Details of the Target

General Information of Target

Target ID LDTP12444
Target Name Xaa-Pro aminopeptidase 1 (XPNPEP1)
Gene Name XPNPEP1
Gene ID 7511
Synonyms
XPNPEPL; XPNPEPL1; Xaa-Pro aminopeptidase 1; EC 3.4.11.9; Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; Soluble aminopeptidase P; sAmp; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1, soluble
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKS
CTKPSPSKKRCSDNTEVEVSNLENKQPVESTSAKSCSPSPVSPQVQPQAADTISDSVAVP
ASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKA
ASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSS
ASGASARINSSSVKQEATFCSQRDGDASLNKALSSSADDASLVNASISSSVKATSPVKST
TSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKD
KSTTPGGTGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSST
THLAQQLKQERQKELACLRGRFDKGNIWSAEKGGNSKSKQLETKQETHCQSTPLKKHQGV
SKTQSLPVTEKVTENQIPAKNSSTEPKGFTECEMTKSSPLKITLFLEEDKSLKVTSDPKV
EQKIEVIREIEMSVDDDDINSSKVINDLFSDVLEEGELDMEKSQEEMDQALAESSEEQED
ALNISSMSLLAPLAQTVGVVSPESLVSTPRLELKDTSRSDESPKPGKFQRTRVPRAESGD
SLGSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKM
QELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATGKRTLLIDELNKL
KNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCSTVQKPDAANYYYLIILKAGA
ENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTS
KSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNTKFVLD
KVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYP
DDEKRKNPIGRINLANCTSRQIEPANREFCARRNTFELITVRPQREDDRETLVSQCRDTL
CVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP
Target Bioclass
Enzyme
Family
Peptidase M24B family
Subcellular location
Cytoplasm, cytosol
Function Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin.
Uniprot ID
Q9NQW7
Ensemble ID
ENST00000322238.12
HGNC ID
HGNC:12822
ChEMBL ID
CHEMBL3782

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 3
 Probe Info  		14.14  LDD0381  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P8
 Probe Info  		10.00  LDD0455  [2]
TH211
 Probe Info  		Y128(9.88)  LDD0257  [3]
STPyne
 Probe Info  		K130(10.00); K621(9.72)  LDD0277  [4]
Probe 1
 Probe Info  		Y296(41.70)  LDD3495  [5]
DBIA
 Probe Info  		C322(3.68)  LDD3311  [6]
BTD
 Probe Info  		C279(0.83)  LDD2097  [7]
Johansson_61
 Probe Info  		_(10.45)  LDD1485  [8]
HHS-482
 Probe Info  		Y128(1.13); Y78(0.86)  LDD0285  [9]
HHS-475
 Probe Info  		Y78(0.67); Y128(1.08)  LDD0264  [10]
HHS-465
 Probe Info  		Y78(7.58)  LDD2237  [11]
ATP probe
 Probe Info  		K130(0.00); K131(0.00); K304(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C342(0.00); C443(0.00); C163(0.00); C502(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C342(0.00); C279(0.00); C443(0.00); C502(0.00)  LDD0037  [13]
IPM
 Probe Info  		N.A.  LDD2156  [16]
NPM
 Probe Info  		N.A.  LDD0016  [17]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
m-APA
 Probe Info  		N.A.  LDD0404  [19]
NAIA_5
 Probe Info  		C342(0.00); C279(0.00); C443(0.00); C502(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		11.71  LDD1725  [21]
C139
 Probe Info  		11.31  LDD1821  [21]
C161
 Probe Info  		12.13  LDD1841  [21]
C322
 Probe Info  		8.63  LDD1988  [21]
FFF probe13
 Probe Info  		8.39  LDD0475  [22]
FFF probe3
 Probe Info  		12.76  LDD0464  [22]
STS-1
 Probe Info  		1.00  LDD0137  [23]
STS-2
 Probe Info  		1.00  LDD0139  [23]
OEA-DA
 Probe Info  		3.76  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C443(0.99); C342(1.10); C279(0.97); C309(1.10)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C163(0.89); C443(0.99); C342(0.99); C279(1.14)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C163(0.88); C443(0.99); C502(1.01); C342(1.02)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C163(0.85); C342(0.93); C279(1.02); C309(0.98)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C443(0.95); C279(0.91); C316(1.06); C309(1.12)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C443(1.03); C502(0.90); C342(0.99); C316(0.95)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C443(0.93); C342(0.95); C279(1.04); C309(1.11)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C163(0.98); C443(0.95); C342(0.96); C279(1.09)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C163(0.76); C443(0.93); C502(0.64); C342(0.92)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C163(0.93); C443(1.01); C342(0.96); C279(1.53)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C163(0.89); C342(0.98); C279(1.13); C309(1.04)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C443(1.06); C342(1.02); C279(1.04); C316(1.25)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C443(0.84); C279(0.88); C316(0.93); C309(0.99)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C443(0.97); C502(0.95); C342(0.91); C316(0.91)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C443(0.95); C342(0.91); C279(1.01); C316(1.12)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C443(0.95); C342(1.03); C279(0.88); C309(1.05)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C163(0.94); C443(1.00); C342(0.97); C279(1.37)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C163(0.89); C443(0.92); C502(0.84); C342(0.89)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C163(0.88); C342(0.89); C279(1.27); C309(1.00)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C443(1.06); C342(0.94); C279(0.95); C316(1.35)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C163(0.87); C443(0.97); C502(1.02); C342(1.14)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C443(0.95); C279(1.03); C316(0.90); C309(0.94)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C443(0.91); C502(1.59); C342(1.05); C316(0.95)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C443(1.01); C342(0.97); C279(1.09); C316(0.99)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C443(0.99); C342(0.98); C279(0.95); C309(1.12)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C163(0.88); C443(1.00); C342(0.97); C279(1.17)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C163(0.96); C443(1.04); C502(1.03); C342(0.97)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C163(0.96); C342(0.94); C279(0.98); C309(0.96)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C443(1.05); C342(1.01); C279(1.05); C316(1.22)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C443(0.95); C279(1.02); C316(0.78); C309(1.00)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C443(0.93); C502(1.36); C342(0.90); C316(0.94)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C163(0.92); C342(0.94); C279(1.12); C309(0.98)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C443(1.09); C342(0.89); C279(1.09); C316(1.00)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C443(1.04); C342(0.98); C279(1.01); C309(1.13)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C163(0.89); C443(1.07); C342(0.91); C279(1.10)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C163(0.93); C443(0.95); C502(0.89); C342(1.07)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C163(0.89); C342(0.78); C279(1.22); C309(1.00)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C443(1.05); C342(0.98); C279(0.94); C316(1.16)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C443(0.99); C279(0.78); C316(1.00); C309(1.08)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C443(1.07); C502(1.16); C342(0.88); C316(1.02)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C443(0.99); C342(0.91); C279(1.11); C316(1.06)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C443(1.01); C342(1.00); C279(0.94); C309(1.20)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C443(1.07); C342(1.04); C279(0.95); C316(1.18)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C163(0.91); C443(1.05); C342(0.98); C279(1.30)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C163(1.00); C443(0.98); C502(1.03); C342(0.89)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C163(0.92); C342(0.90); C279(1.12); C309(0.97)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C443(0.99); C342(0.94); C279(0.94); C316(1.04)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C443(1.01); C279(0.94); C316(0.85); C309(1.08)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C443(0.91); C502(0.86); C342(0.86); C316(1.11)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C443(1.03); C342(0.94); C279(1.05); C316(1.07)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C443(0.99); C342(0.96); C279(0.98); C309(1.15)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C163(0.96); C443(1.05); C342(1.02); C279(1.31)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C163(0.95); C443(0.99); C502(1.20); C342(0.99)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C443(1.02); C279(0.92); C316(0.91); C309(0.96)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C163(0.91); C342(0.95); C279(1.06); C309(1.08)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C443(1.08); C342(0.93); C279(0.88); C316(1.27)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C443(0.94); C279(0.93); C316(0.97); C309(1.08)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C443(0.96); C502(1.11); C342(0.89); C316(1.07)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C443(1.09); C342(0.97); C279(0.99); C316(1.00)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C443(1.04); C502(0.79); C342(1.11); C316(0.98)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C443(1.05); C342(0.94); C279(1.03); C316(1.08)  LDD1569  [25]
 LDCM0248  AKOS034007472 HEK-293T C443(1.04); C342(0.99); C279(0.91); C316(1.12)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C443(1.02); C342(0.95); C279(0.95); C309(1.08)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C443(0.99); C342(0.99); C279(1.04); C316(1.07)  LDD1514  [25]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [19]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0367  CL1 HEK-293T C163(0.89); C443(0.97); C342(0.98); C279(0.89)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C443(1.00); C279(0.92); C316(0.71); C309(0.98)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C443(0.95); C502(1.06); C342(0.88); C279(1.20)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C163(0.86); C443(1.03); C342(0.89); C279(0.91)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C163(0.89); C443(0.87); C342(1.08); C279(1.03)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C443(1.06); C502(1.08); C342(0.94); C279(0.95)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C443(1.04); C502(0.99); C342(0.90); C279(1.17)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C163(0.97); C443(0.87); C342(0.83); C279(0.97)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C163(1.04); C443(1.00); C342(1.10); C279(0.96)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C443(0.93); C502(1.00); C342(0.95); C279(1.20)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C443(1.09); C502(0.97); C342(0.92); C279(1.18)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C163(0.92); C443(1.03); C342(0.89); C279(1.01)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C443(1.11); C502(1.51); C342(0.95); C316(0.79)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C163(1.15); C443(0.87); C342(1.15); C279(0.91)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C443(0.96); C502(1.00); C342(1.01); C279(1.14)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C443(0.97); C502(1.10); C342(0.85); C279(1.04)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C163(0.90); C443(1.06); C342(0.95); C279(0.83)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C163(1.13); C443(0.96); C342(0.98); C279(1.04)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C443(0.98); C502(1.18); C342(1.02); C279(0.97)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C443(0.98); C502(1.02); C342(0.86); C279(1.40)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C163(0.93); C443(0.93); C342(0.95); C279(1.02)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C163(0.90); C443(0.95); C342(0.99); C279(0.96)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C443(1.03); C502(0.97); C342(0.93); C279(1.28)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C443(1.01); C342(1.07); C279(0.93); C316(0.88)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C443(1.10); C502(1.15); C342(0.92); C279(1.64)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C163(0.95); C443(1.03); C342(0.88); C279(0.91)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C163(0.91); C443(0.92); C342(0.95); C279(0.91)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C443(1.01); C502(0.83); C342(0.98); C279(1.16)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C443(0.91); C502(0.90); C342(0.88); C279(1.26)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C163(0.96); C443(1.14); C342(0.89); C279(1.03)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C163(1.21); C443(0.96); C342(1.12); C279(1.08)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C443(1.01); C502(0.76); C342(0.98); C279(1.04)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C443(1.00); C502(0.80); C342(0.85); C279(1.12)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C163(0.78); C443(1.03); C342(0.95); C279(0.96)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C163(1.02); C443(0.92); C342(0.92); C279(0.97)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C443(0.99); C502(0.89); C342(1.02); C279(0.93)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C443(1.06); C502(0.97); C342(0.96); C279(1.00)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C443(1.07); C342(1.01); C279(0.94); C309(1.11)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C163(0.92); C443(1.03); C342(0.91); C279(0.98)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C163(0.99); C443(1.07); C502(1.05); C342(1.01)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C163(1.04); C443(0.95); C342(1.03); C279(0.98)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C163(1.15); C342(1.00); C279(1.02); C309(1.01)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C443(0.98); C342(0.99); C279(0.84); C316(1.22)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C443(1.09); C279(0.93); C316(0.91); C309(1.08)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C443(1.26); C502(1.24); C342(1.07); C316(1.03)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C443(1.05); C342(0.96); C279(1.13); C316(1.04)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C163(0.92); C443(0.98); C342(0.86); C279(0.94)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C163(1.04); C443(0.94); C342(0.93); C279(0.94)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C443(0.90); C502(0.89); C342(1.00); C279(1.07)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C443(1.03); C502(1.04); C342(0.95); C279(1.22)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C443(1.08); C342(0.97); C279(1.01); C309(1.08)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C443(1.06); C502(1.06); C342(1.13); C279(0.90)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C163(1.01); C443(0.95); C342(0.92); C279(1.18)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C163(1.03); C443(0.93); C502(1.12); C342(0.97)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C163(1.21); C342(0.85); C279(1.10); C309(1.01)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C443(1.05); C342(0.92); C279(1.07); C316(1.04)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C443(1.07); C279(0.92); C316(1.00); C309(0.97)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C443(1.09); C502(0.85); C342(1.03); C316(0.99)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C443(1.07); C342(0.98); C279(0.99); C316(1.00)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C163(0.91); C443(1.01); C342(1.12); C279(0.94)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C443(0.93); C502(1.04); C342(0.98); C279(0.99)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C443(1.00); C502(0.83); C342(0.96); C279(0.98)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C443(1.07); C502(1.19); C342(0.94); C279(1.42)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C443(0.95); C342(1.00); C279(1.03); C309(1.07)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C163(1.21); C443(1.03); C342(0.97); C279(1.05)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C163(1.12); C443(1.04); C502(0.88); C342(1.02)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C163(1.17); C342(0.97); C279(1.16); C309(1.07)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C443(1.06); C342(1.19); C279(1.14); C316(1.27)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C443(1.09); C279(0.89); C316(1.10); C309(1.03)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C443(1.05); C502(1.03); C342(1.00); C316(0.95)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C443(1.12); C342(0.99); C279(0.95); C316(0.98)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C163(0.89); C443(1.09); C342(1.01); C279(1.12)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C443(1.14); C342(0.98); C279(0.97); C309(1.17)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C163(0.99); C443(0.89); C342(0.97); C279(1.00)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C443(1.12); C502(1.03); C342(0.95); C279(1.00)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C443(0.97); C342(1.07); C279(0.87); C309(1.07)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C163(0.93); C443(1.06); C342(1.08); C279(1.02)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C163(1.00); C443(0.99); C502(0.95); C342(1.04)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C163(1.25); C342(1.03); C279(1.14); C309(0.94)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C443(1.07); C342(1.01); C279(0.97); C316(1.04)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C443(1.08); C279(1.00); C316(0.74); C309(1.09)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C443(1.06); C502(1.10); C342(0.98); C316(0.87)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C163(0.94); C443(1.04); C342(1.11); C279(1.14)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C443(1.17); C342(0.97); C279(1.13); C316(0.88)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C163(0.94); C443(1.06); C342(0.98); C279(0.99)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C163(1.01); C443(0.92); C342(0.99); C279(1.00)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C443(0.99); C502(1.03); C342(1.03); C279(1.27)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C443(0.97); C502(1.01); C342(0.93); C279(1.02)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C443(1.03); C342(1.02); C279(1.00); C309(1.14)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C163(0.93); C443(1.07); C342(0.94); C279(1.06)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C163(0.96); C443(1.01); C502(1.08); C342(0.99)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C163(1.24); C342(1.01); C279(1.14); C309(0.94)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C443(1.12); C342(1.06); C279(0.84); C316(1.01)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C163(0.95); C443(1.18); C502(0.90); C342(1.02)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C443(1.09); C279(1.07); C316(1.04); C309(1.05)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C443(1.04); C502(1.06); C342(0.93); C316(0.86)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C443(1.13); C342(1.01); C279(1.19); C316(0.89)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C163(1.01); C443(1.04); C342(1.00); C279(1.02)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C163(1.10); C443(0.95); C342(0.99); C279(0.92)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C443(1.05); C502(0.87); C342(0.89); C279(1.17)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C443(0.97); C342(0.95); C279(1.05); C309(1.03)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C163(1.01); C443(1.08); C342(1.00); C279(1.19)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C163(1.15); C443(1.06); C502(0.93); C342(1.03)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C163(1.04); C342(1.07); C279(1.08); C309(0.78)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C163(1.20); C342(1.01); C279(1.08); C309(0.93)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C443(1.02); C342(0.99); C279(1.10); C316(0.98)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C443(1.08); C279(0.88); C316(0.82); C309(1.04)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C443(1.02); C502(0.85); C342(1.01); C316(1.07)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C443(1.16); C342(1.13); C279(1.25); C316(0.91)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C163(0.89); C443(1.17); C342(1.05); C279(1.06)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C163(0.91); C443(1.03); C342(1.03); C279(0.89)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C443(1.15); C502(0.73); C342(1.02); C279(1.06)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C443(1.11); C502(0.81); C342(0.92); C279(1.16)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C443(1.08); C342(1.00); C279(0.97); C309(1.12)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C443(1.12); C342(1.01); C279(1.03); C316(1.17)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C163(0.92); C443(1.04); C342(1.06); C279(0.97)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C163(1.06); C443(1.12); C502(0.63); C342(1.09)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C163(1.01); C342(1.07); C279(0.99); C309(0.93)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C443(1.08); C342(0.95); C279(0.88); C316(1.36)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C443(1.03); C279(0.79); C316(1.14); C309(1.13)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C443(1.04); C502(0.93); C342(1.05); C316(0.81)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C443(1.19); C342(0.96); C279(1.11); C316(0.99)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C163(0.89); C443(0.97); C342(1.00); C279(0.95)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C163(1.06); C443(0.94); C342(1.10); C279(1.02)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C443(1.08); C502(0.90); C342(0.95); C279(1.54)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C443(1.01); C502(1.13); C342(0.94); C279(0.41)  LDD1698  [25]
 LDCM0573  Fragment11 Ramos C502(0.84)  LDD2190  [26]
 LDCM0468  Fragment33 HEK-293T C443(1.06); C502(0.94); C342(0.88); C279(1.08)  LDD1671  [25]
 LDCM0427  Fragment51 HEK-293T C163(1.05); C443(0.89); C342(1.04); C279(1.13)  LDD1631  [25]
 LDCM0616  Fragment61 Jurkat _(10.31)  LDD1489  [8]
 LDCM0615  Fragment63-R Jurkat _(10.34)  LDD1488  [8]
 LDCM0569  Fragment7 Jurkat _(10.45)  LDD1485  [8]
 LDCM0116  HHS-0101 DM93 Y78(0.67); Y128(1.08)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y78(0.70); Y128(0.89)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y78(0.65); Y128(0.83)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y78(0.75); Y128(0.90)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y78(0.79); Y128(1.71)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0123  JWB131 DM93 Y128(1.13); Y78(0.86)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y128(0.98); Y78(1.01)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y128(1.20); Y78(0.96)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y128(6.23); Y78(1.85)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y128(4.34); Y78(1.87)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y128(4.75); Y78(1.01)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y128(0.90); Y78(1.02)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y128(0.80); Y78(1.33)  LDD0292  [9]
 LDCM0022  KB02 HEK-293T C279(0.83); C443(0.97); C316(1.07); C342(0.78)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C279(1.01); C443(0.99); C316(1.02); C342(0.81)  LDD1497  [25]
 LDCM0024  KB05 G361 C322(3.68)  LDD3311  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C279(0.83)  LDD2097  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C279(0.86)  LDD2125  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C279(1.45)  LDD2136  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C279(0.73)  LDD2140  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C279(1.54)  LDD2148  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C308(0.94)  LDD2207  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rho-related GTP-binding protein RhoH (RHOH) Rho family Q15669
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Hemoglobin subunit gamma-2 (HBG2) Globin family P69892
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.