Details of the Target

General Information of Target

Target ID LDTP11595
Target Name Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)
Gene Name FTO
Gene ID 79068
Synonyms
KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein; U6 small nuclear RNA; 2'-O-methyladenosine-N(6)-)-demethylase FTO; EC 1.14.11.-; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; EC 1.14.11.-; mRNA; 2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethylase FTO; EC 1.14.11.-; mRNA N(6)-methyladenosine demethylase FTO; EC 1.14.11.53; tRNA N1-methyl adenine demethylase FTO; EC 1.14.11.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKGPGPGGSAASSAPPAATAQVLQAQPEKPQHYTYLKEFRTEQCPLFVQHKCTQHRPYT
CFHWHFVNQRRRRSIRRRDGTFNYSPDVYCTKYDEATGLCPEGDECPFLHRTTGDTERRY
HLRYYKTGICIHETDSKGNCTKNGLHCAFAHGPHDLRSPVYDIRELQAMEALQNGQTTVE
GSIEGQSAGAASHAMIEKILSEEPRWQETAYVLGNYKTEPCKKPPRLCRQGYACPYYHNS
KDRRRSPRKHKYRSSPCPNVKHGDEWGDPGKCENGDACQYCHTRTEQQFHPEIYKSTKCN
DMQQSGSCPRGPFCAFAHVEQPPLSDDLQPSSAVSSPTQPGPVLYMPSAAGDSVPVSPSS
PHAPDLSALLCRNSSLGSPSNLCGSPPGSIRKPPNLEGIVFPGESGLAPGSYKKAPGFER
EDQVGAEYLKNFKCQAKLKPHSLEPRSQEQPLLQPKQDMLGILPAGSPLTSSISSSITSS
LAATPPSPVGTSSVPGMNANALPFYPTSDTVESVIESALDDLDLNEFGVAALEKTFDNST
VPHPGSITIGGSLLQSSAPVNIPGSLGSSASFHSASPSPPVSLSSHFLQQPQGHLSQSEN
TFLGTSASHGSLGLNGMNSSIWEHFASGSFSPGTSPAFLSGPGAAELARLRQELDEANST
IKQWEESWKQAKQACDAWKKEAEEAGERASAAGAECELAREQRDALEVQVKKLQEELERL
HAGPEPQALPAFSDLEALSLSTLYSLQKQLRAHLEQVDKAVFHMQSVKCLKCQEQKRAVL
PCQHAALCELCAEGSECPICQPGRAHTLQS
Target Bioclass
Enzyme
Family
Fto family
Subcellular location
Nucleus
Function
RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis . Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Ability to repair alkylated DNA and RNA is however unsure in vivo. Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation. Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells. Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs. Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression.
Uniprot ID
Q9C0B1
Ensemble ID
ENST00000431610.6
HGNC ID
HGNC:24678
ChEMBL ID
CHEMBL2331065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.M297T DBIA    Probe Info 
COLO678 SNV: p.A311S DBIA    Probe Info 
HCT15 SNV: p.I50F .
MCC13 SNV: p.W476Ter DBIA    Probe Info 
RPMI8226 SNV: p.E161G DBIA    Probe Info 
SNGM SNV: p.R388Q DBIA    Probe Info 
TE4 SNV: p.A68S DBIA    Probe Info 
WM793 SNV: p.V345D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.62  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		13.00  LDD0389  [2]
STPyne
 Probe Info  		K216(4.65); K88(9.50)  LDD0277  [3]
Probe 1
 Probe Info  		Y185(13.82)  LDD3495  [4]
BTD
 Probe Info  		C472(0.87)  LDD2089  [5]
AHL-Pu-1
 Probe Info  		C397(2.65); C392(2.82)  LDD0168  [6]
HHS-475
 Probe Info  		Y220(1.15)  LDD0264  [7]
HHS-465
 Probe Info  		Y214(6.85); Y220(10.00)  LDD2237  [8]
DBIA
 Probe Info  		C171(0.99)  LDD0078  [9]
W1
 Probe Info  		C171(0.62)  LDD0239  [10]
ATP probe
 Probe Info  		K88(0.00); K216(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C171(0.00); C136(0.00); C326(0.00); C392(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C338(0.00); C472(0.00)  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C171(0.00); C136(0.00); C104(0.00); C326(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
NAIA_5
 Probe Info  		N.A.  LDD2225  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
IPM
 Probe Info  		C171(0.00); C326(0.00)  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [18]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		C397(0.00); C171(0.00)  LDD0018  [19]
Ox-W18
 Probe Info  		N.A.  LDD2175  [20]
Acrolein
 Probe Info  		C171(0.00); C472(0.00); C104(0.00); C326(0.00)  LDD0217  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
AOyne
 Probe Info  		10.10  LDD0443  [22]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C238
 Probe Info  		12.13  LDD1911  [23]
C431
 Probe Info  		19.29  LDD2086  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C472(0.98)  LDD2117  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C171(1.34)  LDD2131  [5]
 LDCM0025  4SU-RNA HEK-293T C397(2.65); C392(2.82)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C392(3.46); C346(2.65); C397(8.60); C171(3.76)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C104(1.22); C171(0.90); C326(1.08); C338(1.10)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C104(0.74); C171(1.08); C326(1.13); C338(1.38)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C104(0.64); C326(0.95); C338(1.12); C346(1.12)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C104(0.47); C326(1.01); C338(1.09); C346(1.09)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C104(0.54); C326(0.92); C338(0.84); C346(0.84)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C104(0.45); C326(0.97); C338(0.94); C346(0.94)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C104(0.50); C326(1.05); C338(1.22); C346(1.22)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C104(0.47); C326(1.07); C338(1.05); C346(1.05)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C104(0.54); C326(1.01); C338(1.32); C346(1.32)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C104(0.63); C326(1.19); C338(1.29); C346(1.29)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C104(0.70); C326(0.89); C338(1.49); C346(1.49)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C104(0.77); C326(0.76); C338(1.41); C346(1.41)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C104(0.77); C171(1.30); C326(1.15); C338(1.21)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C104(0.72); C326(0.93); C338(1.05); C346(1.05)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C104(0.63); C326(0.93); C338(0.82); C346(0.82)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C104(0.54); C326(0.99); C338(0.73); C346(0.73)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C104(1.20); C171(1.03); C326(0.99); C338(0.87)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C104(0.90); C171(0.92); C326(1.01); C338(1.01)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C104(0.78); C171(0.93); C326(1.32); C338(0.81)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C104(0.83); C171(1.05); C326(1.00); C338(0.98)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C104(1.06); C171(0.93); C326(0.98); C338(1.13)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C104(1.02); C171(0.88); C326(1.07); C338(1.22)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C104(0.83); C171(0.96); C326(1.02); C338(0.80)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C104(0.90); C171(1.08); C326(1.08); C338(1.19)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C104(1.02); C171(1.28); C326(1.15); C338(0.76)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C104(1.06); C171(0.93); C326(1.05); C338(1.80)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C104(0.83); C171(0.90); C326(0.96); C338(0.98)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C104(0.97); C171(1.15); C326(1.11); C338(1.15)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C104(1.12); C171(0.81); C326(0.98); C338(1.69)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C104(1.11); C171(1.00); C326(1.06); C338(1.09)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C104(0.98); C171(1.01); C326(1.53); C338(1.52)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C104(0.97); C171(0.85); C326(1.20); C338(1.36)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C104(0.97); C326(1.17)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C104(1.11); C326(0.88)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C104(0.81); C326(0.99)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C104(1.03); C326(0.89)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C104(1.26); C326(1.01)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C104(0.85); C326(1.07)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C104(0.77); C326(1.08)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C104(0.90); C326(1.13)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C104(0.95); C326(1.06)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C104(0.95); C326(1.06)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C104(0.88); C326(1.14)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C104(0.93); C326(0.94)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C104(0.67); C171(1.05); C326(1.06); C338(1.09)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C104(0.90); C326(1.23)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C104(0.90); C326(1.19)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C104(0.92); C326(0.93)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C104(0.69); C326(1.18)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C104(0.40); C326(0.78)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C104(0.90); C326(1.12)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C104(0.35); C326(1.60)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C104(0.40); C326(1.52)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C104(0.27); C326(1.29)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C104(0.36); C326(1.41)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C472(0.61); C104(0.68); C326(1.08); C338(1.23)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C104(0.53); C326(1.94)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C104(0.84); C326(1.05)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C104(0.39); C326(1.63)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C104(0.26); C326(1.82)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C104(0.44); C326(1.46)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C104(0.41); C326(1.89)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C104(0.88); C326(1.38)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C104(1.00); C326(1.28)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C104(0.89); C326(1.04); C171(1.06); C338(1.29)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C338(0.80); C346(0.80); C326(1.26); C104(1.28)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C326(1.14); C104(1.15); C338(1.22); C346(1.22)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C171(0.78); C104(0.84); C338(0.92); C346(0.92)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C104(0.87); C171(1.03); C326(1.15); C338(1.18)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C104(1.02); C326(1.14); C171(1.14); C338(1.16)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C104(0.88); C326(1.00); C171(1.06); C338(1.18)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C338(1.08); C346(1.08); C326(1.09); C104(1.10)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C104(0.92); C326(1.00); C171(1.43); C338(1.58)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C104(0.83); C338(0.88); C346(0.88); C171(1.08)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C338(0.50); C346(0.50); C104(0.68); C171(1.16)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C338(0.49); C346(0.49); C104(0.77); C326(1.32)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C338(0.37); C346(0.37); C104(0.71); C171(1.23)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C338(0.50); C346(0.50); C104(0.62); C171(1.16)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C171(0.72); C104(0.91); C338(1.03); C346(1.03)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C338(0.49); C346(0.49); C104(0.63); C171(1.22)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C338(0.32); C346(0.32); C104(0.69); C171(1.26)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C338(0.31); C346(0.31); C104(0.53); C171(1.37)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C338(0.40); C346(0.40); C104(0.58); C326(1.16)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C338(0.28); C346(0.28); C104(0.58); C326(1.36)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C326(0.84); C171(0.98); C338(1.05); C346(1.05)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C338(0.95); C346(0.95); C171(0.96); C326(1.00)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C326(0.96); C171(0.97); C338(1.15); C346(1.15)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C171(0.98); C326(1.01); C338(1.04); C346(1.04)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C171(0.84); C104(0.96); C338(1.02); C346(1.02)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C171(0.71); C326(1.05); C338(1.06); C346(1.06)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C338(0.76); C346(0.76); C104(0.91); C171(1.14)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C338(0.78); C346(0.78); C326(1.06); C104(1.11)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C338(0.88); C346(0.88); C104(1.03); C326(1.08)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C338(0.66); C346(0.66); C104(0.80); C326(1.18)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C338(0.81); C346(0.81); C326(1.13); C171(1.20)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C338(0.86); C346(0.86); C104(1.09); C171(1.14)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C104(0.79); C338(0.80); C346(0.80); C472(0.84)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C338(0.84); C346(0.84); C104(0.89); C326(0.98)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C472(0.50); C104(0.57); C171(0.85); C338(0.91)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C472(0.65); C104(0.71); C338(0.76); C346(0.76)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C171(0.68); C104(1.01); C338(1.14); C346(1.14)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C104(0.63); C338(0.86); C346(0.86); C472(0.96)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C472(0.74); C326(0.86); C104(0.92); C338(0.98)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C338(0.87); C346(0.87); C104(0.97); C326(1.00)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C104(0.87); C472(0.91); C338(0.91); C346(0.91)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C472(0.75); C104(0.77); C171(0.97); C326(1.14)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C472(0.76); C104(0.88); C338(0.98); C346(0.98)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C104(0.58); C338(0.78); C346(0.78); C472(0.80)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C338(0.32); C346(0.32); C472(0.80); C104(0.81)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C338(0.29); C346(0.29); C104(0.82); C171(1.06)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C338(0.43); C346(0.43); C104(0.81); C472(1.08)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C472(0.57); C104(0.69); C171(0.92); C338(1.05)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C338(0.25); C346(0.25); C104(0.61); C472(0.71)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C338(0.21); C346(0.21); C104(0.68); C472(0.69)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C338(0.34); C346(0.34); C104(0.86); C171(1.06)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C338(0.28); C346(0.28); C472(0.75); C104(0.84)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C338(0.29); C346(0.29); C104(0.76); C171(1.06)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C338(0.40); C346(0.40); C104(0.80); C472(0.93)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C338(0.33); C346(0.33); C104(0.81); C472(0.94)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C338(0.21); C346(0.21); C104(0.59); C472(0.72)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C104(0.63); C338(0.85); C346(0.85); C326(1.01)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C104(0.57); C338(0.93); C346(0.93); C326(0.95)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C104(0.74); C171(0.90); C472(0.91); C326(1.04)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C104(0.58); C338(0.81); C346(0.81); C326(1.07)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C326(0.84); C104(0.87); C338(1.28); C346(1.28)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C104(0.69); C338(0.96); C346(0.96); C326(1.27)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C104(0.54); C338(0.77); C346(0.77); C326(0.92)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C104(0.74); C338(0.75); C346(0.75); C326(0.90)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C104(0.52); C338(0.88); C346(0.88); C326(1.03)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C104(0.78); C326(0.85); C338(1.05); C346(1.05)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C104(0.63); C326(0.88); C338(0.94); C346(0.94)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C104(0.61); C338(0.78); C346(0.78); C326(1.00)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C104(0.78); C326(0.98); C338(1.04); C346(1.04)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C472(0.57); C104(0.81); C338(1.07); C346(1.07)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C326(0.85); C338(0.86); C346(0.86); C104(0.95)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C104(0.74); C338(0.97); C346(0.97); C326(0.98)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C104(0.60); C338(0.71); C346(0.71); C326(0.88)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C338(0.53); C346(0.53); C104(0.77); C472(0.91)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C338(0.51); C346(0.51); C104(0.74); C472(0.98)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C338(0.57); C346(0.57); C104(0.77); C472(0.82)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C338(0.72); C346(0.72); C104(1.01); C326(1.09)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C338(0.86); C346(0.86); C326(0.96); C104(1.01)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C338(1.04); C346(1.04); C104(1.09); C326(1.17)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C338(0.63); C346(0.63); C104(0.72); C472(0.90)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C104(1.00); C472(1.02); C326(1.03); C338(2.35)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C338(0.65); C346(0.65); C104(0.87); C472(0.99)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C338(0.74); C346(0.74); C104(0.95); C472(1.10)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C338(0.74); C346(0.74); C104(0.88); C472(1.04)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C338(0.55); C346(0.55); C326(1.09); C104(1.19)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C338(0.64); C346(0.64); C104(0.74); C472(0.76)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C338(0.59); C346(0.59); C104(1.09); C326(1.10)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C338(0.59); C346(0.59); C472(0.84); C104(0.85)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C104(0.29); C472(0.67); C338(0.86); C346(0.86)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C104(0.56); C472(0.72); C326(0.85); C338(1.08)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C472(0.49)  LDD2138  [5]
 LDCM0248  AKOS034007472 HCT 116 C104(1.01); C171(0.87); C326(1.05); C338(1.26)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C472(0.50); C104(0.89); C171(0.98); C326(1.10)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C472(0.57); C104(0.60); C338(1.13); C346(1.13)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C171(0.99)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C472(0.73)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C326(0.00); C472(0.00)  LDD0222  [21]
 LDCM0367  CL1 HCT 116 C326(0.92); C472(0.95); C104(1.01); C171(1.13)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C104(0.65); C171(0.92); C472(1.14); C326(1.15)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C326(0.94); C171(0.96); C338(1.12); C346(1.12)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C472(0.57); C104(0.71); C326(1.20); C338(1.23)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C472(0.56); C104(0.84); C326(1.00); C171(1.10)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C472(0.57); C104(0.91); C326(0.99); C338(1.25)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C472(0.48); C104(0.81); C326(0.98); C171(1.09)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C338(0.94); C346(0.94); C326(1.08); C171(1.26)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C171(1.04); C338(1.21); C346(1.21); C326(1.28)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C338(0.97); C346(0.97); C171(1.26); C326(1.38)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C104(1.10); C171(1.13); C326(1.25); C338(1.91)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C104(1.00); C338(1.01); C346(1.01); C326(1.28)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C104(0.81); C472(0.92); C171(0.99); C326(1.33)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C171(1.01); C104(1.11); C326(1.19); C338(1.68)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C104(0.84); C338(0.91); C346(0.91); C326(1.15)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C338(0.59); C346(0.59); C104(0.98); C171(0.99)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C338(0.33); C346(0.33); C104(0.60); C326(1.29)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C338(0.57); C346(0.57); C104(0.60); C171(1.23)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C338(0.47); C346(0.47); C104(0.68); C171(1.16)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C338(0.48); C346(0.48); C104(0.65); C171(1.03)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C338(0.64); C346(0.64); C104(0.69); C171(1.29)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C338(0.81); C346(0.81); C171(0.91); C104(0.94)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C338(0.73); C346(0.73); C104(0.90); C171(0.98)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C104(0.82); C472(0.97); C171(1.09); C326(1.46)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C338(0.97); C346(0.97); C171(1.04); C104(1.15)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C104(0.70); C338(0.92); C346(0.92); C472(1.04)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C104(0.68); C338(0.84); C346(0.84); C472(0.87)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C104(0.71); C338(0.79); C346(0.79); C171(0.97)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C104(0.65); C472(0.74); C338(0.89); C346(0.89)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C338(0.82); C346(0.82); C104(0.91); C472(1.00)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C338(0.59); C346(0.59); C104(0.83); C171(1.04)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C338(0.52); C346(0.52); C104(0.80); C171(1.00)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C338(0.46); C346(0.46); C104(0.80); C171(0.98)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C104(0.76); C171(1.03); C472(1.14); C326(1.24)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C104(0.79); C472(0.91); C171(1.02); C326(1.03)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C104(0.75); C472(0.96); C171(1.06); C326(1.21)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C104(0.59); C338(0.85); C346(0.85); C171(0.90)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C104(0.70); C338(0.77); C346(0.77); C326(0.89)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C104(0.41); C171(0.99); C326(1.02); C338(1.30)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C104(0.55); C338(1.01); C346(1.01); C171(1.09)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C472(0.96); C326(0.99); C171(1.00); C104(1.85)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C338(0.55); C346(0.55); C104(0.59); C171(1.02)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C104(0.60); C338(0.93); C346(0.93); C171(1.16)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C104(0.54); C338(1.01); C346(1.01); C171(1.34)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C104(0.55); C171(0.93); C338(1.00); C346(1.00)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C104(0.46); C338(1.02); C346(1.02); C171(1.23)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C104(0.48); C171(0.95); C326(1.26); C338(1.06)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C104(0.49); C171(0.97); C326(1.13); C338(0.86)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C104(0.60); C171(0.99); C326(1.13); C338(1.05)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C104(0.40); C171(0.96); C326(1.18); C338(0.87)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C104(0.51); C171(1.05); C326(1.24); C338(0.72)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C104(0.79); C171(1.04); C326(1.09); C472(0.84)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C104(0.57); C171(0.92); C326(1.11); C338(1.10)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C104(0.71); C171(0.89); C326(1.26); C338(0.85)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C104(0.40); C171(1.05); C326(1.18); C338(0.42)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C104(0.36); C171(0.96); C326(1.02); C338(0.52)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C104(0.39); C171(1.10); C326(1.21); C338(0.69)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C104(0.51); C171(1.22); C326(1.32); C338(0.73)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C104(0.54); C171(1.36); C326(1.26); C338(0.79)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C104(0.45); C171(1.25); C326(1.31); C338(0.78)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C104(0.51); C171(1.13); C326(1.20); C338(0.65)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C104(0.85); C171(1.20); C326(1.06); C472(0.69)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C104(0.53); C171(1.32); C326(1.46); C338(0.74)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C104(0.74); C171(1.20); C326(1.38); C338(0.68)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C104(0.46); C171(1.52); C326(1.61); C338(0.68)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C104(0.45); C171(1.19); C326(1.41); C338(0.54)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C104(0.38); C171(1.01); C326(1.42); C338(0.74)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C104(0.32); C171(0.91); C326(1.37); C338(0.68)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C104(1.44); C171(1.03); C326(0.86); C338(2.25)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C104(1.30); C171(1.03); C326(0.88); C338(1.10)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C104(1.40); C171(1.05); C326(0.93); C338(1.41)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C104(1.36); C171(0.94); C326(0.96); C338(2.49)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C104(0.88); C171(0.92); C326(1.08); C472(1.16)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C104(1.41); C171(1.03); C326(0.92); C338(1.23)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C104(1.33); C171(0.98); C326(0.99); C338(1.75)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C104(1.45); C171(1.06); C326(0.99); C338(1.67)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C104(1.41); C171(1.45); C326(0.86); C338(0.66)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C104(1.22); C171(1.12); C326(0.88); C338(1.31)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C104(1.45); C171(1.03); C326(0.84); C338(1.19)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C104(1.07); C171(1.21); C326(0.91); C338(1.02)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C104(1.25); C171(1.23); C326(0.85); C338(1.15)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C104(1.43); C171(1.18); C326(0.93); C338(1.93)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C104(1.30); C171(1.00); C326(0.92); C338(1.19)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C104(0.58); C171(0.97); C326(1.16); C472(1.16)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C104(1.24); C171(0.95); C326(0.94); C338(2.07)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C104(0.91); C171(1.02); C326(1.14)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C104(0.89); C171(0.87); C326(1.18)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C104(0.91); C171(0.95); C326(1.17)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C104(0.83); C171(0.96); C326(1.29)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C104(1.03); C171(1.01); C326(1.07)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C104(0.82); C171(0.86); C326(1.23)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C104(0.87); C171(0.97); C326(1.04)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C104(0.64); C171(1.43); C326(1.11)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C104(0.57); C171(1.03); C326(1.07)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C104(0.81); C171(0.81); C326(1.20); C472(1.16)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C104(0.65); C171(1.05); C326(1.22)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C104(0.83); C171(0.98); C326(1.17)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C104(0.90); C171(1.18); C326(1.16)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C104(0.79); C171(1.11); C326(1.19)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C104(0.83); C171(1.06); C326(1.15)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C104(0.37); C171(1.17); C326(1.00)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C104(0.60); C171(1.31); C326(0.93)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C104(0.69); C171(1.12); C326(1.01)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C104(0.51); C171(1.15); C326(1.10)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C104(0.58); C171(1.07); C326(1.20); C472(1.08)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C104(0.28); C171(0.93); C326(1.09)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C104(0.59); C171(0.97); C326(0.94)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C104(0.37); C171(0.94); C326(1.06)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C104(0.37); C171(0.97); C326(1.10)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C104(0.30); C171(1.12); C326(1.03)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C104(0.60); C171(1.21); C326(1.00)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C104(0.86); C171(1.19); C326(1.06)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C104(0.56); C171(1.15); C326(1.24)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C104(0.40); C171(1.15); C326(1.13)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C104(0.29); C171(1.05); C326(1.06)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C104(0.99); C171(0.99); C326(1.07); C472(1.08)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C104(0.98); C171(1.32); C326(0.99)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C104(0.83); C171(1.25); C326(0.98); C338(0.80)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C104(0.80); C171(1.17); C326(0.85); C338(0.82)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C104(0.98); C171(0.65); C326(0.88); C338(0.95)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C104(1.13); C171(0.93); C326(0.94); C338(1.00)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C104(0.81); C171(0.89); C326(0.95); C338(0.79)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C104(0.71); C171(0.89); C326(1.06); C338(0.82)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C104(0.69); C171(0.90); C326(1.10); C338(0.78)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C104(0.82); C171(0.93); C326(1.18); C338(0.85)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C104(0.87); C171(0.81); C326(1.06); C338(1.06)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C472(1.13); C249(0.92); C171(0.95); C326(0.96)  LDD1698  [24]
 LDCM0625  F8 Ramos C326(0.89); C171(1.29)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C326(0.82); C171(1.25)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C326(7.14); C171(1.39)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C326(0.75); C171(0.79)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C326(1.21); C171(0.95)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C326(1.53); C171(0.74)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C326(0.67); C171(0.74)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C326(1.59); C171(1.06)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C326(1.38); C171(0.92)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C326(1.77); C171(0.98)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C326(1.19); C171(0.66)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C326(0.76); C171(1.27)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C326(1.61); C171(0.88)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C326(0.89); C171(1.20)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C104(0.81); C171(0.93); C326(1.19)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C326(0.65); C171(0.70)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C326(0.78); C171(0.73)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C104(0.53); C171(1.92); C326(1.64); C338(0.86)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C326(1.03); C171(0.98)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C326(0.82); C171(1.12)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C326(0.87); C171(1.03)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C326(0.77); C171(0.90)  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y220(1.15)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y220(0.70)  LDD0265  [7]
 LDCM0119  HHS-0401 DM93 Y220(0.99)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y220(0.55)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C472(0.97); C249(0.78); C171(0.93); C136(0.99)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C472(0.99); C249(1.02); C171(0.92); C136(0.95)  LDD1497  [24]
 LDCM0024  KB05 COLO792 C104(2.73)  LDD3310  [26]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C472(0.63)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C472(0.87)  LDD2089  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C472(0.98); C104(0.78)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C472(0.63); C326(1.15)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C104(0.94)  LDD2111  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C472(0.80); C326(0.83)  LDD2125  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C472(0.93)  LDD2128  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C472(0.86); C104(0.92)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C472(0.92); C104(0.81)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C472(0.80); C326(1.00)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C472(0.84)  LDD2140  [5]
 LDCM0099  Phenelzine HEK-293T 5.00  LDD0390  [2]
 LDCM0131  RA190 MM1.R C346(1.85); C249(1.47); C171(1.39)  LDD0304  [27]
 LDCM0112  W16 Hep-G2 C171(0.62)  LDD0239  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1) Clp1 family Q92989
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 77 (ZNF77) Krueppel C2H2-type zinc-finger protein family Q15935
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) . Q9UI95
MORN repeat-containing protein 3 (MORN3) . Q6PF18
SHC-transforming protein 3 (SHC3) . Q92529

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

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2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.