Details of the Target

General Information of Target

Target ID LDTP04988
Target Name Thioredoxin reductase-like selenoprotein T (SELENOT)
Gene Name SELENOT
Gene ID 51714
Synonyms
SELT; Thioredoxin reductase-like selenoprotein T; SelT; EC 1.8.1.9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLLLLLVAASAMVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMR
VISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQW
GQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNE
MKLNVHMDSIPHHRS
Target Bioclass
Enzyme
Family
SelWTH family, Selenoprotein T subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress and cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion.
Uniprot ID
P62341
Ensemble ID
ENST00000471696.6
HGNC ID
HGNC:18136

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [1]
YY4-yne
 Probe Info  		8.08  LDD0400  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [1]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [1]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [1]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [1]
 LDCM0154  YY4 T cell 8.08  LDD0400  [2]

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
2 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.