Details of the Target

General Information of Target

Target ID LDTP07242
Target Name Terminal nucleotidyltransferase 5C (TENT5C)
Gene Name TENT5C
Gene ID 54855
Synonyms
FAM46C; Terminal nucleotidyltransferase 5C; EC 2.7.7.19; Non-canonical poly(A) polymerase FAM46C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEESSCTRDCMSFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTLEITLKDIVQTVRSRLE
EAGIKVHDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTEAEFQLVRDVVLCSLLNFL
PEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNKNGKNVELKFVDSIRRQFEFS
VDSFQIILDSLLFFYDCSNNPISEHFHPTVIGESMYGDFEEAFDHLQNRLIATKNPEEIR
GGGLLKYSNLLVRDFRPTDQEEIKTLERYMCSRFFIDFPDILEQQRKLETYLQNHFAEEE
RSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALRVLAEQNIIPSATNVTCYYQPA
PYVSDGNFSNYYVAHPPVTYSQPYPTWLPCN
Target Bioclass
Enzyme
Family
TENT family
Subcellular location
Nucleus
Function
Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.; (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
Uniprot ID
Q5VWP2
Ensemble ID
ENST00000369448.4
HGNC ID
HGNC:24712

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C88(1.16)  LDD3336  [1]
Johansson_61
 Probe Info  		_(10.30)  LDD1488  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C11(0.00); C114(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0615  Fragment63-R Jurkat _(10.30)  LDD1488  [2]
 LDCM0022  KB02 DEL C114(1.83)  LDD2315  [1]
 LDCM0023  KB03 DEL C114(1.84)  LDD2732  [1]
 LDCM0024  KB05 MONO-MAC-6 C88(1.16)  LDD3336  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853