Details of the Target

General Information of Target

Target ID LDTP11294
Target Name Protein adenylyltransferase SelO, mitochondrial (SELENOO)
Gene Name SELENOO
Gene ID 83642
Synonyms
SELO; Protein adenylyltransferase SelO, mitochondrial; EC 2.7.7.-; EC 2.7.7.108; Selenoprotein O; SelO
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPS
SGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASAT
PFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGG
SLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSK
ALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANG
IQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQY
RQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGY
RKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGP
QPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGS
LSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR
Target Bioclass
Enzyme
Family
SELO family
Subcellular location
Mitochondrion
Function
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein.
Uniprot ID
Q9BVL4
Ensemble ID
ENST00000380903.7
HGNC ID
HGNC:30395

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
Johansson_61
 Probe Info  		_(19.53)  LDD1485  [2]
YY4-yne
 Probe Info  		2.19  LDD0400  [3]
AHL-Pu-1
 Probe Info  		C364(6.16)  LDD0170  [4]
DBIA
 Probe Info  		C81(13.21); C382(40.83)  LDD0209  [5]
IPM
 Probe Info  		C81(0.72)  LDD1702  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
IA-alkyne
 Probe Info  		C382(0.00); C81(0.00); C202(0.00)  LDD0162  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C364(6.16)  LDD0170  [4]
 LDCM0214  AC1 HEK-293T C219(0.85)  LDD0812  [13]
 LDCM0215  AC10 HEK-293T C219(0.70); C364(1.03)  LDD0813  [13]
 LDCM0216  AC100 HEK-293T C219(1.11)  LDD0814  [13]
 LDCM0217  AC101 HEK-293T C219(1.03)  LDD0815  [13]
 LDCM0218  AC102 HEK-293T C219(1.01)  LDD0816  [13]
 LDCM0219  AC103 HEK-293T C219(1.12)  LDD0817  [13]
 LDCM0220  AC104 HEK-293T C219(1.02)  LDD0818  [13]
 LDCM0221  AC105 HEK-293T C219(1.06)  LDD0819  [13]
 LDCM0222  AC106 HEK-293T C219(1.26)  LDD0820  [13]
 LDCM0223  AC107 HEK-293T C219(1.21)  LDD0821  [13]
 LDCM0224  AC108 HEK-293T C219(1.06)  LDD0822  [13]
 LDCM0225  AC109 HEK-293T C219(1.14)  LDD0823  [13]
 LDCM0226  AC11 HEK-293T C219(0.66); C364(1.29)  LDD0824  [13]
 LDCM0227  AC110 HEK-293T C219(1.25)  LDD0825  [13]
 LDCM0228  AC111 HEK-293T C219(1.60)  LDD0826  [13]
 LDCM0229  AC112 HEK-293T C219(1.39)  LDD0827  [13]
 LDCM0230  AC113 HEK-293T C219(1.41)  LDD0828  [13]
 LDCM0231  AC114 HEK-293T C219(1.31)  LDD0829  [13]
 LDCM0232  AC115 HEK-293T C219(1.59)  LDD0830  [13]
 LDCM0233  AC116 HEK-293T C219(1.20)  LDD0831  [13]
 LDCM0234  AC117 HEK-293T C219(1.16)  LDD0832  [13]
 LDCM0235  AC118 HEK-293T C219(1.28)  LDD0833  [13]
 LDCM0236  AC119 HEK-293T C219(1.21)  LDD0834  [13]
 LDCM0237  AC12 HEK-293T C219(0.50); C364(1.23)  LDD0835  [13]
 LDCM0238  AC120 HEK-293T C219(1.17)  LDD0836  [13]
 LDCM0239  AC121 HEK-293T C219(1.31)  LDD0837  [13]
 LDCM0240  AC122 HEK-293T C219(1.17)  LDD0838  [13]
 LDCM0241  AC123 HEK-293T C219(1.16)  LDD0839  [13]
 LDCM0242  AC124 HEK-293T C219(1.17)  LDD0840  [13]
 LDCM0243  AC125 HEK-293T C219(1.43)  LDD0841  [13]
 LDCM0244  AC126 HEK-293T C219(1.53)  LDD0842  [13]
 LDCM0245  AC127 HEK-293T C219(1.54)  LDD0843  [13]
 LDCM0246  AC128 HEK-293T C219(0.85)  LDD0844  [13]
 LDCM0247  AC129 HEK-293T C219(0.80)  LDD0845  [13]
 LDCM0249  AC130 HEK-293T C219(0.86)  LDD0847  [13]
 LDCM0250  AC131 HEK-293T C219(0.94)  LDD0848  [13]
 LDCM0251  AC132 HEK-293T C219(0.84)  LDD0849  [13]
 LDCM0252  AC133 HEK-293T C219(1.01)  LDD0850  [13]
 LDCM0253  AC134 HEK-293T C219(0.83)  LDD0851  [13]
 LDCM0254  AC135 HEK-293T C219(0.91)  LDD0852  [13]
 LDCM0255  AC136 HEK-293T C219(0.77)  LDD0853  [13]
 LDCM0256  AC137 HEK-293T C219(1.22)  LDD0854  [13]
 LDCM0257  AC138 HEK-293T C219(1.15)  LDD0855  [13]
 LDCM0258  AC139 HEK-293T C219(1.01)  LDD0856  [13]
 LDCM0259  AC14 HEK-293T C219(0.55); C364(1.04)  LDD0857  [13]
 LDCM0260  AC140 HEK-293T C219(0.89)  LDD0858  [13]
 LDCM0261  AC141 HEK-293T C219(1.07)  LDD0859  [13]
 LDCM0262  AC142 HEK-293T C219(0.89)  LDD0860  [13]
 LDCM0270  AC15 HEK-293T C219(0.54); C364(0.95)  LDD0868  [13]
 LDCM0276  AC17 HEK-293T C219(0.49)  LDD0874  [13]
 LDCM0277  AC18 HEK-293T C219(0.62)  LDD0875  [13]
 LDCM0278  AC19 HEK-293T C219(0.63)  LDD0876  [13]
 LDCM0279  AC2 HEK-293T C219(0.65)  LDD0877  [13]
 LDCM0280  AC20 HEK-293T C219(0.54)  LDD0878  [13]
 LDCM0281  AC21 HEK-293T C219(0.63)  LDD0879  [13]
 LDCM0282  AC22 HEK-293T C219(0.59)  LDD0880  [13]
 LDCM0283  AC23 HEK-293T C219(0.52)  LDD0881  [13]
 LDCM0284  AC24 HEK-293T C219(0.69)  LDD0882  [13]
 LDCM0285  AC25 HEK-293T C81(1.06); C629(1.18); C219(1.16)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C629(1.09); C219(1.19)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C81(1.05); C629(0.98); C219(1.03)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C81(0.96); C629(1.13); C219(0.94)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C81(0.97); C629(1.00); C219(0.93)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C219(0.89)  LDD0888  [13]
 LDCM0291  AC30 HEK-293T C81(1.11); C629(1.10); C219(1.30)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C81(1.16); C629(0.95); C219(1.02)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C81(1.07); C629(1.04); C219(1.00)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C81(0.99); C629(1.06); C219(0.90)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C629(1.12); C219(0.96)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C219(0.83)  LDD0894  [13]
 LDCM0297  AC36 HEK-293T C219(0.85)  LDD0895  [13]
 LDCM0298  AC37 HEK-293T C219(0.85)  LDD0896  [13]
 LDCM0299  AC38 HEK-293T C219(0.80)  LDD0897  [13]
 LDCM0300  AC39 HEK-293T C219(1.23)  LDD0898  [13]
 LDCM0301  AC4 HEK-293T C219(1.18)  LDD0899  [13]
 LDCM0302  AC40 HEK-293T C219(0.68)  LDD0900  [13]
 LDCM0303  AC41 HEK-293T C219(0.99)  LDD0901  [13]
 LDCM0304  AC42 HEK-293T C219(0.86)  LDD0902  [13]
 LDCM0305  AC43 HEK-293T C219(0.76)  LDD0903  [13]
 LDCM0306  AC44 HEK-293T C219(0.98)  LDD0904  [13]
 LDCM0307  AC45 HEK-293T C219(0.94)  LDD0905  [13]
 LDCM0308  AC46 HEK-293T C81(1.04); C629(1.07); C219(1.20)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C81(1.13); C629(1.18); C219(1.06)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C81(1.05); C629(0.84); C219(1.04)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C81(1.03); C629(1.16); C219(1.08)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C219(1.00)  LDD0910  [13]
 LDCM0313  AC50 HEK-293T C629(1.08); C219(0.80)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C81(1.02); C629(1.05); C219(1.12)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C81(0.97); C629(1.14); C219(1.09)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C81(0.95); C629(1.03); C219(0.83)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C81(1.02); C629(0.95); C219(1.03)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C81(1.30); C629(0.93); C219(1.07)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C81(0.98); C629(0.99); C219(1.07)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C81(1.00); C629(1.07); C219(0.77)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C629(1.05); C219(0.92)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C81(1.17); C629(0.97); C219(1.01)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C219(0.76); C364(1.12)  LDD0921  [13]
 LDCM0324  AC60 HEK-293T C81(1.05); C629(0.99); C219(1.08)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C81(0.79); C629(0.98); C219(0.95)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C81(1.04); C629(0.98); C219(0.95)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C81(1.20); C629(1.34); C219(0.99)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C81(1.24); C629(0.99); C219(1.26)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C219(0.66); C364(0.85)  LDD0932  [13]
 LDCM0345  AC8 HEK-293T C219(0.60); C364(0.98)  LDD0943  [13]
 LDCM0349  AC83 HEK-293T C219(0.96)  LDD0947  [13]
 LDCM0350  AC84 HEK-293T C219(0.91)  LDD0948  [13]
 LDCM0351  AC85 HEK-293T C219(1.31)  LDD0949  [13]
 LDCM0352  AC86 HEK-293T C219(1.26)  LDD0950  [13]
 LDCM0353  AC87 HEK-293T C219(0.88)  LDD0951  [13]
 LDCM0354  AC88 HEK-293T C219(1.24)  LDD0952  [13]
 LDCM0355  AC89 HEK-293T C219(1.03)  LDD0953  [13]
 LDCM0357  AC90 HEK-293T C219(0.66)  LDD0955  [13]
 LDCM0358  AC91 HEK-293T C219(1.64)  LDD0956  [13]
 LDCM0359  AC92 HEK-293T C219(0.75)  LDD0957  [13]
 LDCM0360  AC93 HEK-293T C219(1.26)  LDD0958  [13]
 LDCM0361  AC94 HEK-293T C219(1.01)  LDD0959  [13]
 LDCM0362  AC95 HEK-293T C219(1.55)  LDD0960  [13]
 LDCM0363  AC96 HEK-293T C219(0.85)  LDD0961  [13]
 LDCM0364  AC97 HEK-293T C219(1.06)  LDD0962  [13]
 LDCM0365  AC98 HEK-293T C219(1.05)  LDD0963  [13]
 LDCM0366  AC99 HEK-293T C219(1.06)  LDD0964  [13]
 LDCM0248  AKOS034007472 HEK-293T C219(0.48); C364(0.96)  LDD0846  [13]
 LDCM0356  AKOS034007680 HEK-293T C219(0.52); C364(0.88)  LDD0954  [13]
 LDCM0275  AKOS034007705 HEK-293T C219(0.33); C364(0.83)  LDD0873  [13]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C219(0.00); C484(0.00)  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C364(1.20)  LDD0965  [13]
 LDCM0368  CL10 HEK-293T C364(1.16)  LDD0966  [13]
 LDCM0369  CL100 HEK-293T C219(0.85)  LDD0967  [13]
 LDCM0370  CL101 HEK-293T C219(0.35); C364(0.77)  LDD0968  [13]
 LDCM0371  CL102 HEK-293T C219(0.47); C364(0.97)  LDD0969  [13]
 LDCM0372  CL103 HEK-293T C219(0.43); C364(0.78)  LDD0970  [13]
 LDCM0373  CL104 HEK-293T C219(0.58); C364(0.93)  LDD0971  [13]
 LDCM0374  CL105 HEK-293T C219(0.66)  LDD0972  [13]
 LDCM0375  CL106 HEK-293T C219(0.65)  LDD0973  [13]
 LDCM0376  CL107 HEK-293T C219(0.73)  LDD0974  [13]
 LDCM0377  CL108 HEK-293T C219(0.58)  LDD0975  [13]
 LDCM0378  CL109 HEK-293T C219(0.74)  LDD0976  [13]
 LDCM0379  CL11 HEK-293T C364(0.98)  LDD0977  [13]
 LDCM0380  CL110 HEK-293T C219(0.81)  LDD0978  [13]
 LDCM0381  CL111 HEK-293T C219(0.69)  LDD0979  [13]
 LDCM0382  CL112 HEK-293T C81(1.14); C629(0.66)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C81(0.99); C629(1.05)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C81(1.07); C629(1.13); C219(0.93)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C81(1.03); C629(0.88)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C81(1.07); C629(0.67)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C219(0.90)  LDD0985  [13]
 LDCM0388  CL118 HEK-293T C219(1.17)  LDD0986  [13]
 LDCM0389  CL119 HEK-293T C219(1.28)  LDD0987  [13]
 LDCM0390  CL12 HEK-293T C364(1.03)  LDD0988  [13]
 LDCM0391  CL120 HEK-293T C219(0.86)  LDD0989  [13]
 LDCM0392  CL121 HEK-293T C81(1.35); C629(1.00)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C81(1.08); C629(1.45); C219(1.20)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C81(0.89); C629(0.94)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C81(1.25); C629(0.53)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C81(1.53); C629(1.04)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C81(1.00); C629(1.17); C219(1.10)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C81(1.17); C629(0.80)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C81(1.23); C629(0.77)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C364(0.98)  LDD0998  [13]
 LDCM0401  CL14 HEK-293T C364(0.89)  LDD0999  [13]
 LDCM0402  CL15 HEK-293T C364(0.90)  LDD1000  [13]
 LDCM0403  CL16 HEK-293T C219(1.06); C364(0.93)  LDD1001  [13]
 LDCM0404  CL17 HEK-293T C219(0.99); C364(0.92)  LDD1002  [13]
 LDCM0405  CL18 HEK-293T C219(0.98); C364(0.86)  LDD1003  [13]
 LDCM0406  CL19 HEK-293T C219(0.89); C364(0.99)  LDD1004  [13]
 LDCM0407  CL2 HEK-293T C364(0.80)  LDD1005  [13]
 LDCM0408  CL20 HEK-293T C219(0.82); C364(0.88)  LDD1006  [13]
 LDCM0409  CL21 HEK-293T C219(0.87); C364(1.03)  LDD1007  [13]
 LDCM0410  CL22 HEK-293T C219(0.91); C364(0.80)  LDD1008  [13]
 LDCM0411  CL23 HEK-293T C219(1.03); C364(0.93)  LDD1009  [13]
 LDCM0412  CL24 HEK-293T C219(1.00); C364(0.94)  LDD1010  [13]
 LDCM0413  CL25 HEK-293T C219(0.85); C364(0.97)  LDD1011  [13]
 LDCM0414  CL26 HEK-293T C219(0.87); C364(1.00)  LDD1012  [13]
 LDCM0415  CL27 HEK-293T C219(0.99); C364(1.01)  LDD1013  [13]
 LDCM0416  CL28 HEK-293T C219(1.00); C364(1.01)  LDD1014  [13]
 LDCM0417  CL29 HEK-293T C219(0.96); C364(0.98)  LDD1015  [13]
 LDCM0418  CL3 HEK-293T C364(0.79)  LDD1016  [13]
 LDCM0419  CL30 HEK-293T C219(0.86); C364(0.95)  LDD1017  [13]
 LDCM0420  CL31 HEK-293T C219(0.88); C364(0.69)  LDD1018  [13]
 LDCM0421  CL32 HEK-293T C219(0.66); C364(0.75)  LDD1019  [13]
 LDCM0422  CL33 HEK-293T C219(0.76); C364(0.88)  LDD1020  [13]
 LDCM0423  CL34 HEK-293T C219(0.74); C364(0.86)  LDD1021  [13]
 LDCM0424  CL35 HEK-293T C219(0.62); C364(0.66)  LDD1022  [13]
 LDCM0425  CL36 HEK-293T C219(0.67); C364(0.72)  LDD1023  [13]
 LDCM0426  CL37 HEK-293T C219(0.64); C364(0.72)  LDD1024  [13]
 LDCM0428  CL39 HEK-293T C219(0.56); C364(0.72)  LDD1026  [13]
 LDCM0429  CL4 HEK-293T C364(0.96)  LDD1027  [13]
 LDCM0430  CL40 HEK-293T C219(0.65); C364(0.61)  LDD1028  [13]
 LDCM0431  CL41 HEK-293T C219(0.59); C364(0.67)  LDD1029  [13]
 LDCM0432  CL42 HEK-293T C219(0.47); C364(0.67)  LDD1030  [13]
 LDCM0433  CL43 HEK-293T C219(0.54); C364(0.68)  LDD1031  [13]
 LDCM0434  CL44 HEK-293T C219(0.57); C364(0.65)  LDD1032  [13]
 LDCM0435  CL45 HEK-293T C219(0.56); C364(0.62)  LDD1033  [13]
 LDCM0436  CL46 HEK-293T C219(0.93); C364(0.89)  LDD1034  [13]
 LDCM0437  CL47 HEK-293T C219(0.91); C364(0.90)  LDD1035  [13]
 LDCM0438  CL48 HEK-293T C219(0.91); C364(1.05)  LDD1036  [13]
 LDCM0439  CL49 HEK-293T C219(0.88); C364(0.96)  LDD1037  [13]
 LDCM0440  CL5 HEK-293T C364(0.78)  LDD1038  [13]
 LDCM0441  CL50 HEK-293T C219(1.23); C364(1.22)  LDD1039  [13]
 LDCM0442  CL51 HEK-293T C219(0.95); C364(1.09)  LDD1040  [13]
 LDCM0443  CL52 HEK-293T C219(1.53); C364(1.44)  LDD1041  [13]
 LDCM0444  CL53 HEK-293T C219(0.78); C364(1.31)  LDD1042  [13]
 LDCM0445  CL54 HEK-293T C219(0.88); C364(1.59)  LDD1043  [13]
 LDCM0446  CL55 HEK-293T C219(0.95); C364(1.03)  LDD1044  [13]
 LDCM0447  CL56 HEK-293T C219(0.73); C364(1.05)  LDD1045  [13]
 LDCM0448  CL57 HEK-293T C219(1.04); C364(1.05)  LDD1046  [13]
 LDCM0449  CL58 HEK-293T C219(1.05); C364(1.21)  LDD1047  [13]
 LDCM0450  CL59 HEK-293T C219(0.89); C364(1.05)  LDD1048  [13]
 LDCM0451  CL6 HEK-293T C364(0.84)  LDD1049  [13]
 LDCM0452  CL60 HEK-293T C219(0.97); C364(1.13)  LDD1050  [13]
 LDCM0453  CL61 HEK-293T C81(1.53); C629(1.01)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C81(0.97); C629(1.61); C219(1.65)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C81(1.06); C629(0.82)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C81(1.01); C629(0.83)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C81(0.97); C629(1.04); C219(1.04)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C629(1.14); C219(1.32)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C81(1.13); C629(0.98); C219(1.67)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C81(0.92); C629(1.25); C219(1.24)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C81(1.09); C629(1.00); C219(1.03)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C364(0.84)  LDD1060  [13]
 LDCM0463  CL70 HEK-293T C81(0.84); C629(0.90); C219(1.21)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C81(1.40); C629(1.34); C219(1.27)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C81(1.01); C629(1.08); C219(1.12)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C81(1.46); C629(1.28)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C81(1.05); C629(1.60); C219(1.58)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C81(1.05); C629(0.82)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C81(1.07); C629(1.12); C219(1.10)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C629(1.04); C219(0.96)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C81(0.95); C629(0.97); C219(1.13)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C364(0.88)  LDD1071  [13]
 LDCM0474  CL80 HEK-293T C81(1.03); C629(0.95); C219(0.95)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C81(0.85); C629(1.02); C219(0.83)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C81(0.91); C629(0.90); C219(1.26)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C81(1.19); C629(0.85); C219(0.98)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C81(1.09); C629(0.93); C219(1.17)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C81(1.66); C629(1.01)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C81(1.23); C629(1.19); C219(1.16)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C81(1.09); C629(0.93)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C81(1.09); C629(0.92)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C81(1.09); C629(0.88); C219(0.99)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C364(0.80)  LDD1082  [13]
 LDCM0485  CL90 HEK-293T C629(0.87); C219(1.06)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C219(0.98)  LDD1084  [13]
 LDCM0487  CL92 HEK-293T C219(1.08)  LDD1085  [13]
 LDCM0488  CL93 HEK-293T C219(0.94)  LDD1086  [13]
 LDCM0489  CL94 HEK-293T C219(0.82)  LDD1087  [13]
 LDCM0490  CL95 HEK-293T C219(0.85)  LDD1088  [13]
 LDCM0491  CL96 HEK-293T C219(0.83)  LDD1089  [13]
 LDCM0492  CL97 HEK-293T C219(0.99)  LDD1090  [13]
 LDCM0493  CL98 HEK-293T C219(1.01)  LDD1091  [13]
 LDCM0494  CL99 HEK-293T C219(0.99)  LDD1092  [13]
 LDCM0495  E2913 HEK-293T C81(1.03); C629(1.06)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C81(0.72)  LDD1702  [6]
 LDCM0625  F8 Ramos C81(0.83); C241(0.93); C219(2.72); C629(1.47)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C81(0.98); C629(1.25)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C81(0.07); C241(0.46); C219(2.13); C629(11.08)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C81(0.71); C629(0.99)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C81(0.97); C241(1.06); C629(0.80)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C81(0.65); C241(0.77); C629(0.59)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C81(1.47); C629(0.94)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C81(0.70); C241(0.93); C629(0.81)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C81(0.85); C629(0.91)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C81(0.99); C241(1.13); C629(0.94)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C81(0.64); C241(0.95); C629(0.67)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C81(0.92); C241(0.77); C629(1.18)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C81(0.72); C241(0.65); C629(0.70)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C81(0.63); C241(0.99); C629(2.57)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C81(1.03); C629(0.74)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C81(0.73); C241(0.73); C629(0.79)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C81(1.30); C219(1.62); C629(0.97)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C219(0.43); C364(0.74)  LDD1025  [13]
 LDCM0610  Fragment52 Ramos C81(0.92); C241(0.50); C629(1.35)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C81(1.05); C241(0.89); C629(0.90)  LDD2205  [15]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [2]
 LDCM0615  Fragment63-R Jurkat _(9.63)  LDD1487  [2]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [2]
 LDCM0569  Fragment7 Jurkat _(19.53)  LDD1485  [2]
 LDCM0571  Fragment9 Ramos C81(1.65); C629(1.16)  LDD2188  [15]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C364(1.17); C629(1.42); C81(1.06)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C81(13.21); C382(40.83)  LDD0209  [5]
 LDCM0024  KB05 G361 C219(1.79); C81(1.66)  LDD3311  [16]
 LDCM0154  YY4 T cell 2.19  LDD0400  [3]

References

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2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840