Details of the Target

General Information of Target

Target ID LDTP13330
Target Name rRNA methyltransferase 2, mitochondrial (MRM2)
Gene Name MRM2
Gene ID 29960
Synonyms
FJH1; FTSJ2; rRNA methyltransferase 2, mitochondrial; EC 2.1.1.-; 16S rRNA; uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; Protein ftsJ homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSF
NRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNY
GAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGI
HSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRK
TRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGN
FKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVY
PASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNL
Y
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family
Subcellular location
Mitochondrion
Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Uniprot ID
Q9UI43
Ensemble ID
ENST00000242257.14
HGNC ID
HGNC:16352

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		14.13  LDD0066  [1]
IA-alkyne
 Probe Info  		C79(5.29)  LDD2157  [2]
m-APA
 Probe Info  		13.29  LDD0403  [3]
Johansson_61
 Probe Info  		_(20.00)  LDD1488  [4]
DBIA
 Probe Info  		C79(1.06)  LDD0080  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
AOyne
 Probe Info  		12.50  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C79(0.71)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C79(0.73)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C79(0.82)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C79(0.90)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C79(0.78)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C79(0.77)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C79(1.04)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C79(0.92)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C79(0.83)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C79(0.72)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C79(0.73)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C79(1.05)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C79(0.71)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C79(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C79(0.85)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C79(0.79)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C79(0.91)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C79(0.74)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C79(0.95)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C79(0.44)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C79(0.75)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C79(0.51)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C79(0.40)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C79(0.32)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C79(0.46)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C79(0.66)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C79(0.80)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C79(0.79)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C79(0.38)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C79(0.30)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C79(0.42)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C79(0.46)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C79(0.92)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C79(0.93)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C79(0.90)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C79(0.46)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C79(0.75)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C79(0.71)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C79(0.94)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C79(0.67)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C79(0.99)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C79(0.88)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C79(1.00)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C79(0.72)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C79(0.76)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C79(0.59)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C79(0.63)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C79(0.61)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C79(0.77)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C79(0.58)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C79(0.65)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C79(0.47)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C79(0.52)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C79(0.48)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C79(1.12)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C79(1.16)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C79(0.97)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C79(0.99)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C79(1.04)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C79(0.63)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C79(0.89)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C79(0.85)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C79(0.83)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C79(0.92)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C79(0.86)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C79(0.88)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C79(1.24)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C79(0.99)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C79(1.35)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C79(0.96)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C79(0.65)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C79(0.98)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C79(1.68)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C79(1.03)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C79(0.87)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C79(0.88)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C79(0.98)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C79(1.21)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C79(0.38)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C79(0.34)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C79(0.33)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C79(0.65)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C79(0.46)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C79(0.48)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C79(0.32)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C79(0.38)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C79(0.36)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C79(0.48)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C79(0.50)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C79(0.37)  LDD0648  [5]
 LDCM0334  AC7 HCT 116 C79(0.81)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C79(0.71)  LDD0662  [5]
 LDCM0349  AC83 HCT 116 C79(0.49)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C79(0.45)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C79(0.63)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C79(0.53)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C79(0.93)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C79(0.59)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C79(0.45)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C79(1.51)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C79(0.41)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C79(0.45)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C79(0.53)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C79(0.72)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C79(0.89)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C79(0.51)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C79(0.41)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C79(0.82)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C79(0.86)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C79(1.16)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C79(1.05)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C79(0.54)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 13.29  LDD0403  [3]
 LDCM0367  CL1 HCT 116 C79(0.93)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C79(0.70)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C79(0.57)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C79(0.53)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C79(0.81)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C79(0.83)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C79(0.77)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C79(0.55)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C79(0.50)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C79(0.53)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C79(0.44)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C79(0.54)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C79(0.77)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C79(0.42)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C79(0.59)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C79(0.78)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C79(0.48)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C79(0.63)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C79(0.51)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C79(0.63)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C79(0.99)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C79(0.93)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C79(0.83)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C79(0.81)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C79(0.93)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C79(0.60)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C79(1.10)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C79(0.85)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C79(0.92)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C79(0.69)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C79(0.46)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C79(0.68)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C79(0.33)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C79(0.92)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C79(0.83)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C79(0.87)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C79(0.84)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C79(1.15)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C79(1.06)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C79(0.98)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C79(1.19)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C79(1.16)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C79(0.92)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C79(1.21)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C79(0.94)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C79(0.95)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C79(0.91)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C79(0.96)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C79(1.13)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C79(0.91)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C79(0.99)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C79(0.75)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C79(1.06)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C79(1.20)  LDD1624  [10]
 LDCM0422  CL33 HEK-293T C79(0.94)  LDD1626  [10]
 LDCM0425  CL36 HEK-293T C79(1.01)  LDD1629  [10]
 LDCM0429  CL4 HCT 116 C79(0.72)  LDD0746  [5]
 LDCM0431  CL41 HEK-293T C79(0.96)  LDD1635  [10]
 LDCM0433  CL43 HEK-293T C79(1.02)  LDD1637  [10]
 LDCM0435  CL45 HEK-293T C79(0.90)  LDD1639  [10]
 LDCM0436  CL46 HCT 116 C79(1.43)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C79(1.28)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C79(1.35)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C79(1.09)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C79(0.91)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C79(1.22)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C79(1.13)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C79(1.10)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C79(1.17)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C79(1.29)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C79(1.01)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C79(0.94)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C79(1.02)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C79(1.30)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C79(1.04)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C79(0.96)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C79(0.99)  LDD0769  [5]
 LDCM0457  CL65 HEK-293T C79(1.02)  LDD1660  [10]
 LDCM0459  CL67 HEK-293T C79(1.09)  LDD1662  [10]
 LDCM0461  CL69 HEK-293T C79(0.86)  LDD1664  [10]
 LDCM0462  CL7 HCT 116 C79(0.77)  LDD0779  [5]
 LDCM0465  CL72 HEK-293T C79(1.12)  LDD1668  [10]
 LDCM0469  CL76 HCT 116 C79(0.94)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C79(0.59)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C79(0.66)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C79(0.61)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C79(0.76)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C79(0.99)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C79(0.65)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C79(0.62)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C79(0.66)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C79(0.70)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C79(0.68)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C79(0.94)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C79(0.68)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C79(0.67)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C79(0.79)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C79(0.73)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C79(0.85)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C79(0.59)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C79(0.71)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C79(0.67)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C79(0.55)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C79(0.52)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C79(0.52)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C79(0.49)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C79(0.53)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C79(0.59)  LDD0811  [5]
 LDCM0625  F8 Ramos C79(1.00)  LDD2187  [11]
 LDCM0573  Fragment11 Ramos C79(0.27)  LDD2190  [11]
 LDCM0576  Fragment14 Ramos C79(0.93)  LDD2193  [11]
 LDCM0586  Fragment28 Ramos C79(0.41)  LDD2198  [11]
 LDCM0566  Fragment4 Ramos C79(0.39)  LDD2184  [11]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1488  [4]
 LDCM0569  Fragment7 Ramos C79(0.87)  LDD2186  [11]
 LDCM0022  KB02 HCT 116 C79(1.06)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C79(1.79)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C79(1.29)  LDD0082  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C79(1.33)  LDD2206  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C79(1.31)  LDD2207  [12]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Plazomicin Small molecular drug D0E6BB

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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