Details of the Target

General Information of Target

Target ID LDTP04398
Target Name Ras-related protein Rab-5C (RAB5C)
Gene Name RAB5C
Gene ID 5878
Synonyms
RABL; Ras-related protein Rab-5C; EC 3.6.5.2; L1880; RAB5L
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLT
QTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQ
RQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAK
KLPKNEPQNATGAPGRNRGVDLQENNPASRSQCCSN
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cell membrane
Function Protein transport. Probably involved in vesicular traffic.
Uniprot ID
P51148
Ensemble ID
ENST00000346213.9
HGNC ID
HGNC:9785

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.E29Ter .
KASUMI1 SNV: p.L37V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
W1
 Probe Info  		15.93  LDD0235  [3]
STPyne
 Probe Info  		K135(6.67); K141(5.11); K180(5.43)  LDD0277  [4]
AZ-9
 Probe Info  		D201(1.30); E204(0.96)  LDD2208  [5]
ONAyne
 Probe Info  		K18(7.20); K184(1.49)  LDD0275  [4]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0392  [6]
DBIA
 Probe Info  		C97(1.44)  LDD3312  [7]
BTD
 Probe Info  		C20(0.16)  LDD2118  [8]
DA-P3
 Probe Info  		6.43  LDD0180  [9]
AHL-Pu-1
 Probe Info  		C64(2.05)  LDD0169  [10]
HPAP
 Probe Info  		3.36  LDD0064  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
IPM
 Probe Info  		N.A.  LDD0025  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
SF
 Probe Info  		Y90(0.00); Y83(0.00); Y91(0.00)  LDD0028  [15]
AOyne
 Probe Info  		12.20  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		7.62  LDD1977  [18]
FFF probe13
 Probe Info  		6.12  LDD0475  [19]
FFF probe2
 Probe Info  		16.03  LDD0463  [19]
FFF probe3
 Probe Info  		19.57  LDD0464  [19]
JN0003
 Probe Info  		5.00  LDD0469  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C64(2.05)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C64(1.04); C20(0.92)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C64(1.05)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C64(0.98); C20(0.84)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C64(1.00)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C64(1.00)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C64(0.97)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C64(0.98); C20(0.79)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C64(1.11)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C64(0.94); C20(0.80)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C64(1.12)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C64(1.03)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C64(1.03)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C64(1.06)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C64(0.96)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C64(1.05)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C64(0.94); C20(0.88)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C64(0.99)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C64(1.00); C20(0.83)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C64(1.02)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C64(1.03)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C64(1.04); C20(0.81)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C64(0.98)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C64(0.93)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C64(0.96)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C64(1.02); C20(0.92)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C64(1.05)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C64(1.02); C20(0.82)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C64(0.99)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C64(1.06)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C64(0.93)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C64(0.94)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C64(1.05)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C64(1.02)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C64(0.97); C20(0.98)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C64(1.02)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C64(0.95); C20(0.87)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C64(1.08)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C64(0.98)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C64(0.96)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C64(1.01)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C64(0.97)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C64(0.99); C20(0.95)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C64(1.02)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C64(1.02)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C64(0.98); C20(0.96)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C64(1.07)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C64(0.95)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C64(0.99)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C64(0.99)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C64(0.95)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C64(1.01); C20(0.83)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C64(1.01)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C64(1.01); C20(0.90)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C64(0.99)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C64(1.04)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C64(1.05)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C64(1.01)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C64(0.97)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C64(1.04)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C64(1.04)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C64(0.92)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C64(1.01)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C64(0.96); C20(1.11)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C64(0.97)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 13.06  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 17.75  LDD0185  [9]
 LDCM0367  CL1 HEK-293T C64(0.96)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C64(1.12)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C64(0.99)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C64(1.04)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C64(1.08); C20(0.79)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C64(0.89)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C64(0.97)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C64(0.96)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C64(1.00); C20(0.84)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C64(0.94)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C64(0.88)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C64(0.94)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C64(1.27)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C64(0.97); C20(0.82)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C64(0.95)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C64(0.84)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C64(1.01)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C64(0.95); C20(0.89)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C64(0.91)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C64(0.93)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C64(1.01)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C64(0.98); C20(0.87)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C64(0.97)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C64(1.46)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C64(0.94)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C64(0.93)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C64(1.03); C20(0.98)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C64(0.86)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C64(0.94)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C64(1.00)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C64(1.04); C20(1.04)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C64(0.88)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C64(0.99)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C64(1.00)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C64(1.00); C20(0.93)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C64(0.86)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C64(1.03)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C64(1.00); C20(0.82)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C64(1.23)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C64(1.20); C20(1.00)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C64(1.00); C20(1.10)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C64(1.21)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C64(1.12)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C64(1.27)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C64(1.38)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C64(1.52)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C64(0.89)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C64(1.01); C20(0.94)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C64(0.92)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C64(0.89)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C64(0.99); C20(0.79)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C64(0.89)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C64(1.08)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C64(1.05); C20(0.70)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C64(1.21)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C64(1.09)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C64(1.26)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C64(1.32)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C64(1.38)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C64(0.99)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C64(0.95)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C64(1.04)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C64(1.05)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C64(1.04); C20(0.76)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C64(1.11)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C64(1.18); C20(0.77)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C64(1.21)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C64(1.14)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C64(1.26)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C64(1.16)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C64(1.35)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C64(0.96)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C64(1.06); C20(1.00)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C64(0.98); C20(0.92)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C64(1.05)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C64(0.97); C20(0.87)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C64(1.06)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C64(1.15); C20(0.89)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C64(1.15)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C64(1.15)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C64(1.31)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C64(1.32)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C64(1.02)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C64(1.34)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C64(1.00)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C64(1.07); C20(0.98)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C64(0.89)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C64(0.96)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C64(0.99); C20(0.91)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C64(1.07)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C64(1.10); C20(0.77)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C64(1.11)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C64(1.16)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C64(1.21); C20(0.86)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C64(1.21)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C64(1.15)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C64(1.39)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C64(0.90)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C64(1.00); C20(0.97)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C64(0.98)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C64(0.94); C20(0.78)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C64(1.03)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C64(1.06); C20(0.69)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C64(1.11)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C64(1.17)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C64(1.07)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C64(1.10)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C64(1.09)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C64(1.25)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C64(1.09)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C64(1.09); C20(1.11)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C64(1.01)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C64(1.04)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C64(1.02); C20(0.99)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C64(1.29)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C64(0.96)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C64(1.07); C20(0.79)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C64(1.08)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C64(1.11)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C64(1.11)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C64(0.95)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C64(1.24)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C64(0.94)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C64(1.00); C20(0.91)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C64(0.95)  LDD1697  [20]
 LDCM0028  Dobutamine HEK-293T 6.43  LDD0180  [9]
 LDCM0495  E2913 HEK-293T C64(0.93)  LDD1698  [20]
 LDCM0572  Fragment10 Ramos C20(1.67)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C20(0.73)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C20(2.57)  LDD2191  [21]
 LDCM0576  Fragment14 Ramos C20(0.53)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C20(1.55)  LDD2194  [21]
 LDCM0586  Fragment28 Ramos C20(0.72)  LDD2198  [21]
 LDCM0468  Fragment33 HEK-293T C64(0.88)  LDD1671  [20]
 LDCM0427  Fragment51 HEK-293T C64(1.08); C20(0.96)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C20(1.87)  LDD2204  [21]
 LDCM0571  Fragment9 Ramos C20(1.26)  LDD2188  [21]
 LDCM0022  KB02 HEK-293T C64(0.96)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C64(1.03)  LDD1497  [20]
 LDCM0024  KB05 HMCB C97(1.44)  LDD3312  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C20(0.16)  LDD2118  [8]
 LDCM0014  Panhematin hPBMC 3.36  LDD0064  [11]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0392  [6]
 LDCM0131  RA190 MM1.R C64(1.24)  LDD0304  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
ALS2 C-terminal-like protein (ALS2CL) . Q60I27
DCC-interacting protein 13-beta (APPL2) . Q8NEU8
Early endosome antigen 1 (EEA1) . Q15075

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.