Details of the Target

General Information of Target

Target ID LDTP15725
Target Name Secernin-2 (SCRN2)
Gene Name SCRN2
Gene ID 90507
Synonyms
Secernin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGSRIPQARALLQQCLHARLQIRPADGDVAAQWVEVQRGLVIYVCFFKGADKELLPKM
VNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYS
QFVTLCEKEVAANSKCAEARVVVEHGTYGNRQVLKLDTNGPFTHLIEF
Target Bioclass
Enzyme
Family
Peptidase C69 family, Secernin subfamily
Uniprot ID
Q96FV2
Ensemble ID
ENST00000290216.14
HGNC ID
HGNC:30381

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.S312F .
IGROV1 Deletion: p.G259AfsTer6 .
Ishikawa (Heraklio) 02 ER SNV: p.E392G .
KMCH1 SNV: p.L122F .
RKO SNV: p.S126G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		20.00  LDD0385  [1]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0389  [1]
P11
 Probe Info  		11.87  LDD0201  [2]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0282  [3]
DBIA
 Probe Info  		C277(2.07)  LDD3411  [4]
Johansson_61
 Probe Info  		_(7.69)  LDD1488  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C59(0.00); C148(0.00); C301(0.00); C277(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C277(0.00); C59(0.00); C301(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C277(0.00); C59(0.00); C148(0.00); C301(0.00)  LDD0037  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0088  C45 HEK-293T 11.87  LDD0201  [2]
 LDCM0108  Chloroacetamide HeLa C59(0.00); C277(0.00); C301(0.00)  LDD0222  [7]
 LDCM0615  Fragment63-R Jurkat _(7.69)  LDD1488  [5]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HuH-1 C277(1.31)  LDD2374  [4]
 LDCM0023  KB03 A3-KAW C277(1.59)  LDD2674  [4]
 LDCM0024  KB05 RPMI-8226 C277(2.07)  LDD3411  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [7]
 LDCM0099  Phenelzine HEK-293T 20.00  LDD0282  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264