Details of the Target

General Information of Target

Target ID LDTP06658
Target Name Thioredoxin reductase 1, cytoplasmic (TXNRD1)
Gene Name TXNRD1
Gene ID 7296
Synonyms
GRIM12; KDRF; Thioredoxin reductase 1, cytoplasmic; TR; EC 1.8.1.9; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Peroxidase TXNRD1; EC 1.11.1.2; Thioredoxin reductase TR1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
Target Type
Successful
Target Bioclass
Enzyme
Family
Class-I pyridine nucleotide-disulfide oxidoreductase family
Subcellular location
Cytoplasm
Function
Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2).; [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.; [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.; [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only. Mediates cell death induced by a combination of interferon-beta and retinoic acid.
TTD ID
T84581
Uniprot ID
Q16881
DrugMap ID
TTR7UJ3
Ensemble ID
ENST00000503506.6
HGNC ID
HGNC:12437
ChEMBL ID
CHEMBL1927

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.N519D .
CCK81 SNV: p.M382R .
D283MED SNV: p.N152S .
EFO27 SNV: p.A8V .
HCT116 Insertion: p.M151IfsTer5 .
HEC1 SNV: p.H622R .
HT115 SNV: p.E113G .
HUH1 SNV: p.A310V .
JHH7 Deletion: p.K84IfsTer2 .
JURKAT SNV: p.E537G .
NALM6 Insertion: p.L528FfsTer10 DBIA    Probe Info 
PEO1 SNV: p.D516Y .
SBC5 SNV: p.A4S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.79  LDD0402  [1]
A-EBA
 Probe Info  		5.41  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		111.95  LDD0244  [3]
N1
 Probe Info  		16.11  LDD0242  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K396(7.32); K449(1.43)  LDD0274  [5]
STPyne
 Probe Info  		K129(4.88); K150(8.74); K186(3.45); K187(5.11)  LDD0277  [5]
AZ-9
 Probe Info  		E410(10.00)  LDD2208  [6]
OPA-S-S-alkyne
 Probe Info  		K396(2.09); K405(5.51); K245(7.79)  LDD3494  [7]
Probe 1
 Probe Info  		Y508(23.73)  LDD3495  [8]
BTD
 Probe Info  		C571(1.55)  LDD1700  [9]
Johansson_61
 Probe Info  		_(9.69)  LDD1485  [10]
YY4-yne
 Probe Info  		3.27  LDD0400  [11]
HHS-475
 Probe Info  		Y163(0.76); Y161(0.81); Y266(1.02); Y552(1.12)  LDD0264  [12]
DBIA
 Probe Info  		C339(1.36); C209(1.28); C214(1.21); C647(1.06)  LDD0078  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
ATP probe
 Probe Info  		K449(0.00); K187(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C625(0.00); C339(0.00); C327(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C515(0.00); C209(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C625(0.00); C214(0.00); C209(0.00); C327(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		K449(0.00); K217(0.00); K300(0.00)  LDD0035  [19]
WYneN
 Probe Info  		C339(0.00); C209(0.00)  LDD0021  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [21]
IPM
 Probe Info  		N.A.  LDD0147  [22]
1c-yne
 Probe Info  		N.A.  LDD0228  [23]
Acrolein
 Probe Info  		H393(0.00); C339(0.00); H221(0.00); C515(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		N.A.  LDD0218  [24]
W1
 Probe Info  		C209(0.00); C214(0.00); C339(0.00)  LDD0236  [25]
AOyne
 Probe Info  		10.10  LDD0443  [26]
NAIA_5
 Probe Info  		C577(0.00); C625(0.00); C446(0.00); C608(0.00)  LDD2223  [27]
HHS-465
 Probe Info  		Y555(0.00); Y161(0.00)  LDD2240  [28]
HHS-482
 Probe Info  		Y140(1.63); Y555(1.70)  LDD2239  [29]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		5.04  LDD0465  [30]
JN0003
 Probe Info  		20.00  LDD0469  [30]
STS-1
 Probe Info  		3.80  LDD0136  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [31]
Kambe_8
 Probe Info  		6.92  LDD0124  [32]
DA-2
 Probe Info  		N.A.  LDD0071  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C571(0.34)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C571(0.67)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C571(0.38)  LDD2095  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C571(0.78)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C571(1.31)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C571(1.35)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C571(0.29)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C571(0.66)  LDD2131  [9]
 LDCM0214  AC1 HEK-293T C339(0.93)  LDD1507  [34]
 LDCM0215  AC10 HEK-293T C625(1.02); C339(1.21); C214(0.96); C209(0.89)  LDD1508  [34]
 LDCM0226  AC11 HEK-293T C339(1.13); C214(1.02); C209(0.94)  LDD1509  [34]
 LDCM0237  AC12 HEK-293T C625(0.80); C339(0.85); C214(1.03); C209(0.97)  LDD1510  [34]
 LDCM0259  AC14 HEK-293T C625(0.96); C339(1.31); C214(0.92)  LDD1512  [34]
 LDCM0270  AC15 HEK-293T C339(0.93); C209(0.86); C327(1.04)  LDD1513  [34]
 LDCM0276  AC17 HEK-293T C339(0.99)  LDD1515  [34]
 LDCM0277  AC18 HEK-293T C625(0.78); C339(1.19); C214(1.01); C209(0.82)  LDD1516  [34]
 LDCM0278  AC19 HEK-293T C339(1.00); C214(1.02); C209(0.87)  LDD1517  [34]
 LDCM0279  AC2 HEK-293T C625(0.86); C339(1.35); C214(0.91); C209(1.04)  LDD1518  [34]
 LDCM0280  AC20 HEK-293T C625(1.10); C339(1.00); C214(1.07); C209(0.96)  LDD1519  [34]
 LDCM0281  AC21 HEK-293T C339(1.14); C214(1.03)  LDD1520  [34]
 LDCM0282  AC22 HEK-293T C625(1.38); C339(1.18); C214(0.88)  LDD1521  [34]
 LDCM0283  AC23 HEK-293T C339(1.12); C209(1.04); C327(1.37)  LDD1522  [34]
 LDCM0284  AC24 HEK-293T C339(1.24); C214(0.99)  LDD1523  [34]
 LDCM0285  AC25 HEK-293T C339(0.83)  LDD1524  [34]
 LDCM0286  AC26 HEK-293T C625(0.87); C339(1.21); C214(0.97); C209(0.87)  LDD1525  [34]
 LDCM0287  AC27 HEK-293T C339(1.10); C214(1.06); C209(0.88)  LDD1526  [34]
 LDCM0288  AC28 HEK-293T C625(0.89); C339(0.94); C214(0.98); C209(0.87)  LDD1527  [34]
 LDCM0289  AC29 HEK-293T C339(1.00); C214(1.06)  LDD1528  [34]
 LDCM0290  AC3 HEK-293T C339(1.22); C214(0.89); C209(0.92)  LDD1529  [34]
 LDCM0291  AC30 HEK-293T C625(1.13); C339(1.21); C214(0.95)  LDD1530  [34]
 LDCM0292  AC31 HEK-293T C339(1.00); C209(0.94); C327(1.05)  LDD1531  [34]
 LDCM0293  AC32 HEK-293T C339(1.16); C214(1.00)  LDD1532  [34]
 LDCM0294  AC33 HEK-293T C339(1.18)  LDD1533  [34]
 LDCM0295  AC34 HEK-293T C625(1.19); C339(1.28); C214(0.95); C209(0.92)  LDD1534  [34]
 LDCM0296  AC35 HEK-293T C339(0.99); C214(1.09); C209(0.87)  LDD1535  [34]
 LDCM0297  AC36 HEK-293T C625(1.02); C339(1.05); C214(1.12); C209(0.91)  LDD1536  [34]
 LDCM0298  AC37 HEK-293T C339(1.12); C214(1.09)  LDD1537  [34]
 LDCM0299  AC38 HEK-293T C625(1.28); C339(1.32); C214(1.07)  LDD1538  [34]
 LDCM0300  AC39 HEK-293T C339(0.70); C209(0.86); C327(1.08)  LDD1539  [34]
 LDCM0301  AC4 HEK-293T C625(0.78); C339(0.98); C214(0.90); C209(0.89)  LDD1540  [34]
 LDCM0302  AC40 HEK-293T C339(1.09); C214(0.95)  LDD1541  [34]
 LDCM0303  AC41 HEK-293T C339(0.82)  LDD1542  [34]
 LDCM0304  AC42 HEK-293T C625(0.90); C339(1.06); C214(0.96); C209(1.01)  LDD1543  [34]
 LDCM0305  AC43 HEK-293T C339(1.00); C214(0.99); C209(0.85)  LDD1544  [34]
 LDCM0306  AC44 HEK-293T C625(1.06); C339(0.98); C214(1.01); C209(1.00)  LDD1545  [34]
 LDCM0307  AC45 HEK-293T C339(0.95); C214(0.99)  LDD1546  [34]
 LDCM0308  AC46 HEK-293T C625(1.01); C339(1.06); C214(0.93)  LDD1547  [34]
 LDCM0309  AC47 HEK-293T C339(1.05); C209(0.88); C327(1.13)  LDD1548  [34]
 LDCM0310  AC48 HEK-293T C339(1.07); C214(1.07)  LDD1549  [34]
 LDCM0311  AC49 HEK-293T C339(0.89)  LDD1550  [34]
 LDCM0312  AC5 HEK-293T C339(1.14); C214(1.00)  LDD1551  [34]
 LDCM0313  AC50 HEK-293T C625(0.95); C339(1.19); C214(1.06); C209(0.78)  LDD1552  [34]
 LDCM0314  AC51 HEK-293T C339(1.08); C214(0.95); C209(1.02)  LDD1553  [34]
 LDCM0315  AC52 HEK-293T C625(0.98); C339(1.06); C214(1.07); C209(0.95)  LDD1554  [34]
 LDCM0316  AC53 HEK-293T C339(1.15); C214(1.00)  LDD1555  [34]
 LDCM0317  AC54 HEK-293T C625(1.07); C339(1.33); C214(0.92)  LDD1556  [34]
 LDCM0318  AC55 HEK-293T C339(1.10); C209(0.87); C327(1.11)  LDD1557  [34]
 LDCM0319  AC56 HEK-293T C339(1.16); C214(1.00)  LDD1558  [34]
 LDCM0320  AC57 HEK-293T C339(1.10)  LDD1559  [34]
 LDCM0321  AC58 HEK-293T C625(0.95); C339(1.22); C214(1.03); C209(0.93)  LDD1560  [34]
 LDCM0322  AC59 HEK-293T C339(1.10); C214(1.11); C209(0.91)  LDD1561  [34]
 LDCM0323  AC6 HEK-293T C625(1.14); C339(1.30); C214(0.94)  LDD1562  [34]
 LDCM0324  AC60 HEK-293T C625(1.07); C339(0.95); C214(0.90); C209(1.10)  LDD1563  [34]
 LDCM0325  AC61 HEK-293T C339(0.92); C214(0.94)  LDD1564  [34]
 LDCM0326  AC62 HEK-293T C625(0.98); C339(1.18); C214(0.90)  LDD1565  [34]
 LDCM0327  AC63 HEK-293T C339(0.99); C209(0.81); C327(1.14)  LDD1566  [34]
 LDCM0328  AC64 HEK-293T C339(1.19); C214(1.02)  LDD1567  [34]
 LDCM0334  AC7 HEK-293T C339(1.22); C209(1.11); C327(1.08)  LDD1568  [34]
 LDCM0345  AC8 HEK-293T C339(1.14); C214(1.00)  LDD1569  [34]
 LDCM0545  Acetamide MDA-MB-231 C571(0.44)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C571(0.70)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C339(1.12); C214(0.97)  LDD1511  [34]
 LDCM0356  AKOS034007680 HEK-293T C339(0.92)  LDD1570  [34]
 LDCM0275  AKOS034007705 HEK-293T C339(1.14); C214(0.98)  LDD1514  [34]
 LDCM0156  Aniline NCI-H1299 11.88  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C339(1.36); C209(1.28); C214(1.21); C647(1.06)  LDD0078  [13]
 LDCM0108  Chloroacetamide HeLa H288(0.00); H393(0.00); C339(0.00)  LDD0222  [24]
 LDCM0367  CL1 HEK-293T C339(1.39); C214(1.10); C209(0.99)  LDD1571  [34]
 LDCM0368  CL10 HEK-293T C625(0.93); C339(1.01); C214(1.15)  LDD1572  [34]
 LDCM0369  CL100 HEK-293T C339(0.89); C209(0.92)  LDD1573  [34]
 LDCM0370  CL101 HEK-293T C339(1.18); C214(1.06); C209(1.06)  LDD1574  [34]
 LDCM0371  CL102 HEK-293T C339(0.99); C214(0.82); C209(0.82); C515(1.00)  LDD1575  [34]
 LDCM0372  CL103 HEK-293T C339(1.06); C214(0.93); C209(1.06)  LDD1576  [34]
 LDCM0373  CL104 HEK-293T C339(0.97); C209(0.92)  LDD1577  [34]
 LDCM0374  CL105 HEK-293T C339(1.01); C214(1.04); C209(1.05)  LDD1578  [34]
 LDCM0375  CL106 HEK-293T C339(0.92); C214(0.86); C209(0.82); C515(0.96)  LDD1579  [34]
 LDCM0376  CL107 HEK-293T C339(1.14); C214(0.97); C209(0.67)  LDD1580  [34]
 LDCM0377  CL108 HEK-293T C339(0.85); C209(0.86)  LDD1581  [34]
 LDCM0378  CL109 HEK-293T C339(1.12); C214(0.98); C209(0.49)  LDD1582  [34]
 LDCM0379  CL11 HEK-293T C339(0.93); C209(0.86); C327(1.36)  LDD1583  [34]
 LDCM0380  CL110 HEK-293T C339(0.85); C214(0.90); C209(0.77); C515(1.04)  LDD1584  [34]
 LDCM0381  CL111 HEK-293T C339(0.91); C214(1.08); C209(0.52)  LDD1585  [34]
 LDCM0382  CL112 HEK-293T C339(0.88); C209(0.84)  LDD1586  [34]
 LDCM0383  CL113 HEK-293T C339(1.18); C214(1.08); C209(0.89)  LDD1587  [34]
 LDCM0384  CL114 HEK-293T C339(0.85); C214(0.87); C209(0.85); C515(1.05)  LDD1588  [34]
 LDCM0385  CL115 HEK-293T C339(1.01); C214(1.01); C209(0.72)  LDD1589  [34]
 LDCM0386  CL116 HEK-293T C339(1.01); C209(0.90)  LDD1590  [34]
 LDCM0387  CL117 HEK-293T C339(0.97); C214(1.09); C209(0.97)  LDD1591  [34]
 LDCM0388  CL118 HEK-293T C339(1.02); C214(1.04); C209(0.93); C515(0.98)  LDD1592  [34]
 LDCM0389  CL119 HEK-293T C339(1.02); C214(0.99); C209(0.67)  LDD1593  [34]
 LDCM0390  CL12 HEK-293T C339(1.34); C214(1.11)  LDD1594  [34]
 LDCM0391  CL120 HEK-293T C339(0.93); C209(0.89)  LDD1595  [34]
 LDCM0392  CL121 HEK-293T C339(1.36); C214(1.01); C209(0.92)  LDD1596  [34]
 LDCM0393  CL122 HEK-293T C339(0.98); C214(0.93); C209(0.87); C515(1.15)  LDD1597  [34]
 LDCM0394  CL123 HEK-293T C339(1.04); C214(1.03); C209(0.66)  LDD1598  [34]
 LDCM0395  CL124 HEK-293T C339(1.04); C209(0.81)  LDD1599  [34]
 LDCM0396  CL125 HEK-293T C339(1.05); C214(1.14); C209(0.85)  LDD1600  [34]
 LDCM0397  CL126 HEK-293T C339(0.94); C214(0.95); C209(0.82); C515(1.09)  LDD1601  [34]
 LDCM0398  CL127 HEK-293T C339(1.07); C214(0.95); C209(0.73)  LDD1602  [34]
 LDCM0399  CL128 HEK-293T C339(1.07); C209(0.99)  LDD1603  [34]
 LDCM0400  CL13 HEK-293T C339(1.30); C214(1.03); C209(1.33)  LDD1604  [34]
 LDCM0401  CL14 HEK-293T C339(1.01); C214(1.09); C209(0.90); C515(1.24)  LDD1605  [34]
 LDCM0402  CL15 HEK-293T C339(0.87); C214(1.04); C209(0.69)  LDD1606  [34]
 LDCM0403  CL16 HEK-293T C339(1.03); C209(0.93)  LDD1607  [34]
 LDCM0404  CL17 HEK-293T C339(0.91)  LDD1608  [34]
 LDCM0405  CL18 HEK-293T C625(0.96); C339(1.31); C214(1.23); C209(0.92)  LDD1609  [34]
 LDCM0406  CL19 HEK-293T C339(1.17); C214(1.25); C209(0.87)  LDD1610  [34]
 LDCM0407  CL2 HEK-293T C339(1.10); C214(1.07); C209(0.97); C515(1.09)  LDD1611  [34]
 LDCM0408  CL20 HEK-293T C625(1.07); C339(1.12); C214(1.17); C209(0.98)  LDD1612  [34]
 LDCM0409  CL21 HEK-293T C339(1.02); C214(1.37)  LDD1613  [34]
 LDCM0410  CL22 HEK-293T C625(1.22); C339(1.36); C214(1.06)  LDD1614  [34]
 LDCM0411  CL23 HEK-293T C339(1.00); C209(0.89); C327(1.29)  LDD1615  [34]
 LDCM0412  CL24 HEK-293T C339(1.34); C214(1.14)  LDD1616  [34]
 LDCM0413  CL25 HEK-293T C339(1.00); C214(1.08); C209(0.66)  LDD1617  [34]
 LDCM0414  CL26 HEK-293T C339(0.99); C214(0.77); C209(0.83); C515(1.10)  LDD1618  [34]
 LDCM0415  CL27 HEK-293T C339(1.11); C214(1.02); C209(0.81)  LDD1619  [34]
 LDCM0416  CL28 HEK-293T C339(1.03); C209(0.86)  LDD1620  [34]
 LDCM0417  CL29 HEK-293T C339(1.06)  LDD1621  [34]
 LDCM0418  CL3 HEK-293T C339(0.91); C214(0.94); C209(0.76)  LDD1622  [34]
 LDCM0419  CL30 HEK-293T C625(0.91); C339(1.45); C214(0.95); C209(0.82)  LDD1623  [34]
 LDCM0420  CL31 HEK-293T C339(1.16); C214(1.04); C209(0.93)  LDD1624  [34]
 LDCM0421  CL32 HEK-293T C625(0.83); C339(0.96); C214(1.07); C209(0.92)  LDD1625  [34]
 LDCM0422  CL33 HEK-293T C339(0.92); C214(1.07)  LDD1626  [34]
 LDCM0423  CL34 HEK-293T C625(0.90); C339(1.63); C214(1.07)  LDD1627  [34]
 LDCM0424  CL35 HEK-293T C339(1.01); C209(0.74); C327(1.06)  LDD1628  [34]
 LDCM0425  CL36 HEK-293T C339(1.24); C214(1.07)  LDD1629  [34]
 LDCM0426  CL37 HEK-293T C339(1.13); C214(1.19); C209(0.91)  LDD1630  [34]
 LDCM0428  CL39 HEK-293T C339(0.94); C214(1.15); C209(1.15)  LDD1632  [34]
 LDCM0429  CL4 HEK-293T C339(1.14); C209(0.99)  LDD1633  [34]
 LDCM0430  CL40 HEK-293T C339(0.99); C209(0.95)  LDD1634  [34]
 LDCM0431  CL41 HEK-293T C339(0.90)  LDD1635  [34]
 LDCM0432  CL42 HEK-293T C625(0.91); C339(1.42); C214(1.07); C209(0.90)  LDD1636  [34]
 LDCM0433  CL43 HEK-293T C339(1.20); C214(1.04); C209(0.88)  LDD1637  [34]
 LDCM0434  CL44 HEK-293T C625(0.88); C339(1.01); C214(1.19); C209(0.96)  LDD1638  [34]
 LDCM0435  CL45 HEK-293T C339(0.87); C214(0.99)  LDD1639  [34]
 LDCM0436  CL46 HEK-293T C625(1.11); C339(1.37); C214(0.98)  LDD1640  [34]
 LDCM0437  CL47 HEK-293T C339(1.11); C209(0.77); C327(1.26)  LDD1641  [34]
 LDCM0438  CL48 HEK-293T C339(1.29); C214(1.01)  LDD1642  [34]
 LDCM0439  CL49 HEK-293T C339(1.17); C214(1.13); C209(0.82)  LDD1643  [34]
 LDCM0440  CL5 HEK-293T C339(1.08)  LDD1644  [34]
 LDCM0441  CL50 HEK-293T C339(1.04); C214(1.04); C209(0.80); C515(1.10)  LDD1645  [34]
 LDCM0443  CL52 HEK-293T C339(0.90); C209(0.93)  LDD1646  [34]
 LDCM0444  CL53 HEK-293T C339(0.82)  LDD1647  [34]
 LDCM0445  CL54 HEK-293T C625(0.73); C339(1.19); C214(0.84); C209(0.74)  LDD1648  [34]
 LDCM0446  CL55 HEK-293T C339(1.26); C214(1.06); C209(0.85)  LDD1649  [34]
 LDCM0447  CL56 HEK-293T C625(0.87); C339(1.05); C214(1.16); C209(0.83)  LDD1650  [34]
 LDCM0448  CL57 HEK-293T C339(0.97); C214(1.06)  LDD1651  [34]
 LDCM0449  CL58 HEK-293T C625(1.03); C339(1.20); C214(1.02)  LDD1652  [34]
 LDCM0450  CL59 HEK-293T C339(0.87); C209(0.70); C327(1.28)  LDD1653  [34]
 LDCM0451  CL6 HEK-293T C625(0.99); C339(1.23); C214(1.09); C209(0.96)  LDD1654  [34]
 LDCM0452  CL60 HEK-293T C339(1.17); C214(1.11)  LDD1655  [34]
 LDCM0453  CL61 HEK-293T C339(1.16); C214(0.96); C209(0.88)  LDD1656  [34]
 LDCM0454  CL62 HEK-293T C339(1.10); C214(1.07); C209(0.92); C515(0.94)  LDD1657  [34]
 LDCM0455  CL63 HEK-293T C339(1.12); C214(0.98); C209(0.68)  LDD1658  [34]
 LDCM0456  CL64 HEK-293T C339(0.93); C209(0.92)  LDD1659  [34]
 LDCM0457  CL65 HEK-293T C339(0.98)  LDD1660  [34]
 LDCM0458  CL66 HEK-293T C625(0.81); C339(1.35); C214(1.16); C209(0.84)  LDD1661  [34]
 LDCM0459  CL67 HEK-293T C339(1.24); C214(1.10); C209(0.90)  LDD1662  [34]
 LDCM0460  CL68 HEK-293T C625(1.10); C339(1.05); C214(1.19); C209(0.90)  LDD1663  [34]
 LDCM0461  CL69 HEK-293T C339(1.10); C214(1.19)  LDD1664  [34]
 LDCM0462  CL7 HEK-293T C339(1.35); C214(1.06); C209(0.93)  LDD1665  [34]
 LDCM0463  CL70 HEK-293T C625(0.90); C339(1.43); C214(1.06)  LDD1666  [34]
 LDCM0464  CL71 HEK-293T C339(0.86); C209(0.76); C327(1.33)  LDD1667  [34]
 LDCM0465  CL72 HEK-293T C339(1.31); C214(1.12)  LDD1668  [34]
 LDCM0466  CL73 HEK-293T C339(1.05); C214(1.03); C209(1.00)  LDD1669  [34]
 LDCM0467  CL74 HEK-293T C339(1.05); C214(0.98); C209(0.95); C515(1.27)  LDD1670  [34]
 LDCM0469  CL76 HEK-293T C339(1.01); C209(0.96)  LDD1672  [34]
 LDCM0470  CL77 HEK-293T C339(0.80)  LDD1673  [34]
 LDCM0471  CL78 HEK-293T C625(0.72); C339(1.32); C214(1.14); C209(0.86)  LDD1674  [34]
 LDCM0472  CL79 HEK-293T C339(1.28); C214(1.11); C209(0.83)  LDD1675  [34]
 LDCM0473  CL8 HEK-293T C625(0.68); C339(0.67); C214(0.78); C209(0.80)  LDD1676  [34]
 LDCM0474  CL80 HEK-293T C625(1.16); C339(1.16); C214(1.08); C209(0.90)  LDD1677  [34]
 LDCM0475  CL81 HEK-293T C339(1.04); C214(1.16)  LDD1678  [34]
 LDCM0476  CL82 HEK-293T C625(0.97); C339(1.31); C214(0.93)  LDD1679  [34]
 LDCM0477  CL83 HEK-293T C339(0.99); C209(0.83); C327(1.08)  LDD1680  [34]
 LDCM0478  CL84 HEK-293T C339(1.21); C214(1.06)  LDD1681  [34]
 LDCM0479  CL85 HEK-293T C339(1.28); C214(1.17); C209(0.75)  LDD1682  [34]
 LDCM0480  CL86 HEK-293T C339(1.01); C214(0.97); C209(1.04); C515(0.89)  LDD1683  [34]
 LDCM0481  CL87 HEK-293T C339(0.92); C214(0.96); C209(0.74)  LDD1684  [34]
 LDCM0482  CL88 HEK-293T C339(1.02); C209(1.00)  LDD1685  [34]
 LDCM0483  CL89 HEK-293T C339(0.96)  LDD1686  [34]
 LDCM0484  CL9 HEK-293T C339(1.07); C214(1.24)  LDD1687  [34]
 LDCM0485  CL90 HEK-293T C625(0.86); C339(1.03); C214(0.86); C209(0.87)  LDD1688  [34]
 LDCM0486  CL91 HEK-293T C339(1.33); C214(1.00); C209(0.85)  LDD1689  [34]
 LDCM0487  CL92 HEK-293T C625(0.81); C339(0.95); C214(0.97); C209(1.01)  LDD1690  [34]
 LDCM0488  CL93 HEK-293T C339(1.30); C214(1.16)  LDD1691  [34]
 LDCM0489  CL94 HEK-293T C625(1.00); C339(1.31); C214(0.95)  LDD1692  [34]
 LDCM0490  CL95 HEK-293T C339(0.72); C209(0.66); C327(1.07)  LDD1693  [34]
 LDCM0491  CL96 HEK-293T C339(1.08); C214(0.99)  LDD1694  [34]
 LDCM0492  CL97 HEK-293T C339(1.17); C214(0.93); C209(1.06)  LDD1695  [34]
 LDCM0493  CL98 HEK-293T C339(0.97); C214(0.97); C209(0.85); C515(1.06)  LDD1696  [34]
 LDCM0494  CL99 HEK-293T C339(1.02); C214(1.02); C209(0.77)  LDD1697  [34]
 LDCM0495  E2913 HEK-293T C339(1.14); C214(0.92); C209(0.62)  LDD1698  [34]
 LDCM0468  Fragment33 HEK-293T C339(1.00); C214(1.03); C209(0.93)  LDD1671  [34]
 LDCM0427  Fragment51 HEK-293T C339(0.98); C214(0.83); C209(1.08); C515(1.09)  LDD1631  [34]
 LDCM0615  Fragment63-R Jurkat _(14.22)  LDD1487  [10]
 LDCM0617  Fragment63-S Jurkat _(11.37)  LDD1490  [10]
 LDCM0569  Fragment7 Jurkat _(9.69)  LDD1485  [10]
 LDCM0116  HHS-0101 DM93 Y163(0.76); Y161(0.81); Y266(1.02); Y552(1.12)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y163(0.79); Y552(0.79); Y161(0.88); Y555(1.04)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y163(0.66); Y161(0.73); Y552(0.91); Y555(1.25)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y552(0.46); Y163(0.73); Y161(0.77); Y266(1.67)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y552(0.58); Y163(0.81); Y161(0.85); Y555(0.93)  LDD0268  [12]
 LDCM0107  IAA HeLa H288(0.00); H393(0.00); H221(0.00)  LDD0221  [24]
 LDCM0073  Kambe_cp3 PC-3 6.92  LDD0124  [32]
 LDCM0022  KB02 HCT 116 C209(3.57); C214(3.57); C515(4.29); C533(4.29)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C209(5.14); C214(5.14); C515(3.06); C533(3.06)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C209(3.31); C214(3.31); C515(3.02); C533(3.02)  LDD0082  [13]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C571(0.43)  LDD2121  [9]
 LDCM0109  NEM HeLa H221(0.00); H288(0.00); H393(0.00); H589(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C571(0.49)  LDD2089  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C571(1.35)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C571(0.90)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C571(2.94)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C571(0.20); C577(0.03)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C571(0.67)  LDD2097  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C571(0.80)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C571(0.30)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C571(0.77)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C571(0.34)  LDD2104  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C571(0.35)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C571(0.89)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C571(0.44)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C571(0.57)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C571(0.71)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C571(0.47)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C571(0.50)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C571(0.57)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C571(0.66); C577(0.45)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C571(2.49)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C571(0.70)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C571(0.32); C577(0.11)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C571(0.90); C209(1.00)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C571(0.35); C577(0.22)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C571(0.69)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C571(0.31); C577(0.22)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C571(1.06)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C571(0.69)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C571(0.82)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C571(0.67)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C571(0.37)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C571(1.01)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C571(1.00)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C571(0.98); C209(0.94)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C571(1.55)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C571(0.70)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C571(0.45)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C571(0.70)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C571(3.51)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C571(0.18)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C571(0.58)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C571(3.74)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C571(0.43)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C571(0.35)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C571(0.33)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C571(0.51)  LDD2151  [9]
 LDCM0131  RA190 MM1.R C515(1.14); C533(1.14)  LDD0304  [35]
 LDCM0021  THZ1 HCT 116 C647(1.08); C209(0.98); C214(0.98); C515(0.97)  LDD2173  [13]
 LDCM0154  YY4 T cell 3.27  LDD0400  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Estrogen receptor beta (ESR2) Nuclear hormone receptor family Q92731

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Arsenic Trioxide Small molecular drug DB01169
Ascorbic Acid Small molecular drug DB00126
Flavin Adenine Dinucleotide Small molecular drug DB03147
Fotemustine Small molecular drug D0S1ZB
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Spermidine Small molecular drug D08BXT
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-formyl-4-phenyl-1,2,5-oxadiazole 2-oxide Small molecular drug D05ABT
4,6-dinitrobenzo[C][1,2,5]Thiadiazole Small molecular drug D0AA8E
5,8-dihydroxy-1,4-naphthoquinone Small molecular drug D0AS0V
Bis(2,4-dinitrophenyl)Sulfane Small molecular drug D09GTJ
Flavin-adenine Dinucleotide Small molecular drug D00IMW
Motexafin Gadolinium Small molecular drug DB05428
Nadph Small molecular drug DB02338
Px-12 Small molecular drug DB05448
Patented
Click To Hide/Show 57 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-aryl Quinol Derivative 1 Small molecular drug D0L2NG
4-aryl Quinol Derivative 2 Small molecular drug D00TXZ
4-aryl Quinol Derivative 3 Small molecular drug D07PKU
4-aryl Quinol Derivative 4 Small molecular drug D01WCU
4-aryl Quinol Derivative 5 Small molecular drug D0VA1R
4-aryl Quinol Derivative 7 Small molecular drug D04ONQ
Acyl Oxymethyl Acrylamide Ester Derivative 1 Small molecular drug D0Z2MX
Acyl Oxymethyl Acrylamide Ester Derivative 2 Small molecular drug D0J4PE
Benzisoselenazolone Difluorocytidine Derivative 1 Small molecular drug D0KV5Z
Binuclear Gold(I) Compound 1 Small molecular drug D02UTG
Binuclear Gold(I) Compound 2 Small molecular drug D0WK9J
Binuclear Gold(I) Compound 3 Small molecular drug D0F3BO
Bis-sulfonamide Derivative 1 Small molecular drug D0I2HK
Bis-sulfonamide Derivative 2 Small molecular drug D0RK3P
Disulfide Compound 1 Small molecular drug D0XV4L
Disulfide Compound 2 Small molecular drug D0RC5J
Golden Phosphorous Acetyletic Compound 1 Small molecular drug D0W1DK
Golden Phosphorous Acetyletic Compound 2 Small molecular drug D02NYT
Golden Phosphorous Acetyletic Compound 3 Small molecular drug D0RR2D
Metal Complex Derivative 1 Small molecular drug D08VQU
Metal Complex Derivative 2 Small molecular drug D0VK1L
Metal Complex Derivative 3 Small molecular drug D07CDS
Palmarumycin Derivative 1 Small molecular drug D0HH1K
Palmarumycin Derivative 2 Small molecular drug D0SC3B
Palmarumycin Derivative 3 Small molecular drug D0ZZ6N
Palmarumycin Derivative 4 Small molecular drug D02ODA
Pmid27977313-compound-17 Small molecular drug D03CQQ
Pmid27977313-compound-18 Small molecular drug D00CLK
Pmid27977313-compound-19 Small molecular drug D0LB6Q
Pmid27977313-compound-27 Small molecular drug D08BVX
Pmid27977313-compound-28 Small molecular drug D0QA9N
Pmid27977313-compound-29 Small molecular drug D0PT8T
Pmid27977313-compound-30 Small molecular drug D0S3QX
Pmid27977313-compound-31 Small molecular drug D01XRW
Pmid27977313-compound-32 Small molecular drug D05HHG
Pmid27977313-compound-39 Small molecular drug D0Q6PR
Pmid27977313-compound-42 Small molecular drug D0L2LF
Pmid27977313-compound-43 Small molecular drug D0V1XY
Pmid27977313-compound-44 Small molecular drug D0K2GG
Pmid27977313-compound-45 Small molecular drug D0D1LI
Pmid27977313-compound-46 Small molecular drug D01BXV
Pmid27977313-compound-47 Small molecular drug D0KM8V
Pmid27977313-compound-48 Small molecular drug D01PYM
Pmid27977313-compound-5 Small molecular drug D0CV1Q
Pmid27977313-compound-6 Small molecular drug D0S2AY
Pmid27977313-compound-7 Small molecular drug D0G9QO
Pmid27977313-compound-8 Small molecular drug D09ACU
Pmid27977313-compound-figure4b Small molecular drug D0NM0B
Pmid27977313-compound-figure6c Small molecular drug D0NU8U
Terpyridineplatinum(Ii) Complexe 1 Small molecular drug D0K8NP
Terpyridineplatinum(Ii) Complexe 2 Small molecular drug D0RE1D
Terpyridineplatinum(Ii) Complexe 3 Small molecular drug D03BPZ
Terpyridineplatinum(Ii) Complexe 4 Small molecular drug D05SHW
Terpyridineplatinum(Ii) Complexe 5 Small molecular drug D0E0EF
Triazole Gold Complexe 1 Small molecular drug D00LBC
Triazole Gold Complexe 2 Small molecular drug D01IPU
Triazole Gold Complexe 3 Small molecular drug D0NX8E

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
28 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
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Mass spectrometry data entry: PXD044402
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.