Details of the Target

General Information of Target

Target ID LDTP13112
Target Name Phosphatidylinositol 4-kinase beta (PI4KB)
Gene Name PI4KB
Gene ID 5298
Synonyms
PIK4CB; Phosphatidylinositol 4-kinase beta; PI4K-beta; PI4Kbeta; PtdIns 4-kinase beta; EC 2.7.1.67; NPIK; PI4K92; PI4KIII
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADVEDGEETCALASHSGSSGSKSGGDKMFSLKKWNAVAMWSWDVECDTCAICRVQVMDA
CLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family, Type III PI4K subfamily
Subcellular location
Endomembrane system
Function
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. May play an important role in the inner ear development.; (Microbial infection) Plays an essential role in Aichi virus RNA replication. Recruited by ACBD3 at the viral replication sites.; (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
TTD ID
T12541
Uniprot ID
Q9UBF8
DrugMap ID
TTNPL3B
Ensemble ID
ENST00000368872.5
HGNC ID
HGNC:8984
ChEMBL ID
CHEMBL3268

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.S307C .
HCT15 SNV: p.L332M DBIA    Probe Info 
JURKAT SNV: p.D44N; p.S478N .
NCIH1793 SNV: p.R523L DBIA    Probe Info 
OVK18 SNV: p.R651H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Johansson_61
 Probe Info  		_(10.42)  LDD1488  [2]
DA-P3
 Probe Info  		5.53  LDD0181  [3]
AHL-Pu-1
 Probe Info  		C89(2.13); C435(2.02)  LDD0169  [4]
DBIA
 Probe Info  		C435(1.95)  LDD0080  [5]
ATP probe
 Probe Info  		K392(0.00); K394(0.00); K345(0.00); K348(0.00)  LDD0199  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		C52(0.00); C435(0.00)  LDD2226  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [10]
IPM
 Probe Info  		N.A.  LDD0005  [9]
VSF
 Probe Info  		C435(0.00); C52(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C52(0.00); C435(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C220
 Probe Info  		11.47  LDD1894  [14]
C351
 Probe Info  		7.94  LDD2012  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		17.27  LDD0477  [15]
OEA-DA
 Probe Info  		20.00  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C89(2.13); C435(2.02)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C435(1.02); C89(0.94); C52(1.10); C406(1.03)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C435(1.07); C89(0.97); C52(0.99); C406(1.15)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C435(1.10); C89(1.01); C52(0.93); C406(0.73)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C435(1.09); C89(1.08); C52(0.99); C406(0.98)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C435(0.91); C89(1.09); C52(1.01); C406(1.33)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C435(1.02); C89(1.13); C52(1.01); C406(1.43)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C435(1.02); C89(0.95); C52(0.99); C406(0.92)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C435(1.02); C89(0.91); C52(1.02); C406(1.10)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C435(1.23); C89(1.22); C52(1.13); C406(0.64)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C435(0.95); C89(0.91); C52(0.97); C406(1.30)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C435(0.97); C89(1.01); C52(1.01); C406(1.18)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C435(0.93); C89(1.24); C52(1.00); C565(1.00)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C435(0.94); C89(0.94); C52(1.02); C406(1.27)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C435(0.93); C89(1.03); C52(1.03); C406(0.92)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C435(1.04); C89(1.01); C52(1.03); C406(1.10)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C435(1.04); C89(0.94); C52(1.02); C406(1.06)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C435(1.06); C89(1.00); C52(1.06); C406(1.39)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C435(1.03); C89(1.02); C52(1.02); C406(0.90)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C435(1.03); C89(1.04); C52(1.00); C406(0.90)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C435(0.99); C89(1.25); C52(1.02); C565(0.97)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C435(1.18); C89(0.88); C52(1.00); C406(0.88)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C435(0.90); C89(1.01); C52(0.98); C406(1.35)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C435(0.99); C89(1.08); C52(0.98); C406(1.10)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C435(1.02); C89(0.97); C52(1.04); C406(0.99)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C435(1.03); C89(1.02); C52(1.06); C406(0.95)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C435(1.09); C89(1.05); C52(0.97); C406(1.19)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C435(1.03); C89(1.08); C52(0.92); C406(0.76)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C435(1.03); C89(0.98); C52(0.96); C406(0.95)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C435(0.94); C89(1.06); C52(0.98); C565(1.14)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C435(0.88); C89(1.10); C52(1.02); C406(0.95)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C435(1.00); C89(1.06); C52(0.93); C406(0.97)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C435(1.09); C89(0.98); C52(1.02); C406(0.99)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C435(0.91); C89(1.01); C52(1.14); C406(0.99)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C435(1.02); C89(0.97); C52(1.06); C406(0.97)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C435(1.10); C89(1.11); C52(1.02); C406(1.16)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C435(1.08); C89(1.04); C52(0.96); C406(0.82)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C435(1.07); C89(1.06); C52(1.04); C406(1.18)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C435(0.98); C89(0.83); C52(1.07); C565(1.06)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C435(1.01); C89(1.04); C52(1.04); C406(1.14)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C435(0.98); C89(1.08); C52(0.93); C406(1.30)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C435(1.01); C89(0.99); C52(1.14); C406(0.97)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C435(1.07); C89(1.01); C52(0.98); C406(0.93)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C435(0.96); C89(0.66); C52(1.01); C565(1.09)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C435(1.01); C89(1.00); C52(0.98); C406(1.33)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C435(1.05); C89(1.05); C52(0.97); C406(0.80)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C435(1.10); C89(1.07); C52(0.97); C406(0.92)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C435(0.93); C89(0.72); C52(1.00); C565(1.04)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C435(0.92); C89(1.02); C52(1.03); C406(1.43)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C435(0.97); C89(1.03); C52(1.00); C406(0.87)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C435(0.95); C89(0.97); C52(1.04); C406(0.98)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C435(1.05); C89(1.00); C52(1.11); C406(1.01)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C435(1.05); C89(1.01); C52(0.98); C406(1.02)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C435(1.01); C89(0.88); C52(0.94); C406(0.79)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C435(0.95); C89(0.94); C52(1.06); C406(0.93)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C435(1.02); C89(0.98); C52(0.96); C406(1.02)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C435(0.94); C89(0.72); C52(1.04); C565(1.23)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C435(0.92); C89(0.95); C52(1.01); C406(1.25)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C435(1.04); C89(1.00); C52(0.95); C406(1.14)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C435(0.96); C89(0.89); C52(1.09); C406(1.08)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C435(1.00); C89(1.08); C52(1.03); C406(0.83)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C435(0.96); C89(0.98); C52(1.09); C406(1.04)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C435(0.94); C89(0.94); C52(1.04); C565(0.99)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C435(1.02); C89(0.94); C52(1.08); C406(0.95)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C435(0.98); C89(1.04); C52(1.07); C406(0.92)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C52(1.15)  LDD2171  [5]
 LDCM0632  CL-Sc Hep-G2 C52(20.00); C762(6.52); C435(1.65)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C435(1.07); C89(0.96); C52(0.91)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C435(1.03); C89(1.19); C52(0.99); C406(1.09)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C435(0.86); C89(0.96); C52(1.04); C661(1.20)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C435(0.97); C89(0.99); C52(0.97)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C435(0.94); C89(0.96); C52(0.94)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C435(1.03); C89(1.05); C52(1.01); C406(1.10)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C435(0.93); C89(1.03); C52(1.01); C661(1.22)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C435(1.03); C89(0.96); C52(0.95)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C435(0.85); C89(1.07); C52(0.97)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C435(1.00); C89(1.02); C52(0.94); C406(0.90)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C435(0.89); C89(1.02); C52(1.01); C661(1.18)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C435(0.98); C89(0.98); C52(0.96)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C435(1.10); C89(1.40); C52(1.03); C406(1.09)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C435(0.90); C89(0.94); C52(1.04)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C435(1.02); C89(0.98); C52(0.97); C406(1.10)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C435(0.84); C89(1.02); C52(1.04); C661(1.17)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C435(0.98); C89(1.18); C52(0.99)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C435(0.95); C89(0.98); C52(0.97)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C435(0.95); C89(1.04); C52(0.97); C406(1.20)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C435(0.90); C89(0.98); C52(1.04); C661(1.06)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C435(1.02); C89(0.90); C52(0.96)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C435(0.98); C89(1.05); C52(0.96)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C435(1.03); C89(1.04); C52(0.98); C406(1.14)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C435(1.01); C89(1.20); C52(1.15); C406(1.06)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C435(0.84); C89(1.07); C52(1.05); C661(1.09)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C435(1.04); C89(0.99); C52(0.97)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C435(0.90); C89(1.09); C52(0.99)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C435(1.14); C89(0.97); C52(0.88); C406(0.86)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C435(0.86); C89(0.96); C52(0.99); C661(1.59)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C435(1.08); C89(0.72); C52(0.98)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C435(0.89); C89(0.99); C52(1.01)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C435(1.05); C89(0.94); C52(1.05); C406(1.01)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C435(0.83); C89(0.89); C52(1.05); C661(1.11)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C435(1.11); C89(0.99); C52(1.04)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C435(0.99); C89(1.07); C52(0.99)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C435(1.08); C89(1.06); C52(0.91); C406(0.83)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C435(0.89); C89(1.15); C52(1.04); C661(1.32)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C435(1.13); C89(1.06); C52(1.05); C406(0.94)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C435(1.10); C89(1.29); C52(0.92); C406(1.29)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C435(1.18); C89(1.12); C52(0.94); C406(0.81)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C435(1.05); C89(1.06); C52(1.03)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C435(1.21); C89(1.31); C52(0.95); C406(0.95)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C435(1.24); C89(1.67); C52(1.04); C565(0.77)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C435(0.99); C89(1.31); C52(1.05); C406(1.16)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C435(1.20); C89(1.48); C52(0.99); C406(0.98)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C435(1.00); C89(1.25); C52(1.08); C406(1.02)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C435(0.95); C89(0.84); C52(0.91)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C435(0.94); C89(1.05); C52(0.93)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C435(1.01); C89(0.99); C52(0.95); C406(1.04)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C435(0.91); C89(1.08); C52(1.00); C661(1.09)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C435(1.05); C89(1.01); C52(0.99); C406(1.01)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C435(1.19); C89(1.06); C52(0.91); C406(0.86)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C435(1.11); C89(1.08); C52(0.96); C406(1.02)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C435(1.04); C89(1.31); C52(1.01); C406(0.79)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C435(1.11); C89(1.37); C52(1.00); C406(0.99)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C435(1.17); C89(1.35); C52(1.07); C565(0.75)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C435(0.95); C89(1.29); C52(1.01); C406(1.30)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C435(1.19); C89(1.56); C52(0.97); C406(1.43)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C435(0.99); C89(1.15); C52(1.10); C406(1.01)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C435(1.04); C89(0.80); C52(0.94)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C435(1.13); C89(1.06); C52(0.89); C406(1.33)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C435(0.94); C89(1.01); C52(0.96); C661(0.99)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C435(0.99); C89(1.12); C52(1.04); C661(1.11)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C435(1.15); C89(1.00); C52(0.99); C406(0.92)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C435(1.08); C89(0.97); C52(0.97); C406(1.16)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C435(1.03); C89(1.23); C52(1.01); C406(0.83)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C435(1.27); C89(1.24); C52(1.04); C406(1.03)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C435(1.10); C89(1.52); C52(1.02); C565(0.73)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C435(1.00); C89(1.26); C52(1.00); C406(1.04)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C435(1.03); C89(1.54); C52(1.02); C406(1.07)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C435(1.28); C89(1.07); C52(1.11); C406(0.96)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C435(0.98); C89(0.78); C52(0.95)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C435(1.12); C89(0.96); C52(1.03); C406(1.02)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C435(1.02); C89(0.97); C52(0.96)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C435(0.98); C89(1.08); C52(1.04); C661(1.15)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C435(0.99); C89(1.04); C52(1.12); C406(0.91)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C435(1.00); C89(1.09); C52(0.92); C406(0.86)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C435(1.07); C89(1.32); C52(0.96); C406(0.74)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C435(1.18); C89(1.22); C52(0.91); C406(0.85)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C435(1.22); C89(1.58); C52(1.08); C565(0.88)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C435(1.00); C89(1.28); C52(1.09); C406(1.33)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C435(1.13); C89(1.48); C52(1.00); C406(1.50)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C435(1.18); C89(1.13); C52(0.93); C406(1.37)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C435(0.97); C89(1.10); C52(1.16); C406(1.00)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C435(0.92); C89(0.75); C52(0.95)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C435(0.95); C89(0.99); C52(1.02)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C435(1.00); C89(1.04); C52(0.93); C406(1.14)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C435(0.86); C89(1.02); C52(1.00); C661(0.97)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C435(1.04); C89(1.04); C52(1.06); C406(0.96)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C435(1.17); C89(1.15); C52(0.99); C406(1.23)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C435(1.02); C89(1.17); C52(0.96); C406(0.77)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C435(1.12); C89(1.25); C52(0.97); C406(1.00)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C435(1.02); C89(1.19); C52(1.05); C565(0.91)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C435(1.18); C89(1.20); C52(0.89); C406(0.67)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C435(1.05); C89(1.31); C52(1.11); C406(1.35)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C435(1.15); C89(1.40); C52(1.02); C406(1.00)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C435(1.05); C89(1.21); C52(1.12); C406(1.19)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C435(0.97); C89(0.72); C52(0.95)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C435(0.94); C89(1.00); C52(1.03)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C435(0.90); C89(1.09); C52(1.01); C661(1.10)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C435(1.05); C89(0.97); C52(1.02); C406(0.88)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C435(1.15); C89(1.04); C52(0.97); C406(1.21)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C435(1.01); C89(1.09); C52(0.95); C406(0.73)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C435(1.40); C89(0.98); C52(0.98); C406(0.85)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C435(1.17); C89(1.20); C52(1.00); C406(1.05)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C435(0.98); C89(1.31); C52(1.02); C565(0.91)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C435(1.04); C89(1.23); C52(1.08); C406(1.44)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C435(1.11); C89(1.29); C52(0.96); C406(1.11)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C435(0.91); C89(1.08); C52(1.08); C406(0.97)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C435(0.95); C89(0.72); C52(0.88)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C435(0.88); C89(0.88); C52(0.96)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C435(0.96); C89(0.82); C52(0.96); C406(1.20)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C435(0.95); C89(0.82); C52(1.04); C661(1.16)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C435(1.10); C89(0.92); C52(1.08); C406(1.16)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C435(1.09); C89(1.43); C52(1.08); C565(0.88)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C435(1.07); C89(0.93); C52(0.92); C406(1.15)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C435(1.19); C89(0.98); C52(0.92); C406(0.78)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C435(1.12); C89(1.08); C52(0.93); C406(1.10)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C435(1.06); C89(1.42); C52(1.03); C565(0.87)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C435(1.00); C89(1.15); C52(1.11); C406(0.97)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C435(1.10); C89(1.34); C52(0.99); C406(0.92)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C435(0.97); C89(0.89); C52(1.16); C406(1.01)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C435(1.02); C89(0.94); C52(1.01)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C435(0.88); C89(0.93); C52(1.01)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C435(1.02); C89(0.94); C52(0.91); C406(1.02)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C435(0.98); C89(0.95); C52(0.91); C406(1.12)  LDD1698  [17]
 LDCM0573  Fragment11 Ramos C52(3.59)  LDD2190  [18]
 LDCM0468  Fragment33 HEK-293T C435(1.04); C89(0.96); C52(0.93); C406(1.08)  LDD1671  [17]
 LDCM0566  Fragment4 Ramos C52(0.17)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C435(0.95); C89(1.01); C52(1.05)  LDD1631  [17]
 LDCM0615  Fragment63-R Jurkat _(10.42)  LDD1488  [2]
 LDCM0022  KB02 HCT 116 C435(1.95)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C435(1.45)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C435(1.61)  LDD0082  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C52(0.20)  LDD2206  [19]
 LDCM0032  Oleacein HEK-293T 11.57  LDD0184  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C52(0.72)  LDD2207  [19]
 LDCM0029  Quercetin HEK-293T 5.53  LDD0181  [3]
 LDCM0021  THZ1 HCT 116 C52(1.15)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-11A (RAB11A) Rab family P62491
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi resident protein GCP60 (ACBD3) . Q9H3P7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pik-93 Small molecular drug D0S5YV

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.