Details of the Target

General Information of Target

Target ID LDTP00544
Target Name Sphingolipid delta(4)-desaturase DES1 (DEGS1)
Gene Name DEGS1
Gene ID 8560
Synonyms
DES1; MLD; Sphingolipid delta(4)-desaturase DES1; EC 1.14.19.17; Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Membrane lipid desaturase; Retinol isomerase; EC 5.2.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYI
VKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPY
SISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPK
PITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGH
ETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDF
VMDDTISPYSRMKRHQKGEMVLE
Target Bioclass
Enzyme
Family
Fatty acid desaturase type 1 family, DEGS subfamily
Subcellular location
Mitochondrion membrane
Function Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols.
Uniprot ID
O15121
Ensemble ID
ENST00000323699.9
HGNC ID
HGNC:13709
ChEMBL ID
CHEMBL2021749

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		6.81  LDD0348  [1]
HRP
 Probe Info  		4.91  LDD0347  [1]
FBP2
 Probe Info  		5.55  LDD0317  [2]
Alkylaryl probe 2
 Probe Info  		5.00  LDD0390  [3]
Sulforaphane-probe2
 Probe Info  		2.61  LDD0160  [4]
Johansson_61
 Probe Info  		_(20.00)  LDD1490  [5]
DA-P3
 Probe Info  		11.97  LDD0183  [1]
AOyne
 Probe Info  		6.10  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		15.78  LDD1760  [7]
C070
 Probe Info  		25.11  LDD1766  [7]
C112
 Probe Info  		33.36  LDD1799  [7]
C153
 Probe Info  		24.08  LDD1834  [7]
C159
 Probe Info  		62.25  LDD1839  [7]
C160
 Probe Info  		11.63  LDD1840  [7]
C161
 Probe Info  		17.15  LDD1841  [7]
C183
 Probe Info  		5.13  LDD1861  [7]
C218
 Probe Info  		13.55  LDD1892  [7]
C219
 Probe Info  		10.48  LDD1893  [7]
C220
 Probe Info  		18.38  LDD1894  [7]
C231
 Probe Info  		17.03  LDD1904  [7]
C233
 Probe Info  		9.99  LDD1906  [7]
C235
 Probe Info  		27.28  LDD1908  [7]
C355
 Probe Info  		30.27  LDD2016  [7]
C356
 Probe Info  		11.31  LDD2017  [7]
C399
 Probe Info  		9.51  LDD2058  [7]
C403
 Probe Info  		26.35  LDD2061  [7]
C407
 Probe Info  		44.32  LDD2064  [7]
C413
 Probe Info  		24.59  LDD2069  [7]
C429
 Probe Info  		13.09  LDD2084  [7]
C430
 Probe Info  		7.36  LDD2085  [7]
C431
 Probe Info  		15.24  LDD2086  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [8]
FFF probe14
 Probe Info  		15.97  LDD0477  [8]
FFF probe15
 Probe Info  		20.00  LDD0478  [8]
FFF probe3
 Probe Info  		20.00  LDD0464  [8]
FFF probe9
 Probe Info  		20.00  LDD0470  [8]
JN0003
 Probe Info  		20.00  LDD0469  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]
OEA-DA
 Probe Info  		9.70  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0031  Epigallocatechin gallate HEK-293T 11.97  LDD0183  [1]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [5]
 LDCM0032  Oleacein HEK-293T 9.88  LDD0184  [1]
 LDCM0099  Phenelzine HEK-293T 5.00  LDD0390  [3]
 LDCM0003  Sulforaphane MDA-MB-231 2.61  LDD0160  [4]

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
4 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570