Details of the Target

General Information of Target

Target ID LDTP10884
Target Name Sialidase-1 (NEU1)
Gene Name NEU1
Gene ID 4758
Synonyms
NANH; Sialidase-1; EC 3.2.1.18; Acetylneuraminyl hydrolase; G9 sialidase; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVT
NTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFS
SSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPD
GFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFR
SMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVK
STVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAH
LDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLF
GESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQ
WEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 33 family
Subcellular location
Lysosome membrane
Function
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Uniprot ID
Q99519
Ensemble ID
ENST00000229725.4
HGNC ID
HGNC:7758
ChEMBL ID
CHEMBL2726

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.06  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		5.00  LDD0391  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
IPM
 Probe Info  		C299(0.00); C289(0.00); C287(0.00); C164(0.00)  LDD0241  [4]
Probe 1
 Probe Info  		Y296(13.76)  LDD3495  [5]
DBIA
 Probe Info  		C289(1.80)  LDD3311  [6]
FBPP2
 Probe Info  		13.03  LDD0054  [7]
IA-alkyne
 Probe Info  		C218(0.00); C230(0.00)  LDD0162  [8]
Phosphinate-6
 Probe Info  		C287(0.00); C299(0.00)  LDD0018  [9]
NAIA_5
 Probe Info  		C230(0.00); C218(0.00); C299(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		19.16  LDD1850  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C299(0.84)  LDD1094  [12]
 LDCM0216  AC100 PaTu 8988t C289(0.81); C299(0.79)  LDD1095  [12]
 LDCM0217  AC101 PaTu 8988t C289(0.93); C299(1.31)  LDD1096  [12]
 LDCM0218  AC102 PaTu 8988t C289(1.28); C299(1.85)  LDD1097  [12]
 LDCM0219  AC103 PaTu 8988t C289(0.74); C299(0.92)  LDD1098  [12]
 LDCM0220  AC104 PaTu 8988t C289(1.16); C299(1.05)  LDD1099  [12]
 LDCM0221  AC105 PaTu 8988t C289(1.12); C299(1.65)  LDD1100  [12]
 LDCM0222  AC106 PaTu 8988t C289(1.93); C299(0.89)  LDD1101  [12]
 LDCM0223  AC107 PaTu 8988t C289(1.00); C299(1.57)  LDD1102  [12]
 LDCM0224  AC108 PaTu 8988t C289(1.03); C299(1.08)  LDD1103  [12]
 LDCM0225  AC109 PaTu 8988t C289(1.33); C299(1.22)  LDD1104  [12]
 LDCM0226  AC11 PaTu 8988t C299(0.79)  LDD1105  [12]
 LDCM0227  AC110 PaTu 8988t C289(1.38); C299(1.49)  LDD1106  [12]
 LDCM0228  AC111 PaTu 8988t C289(3.45); C299(0.62)  LDD1107  [12]
 LDCM0229  AC112 PaTu 8988t C289(1.27); C299(1.24)  LDD1108  [12]
 LDCM0230  AC113 PaTu 8988t C299(0.59)  LDD1109  [12]
 LDCM0231  AC114 PaTu 8988t C299(0.85)  LDD1110  [12]
 LDCM0232  AC115 PaTu 8988t C299(0.58)  LDD1111  [12]
 LDCM0233  AC116 PaTu 8988t C299(0.64)  LDD1112  [12]
 LDCM0234  AC117 PaTu 8988t C299(0.56)  LDD1113  [12]
 LDCM0235  AC118 PaTu 8988t C299(0.87)  LDD1114  [12]
 LDCM0236  AC119 PaTu 8988t C299(0.42)  LDD1115  [12]
 LDCM0237  AC12 PaTu 8988t C299(0.74)  LDD1116  [12]
 LDCM0238  AC120 PaTu 8988t C299(0.75)  LDD1117  [12]
 LDCM0239  AC121 PaTu 8988t C299(0.37)  LDD1118  [12]
 LDCM0240  AC122 PaTu 8988t C299(0.80)  LDD1119  [12]
 LDCM0241  AC123 PaTu 8988t C299(0.56)  LDD1120  [12]
 LDCM0242  AC124 PaTu 8988t C299(0.33)  LDD1121  [12]
 LDCM0243  AC125 PaTu 8988t C299(0.74)  LDD1122  [12]
 LDCM0244  AC126 PaTu 8988t C299(0.88)  LDD1123  [12]
 LDCM0245  AC127 PaTu 8988t C299(0.46)  LDD1124  [12]
 LDCM0259  AC14 PaTu 8988t C299(0.98)  LDD1138  [12]
 LDCM0270  AC15 PaTu 8988t C299(0.89)  LDD1149  [12]
 LDCM0277  AC18 HEK-293T C289(1.11)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C289(1.00)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C289(1.01)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C299(1.02); C289(0.96)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C299(1.05); C289(1.00)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C299(1.04); C289(1.05); C287(1.24)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C299(0.99); C289(0.90)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C299(0.99); C289(1.12)  LDD1523  [13]
 LDCM0286  AC26 HEK-293T C289(1.05)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C289(1.04)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C299(0.99); C289(0.99)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C299(1.01); C289(1.07)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C289(1.04)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C299(1.02); C289(1.14); C287(1.38)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C299(1.03); C289(1.15)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C299(0.98); C289(1.21)  LDD1532  [13]
 LDCM0295  AC34 HEK-293T C289(1.17)  LDD1534  [13]
 LDCM0296  AC35 PaTu 8988t C289(1.11)  LDD1175  [12]
 LDCM0297  AC36 PaTu 8988t C289(1.62)  LDD1176  [12]
 LDCM0298  AC37 PaTu 8988t C289(2.41)  LDD1177  [12]
 LDCM0299  AC38 PaTu 8988t C289(1.53)  LDD1178  [12]
 LDCM0300  AC39 PaTu 8988t C289(1.20)  LDD1179  [12]
 LDCM0301  AC4 HEK-293T C299(1.07); C289(1.04)  LDD1540  [13]
 LDCM0302  AC40 PaTu 8988t C289(1.55)  LDD1181  [12]
 LDCM0303  AC41 PaTu 8988t C289(0.64)  LDD1182  [12]
 LDCM0304  AC42 PaTu 8988t C289(0.92)  LDD1183  [12]
 LDCM0305  AC43 PaTu 8988t C289(1.49)  LDD1184  [12]
 LDCM0306  AC44 PaTu 8988t C289(1.20)  LDD1185  [12]
 LDCM0307  AC45 PaTu 8988t C289(1.50)  LDD1186  [12]
 LDCM0308  AC46 PaTu 8988t C289(1.18); C299(0.98)  LDD1187  [12]
 LDCM0309  AC47 PaTu 8988t C289(1.27); C299(1.14)  LDD1188  [12]
 LDCM0310  AC48 PaTu 8988t C289(1.11); C299(0.94)  LDD1189  [12]
 LDCM0311  AC49 PaTu 8988t C289(2.30); C299(0.54)  LDD1190  [12]
 LDCM0312  AC5 HEK-293T C299(1.01); C289(0.98)  LDD1551  [13]
 LDCM0313  AC50 PaTu 8988t C289(2.16); C299(0.50)  LDD1192  [12]
 LDCM0314  AC51 PaTu 8988t C289(0.38); C299(0.23)  LDD1193  [12]
 LDCM0315  AC52 PaTu 8988t C289(1.06); C299(0.83)  LDD1194  [12]
 LDCM0316  AC53 PaTu 8988t C289(1.71); C299(0.44)  LDD1195  [12]
 LDCM0317  AC54 PaTu 8988t C289(2.11); C299(0.35)  LDD1196  [12]
 LDCM0318  AC55 PaTu 8988t C289(1.46); C299(1.33)  LDD1197  [12]
 LDCM0319  AC56 PaTu 8988t C289(1.37); C299(1.07)  LDD1198  [12]
 LDCM0321  AC58 HEK-293T C289(1.11)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C289(1.09)  LDD1561  [13]
 LDCM0323  AC6 PaTu 8988t C299(1.03)  LDD1202  [12]
 LDCM0324  AC60 HEK-293T C299(1.16); C289(1.12)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C299(1.08); C289(1.14)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C299(0.99); C289(1.08); C287(1.50)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C299(1.03); C289(1.01)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C299(0.95); C289(1.31)  LDD1567  [13]
 LDCM0334  AC7 PaTu 8988t C299(0.87)  LDD1213  [12]
 LDCM0345  AC8 PaTu 8988t C299(0.96)  LDD1224  [12]
 LDCM0365  AC98 PaTu 8988t C289(1.23); C299(1.49)  LDD1244  [12]
 LDCM0366  AC99 PaTu 8988t C289(0.92); C299(1.15)  LDD1245  [12]
 LDCM0248  AKOS034007472 PaTu 8988t C299(1.12)  LDD1127  [12]
 LDCM0356  AKOS034007680 PaTu 8988t C299(0.63)  LDD1235  [12]
 LDCM0275  AKOS034007705 PaTu 8988t C299(0.77)  LDD1154  [12]
 LDCM0156  Aniline NCI-H1299 11.41  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C299(1.00)  LDD1246  [12]
 LDCM0368  CL10 PaTu 8988t C299(0.35)  LDD1247  [12]
 LDCM0369  CL100 HEK-293T C299(0.98); C287(1.25)  LDD1573  [13]
 LDCM0370  CL101 PaTu 8988t C299(0.93)  LDD1249  [12]
 LDCM0371  CL102 PaTu 8988t C299(0.72)  LDD1250  [12]
 LDCM0372  CL103 PaTu 8988t C299(0.83)  LDD1251  [12]
 LDCM0373  CL104 PaTu 8988t C299(0.85)  LDD1252  [12]
 LDCM0374  CL105 HEK-293T C299(1.01); C289(0.99)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C299(0.91)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C299(0.99); C289(1.12)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C299(0.95); C287(1.30)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C299(0.97); C289(0.90)  LDD1582  [13]
 LDCM0379  CL11 PaTu 8988t C299(0.83)  LDD1258  [12]
 LDCM0380  CL110 HEK-293T C299(1.02)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C299(0.98); C289(1.19)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C299(1.08); C287(1.19)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C299(1.04); C289(1.01)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C299(0.99)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C299(1.08); C289(1.30)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C299(0.90); C287(1.19)  LDD1590  [13]
 LDCM0387  CL117 PaTu 8988t C289(0.87)  LDD1266  [12]
 LDCM0388  CL118 PaTu 8988t C289(1.02)  LDD1267  [12]
 LDCM0389  CL119 PaTu 8988t C289(1.34)  LDD1268  [12]
 LDCM0390  CL12 PaTu 8988t C299(0.72)  LDD1269  [12]
 LDCM0391  CL120 PaTu 8988t C289(1.43)  LDD1270  [12]
 LDCM0392  CL121 PaTu 8988t C289(1.32); C299(1.54)  LDD1271  [12]
 LDCM0393  CL122 PaTu 8988t C289(1.41); C299(1.05)  LDD1272  [12]
 LDCM0394  CL123 PaTu 8988t C289(1.20); C299(0.79)  LDD1273  [12]
 LDCM0395  CL124 PaTu 8988t C289(1.59); C299(0.64)  LDD1274  [12]
 LDCM0396  CL125 HEK-293T C299(0.99); C289(1.10)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C299(0.94)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C299(1.00); C289(1.31)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C299(0.93); C287(1.15)  LDD1603  [13]
 LDCM0400  CL13 PaTu 8988t C299(0.26)  LDD1279  [12]
 LDCM0401  CL14 PaTu 8988t C299(0.26)  LDD1280  [12]
 LDCM0402  CL15 PaTu 8988t C299(0.48)  LDD1281  [12]
 LDCM0403  CL16 PaTu 8988t C299(0.64)  LDD1282  [12]
 LDCM0404  CL17 PaTu 8988t C299(0.37)  LDD1283  [12]
 LDCM0405  CL18 PaTu 8988t C299(0.41)  LDD1284  [12]
 LDCM0406  CL19 PaTu 8988t C299(0.32)  LDD1285  [12]
 LDCM0407  CL2 PaTu 8988t C299(0.82)  LDD1286  [12]
 LDCM0408  CL20 PaTu 8988t C299(0.24)  LDD1287  [12]
 LDCM0409  CL21 PaTu 8988t C299(0.25)  LDD1288  [12]
 LDCM0410  CL22 PaTu 8988t C299(0.30)  LDD1289  [12]
 LDCM0411  CL23 PaTu 8988t C299(0.32)  LDD1290  [12]
 LDCM0412  CL24 PaTu 8988t C299(0.62)  LDD1291  [12]
 LDCM0413  CL25 PaTu 8988t C299(0.86)  LDD1292  [12]
 LDCM0414  CL26 PaTu 8988t C299(0.26)  LDD1293  [12]
 LDCM0415  CL27 PaTu 8988t C299(0.42)  LDD1294  [12]
 LDCM0416  CL28 PaTu 8988t C299(0.25)  LDD1295  [12]
 LDCM0417  CL29 PaTu 8988t C299(0.23)  LDD1296  [12]
 LDCM0418  CL3 PaTu 8988t C299(1.40)  LDD1297  [12]
 LDCM0419  CL30 PaTu 8988t C299(0.55)  LDD1298  [12]
 LDCM0420  CL31 PaTu 8988t C299(0.98)  LDD1299  [12]
 LDCM0421  CL32 PaTu 8988t C299(1.26)  LDD1300  [12]
 LDCM0422  CL33 PaTu 8988t C299(0.77)  LDD1301  [12]
 LDCM0423  CL34 PaTu 8988t C299(1.09)  LDD1302  [12]
 LDCM0424  CL35 PaTu 8988t C299(0.95)  LDD1303  [12]
 LDCM0425  CL36 PaTu 8988t C299(1.25)  LDD1304  [12]
 LDCM0426  CL37 PaTu 8988t C299(1.01)  LDD1305  [12]
 LDCM0428  CL39 PaTu 8988t C299(1.31)  LDD1307  [12]
 LDCM0429  CL4 PaTu 8988t C299(1.44)  LDD1308  [12]
 LDCM0430  CL40 PaTu 8988t C299(0.85)  LDD1309  [12]
 LDCM0431  CL41 PaTu 8988t C299(0.80)  LDD1310  [12]
 LDCM0432  CL42 PaTu 8988t C299(0.93)  LDD1311  [12]
 LDCM0433  CL43 PaTu 8988t C299(0.81)  LDD1312  [12]
 LDCM0434  CL44 PaTu 8988t C299(1.11)  LDD1313  [12]
 LDCM0435  CL45 PaTu 8988t C299(1.11)  LDD1314  [12]
 LDCM0436  CL46 PaTu 8988t C299(1.06)  LDD1315  [12]
 LDCM0437  CL47 PaTu 8988t C299(0.87)  LDD1316  [12]
 LDCM0438  CL48 PaTu 8988t C299(1.15)  LDD1317  [12]
 LDCM0439  CL49 PaTu 8988t C299(1.00)  LDD1318  [12]
 LDCM0440  CL5 PaTu 8988t C299(0.28)  LDD1319  [12]
 LDCM0441  CL50 PaTu 8988t C299(0.84)  LDD1320  [12]
 LDCM0442  CL51 PaTu 8988t C299(0.88)  LDD1321  [12]
 LDCM0443  CL52 PaTu 8988t C299(0.95)  LDD1322  [12]
 LDCM0444  CL53 PaTu 8988t C299(0.58)  LDD1323  [12]
 LDCM0445  CL54 PaTu 8988t C299(1.04)  LDD1324  [12]
 LDCM0446  CL55 PaTu 8988t C299(1.09)  LDD1325  [12]
 LDCM0447  CL56 PaTu 8988t C299(0.42)  LDD1326  [12]
 LDCM0448  CL57 PaTu 8988t C299(0.36)  LDD1327  [12]
 LDCM0449  CL58 PaTu 8988t C299(0.68)  LDD1328  [12]
 LDCM0450  CL59 PaTu 8988t C299(0.31)  LDD1329  [12]
 LDCM0451  CL6 PaTu 8988t C299(0.40)  LDD1330  [12]
 LDCM0452  CL60 PaTu 8988t C299(0.52)  LDD1331  [12]
 LDCM0453  CL61 PaTu 8988t C299(1.48)  LDD1332  [12]
 LDCM0454  CL62 PaTu 8988t C299(1.43)  LDD1333  [12]
 LDCM0455  CL63 PaTu 8988t C299(0.93)  LDD1334  [12]
 LDCM0456  CL64 PaTu 8988t C299(0.91)  LDD1335  [12]
 LDCM0457  CL65 PaTu 8988t C299(0.83)  LDD1336  [12]
 LDCM0458  CL66 PaTu 8988t C299(0.85)  LDD1337  [12]
 LDCM0459  CL67 PaTu 8988t C299(0.52)  LDD1338  [12]
 LDCM0460  CL68 PaTu 8988t C299(0.43)  LDD1339  [12]
 LDCM0461  CL69 PaTu 8988t C299(0.48)  LDD1340  [12]
 LDCM0462  CL7 PaTu 8988t C299(0.30)  LDD1341  [12]
 LDCM0463  CL70 PaTu 8988t C299(0.54)  LDD1342  [12]
 LDCM0464  CL71 PaTu 8988t C299(0.97)  LDD1343  [12]
 LDCM0465  CL72 PaTu 8988t C299(1.21)  LDD1344  [12]
 LDCM0466  CL73 PaTu 8988t C299(0.60)  LDD1345  [12]
 LDCM0467  CL74 PaTu 8988t C299(1.17)  LDD1346  [12]
 LDCM0469  CL76 PaTu 8988t C289(0.87); C299(0.98)  LDD1348  [12]
 LDCM0470  CL77 PaTu 8988t C289(0.96); C299(1.03)  LDD1349  [12]
 LDCM0471  CL78 PaTu 8988t C289(1.17); C299(0.85)  LDD1350  [12]
 LDCM0472  CL79 PaTu 8988t C289(1.08); C299(0.84)  LDD1351  [12]
 LDCM0473  CL8 PaTu 8988t C299(0.73)  LDD1352  [12]
 LDCM0474  CL80 PaTu 8988t C289(1.36); C299(1.00)  LDD1353  [12]
 LDCM0475  CL81 PaTu 8988t C289(1.04); C299(0.85)  LDD1354  [12]
 LDCM0476  CL82 PaTu 8988t C289(0.81); C299(0.90)  LDD1355  [12]
 LDCM0477  CL83 PaTu 8988t C289(1.26); C299(0.66)  LDD1356  [12]
 LDCM0478  CL84 PaTu 8988t C289(1.14); C299(0.58)  LDD1357  [12]
 LDCM0479  CL85 PaTu 8988t C289(1.45); C299(1.09)  LDD1358  [12]
 LDCM0480  CL86 PaTu 8988t C289(1.20); C299(1.16)  LDD1359  [12]
 LDCM0481  CL87 PaTu 8988t C289(1.58); C299(0.58)  LDD1360  [12]
 LDCM0482  CL88 PaTu 8988t C289(1.40); C299(0.64)  LDD1361  [12]
 LDCM0483  CL89 PaTu 8988t C289(1.78); C299(0.51)  LDD1362  [12]
 LDCM0484  CL9 PaTu 8988t C299(0.33)  LDD1363  [12]
 LDCM0485  CL90 PaTu 8988t C289(1.34); C299(0.57)  LDD1364  [12]
 LDCM0486  CL91 HEK-293T C289(0.92)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C299(1.10); C289(0.96)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C299(1.03); C289(0.96)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C299(1.06); C289(0.84); C287(1.15)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C299(1.06); C289(1.02)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C299(1.05); C289(1.01)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C299(0.90); C289(0.88)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C299(1.03)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C299(1.09); C289(1.07)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C299(0.98); C289(1.33)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C299(1.88)  LDD1702  [14]
 LDCM0468  Fragment33 PaTu 8988t C299(0.79)  LDD1347  [12]
 LDCM0427  Fragment51 PaTu 8988t C299(1.42)  LDD1306  [12]
 LDCM0022  KB02 HEK-293T C299(0.92)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C299(0.95)  LDD1497  [13]
 LDCM0024  KB05 G361 C289(1.80)  LDD3311  [6]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0392  [2]
 LDCM0131  RA190 MM1.R C265(1.22)  LDD0304  [15]
 LDCM0008  Tranylcypromine SH-SY5Y 13.03  LDD0054  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Ceramide synthase 3 (CERS3) . Q8IU89
Ceramide synthase 4 (CERS4) . Q9HA82
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetylsalicylic Acid Small molecular drug DB00945
Celecoxib Small molecular drug DB00482
Oseltamivir Small molecular drug DB00198

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.