281(1.12)	LDD0771	[10]
LDCM0455	CL63	HCT 116	C281(1.13)	LDD0772	[10]
LDCM0456	CL64	HCT 116	C281(1.05)	LDD0773	[10]
LDCM0457	CL65	HCT 116	C281(0.94)	LDD0774	[10]
LDCM0458	CL66	HCT 116	C281(1.51)	LDD0775	[10]
LDCM0459	CL67	HCT 116	C281(1.19)	LDD0776	[10]
LDCM0460	CL68	HCT 116	C281(1.13)	LDD0777	[10]
LDCM0461	CL69	HCT 116	C281(0.87)	LDD0778	[10]
LDCM0462	CL7	HEK-293T	C403(0.89)	LDD1665	[21]
LDCM0463	CL70	HCT 116	C281(1.07)	LDD0780	[10]
LDCM0464	CL71	HCT 116	C281(1.04)	LDD0781	[10]
LDCM0465	CL72	HCT 116	C281(1.54)	LDD0782	[10]
LDCM0466	CL73	HCT 116	C281(0.92)	LDD0783	[10]
LDCM0467	CL74	HCT 116	C281(1.09)	LDD0784	[10]
LDCM0469	CL76	HEK-293T	C403(0.93); C362(1.08)	LDD1672	[21]
LDCM0470	CL77	HEK-293T	C403(0.87); C281(0.87)	LDD1673	[21]
LDCM0471	CL78	HEK-293T	C403(1.09)	LDD1674	[21]
LDCM0472	CL79	HEK-293T	C403(0.89)	LDD1675	[21]
LDCM0473	CL8	HEK-293T	C403(0.91); C362(1.08)	LDD1676	[21]
LDCM0474	CL80	HEK-293T	C403(0.90); C362(1.49)	LDD1677	[21]
LDCM0475	CL81	HEK-293T	C403(0.91); C362(1.09)	LDD1678	[21]
LDCM0476	CL82	HEK-293T	C403(0.94); C362(0.95)	LDD1679	[21]
LDCM0477	CL83	HEK-293T	C403(0.87); C362(0.98); C256(1.38); C331(1.08)	LDD1680	[21]
LDCM0478	CL84	HEK-293T	C362(1.07)	LDD1681	[21]
LDCM0479	CL85	HEK-293T	C403(1.04); C362(1.04)	LDD1682	[21]
LDCM0480	CL86	HEK-293T	C403(0.96); C256(1.19)	LDD1683	[21]
LDCM0481	CL87	HEK-293T	C403(1.05); C362(1.13)	LDD1684	[21]
LDCM0482	CL88	HEK-293T	C403(1.18); C362(0.95)	LDD1685	[21]
LDCM0483	CL89	HEK-293T	C403(0.93); C281(1.19)	LDD1686	[21]
LDCM0484	CL9	HEK-293T	C403(0.96); C362(1.16)	LDD1687	[21]
LDCM0485	CL90	HEK-293T	C403(0.93)	LDD1688	[21]
LDCM0486	CL91	HCT 116	C281(1.47)	LDD0803	[10]
LDCM0487	CL92	HCT 116	C281(1.29)	LDD0804	[10]
LDCM0488	CL93	HCT 116	C281(0.99)	LDD0805	[10]
LDCM0489	CL94	HCT 116	C281(1.17)	LDD0806	[10]
LDCM0490	CL95	HCT 116	C281(1.47)	LDD0807	[10]
LDCM0491	CL96	HCT 116	C281(1.42)	LDD0808	[10]
LDCM0492	CL97	HCT 116	C281(1.55)	LDD0809	[10]
LDCM0493	CL98	HCT 116	C281(1.09)	LDD0810	[10]
LDCM0494	CL99	HCT 116	C281(1.26)	LDD0811	[10]
LDCM0495	E2913	HEK-293T	C403(1.10); C362(0.99)	LDD1698	[21]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C240(3.52)	LDD1702	[22]
LDCM0468	Fragment33	HCT 116	C281(1.10)	LDD0785	[10]
LDCM0427	Fragment51	HCT 116	C281(0.97)	LDD0744	[10]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[14]
LDCM0123	JWB131	DM93	Y249(1.18)	LDD0285	[9]
LDCM0124	JWB142	DM93	Y249(1.33)	LDD0286	[9]
LDCM0125	JWB146	DM93	Y249(0.95)	LDD0287	[9]
LDCM0126	JWB150	DM93	Y249(13.28)	LDD0288	[9]
LDCM0127	JWB152	DM93	Y249(8.01)	LDD0289	[9]
LDCM0129	JWB202	DM93	Y249(1.21)	LDD0291	[9]
LDCM0130	JWB211	DM93	Y249(0.85)	LDD0292	[9]
LDCM0022	KB02	HEK-293T	C256(0.92); C246(0.90); C362(1.10)	LDD1492	[21]
LDCM0023	KB03	HEK-293T	C256(1.01); C246(0.96); C362(1.09)	LDD1497	[21]
LDCM0024	KB05	G361	C362(1.58)	LDD3311	[23]
LDCM0099	Phenelzine	MDA-MB-231	3.17	LDD0384	[2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved

Click To Hide/Show 3 Drug(s) Interacting with This Target

Drug Name	Drug Type	External ID
Remdesivir	Small molecular drug	DB14761
Sofosbuvir	Small molecular drug	DB08934
Tenofovir Alafenamide	Small molecular drug	DB09299

Phase 1

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Sar164653				.	D01CIB

Investigative

Click To Hide/Show 2 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Example 166 (Wo2014154727)				Small molecular drug	D01QJT
Pmid22861813c8a				Small molecular drug	D0I9PF

References

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2	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
4	Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
5	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
7	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
9	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
12	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
13	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
14	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16	Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
17	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
18	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
19	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
21	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
22	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
23	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni