Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Johansson_61  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Fragment63-R  Competitor Info 
Competitor Concentration 7.5 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 33 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 20.0
 LDTP02616  Creatine kinase B-type (CKB) 20.0
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 20.0
 LDTP11529  GTP-binding protein 4 (GTPBP4) 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 20.0
 LDTP12691  Pyridoxine-5'-phosphate oxidase (PNPO) 20.0
 LDTP02549  Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB) 20.0
 LDTP13330  rRNA methyltransferase 2, mitochondrial (MRM2) 20.0
 LDTP12215  rRNA methyltransferase 3, mitochondrial (MRM3) 20.0
 LDTP04988  Thioredoxin reductase-like selenoprotein T (SELENOT) 20.0
 LDTP06211  Caspase-8 (CASP8) 18.7
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 16.6
 LDTP11294  Protein adenylyltransferase SelO, mitochondrial (SELENOO) 16.6
 LDTP03163  Sterol carrier protein 2 (SCP2) 12.9
 LDTP13200  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1) 12.6
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 11.7
 LDTP13112  Phosphatidylinositol 4-kinase beta (PI4KB) 10.4
 LDTP12444  Xaa-Pro aminopeptidase 1 (XPNPEP1) 10.3
 LDTP07242  Terminal nucleotidyltransferase 5C (TENT5C) 10.3
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 9.4
 LDTP06658  Thioredoxin reductase 1, cytoplasmic (TXNRD1) 8.1
 LDTP15725  Secernin-2 (SCRN2) 7.7
 LDTP17022  Secernin-3 (SCRN3) 7.6
 LDTP13285  Probable ATP-dependent RNA helicase DDX20 (DDX20) 7.2
 LDTP01311  Ribonuclease H2 subunit A (RNASEH2A) 7.1
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS) 6.3
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 5.4
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 4.8
 LDTP02788  15-hydroxyprostaglandin dehydrogenase [NAD(+)] (HPGD) 4.5
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) 4.4
 LDTP03831  Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) 4.2
 LDTP17604  Peptidyl-tRNA hydrolase (PTRH1) 4.1
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07064  Nucleoporin NUP188 (NUP188) 20.0
 LDTP09579  Nuclear pore complex protein Nup133 (NUP133) 10.3
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06073  Transcription factor Dp-1 (TFDP1) 10.2
Other
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11068  Cytochrome b-245 chaperone 1 (CYBC1) 20.0
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) 20.0
 LDTP05556  Golgin subfamily A member 3 (GOLGA3) 20.0
 LDTP14591  Hemoglobin subunit theta-1 (HBQ1) 20.0
 LDTP10284  Multivesicular body subunit 12A (MVB12A) 20.0
 LDTP14236  Selenoprotein K (SELENOK) 20.0
 LDTP11075  Selenoprotein S (SELENOS) 12.1
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) 10.4
 LDTP11890  Protein unc-45 homolog A (UNC45A) 10.3
 LDTP01012  Selenoprotein F (SELENOF) 5.4
 LDTP14260  Calcineurin-binding protein cabin-1 (CABIN1) 5.1
 LDTP19672  Selenoprotein H (SELENOH) 4.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.