Details of the Target

General Information of Target

Target ID LDTP12215
Target Name rRNA methyltransferase 3, mitochondrial (MRM3)
Gene Name MRM3
Gene ID 55178
Synonyms
RNMTL1; rRNA methyltransferase 3, mitochondrial; EC 2.1.1.-; 16S rRNA; guanosine(1370)-2'-O)-methyltransferase; 16S rRNA [Gm1370] 2'-O-methyltransferase; RNA methyltransferase-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE
KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFI
PSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEER
TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLG
TFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT
DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML
IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL
NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT
HPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVL
DAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGH
SSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVF
GVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNV
SFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTP
PPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNE
ISKEQAKATLLEDQQDPSPSS
Target Bioclass
Enzyme
Family
Class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase TrmH family
Subcellular location
Mitochondrion
Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Uniprot ID
Q9HC36
Ensemble ID
ENST00000304478.9
HGNC ID
HGNC:18485

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.71  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K122(2.96)  LDD0277  [3]
BTD
 Probe Info  		C235(1.21)  LDD1700  [4]
Johansson_61
 Probe Info  		_(20.00)  LDD1488  [5]
AHL-Pu-1
 Probe Info  		C309(5.61)  LDD0171  [6]
DBIA
 Probe Info  		C309(1.18); C290(0.90)  LDD0078  [7]
W1
 Probe Info  		C309(0.68)  LDD0239  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C309(0.00); C235(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C235(0.00); C244(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C309(0.00); C214(0.00); C235(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0025  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
Phosphinate-6
 Probe Info  		C309(0.00); C290(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C309(0.00); C235(0.00)  LDD0218  [17]
AOyne
 Probe Info  		9.30  LDD0443  [18]
NAIA_5
 Probe Info  		C244(0.00); C235(0.00); C214(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C264
 Probe Info  		17.88  LDD1935  [20]
C265
 Probe Info  		14.03  LDD1936  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C235(0.42)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C235(0.66)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C235(1.27)  LDD2152  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C309(5.61)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C235(1.19); C290(1.06); C309(1.10)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C235(0.96); C244(1.31); C290(1.15); C309(0.73)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C235(0.91); C290(1.02); C309(0.97)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C235(0.81); C290(1.02); C309(1.20)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C235(1.08); C290(1.05); C309(1.14)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C235(0.91); C290(1.27); C309(1.45)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C235(1.03); C290(1.09); C309(1.70)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C235(1.02); C290(1.14); C309(1.26)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C235(1.04); C290(1.27); C309(1.32)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C235(1.03); C290(1.27); C309(1.30)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C235(0.94); C290(0.91); C309(0.74)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C235(1.26); C290(0.85); C309(0.92)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C235(0.74); C244(1.58); C290(1.29); C309(0.44)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C235(0.95); C290(0.93); C309(1.38)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C235(0.94); C290(1.03); C309(1.14)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C235(0.95); C290(1.08); C309(1.32)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C235(1.01); C244(0.98); C290(1.18); C309(1.06)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C235(0.91); C244(1.23); C290(1.25); C309(0.92)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C235(0.90); C244(0.89); C290(1.64); C309(0.97)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C235(0.95); C244(1.02); C290(1.60); C309(1.03)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C235(0.94); C244(0.90); C290(1.23); C309(0.99)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C235(1.10); C244(1.09); C290(1.23); C309(0.98)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C235(0.95); C244(1.25); C290(1.26); C309(1.12)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C235(1.14); C244(1.26); C290(1.26); C309(1.04)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C235(1.10); C244(1.17); C290(1.31); C309(1.06)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C235(1.17); C244(0.97); C290(1.17); C309(0.95)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C235(1.07); C244(1.16); C290(1.14); C309(0.81)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C235(0.96); C244(0.81); C290(1.34); C309(0.88)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C235(1.01); C244(1.35); C290(1.07); C309(0.75)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C235(1.16); C244(1.25); C290(1.30); C309(0.89)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C235(1.28); C244(1.21); C290(1.58); C309(0.80)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C235(1.13); C244(1.16); C290(1.33); C309(0.78)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C235(1.19); C244(1.08); C290(1.18)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C235(1.06); C244(1.07); C290(0.93)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C235(1.06); C244(1.13); C290(1.10)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C235(0.92); C244(1.05); C290(0.99)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C235(1.05); C244(0.98); C290(1.02)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C235(1.08); C244(1.10); C290(1.08)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C235(0.84); C244(0.96); C290(1.09)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C235(0.80); C244(1.07); C290(1.13)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C235(0.95); C244(0.90); C290(0.99)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C235(0.98); C244(0.93); C290(1.09)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C235(0.73); C244(0.74); C290(1.11)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C235(0.74); C244(0.84); C290(1.17)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C235(0.90); C244(1.38); C290(0.97); C309(0.84)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C235(0.78); C244(0.80); C290(1.15)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C235(0.70); C244(0.84); C290(1.10)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C235(0.83); C244(0.85); C290(1.02)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C235(0.77); C309(1.14); C290(1.20)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C235(0.91); C290(1.28); C309(1.62)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C235(1.04); C309(1.19); C290(1.20)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C235(0.98); C290(1.63); C309(1.63)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C235(0.89); C309(1.76); C290(1.83)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C235(0.84); C290(1.97); C309(3.14)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C235(0.71); C290(1.63); C309(1.87)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C309(0.89); C290(1.11); C244(1.12); C235(1.16)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C235(0.75); C309(1.40); C290(3.48)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C235(0.75); C309(1.28); C290(1.62)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C235(0.62); C309(1.79); C290(1.91)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C235(0.82); C290(2.51); C309(2.55)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C235(0.93); C290(1.40); C309(1.61)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C235(0.82); C290(3.28); C309(1.43)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C235(0.75); C290(2.57); C309(1.05)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C235(0.83); C290(1.18); C309(1.03)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C235(1.02); C290(1.07); C309(1.10); C244(1.51)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C244(0.52); C235(1.13); C290(1.33); C309(1.41)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C244(0.93); C309(0.97); C290(1.09); C235(1.28)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C235(1.07); C309(1.07); C290(1.09)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C290(1.07); C235(1.09); C309(1.11); C244(1.60)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C235(1.07); C244(1.08); C290(1.15); C309(1.15)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C309(0.74); C290(0.99); C235(1.07); C244(1.18)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C290(1.05); C309(1.09); C235(1.12); C244(1.23)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C309(0.86); C290(0.99); C244(1.17); C235(1.17)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C309(0.90); C290(0.90); C235(0.93)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C235(0.82); C290(1.08); C309(1.32)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C235(0.76); C290(0.93); C309(1.31)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C235(0.63); C290(0.94); C309(1.31)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C235(0.60); C290(1.29); C309(1.38)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C290(1.07); C309(1.07); C235(1.37)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C235(0.49); C309(1.29); C290(1.29)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C235(0.53); C290(1.00); C309(1.34)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C235(0.51); C290(1.17); C309(1.52)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C235(0.64); C290(0.95); C309(1.48)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C235(0.71); C290(1.12); C309(1.76)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C309(0.78); C290(1.03); C235(1.24)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C309(0.75); C235(0.92); C290(1.07)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C309(0.74); C290(0.98); C235(1.14)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C235(0.90); C309(0.91); C290(1.20)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C309(1.00); C290(1.07); C235(1.31)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C309(0.90); C290(1.17); C235(1.25)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C235(1.04); C290(1.16); C309(1.19)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C309(0.81); C235(0.83); C290(1.13)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C309(0.82); C235(0.89); C290(1.25)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C235(0.79); C309(0.81); C290(1.20)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C309(0.83); C290(1.12); C235(1.19)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C235(0.94); C309(1.12); C290(1.20)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C235(0.60); C290(1.03); C309(1.03); C244(1.10)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C235(0.79); C309(0.86); C290(0.98); C244(1.06)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C235(0.75); C290(0.95); C244(1.08); C309(1.10)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C235(0.66); C244(0.66); C290(1.29); C309(1.42)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C309(1.07); C290(1.17); C235(1.49)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C244(0.68); C235(0.73); C290(1.15); C309(1.29)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C309(0.78); C235(0.80); C290(0.89); C244(1.34)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C235(0.81); C290(0.93); C244(1.03); C309(1.04)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C244(0.80); C309(1.03); C290(1.11); C235(1.38)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C244(0.77); C235(0.78); C290(1.12); C309(1.27)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C244(0.67); C309(0.98); C290(1.21); C235(2.01)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C244(0.51); C235(0.83); C290(1.46); C309(1.69)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C235(1.09); C244(1.15); C290(1.24); C309(1.50)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C244(1.11); C235(1.13); C290(1.40); C309(1.66)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C244(0.85); C235(1.32); C309(1.32); C290(1.36)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C235(0.78); C244(1.00); C290(1.09); C309(1.12)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C244(0.91); C235(1.08); C309(1.23); C290(1.28)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C244(1.06); C235(1.06); C290(1.18); C309(1.24)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C244(0.80); C309(1.21); C290(1.26); C235(1.31)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C244(0.99); C290(1.23); C309(1.42); C235(1.61)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C235(0.95); C244(1.09); C290(1.51); C309(1.67)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C235(0.83); C244(0.93); C309(1.45); C290(1.51)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C235(1.00); C244(1.05); C309(1.24); C290(1.43)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C235(0.81); C244(0.87); C309(1.61); C290(1.79)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C290(1.16); C309(1.23)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C309(0.85); C290(1.36)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C235(0.79); C290(0.97); C309(1.12); C244(1.20)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C290(1.13); C309(1.59)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C309(1.01); C290(1.08)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C290(1.19); C309(1.64)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C309(1.42); C290(1.91)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C290(1.68); C309(1.80)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C309(1.52); C290(2.06)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C309(1.26); C290(1.33)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C290(1.18); C309(1.29)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C290(1.09); C309(1.61)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C309(1.20); C290(1.27)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C235(0.81); C244(0.93); C309(1.20); C290(1.24)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C309(1.06); C290(1.24)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C290(0.99); C309(1.47)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C309(1.41); C290(2.09)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C235(0.85); C290(1.34); C309(1.35)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C235(0.72); C290(1.23); C309(1.65)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C235(0.63); C290(1.17); C309(1.49)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C235(0.65); C290(1.11); C309(1.27)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C290(0.97); C235(1.02); C309(1.08)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C235(1.02); C290(1.03); C309(1.07)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C235(0.75); C290(1.04); C309(1.27)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C235(0.77); C309(0.83); C290(0.95)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C235(0.85); C290(1.21); C309(1.34)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C235(0.83); C290(1.17); C309(1.54)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C235(0.81); C290(1.05); C309(1.47)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C235(0.90); C290(1.12); C309(1.40)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C290(1.00); C309(1.09); C235(1.22)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C235(0.80); C309(1.02); C290(1.06)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C235(0.67); C290(1.25); C309(1.51)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C235(0.92); C290(1.53); C309(1.92)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C235(0.91); C290(1.02); C309(1.06)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C235(1.09)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C235(1.00); C244(1.37); C290(0.93); C309(0.64)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C235(0.73); C309(0.79); C290(0.98); C244(1.01)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C244(0.93); C235(1.10); C309(1.21); C290(1.58)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C309(1.18); C290(0.90)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C309(0.53)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C235(0.92); C290(0.93); C309(1.07); C244(1.42)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C244(0.62); C235(0.70); C309(1.21); C290(1.35)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C309(0.76); C235(1.06); C290(1.17)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C235(0.91); C309(0.99); C244(1.06); C290(1.47)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C244(0.97); C290(1.01); C235(1.04); C309(1.35)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C309(0.76); C235(0.91); C290(0.92); C244(1.39)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C235(0.91); C309(0.92); C290(0.96); C244(0.98)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C244(0.90); C235(1.03); C290(1.15); C309(1.30)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C244(0.38); C235(1.16); C290(1.58); C309(1.67)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C244(0.84); C235(1.03); C290(1.35); C309(1.70)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C244(0.63); C235(1.10); C309(1.38); C290(1.41)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C244(0.81); C235(1.09); C290(1.15); C309(1.16)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C244(0.59); C235(0.83); C290(1.30); C309(1.50)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C244(0.71); C235(1.13); C290(1.25); C309(1.26)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C244(0.83); C235(0.91); C309(1.16); C290(1.22)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C235(0.87); C290(0.94); C309(1.02)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C235(0.52); C290(1.10); C309(1.22)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C235(0.50); C290(1.32); C309(1.33)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C235(0.62); C290(1.16); C309(1.24)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C235(0.69); C290(1.10); C309(1.44)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C235(0.99); C290(1.16); C309(1.58)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C235(0.90); C309(0.92); C290(1.13)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C309(0.91); C235(0.94); C290(1.09)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C244(0.74); C235(0.80); C309(0.88); C290(1.22)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C309(0.65); C235(0.81); C290(1.20)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C244(0.82); C235(0.85); C309(0.89); C290(0.91)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C235(0.80); C244(0.85); C290(1.12); C309(1.16)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C244(0.77); C235(0.95); C290(1.43); C309(1.55)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C235(0.74); C244(0.83); C290(1.36); C309(1.43)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C309(0.89); C235(0.95); C290(1.02); C244(1.15)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C309(0.89); C244(0.92); C235(1.00); C290(1.07)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C244(0.83); C309(0.96); C235(1.03); C290(1.07)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C235(0.95); C309(1.16); C244(1.18); C290(1.24)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C244(0.81); C309(0.93); C235(1.01); C290(1.19)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C235(0.75); C309(0.89); C290(1.08); C244(1.35)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C309(0.81); C244(0.85); C235(1.04); C290(1.16)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C235(0.79); C244(0.92); C290(1.04)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C235(0.74); C244(0.91); C290(1.06); C309(1.54)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C244(0.73); C235(0.79); C309(0.91); C290(1.07)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C244(0.75); C309(0.81); C235(1.13); C290(1.16)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C309(0.79); C235(0.81); C290(0.91); C244(2.05)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C235(0.75); C244(0.83); C290(1.18); C309(1.49)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C244(0.66); C235(0.76); C309(1.37); C290(1.40)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C244(0.56); C235(0.73); C309(1.06); C290(1.99)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C244(0.79); C235(0.92); C309(1.07); C290(1.09)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C235(0.78); C244(0.67); C290(1.31); C309(0.93)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C235(0.68); C244(0.69); C290(1.22); C309(1.05)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C235(0.78); C244(0.79); C290(1.01); C309(0.94)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C235(1.01); C244(0.94); C290(1.06); C309(1.08)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C235(0.56); C244(0.71); C290(1.18); C309(0.80)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C235(0.82); C244(0.84); C290(1.21); C309(0.92)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C235(0.79); C244(1.33); C290(0.85); C309(1.14)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C235(0.67); C244(0.96); C290(0.92); C309(1.09)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C235(0.98); C244(0.94); C290(1.20); C309(1.12)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C235(1.49); C244(0.55); C290(1.24); C309(0.94)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C235(1.08); C244(0.57); C290(1.55); C309(1.42)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C235(0.76); C244(0.47); C290(1.67); C309(1.30)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C235(1.12); C244(0.57); C290(1.39); C309(1.39)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C235(1.09); C244(0.60); C290(1.33); C309(1.24)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C235(1.34); C244(0.53); C290(1.59); C309(1.28)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C235(1.25); C244(0.60); C290(1.60); C309(1.69)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C235(0.95); C244(1.09); C290(1.12); C309(2.88)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C235(1.27); C244(0.58); C290(1.58); C309(1.32)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C235(1.11); C244(0.58); C290(1.37); C309(1.18)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C235(1.14); C244(0.32); C290(2.26); C309(1.81)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C235(1.28); C244(0.36); C290(1.55); C309(1.39)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C235(1.36); C244(0.43); C290(1.58); C309(1.21)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C235(1.08); C244(0.35); C290(1.58); C309(1.38)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C235(1.18); C290(0.98); C309(0.64)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C235(1.06); C290(0.96); C309(0.73)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C235(0.93); C290(0.79); C309(0.70)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C235(0.94); C290(0.95); C309(0.58)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C235(0.89); C244(1.10); C290(0.94); C309(0.71)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C235(1.09); C290(0.85); C309(0.85)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C235(1.15); C290(0.92); C309(0.64)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C235(0.93); C290(1.04); C309(0.74)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C235(0.99); C290(1.00); C309(1.73)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C235(1.05); C290(0.83); C309(0.91)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C235(0.95); C290(0.84); C309(0.88)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C235(1.08); C290(1.02); C309(0.91)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C235(1.08); C290(1.01); C309(0.95)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C235(1.03); C290(0.88); C309(0.61)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C235(1.09); C290(0.98); C309(0.71)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C235(0.76); C244(0.81); C290(1.06); C309(0.51)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C235(1.04); C290(0.88); C309(0.53)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C235(0.97); C244(1.68); C290(1.09); C309(0.85)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C235(0.84); C244(1.10); C290(1.07); C309(0.67)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C235(0.83); C244(0.96); C290(1.12); C309(1.27)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C235(0.85); C244(0.84); C290(1.29); C309(0.86)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C235(0.87); C244(1.23); C290(1.08); C309(1.00)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C235(0.89); C244(0.57); C290(1.47); C309(0.79)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C235(1.02); C244(0.73); C290(1.33); C309(0.93)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C235(1.09); C244(0.66); C290(1.20); C309(1.64)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C235(0.68); C244(0.72); C290(1.22); C309(1.11)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C235(0.98); C244(1.04); C290(1.07); C309(0.51)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C235(0.86); C244(0.86); C290(1.16); C309(1.10)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C235(0.77); C244(0.72); C290(1.18); C309(1.20)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C235(0.94); C244(1.01); C290(1.10); C309(0.98)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C235(0.82); C244(0.77); C290(1.30); C309(1.41)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C235(0.88); C244(0.78); C290(1.29); C309(1.30)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C244(0.68); C290(1.06); C309(0.81)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C244(0.69); C290(1.30); C309(0.91)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C244(0.86); C290(1.16); C309(0.92)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C244(0.65); C290(1.38); C309(0.94)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C235(0.74); C244(0.69); C290(1.57); C309(0.95)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C244(0.69); C290(1.18); C309(1.12)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C244(0.65); C290(1.17); C309(1.38)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C244(0.44); C290(1.66); C309(2.04)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C244(0.42); C290(1.55); C309(1.17)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C244(0.35); C290(1.93); C309(2.40)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C244(0.73); C290(1.28); C309(1.24)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C244(0.94); C290(1.09); C309(1.05)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C244(0.97); C290(1.20); C309(1.47)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C244(0.50); C290(1.49); C309(1.32)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C244(0.27); C290(2.39); C309(2.87)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C235(0.76); C244(1.07); C290(1.15); C309(0.96)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C244(0.83); C290(1.35); C309(1.18)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C235(1.02); C290(1.06); C309(1.11)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C235(0.90); C290(1.19); C309(1.06)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C235(1.08); C290(0.98); C309(1.01)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C235(0.99); C290(1.12); C309(0.75)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C235(0.99); C290(1.27); C309(1.16)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C235(0.99); C290(1.04); C309(1.02)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C235(0.85); C290(1.19); C309(1.46)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C235(1.03); C290(1.19); C309(1.19)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C235(0.91); C290(1.11); C309(1.00)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C309(0.78)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C309(1.05); C290(0.86); C235(1.02)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C309(1.62); C235(1.15)  LDD1702  [4]
 LDCM0625  F8 Ramos C235(0.58); C309(1.70)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C235(0.68); C309(3.27)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C235(19.77)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C235(0.53); C309(1.29)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C235(0.83); C309(1.04)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C309(1.90)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C235(0.53); C309(1.35)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C235(0.88); C309(1.11)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C235(1.64); C309(1.35)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C235(0.87); C309(1.39)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C235(0.37); C309(0.55)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C235(1.03); C309(1.56)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C235(1.00); C309(1.30)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C235(0.65); C309(3.18)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C235(1.13); C244(0.84); C290(1.19); C309(0.88)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C235(1.06); C309(0.93)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C235(0.28); C309(1.23)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C235(1.00); C244(0.39); C290(2.38); C309(1.57)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C235(1.18); C309(1.24)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C235(1.43); C309(1.99)  LDD2205  [22]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1488  [5]
 LDCM0569  Fragment7 Ramos C235(0.31)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C235(0.51); C309(1.77)  LDD2188  [22]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C290(1.97)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C290(1.86)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C290(1.06)  LDD0082  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C235(0.51)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C235(0.74)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C235(1.22)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C235(0.96)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C235(0.46)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C235(0.73)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C235(0.96)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C235(0.98)  LDD2119  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C235(0.73)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C235(0.92)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C235(1.22)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C235(0.74)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C235(0.73)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C235(0.93)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C235(0.64)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C235(1.05)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C235(0.93)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C235(1.08)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C235(1.21)  LDD1700  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C235(2.63)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C235(0.61)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C235(0.72)  LDD2148  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C309(2.56); C290(0.91)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C309(0.95); C290(0.71)  LDD2207  [23]
 LDCM0131  RA190 MM1.R C309(2.42); C290(1.25)  LDD0304  [24]
 LDCM0021  THZ1 HCT 116 C290(1.13)  LDD2173  [7]
 LDCM0112  W16 Hep-G2 C309(0.68)  LDD0239  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 3, mitochondrial (MRM3) RNA methyltransferase TrmH family Q9HC36
Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) Glycosyltransferase 2 family Q10471
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Four and a half LIM domains protein 3 (FHL3) . Q13643
Scavenger receptor class F member 1 (SCARF1) . Q14162

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.