Details of the Target

General Information of Target

Target ID LDTP11178
Target Name Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1)
Gene Name ALG1
Gene ID 56052
Synonyms
HMAT1; HMT1; Chitobiosyldiphosphodolichol beta-mannosyltransferase; EC 2.4.1.142; Asparagine-linked glycosylation protein 1 homolog; Beta-1,4-mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; Mannosyltransferase-1; MT-1; hMat-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLTPRALCSAAQAAWRENFPLCGRDVARWFPGHMAKGLKKMQSSLKLVDCIIEVHDARI
PLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGLKNVIFTNCVKDENVK
QIIPMVTELIGRSHRYHRKENLEYCIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGEP
GITRAVMSKIQVSERPLMFLLDTPGVLAPRIESVETGLKLALCGTVLDHLVGEETMADYL
LYTLNKHQRFGYVQHYGLGSACDNVERVLKSVAVKLGKTQKVKVLTGTGNVNIIQPNYPA
AARDFLQTFRRGLLGSVMLDLDVLRGHPPAETLP
Target Bioclass
Enzyme
Family
Glycosyltransferase group 1 family, Glycosyltransferase 33 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function Catalyzes the addition of the first of nine mannose moieties to form a dolichol-lipid linked oligosaccharide intermediate required for proper N-linked glycosylation.
Uniprot ID
Q9BT22
Ensemble ID
ENST00000262374.10
HGNC ID
HGNC:18294

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.S239N .
HUCCT1 SNV: p.P47H; p.Q50K .
LS180 SNV: p.P430H DBIA    Probe Info 
SW1271 SNV: p.R232L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.00  LDD0402  [1]
HDSF-alk
 Probe Info  		3.58  LDD0197  [2]
CHEMBL5175495
 Probe Info  		32.47  LDD0196  [3]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
STPyne
 Probe Info  		K217(6.98); K223(7.63)  LDD0277  [5]
P11
 Probe Info  		11.67  LDD0201  [6]
BTD
 Probe Info  		C194(1.06)  LDD2093  [7]
Curcusone 37
 Probe Info  		5.57  LDD0188  [8]
Johansson_61
 Probe Info  		_(18.43)  LDD1485  [9]
YY4-yne
 Probe Info  		3.59  LDD0400  [10]
HPAP
 Probe Info  		3.07  LDD0062  [11]
IA-alkyne
 Probe Info  		C396(1.06); C194(2.01)  LDD2187  [12]
DBIA
 Probe Info  		C396(1.44)  LDD0080  [13]
IPM
 Probe Info  		C396(0.00); C385(0.00); C390(0.00)  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
AOyne
 Probe Info  		6.90  LDD0443  [17]
PAL-AfBPP Probe
Click To Hide/Show 63 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.36  LDD1725  [18]
C022
 Probe Info  		6.68  LDD1728  [18]
C027
 Probe Info  		15.14  LDD1733  [18]
C040
 Probe Info  		11.00  LDD1740  [18]
C055
 Probe Info  		18.13  LDD1752  [18]
C056
 Probe Info  		32.90  LDD1753  [18]
C063
 Probe Info  		20.25  LDD1760  [18]
C091
 Probe Info  		21.56  LDD1782  [18]
C092
 Probe Info  		25.81  LDD1783  [18]
C094
 Probe Info  		36.50  LDD1785  [18]
C100
 Probe Info  		5.28  LDD1789  [18]
C106
 Probe Info  		19.29  LDD1793  [18]
C107
 Probe Info  		6.50  LDD1794  [18]
C112
 Probe Info  		23.26  LDD1799  [18]
C134
 Probe Info  		29.24  LDD1816  [18]
C135
 Probe Info  		10.93  LDD1817  [18]
C143
 Probe Info  		14.83  LDD1825  [18]
C153
 Probe Info  		22.01  LDD1834  [18]
C158
 Probe Info  		9.06  LDD1838  [18]
C159
 Probe Info  		10.48  LDD1839  [18]
C160
 Probe Info  		7.84  LDD1840  [18]
C161
 Probe Info  		14.12  LDD1841  [18]
C169
 Probe Info  		22.16  LDD1849  [18]
C177
 Probe Info  		7.62  LDD1856  [18]
C178
 Probe Info  		17.75  LDD1857  [18]
C201
 Probe Info  		44.02  LDD1877  [18]
C206
 Probe Info  		25.81  LDD1881  [18]
C207
 Probe Info  		18.13  LDD1882  [18]
C210
 Probe Info  		48.84  LDD1884  [18]
C218
 Probe Info  		24.42  LDD1892  [18]
C220
 Probe Info  		21.11  LDD1894  [18]
C228
 Probe Info  		20.25  LDD1901  [18]
C231
 Probe Info  		20.82  LDD1904  [18]
C234
 Probe Info  		5.66  LDD1907  [18]
C235
 Probe Info  		39.67  LDD1908  [18]
C246
 Probe Info  		16.45  LDD1919  [18]
C251
 Probe Info  		47.84  LDD1924  [18]
C264
 Probe Info  		18.90  LDD1935  [18]
C282
 Probe Info  		14.32  LDD1952  [18]
C285
 Probe Info  		52.71  LDD1955  [18]
C287
 Probe Info  		11.16  LDD1957  [18]
C289
 Probe Info  		39.40  LDD1959  [18]
C293
 Probe Info  		26.35  LDD1963  [18]
C296
 Probe Info  		11.88  LDD1966  [18]
C299
 Probe Info  		8.88  LDD1968  [18]
C310
 Probe Info  		7.73  LDD1977  [18]
C343
 Probe Info  		11.08  LDD2005  [18]
C348
 Probe Info  		13.55  LDD2009  [18]
C349
 Probe Info  		29.45  LDD2010  [18]
C350
 Probe Info  		60.13  LDD2011  [18]
C356
 Probe Info  		9.99  LDD2017  [18]
C362
 Probe Info  		44.32  LDD2023  [18]
C366
 Probe Info  		6.50  LDD2027  [18]
C382
 Probe Info  		9.92  LDD2041  [18]
C388
 Probe Info  		65.80  LDD2047  [18]
C390
 Probe Info  		45.25  LDD2049  [18]
C407
 Probe Info  		16.00  LDD2064  [18]
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe13
 Probe Info  		16.92  LDD0475  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
A-DA
 Probe Info  		2.20  LDD0145  [20]
OEA-DA
 Probe Info  		3.99  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C194(1.06)  LDD2152  [7]
 LDCM0214  AC1 HCT 116 C194(0.79); C396(1.01)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C194(0.97); C390(0.62); C396(0.85)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C194(0.77); C390(0.87); C396(0.50)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C194(0.94); C390(0.72); C396(0.53)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C194(0.92); C390(0.56); C396(0.52)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C194(0.72); C390(0.48); C396(0.39)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C194(0.70); C390(0.65); C396(0.39)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C194(0.79); C390(0.61); C396(0.39)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C194(0.82); C390(0.51); C396(0.44)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C194(0.77); C390(0.65); C396(0.52)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C194(0.74); C390(0.75); C396(0.52)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C194(0.75); C390(0.58); C396(0.44)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C194(0.77); C390(0.60); C396(0.81)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C194(0.66); C390(0.48); C396(0.44)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C194(0.86); C390(0.49); C396(0.51)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C194(0.71); C390(0.58); C396(0.49)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C396(0.97)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C396(0.89)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C396(0.94)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C396(0.88)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C396(0.90)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C396(0.85)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C396(0.89)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C194(0.87); C390(0.80); C396(0.88)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C396(0.83)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C396(0.89)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C396(0.85)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C396(0.78)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C396(0.86)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C396(0.98)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C396(0.91)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C396(0.96)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C194(0.78)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C194(0.79)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C194(0.91)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C194(1.06)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C194(0.84)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C194(0.88)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C194(0.97)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C194(0.89)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C194(1.05)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C194(1.02)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C194(1.01)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C194(1.02)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C194(0.67); C390(0.55); C396(0.91)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C194(1.01)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C194(1.14)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C194(0.87)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C194(1.06)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C194(0.71)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C194(1.03)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C194(0.66)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C194(0.67)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C194(0.39)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C194(0.53)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C194(0.67); C390(0.74); C396(0.85)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C194(0.88)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C194(0.75)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C194(0.71)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C194(0.39)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C194(0.57)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C194(0.67)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C194(0.77)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C194(0.95)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C396(0.81); C194(1.06)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C396(0.69); C194(0.69)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C396(0.74); C194(0.86)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C194(0.94); C396(1.17)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C396(0.80); C194(0.93)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C396(0.73); C194(0.78)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C396(0.86); C194(0.89)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C396(0.70); C194(0.74)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C396(0.75); C194(0.92)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C194(0.81); C396(1.11)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C396(1.02); C194(1.04)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C194(0.94); C396(0.96)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C396(0.91); C194(1.03)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C194(0.91); C396(1.09)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C194(0.85); C396(1.16)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C194(0.90); C396(1.01)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C194(0.93); C396(0.93)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C396(0.86); C194(0.96)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C194(0.86); C396(0.87)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C194(0.77); C396(0.80)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C396(1.00)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C396(0.97)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C396(0.97)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C396(1.05)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C396(1.03)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C194(0.84); C396(0.95)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C396(0.75)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C396(0.82)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C396(0.83)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C396(0.86)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C396(0.81)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C396(0.73)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C396(1.04); C194(1.22)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C396(1.02); C194(1.35)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C194(1.19); C396(1.22)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C396(0.79); C194(0.97)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C194(0.86); C396(1.04)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C396(0.78); C194(1.10)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C194(1.06); C396(1.24)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C396(0.97); C194(1.27)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C396(0.76); C194(0.98)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C396(0.80); C194(1.25)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C396(0.72); C194(1.08)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C396(0.73); C194(0.99)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C194(0.82); C396(0.96)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C194(0.74); C396(0.90)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C194(0.70); C396(0.89)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C390(0.74); C396(0.86); C194(0.88)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C194(0.80); C396(0.88)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C194(0.90); C396(0.94)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C194(0.72); C396(0.86)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C396(0.89); C194(0.90)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C194(0.71); C396(0.87)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C396(0.94); C194(1.00)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C194(0.97); C396(0.97)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C194(0.60); C396(0.75)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C194(0.77); C396(0.93)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C194(0.87); C396(0.88)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C390(0.54); C194(0.78); C396(0.98)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C194(0.73); C396(0.88)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C194(1.00); C396(1.10)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C194(0.76); C396(0.79)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C194(0.57); C396(0.80)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C194(0.68); C396(0.81)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C194(0.60); C396(0.78)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C194(0.69); C396(0.78)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C194(0.74); C396(0.77)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C396(0.92); C194(1.00)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C396(0.91); C194(1.00)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C390(0.71); C194(0.81); C396(0.90)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C194(0.78); C396(0.80)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C194(0.82); C396(1.07)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C194(0.64); C396(0.88)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C194(0.46); C396(0.98)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C396(0.54); C194(0.54)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C194(0.64); C396(1.06)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C194(0.78); C396(1.08)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C194(0.96); C396(0.98)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C194(0.70); C396(0.78)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C194(0.62); C396(0.87)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C396(0.87); C194(1.12)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C194(0.43); C396(1.09)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C194(0.45); C396(1.08)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C194(0.52); C396(0.81)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C194(0.68); C396(0.95)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C194(0.67); C396(0.76)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C194(0.51); C396(0.99)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C194(0.50); C396(0.81)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C390(0.21); C396(0.35); C194(0.77)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C396(0.73); C390(0.76); C194(0.83)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C194(0.90); C390(0.74); C396(0.97)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C390(0.58); C194(0.91); C396(0.93)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C390(0.38); C194(0.64); C396(0.70)  LDD0592  [13]
 LDCM0088  C45 HEK-293T 11.67  LDD0201  [6]
 LDCM0108  Chloroacetamide HeLa C194(0.00); H34(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C396(1.08)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C396(0.80)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C194(0.83); C396(0.96)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C390(0.59); C194(0.74); C396(0.90)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C390(0.67); C194(0.87); C396(0.92)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C390(0.71); C194(0.76); C396(0.86)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C194(0.69); C396(0.89); C390(1.05)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C396(0.83); C194(1.04)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C396(0.64); C194(0.72)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C396(0.70); C194(0.73)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C396(0.76); C194(0.91)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C396(0.82); C194(0.83)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C396(0.74)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C396(0.72); C194(0.93)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C396(0.67); C194(0.88)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C194(0.77); C396(1.02)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C396(0.81); C194(0.86)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C194(0.86); C396(1.10)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C194(0.96); C396(1.03)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C194(0.82); C396(1.05)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C396(0.71)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C396(0.86)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C396(0.83)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C396(0.83)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C396(0.89)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C396(0.86); C194(1.01)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C396(0.96); C194(1.19)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C396(0.74); C194(1.09)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C396(0.74); C194(1.19)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C396(1.09); C194(1.25)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C194(1.05); C396(1.09)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C396(1.10); C194(1.18)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C194(0.71); C396(0.97)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C396(0.86)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C396(0.91)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C396(1.01)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C396(0.78); C390(0.89); C194(1.16)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C390(0.74); C396(0.82); C194(0.84)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C390(0.81); C396(0.85); C194(1.08)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C390(0.69); C396(0.77); C194(1.21)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C396(1.18)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C390(0.56); C396(0.64); C194(1.16)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C390(0.42); C396(0.63); C194(1.27)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C390(0.32); C396(0.64); C194(1.38)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C390(0.67); C396(0.71); C194(1.02)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C390(0.46); C396(0.63); C194(0.86)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C194(0.90); C390(0.51); C396(0.71)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C194(1.55); C390(0.70); C396(0.67)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C194(0.99); C390(0.63); C396(0.77)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C194(0.94); C390(0.68); C396(0.67)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C194(0.94); C390(0.56); C396(0.65)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C396(0.98)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C194(1.22); C390(0.76); C396(0.82)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C390(0.69); C396(0.94)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C390(0.79); C396(0.86)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C390(1.15); C396(0.87)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C390(0.48); C396(0.98)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C390(0.47); C396(0.91)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C390(0.53); C396(0.85)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C390(0.52); C396(0.91)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C390(0.51); C396(0.74)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C396(1.12)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C390(0.42); C396(0.75)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C390(0.62); C396(0.73)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C390(0.25); C396(0.79)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C390(0.39); C396(0.76)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C390(0.92); C396(0.91)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C390(0.44); C396(0.96)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C396(1.08)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C396(1.12)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C396(1.07)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C396(1.04)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C396(1.00)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C396(1.08)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C396(1.04)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C396(1.09)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C396(0.96)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C396(0.92)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C396(0.96)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C396(0.96)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C396(1.00)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C396(1.05)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C396(0.97)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C396(1.05)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C396(0.96)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C194(1.48); C396(0.87)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C194(1.60); C396(0.95)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C194(1.37); C396(0.87)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C194(1.52); C396(0.78)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C194(1.47); C396(0.91)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C194(1.38); C396(0.73)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C194(0.97); C396(0.70)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C194(1.18); C396(0.77)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C194(1.51); C396(0.80)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C396(0.95)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C194(1.30); C396(0.78)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C194(1.09); C396(0.72)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C194(1.80); C396(0.84)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C194(1.08); C396(0.76)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C194(1.01); C396(0.72)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C194(0.97); C396(0.94)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C194(1.58); C396(0.91)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C194(0.95); C396(0.90)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C194(0.84); C396(0.82)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C396(0.80)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C194(1.15); C396(0.92)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C194(0.98); C396(0.88)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C194(0.86); C396(0.75)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C194(0.97); C396(0.76)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C194(0.85); C396(0.74)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C194(1.13); C396(0.84)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C194(1.31); C396(1.00)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C194(1.39); C396(0.84)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C194(0.91); C396(0.77)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C194(0.81); C396(0.76)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C396(0.88)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C194(1.34); C396(1.00)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C194(0.89); C396(1.18)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C194(0.88); C396(1.03)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C194(0.88); C396(1.08)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C194(0.81); C396(1.01)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C194(0.99); C396(0.94)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C194(0.88); C396(1.07)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C194(0.80); C396(0.99)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C194(0.80); C396(0.98)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C194(0.76); C396(0.94)  LDD0811  [13]
 LDCM0033  Curcusone1d MCF-7 5.57  LDD0188  [8]
 LDCM0495  E2913 HEK-293T C396(0.99); C194(0.95); C317(0.95); C386(2.00)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C194(1.36)  LDD1702  [7]
 LDCM0625  F8 Ramos C396(1.06); C194(2.01)  LDD2187  [12]
 LDCM0573  Fragment11 Ramos C396(3.22); C194(3.02)  LDD2190  [12]
 LDCM0580  Fragment21 Ramos C396(2.18)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C396(1.95)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C396(1.62)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C396(0.59); C194(0.47)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C396(2.53)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C396(1.47)  LDD2200  [12]
 LDCM0468  Fragment33 HCT 116 C194(1.51); C396(0.77)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C396(3.46)  LDD2203  [12]
 LDCM0427  Fragment51 HCT 116 C390(0.24); C396(0.83)  LDD0744  [13]
 LDCM0614  Fragment56 Ramos C396(1.47)  LDD2205  [12]
 LDCM0616  Fragment61 Jurkat _(14.77)  LDD1489  [9]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [9]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [9]
 LDCM0569  Fragment7 Jurkat _(18.43)  LDD1485  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C396(1.44)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C396(2.11)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C396(0.99)  LDD0082  [13]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C194(1.06)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C194(1.44)  LDD2094  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C194(1.10)  LDD2099  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C194(0.99)  LDD2107  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C194(1.00)  LDD2111  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C194(1.00)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C194(1.53)  LDD2123  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C194(1.21)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C194(1.50)  LDD2135  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C194(0.89)  LDD2137  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C194(0.86)  LDD2146  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C194(1.08)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C194(0.97)  LDD2207  [23]
 LDCM0014  Panhematin HEK-293T 3.07  LDD0062  [11]
 LDCM0084  Ro 48-8071 A-549 2.20  LDD0145  [20]
 LDCM0154  YY4 T cell 3.59  LDD0400  [10]

References

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Mass spectrometry data entry: PXD028270
6 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
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11 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.