Details of the Target

General Information of Target

Target ID LDTP05373
Target Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1)
Gene Name PLOD1
Gene ID 5351
Synonyms
LLH; PLOD; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; EC 1.14.11.4; Lysyl hydroxylase 1; LH1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPLLLLALLGWLLLAEAKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGL
GEDWNVEKGTSAGGGQKVRLLKKALEKHADKEDLVILFADSYDVLFASGPRELLKKFRQA
RSQVVFSAEELIYPDRRLETKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQ
LFYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGHVRARNLAYDTLPVLI
HGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGIGDEALPTVLVGVFIEQPTPF
VSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVEEFLAQHGSEYQSVKLVGPEVRMANAD
ARNMGADLCRQDRSCTYYFSVDADVALTEPNSLRLLIQQNKNVIAPLMTRHGRLWSNFWG
ALSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRGELQSSDLFHHSKLDPD
MAFCANIRQQDVFMFLTNRHTLGHLLSLDSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYT
KALAGKLVETPCPDVYWFPIFTEVACDELVEEMEHFGQWSLGNNKDNRIQGGYENVPTID
IHMNQIGFEREWHKFLLEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDAS
TFTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTRGTRYI
AVSFVDP
Target Type
Clinical trial
Target Bioclass
Enzyme
Subcellular location
Rough endoplasmic reticulum membrane
Function
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable).
TTD ID
T89065
Uniprot ID
Q02809
DrugMap ID
TTEKJP3
Ensemble ID
ENST00000196061.5
HGNC ID
HGNC:9081

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.Y53H DBIA    Probe Info 
HUH7 SNV: p.R275P DBIA    Probe Info 
JURKAT SNV: p.R644H .
MCC13 SNV: p.R79G; p.P162S DBIA    Probe Info 
MELJUSO SNV: p.R275P DBIA    Probe Info 
MOLT4 SNV: p.E17Ter IA-alkyne    Probe Info 
NCIH1155 SNV: p.A640T DBIA    Probe Info 
NCIH716 SNV: p.R275P .
WM115 SNV: p.N669S DBIA    Probe Info 
WM2664 SNV: p.N669S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		6.00  LDD0387  [1]
STPyne
 Probe Info  		K141(7.99); K19(9.09); K316(3.16); K401(5.32)  LDD0277  [2]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0390  [1]
BTD
 Probe Info  		C680(1.10)  LDD2111  [3]
DBIA
 Probe Info  		C267(2.61); C270(2.61); C680(1.45)  LDD0080  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C369(0.00); C680(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C369(0.00); C680(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
YN-1
 Probe Info  		N.A.  LDD0447  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		H340(0.00); H474(0.00); C680(0.00); C484(0.00)  LDD0217  [12]
Cinnamaldehyde
 Probe Info  		C369(0.00); C484(0.00)  LDD0220  [12]
Crotonaldehyde
 Probe Info  		C680(0.00); C484(0.00); H708(0.00); C369(0.00)  LDD0219  [12]
Methacrolein
 Probe Info  		C680(0.00); C484(0.00); C369(0.00)  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		C566(0.00); C552(0.00)  LDD2223  [14]
HHS-482
 Probe Info  		Y428(0.59)  LDD2239  [15]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0472  [16]
FFF probe3
 Probe Info  		7.84  LDD0464  [16]
FFF probe4
 Probe Info  		10.20  LDD0466  [16]
VE-P
 Probe Info  		N.A.  LDD0396  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C484(1.01)  LDD2112  [3]
 LDCM0214  AC1 HCT 116 C267(0.93); C270(0.72); C484(0.95); C680(1.24)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C267(1.46); C270(1.29); C680(1.34)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C267(0.93); C270(0.88); C369(1.43); C680(1.10)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C267(0.91); C270(0.88); C369(1.05); C680(1.00)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C267(0.87); C270(0.83); C369(0.68); C680(1.08)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C267(0.91); C270(0.87); C369(0.60); C680(1.33)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C267(0.86); C270(0.87); C369(0.61); C680(1.08)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C267(0.98); C270(0.90); C369(0.59); C680(1.19)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C267(0.94); C270(0.90); C369(0.82); C680(1.27)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C267(0.92); C270(0.87); C369(0.47); C680(1.31)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C267(0.85); C270(0.75); C369(1.13); C680(1.16)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C267(0.83); C270(0.77); C369(0.91); C680(1.07)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C267(1.16); C270(0.99); C680(1.24)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C267(0.85); C270(0.80); C369(0.71); C680(1.20)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C267(0.92); C270(0.76); C369(1.16); C680(1.16)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C267(0.83); C270(0.87); C369(0.84); C680(1.28)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C267(1.10); C270(1.20); C369(1.20); C484(1.02)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C267(1.20); C270(1.42); C369(1.00); C484(1.12)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C267(1.16); C270(1.29); C369(0.87); C484(1.13)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C267(1.11); C270(1.26); C369(0.86); C484(0.95)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C267(1.31); C270(1.15); C369(1.04); C484(0.95)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C267(1.16); C270(1.16); C369(1.14); C484(1.07)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C267(1.17); C270(1.46); C369(1.13); C484(1.03)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C267(1.13); C270(1.01); C680(1.16)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C267(1.01); C270(1.25); C369(0.58); C484(1.63)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C267(1.15); C270(1.37); C369(1.18); C484(0.85)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C267(1.21); C270(1.28); C369(1.16); C484(0.98)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C267(1.12); C270(1.03); C369(1.02); C484(0.82)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C267(1.29); C270(1.50); C369(1.15); C484(0.89)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C267(0.94); C270(1.37); C369(1.10); C484(1.24)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C267(1.24); C270(1.47); C369(1.02); C484(1.09)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C267(1.12); C270(1.27); C369(0.89); C484(0.94)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C267(0.93); C270(1.01); C369(0.65); C680(1.50)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C267(0.99); C270(0.89); C369(1.60); C680(1.01)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C267(1.03); C270(0.96); C369(1.33); C680(1.21)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C267(1.26); C270(1.04); C369(1.34); C680(0.99)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C267(1.16); C270(1.04); C369(1.65); C680(1.16)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C267(1.23); C270(1.15); C369(1.35); C680(1.16)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C267(1.28); C270(1.32); C369(1.28); C680(1.31)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C267(1.23); C270(1.23); C369(1.20); C680(1.30)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C267(1.23); C270(1.32); C369(1.13); C680(1.24)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C267(1.42); C270(1.16); C369(1.32); C680(1.20)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C267(1.37); C270(1.23); C369(1.37); C680(1.37)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C267(1.23); C270(1.28); C369(1.47); C680(1.31)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C267(1.16); C270(1.06); C680(1.12)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C267(1.43); C270(1.26); C369(1.33); C680(1.41)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C267(1.54); C270(1.53); C369(1.43); C680(1.31)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C267(1.24); C270(1.09); C369(1.72); C680(1.10)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C267(0.89); C270(0.90); C369(1.05); C680(1.21)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C267(0.90); C369(1.04); C270(1.06); C680(1.29)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C267(0.97); C270(1.12); C369(1.14); C680(1.29)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C267(0.96); C369(1.08); C270(1.22); C680(1.34)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C369(0.96); C267(1.06); C270(1.21); C680(1.33)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C369(0.36); C267(0.64); C270(1.10); C680(2.11)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C267(0.84); C369(0.92); C270(1.21); C680(1.53)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C270(1.16); C680(1.18); C267(1.20)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C267(0.99); C270(1.10); C369(1.15); C680(1.17)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C267(1.02); C270(1.11); C680(1.18); C369(1.24)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C369(0.66); C267(0.88); C270(1.15); C680(1.40)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C369(0.30); C267(0.56); C270(1.09); C680(2.84)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C267(0.89); C270(1.07); C369(1.03); C680(1.24)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C267(0.93); C270(1.15); C369(1.01); C680(1.35)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C267(0.93); C270(1.13); C369(1.00); C680(1.08)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C267(0.91); C270(0.98); C369(1.17); C680(1.02)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C270(0.95); C267(1.05); C680(1.12)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C270(0.83); C267(1.13); C680(1.45)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C270(1.00); C680(1.30); C267(1.31)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C270(0.72); C267(0.99); C484(1.00); C680(1.18)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C680(1.05); C270(1.11); C267(1.15)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C270(0.98); C680(1.10); C267(1.18)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C270(0.90); C267(0.95); C680(1.15)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C270(0.93); C267(0.94); C680(1.45)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C680(0.98); C270(0.99); C267(1.08)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C680(0.98); C270(1.04); C267(1.13)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C270(1.03); C267(1.04); C680(1.30)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C270(1.04); C267(1.09); C680(1.13)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C270(0.97); C267(1.03); C680(1.21)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C270(1.12); C680(1.19); C267(1.19)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C270(0.64); C267(0.75); C484(0.96); C680(1.18)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C680(1.18); C270(1.19); C267(1.27)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C270(1.11); C680(1.18); C267(1.18)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C270(1.03); C267(1.25); C680(1.51)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C270(1.19); C267(1.26); C680(1.26)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C270(1.01); C267(1.17); C680(1.54)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C270(0.87); C680(0.92); C267(1.05)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C270(0.94); C680(0.96); C267(1.04)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C680(0.99); C270(1.05); C267(1.08)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C270(0.91); C680(0.94); C267(1.00)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C267(1.05); C270(1.07); C680(1.18)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C270(0.74); C267(0.98); C484(1.11); C680(1.30)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C267(0.91); C270(1.03); C680(1.18)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C270(0.96); C267(0.97); C680(1.22)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C267(0.91); C270(1.04); C680(1.12)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C270(1.24); C680(1.27); C267(1.37)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C267(1.16); C680(1.17); C270(1.32)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C267(1.04); C270(1.15); C680(1.37)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C267(0.94); C270(0.97); C680(1.14); C369(1.22)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C267(1.01); C270(1.05); C369(1.19); C680(1.25)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C267(0.85); C270(0.91); C680(1.26); C369(1.74)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C369(0.32); C267(0.70); C270(0.89); C680(1.62)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C270(0.73); C267(1.07); C484(1.08); C680(1.42)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C369(0.49); C267(0.76); C270(0.93); C680(1.50)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C270(0.93); C267(0.94); C680(1.13); C369(1.91)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C267(0.86); C270(0.94); C680(1.22); C369(1.28)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C369(0.68); C267(0.84); C270(0.96); C680(1.11)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C369(0.53); C267(0.83); C270(1.00); C680(1.22)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C369(0.41); C267(0.65); C270(0.85); C680(1.54)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C369(0.27); C267(0.60); C270(0.85); C680(2.19)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C369(0.82); C267(0.86); C484(1.04); C270(1.05)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C369(0.68); C267(0.87); C270(0.90); C484(0.98)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C369(0.55); C484(0.70); C267(0.81); C270(1.06)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C270(1.03); C267(1.17); C680(1.19)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C369(0.82); C267(1.09); C484(1.15); C270(1.22)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C267(0.86); C270(1.10); C369(1.16); C680(1.24)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C369(0.48); C484(0.61); C267(0.77); C270(1.03)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C369(0.82); C267(0.90); C270(0.99); C484(1.06)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C369(0.48); C484(0.70); C267(0.83); C270(1.05)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C484(0.84); C369(0.85); C267(1.10); C270(1.33)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C267(0.93); C369(0.97); C484(1.03); C270(1.22)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C369(0.22); C484(0.30); C267(0.69); C270(0.98)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C267(0.78); C484(0.95); C270(0.96); C369(1.11)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C267(0.83); C369(0.84); C270(0.85); C484(0.87)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C270(1.01); C680(1.22); C267(1.24)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C369(0.57); C484(0.58); C267(0.62); C270(0.77)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C267(0.78); C270(0.84); C484(1.05); C680(1.13)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C267(0.79); C369(0.86); C270(0.92); C484(1.09)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C369(0.38); C484(0.40); C267(0.63); C270(0.89)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C369(0.44); C484(0.47); C267(0.61); C270(0.83)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C369(0.33); C484(0.36); C267(0.65); C270(0.81)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C267(0.65); C484(0.83); C270(0.83); C369(0.85)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C267(0.70); C484(0.72); C270(0.87); C369(1.18)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C484(0.98); C267(0.99); C270(1.03); C680(1.24)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C270(1.01); C267(1.01); C484(1.06); C369(1.14)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C270(0.95); C267(1.12); C680(1.33)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C267(0.77); C270(0.84); C369(0.88); C484(0.92)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C484(0.74); C369(0.87); C267(0.88); C270(0.95)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C369(0.27); C484(0.37); C267(0.58); C270(0.86)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C369(0.46); C484(0.68); C267(0.95); C270(1.00)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C369(0.52); C484(0.82); C267(1.11); C270(1.15)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C369(0.93); C267(1.14); C484(1.30); C680(1.32)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C369(0.97); C267(1.12); C680(1.24); C484(1.41)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C267(0.86); C270(1.00); C680(1.05); C369(1.12)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C369(0.92); C680(1.07); C484(1.09); C267(1.14)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C369(0.77); C484(1.07); C267(1.19); C680(1.26)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C484(1.03); C680(1.06); C267(1.28); C369(1.32)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C369(0.44); C484(0.60); C267(0.99); C270(0.99)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C369(0.56); C484(0.79); C267(1.10); C270(1.13)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C369(0.84); C484(1.02); C267(1.08); C680(1.20)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C369(0.83); C267(1.08); C680(1.12); C270(1.45)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C267(0.99); C680(1.11); C270(1.19); C369(1.28)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C369(0.96); C267(1.08); C680(1.19); C270(1.23)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C369(0.59); C484(1.04); C267(1.05); C270(1.20)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C369(0.12); C270(0.74); C267(0.78); C680(2.13)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C270(0.83); C267(0.85); C369(0.92); C680(1.08)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C267(1.07); C270(0.97); C680(0.98)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C270(1.13); C680(1.23); C267(1.41)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C267(1.11); C270(1.23); C680(1.77)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C267(1.24); C270(1.24); C680(1.07)  LDD2171  [4]
 LDCM0108  Chloroacetamide HeLa H340(0.00); H708(0.00); C680(0.00); C484(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C680(1.01); C270(1.23); C267(1.25)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C267(0.88); C270(1.09); C680(2.08)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C270(0.67); C267(0.88); C484(1.01); C680(1.30)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C680(1.02); C270(1.13); C267(1.35)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C680(0.97); C270(1.09); C267(1.22)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C270(0.91); C680(0.95); C267(1.16)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C680(1.01); C270(1.08); C267(1.12)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C267(1.01); C680(1.11); C270(1.14)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C270(1.16); C267(1.43); C680(1.49)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C270(1.04); C267(1.11); C680(1.41)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C270(1.20); C267(1.31); C680(1.32)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C270(1.03); C680(1.12); C267(1.47)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C267(0.80); C270(0.87); C680(1.69)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C270(1.06); C267(1.19); C680(1.28)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C270(0.95); C267(1.04); C680(1.24)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C680(1.00); C270(1.08); C267(1.08)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C270(1.06); C267(1.22); C680(1.41)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C270(1.03); C267(1.08); C680(1.33)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C270(1.08); C267(1.12); C680(1.22)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C270(1.15); C267(1.15); C680(1.25)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C267(0.47); C270(0.79); C680(1.63)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C270(1.05); C680(1.13); C267(1.16)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C267(1.13); C680(1.15); C270(1.24)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C267(0.76); C270(1.08); C680(1.66)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C680(1.19); C270(1.35); C267(1.38)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C680(0.80); C267(1.15); C369(1.16); C270(1.18)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C267(1.01); C369(1.03); C270(1.07); C680(1.37)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C369(0.68); C267(0.75); C270(0.86); C680(1.43)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C369(0.48); C267(0.72); C270(0.88); C680(1.36)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C369(1.00); C270(1.08); C680(1.10); C267(1.10)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C267(0.96); C270(1.00); C369(1.04); C484(1.10)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C369(0.88); C680(1.19); C270(1.22); C267(1.29)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C369(0.55); C484(0.69); C267(1.06); C270(1.12)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C267(1.21); C680(1.27); C270(1.33)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C267(0.95); C270(1.03); C680(1.15)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C680(1.32); C267(1.33); C270(1.43)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C270(1.00); C680(1.01); C267(1.11); C484(1.31)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C680(0.98); C484(0.99); C267(1.09); C270(1.19)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C680(1.10); C484(1.22); C267(1.29); C270(1.29)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C680(1.01); C270(1.24); C484(1.25); C267(1.25)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C680(0.99); C267(1.11); C270(1.18)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C484(0.95); C270(0.95); C267(1.10); C680(1.27)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C484(0.58); C270(0.93); C267(1.11); C680(1.30)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C484(0.27); C270(0.90); C267(1.15); C680(2.36)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C484(0.72); C270(1.06); C680(1.09); C267(1.12)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C484(0.53); C270(0.85); C267(1.08); C680(1.56)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C267(1.13); C270(1.01); C484(0.58); C680(1.38)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C267(1.30); C270(1.25); C484(1.04); C680(1.19)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C267(1.14); C270(0.98); C484(0.92); C680(1.11)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C267(1.15); C270(1.10); C484(0.94); C680(1.21)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C267(1.18); C270(1.11); C484(0.87); C680(1.33)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C267(1.02); C270(1.12); C680(0.99)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C267(1.20); C270(1.07); C484(0.96); C680(1.07)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C267(1.10); C270(1.16); C680(1.21)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C267(0.98); C270(1.05); C680(1.15)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C267(1.11); C270(1.20); C680(2.90)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C267(0.96); C270(0.90); C680(1.42)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C267(0.87); C270(0.79); C680(1.34)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C267(0.98); C270(0.95); C680(1.31)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C267(0.80); C270(0.73); C680(1.58)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C267(0.88); C270(0.85); C680(1.58)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C267(1.35); C270(1.42); C680(1.22)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C267(1.08); C270(1.03); C680(1.45)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C267(1.04); C270(1.03); C680(1.26)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C267(0.81); C270(0.59); C680(2.56)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C267(0.78); C270(0.67); C680(1.81)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C267(0.97); C270(1.06); C680(1.51)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C267(0.93); C270(0.97); C680(1.77)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C267(0.95); C270(0.95); C680(1.10)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C267(0.92); C270(0.94); C680(1.08)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C267(0.92); C270(0.87); C680(1.00)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C267(0.94); C270(0.96); C680(0.98)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C267(1.00); C270(1.13); C680(0.96)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C267(0.97); C270(0.94); C680(0.98)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C267(0.95); C270(1.00); C680(1.09)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C267(0.99); C270(0.96); C680(1.00)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C267(0.98); C270(0.89); C680(0.94)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C267(0.88); C270(0.81); C680(0.98)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C267(0.97); C270(0.90); C680(1.01)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C267(0.91); C270(0.90); C680(1.11)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C267(0.94); C270(0.91); C680(0.96)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C267(0.91); C270(0.93); C680(0.97)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C267(0.92); C270(0.95); C680(1.09)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C267(1.23); C270(1.30); C680(1.17)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C267(0.99); C270(0.97); C680(1.12)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C267(0.85); C270(0.91); C680(1.09)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C267(0.90); C270(0.91); C680(1.15)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C267(1.04); C270(0.89); C680(1.26)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C267(0.97); C270(0.95); C680(1.35)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C267(0.96); C270(1.01); C680(1.14)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C267(0.92); C270(1.04); C680(1.51)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C267(0.98); C270(0.96); C680(1.27)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C267(1.07); C270(1.04); C680(1.33)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C267(0.98); C270(1.02); C680(1.21)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C267(1.22); C270(1.32); C680(1.35)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C267(0.94); C270(0.87); C680(1.26)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C267(0.90); C270(0.95); C680(1.40)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C267(1.02); C270(0.97); C680(1.09)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C267(0.89); C270(0.82); C680(1.21)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C267(1.05); C270(1.01); C680(1.29)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C267(1.09); C270(1.02); C484(1.06); C680(1.11)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C267(0.93); C270(0.87); C484(0.87); C680(1.09)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C267(1.02); C270(1.18); C484(1.03); C680(1.10)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C267(0.96); C270(0.94); C484(1.02); C680(0.97)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C267(0.71); C270(0.93); C680(1.68)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C267(0.93); C270(0.99); C484(1.24); C680(1.01)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C267(0.97); C270(0.92); C484(1.02); C680(1.04)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C267(0.76); C270(0.63); C484(0.60); C680(0.92)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C267(0.85); C270(0.77); C484(0.78); C680(1.03)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C267(0.80); C270(0.65); C484(0.38); C680(1.05)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C267(1.05); C270(1.02); C484(1.33); C680(1.03)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C267(0.96); C270(0.95); C484(1.47); C680(1.04)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C267(1.08); C270(1.12); C484(1.11); C680(0.88)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C267(1.01); C270(0.98); C484(0.82); C680(0.83)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C267(0.75); C270(0.67); C484(0.38); C680(0.95)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C267(1.03); C270(1.07); C680(1.18)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C267(0.73); C270(0.80); C484(0.85); C680(1.84)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C267(1.04); C270(0.83); C484(1.12); C680(1.14)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C267(0.87); C270(0.77); C484(0.99); C680(1.26)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C267(0.88); C270(0.77); C484(1.44); C680(1.32)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C267(0.98); C270(0.83); C484(1.16); C680(1.17)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C267(0.95); C270(0.84); C484(1.13); C680(1.35)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C267(0.96); C270(0.78); C484(1.00); C680(1.21)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C267(0.96); C270(0.83); C484(1.07); C680(1.14)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C267(0.94); C270(0.72); C484(0.87); C680(1.32)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C267(0.93); C270(0.75); C484(1.10); C680(1.26)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C680(0.96)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C680(1.98)  LDD1702  [3]
 LDCM0625  F8 Ramos C680(1.42)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C680(0.99)  LDD2189  [19]
 LDCM0573  Fragment11 MDA-MB-231 C680(1.98)  LDD1391  [20]
 LDCM0574  Fragment12 MDA-MB-231 C680(2.02)  LDD1393  [20]
 LDCM0575  Fragment13 MDA-MB-231 C680(1.83)  LDD1395  [20]
 LDCM0576  Fragment14 MDA-MB-231 C680(1.14)  LDD1397  [20]
 LDCM0579  Fragment20 MDA-MB-231 C680(2.08)  LDD1402  [20]
 LDCM0580  Fragment21 MDA-MB-231 C680(5.62)  LDD1404  [20]
 LDCM0581  Fragment22 MDA-MB-231 C680(1.30)  LDD1406  [20]
 LDCM0582  Fragment23 MDA-MB-231 C680(3.89)  LDD1408  [20]
 LDCM0584  Fragment25 MDA-MB-231 C680(1.10)  LDD1411  [20]
 LDCM0578  Fragment27 MDA-MB-231 C680(0.78)  LDD1401  [20]
 LDCM0586  Fragment28 MDA-MB-231 C680(1.05)  LDD1415  [20]
 LDCM0587  Fragment29 MDA-MB-231 C680(1.64)  LDD1417  [20]
 LDCM0588  Fragment30 MDA-MB-231 C680(1.75)  LDD1419  [20]
 LDCM0589  Fragment31 MDA-MB-231 C680(2.18)  LDD1421  [20]
 LDCM0590  Fragment32 MDA-MB-231 C680(2.68)  LDD1423  [20]
 LDCM0468  Fragment33 HCT 116 C267(1.11); C270(0.99); C680(1.31)  LDD0785  [4]
 LDCM0592  Fragment34 MDA-MB-231 C680(1.05)  LDD1427  [20]
 LDCM0596  Fragment38 MDA-MB-231 C680(1.13)  LDD1433  [20]
 LDCM0566  Fragment4 MDA-MB-231 C680(2.11)  LDD1378  [20]
 LDCM0599  Fragment41 MDA-MB-231 C680(1.46)  LDD1438  [20]
 LDCM0604  Fragment46 MDA-MB-231 C680(0.88)  LDD1445  [20]
 LDCM0605  Fragment47 MDA-MB-231 C680(1.13)  LDD1446  [20]
 LDCM0607  Fragment49 MDA-MB-231 C680(4.08)  LDD1448  [20]
 LDCM0427  Fragment51 HCT 116 C267(0.83); C270(0.60); C680(2.05)  LDD0744  [4]
 LDCM0610  Fragment52 MDA-MB-231 C680(1.15)  LDD1452  [20]
 LDCM0611  Fragment53 MDA-MB-231 C680(1.12)  LDD1454  [20]
 LDCM0612  Fragment54 MDA-MB-231 C680(1.53)  LDD1456  [20]
 LDCM0614  Fragment56 MDA-MB-231 C680(1.17)  LDD1458  [20]
 LDCM0568  Fragment6 MDA-MB-231 C680(1.09)  LDD1382  [20]
 LDCM0569  Fragment7 Ramos C680(1.07)  LDD2186  [19]
 LDCM0570  Fragment8 MDA-MB-231 C680(2.58)  LDD1385  [20]
 LDCM0571  Fragment9 Ramos C680(1.44)  LDD2188  [19]
 LDCM0107  IAA HeLa H340(0.00); H474(0.00); H708(0.00); C484(0.00)  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C267(2.61); C270(2.61); C680(1.45)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C267(2.76); C270(2.76); C680(1.65)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C267(1.96); C270(1.96); C680(1.21)  LDD0082  [4]
 LDCM0109  NEM HeLa H340(0.00); H474(0.00); H708(0.00); H500(0.00)  LDD0223  [12]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C680(1.10)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C484(0.78)  LDD2114  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C680(1.26)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C687(0.86)  LDD2125  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C680(0.91); C369(1.24)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C680(0.77)  LDD2137  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C484(0.18)  LDD2145  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C680(0.84)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C680(1.94)  LDD2207  [21]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0388  [1]
 LDCM0021  THZ1 HCT 116 C267(1.24); C270(1.24); C680(1.07)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) . P55795

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.