Details of the Target

General Information of Target

Target ID	LDTP00428
Target Name	Tripeptidyl-peptidase 1 (TPP1)
Gene Name	TPP1
Gene ID	1200
Synonyms	CLN2; Tripeptidyl-peptidase 1; TPP-1; EC 3.4.14.9; Cell growth-inhibiting gene 1 protein; Lysosomal pepstatin-insensitive protease; LPIC; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I; TPP-I
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVER LSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFL TCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTS SLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDL AQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEG QEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGD SGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPS YQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPV FGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGP GWDPVTGWGTPNFPALLKTLLNP
Target Type	Successful
Target Bioclass	Enzyme
Subcellular location	Lysosome
Function	Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
TTD ID	T56262
Uniprot ID	O14773
DrugMap ID	TTOVYPT
Ensemble ID	ENST00000299427.12
HGNC ID	HGNC:2073

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
EFO27	Deletion: p.P499LfsTer20	DBIA Probe Info
FADU	Insertion: p.R40AfsTer5	.
HCT15	SNV: p.S445N	.
HT115	SNV: p.R245H	.
KMCH1	SNV: p.G501S	.
MFE296	SNV: p.P379H	.
MFE319	SNV: p.A348V	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 20 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
Alkylaryl probe 1 Probe Info	15.00	LDD0387	[1]
Alkylaryl probe 2 Probe Info	18.00	LDD0391	[1]
TH214 Probe Info	Y508(7.16)	LDD0258	[2]
TH216 Probe Info	Y508(5.57)	LDD0259	[2]
YN-4 Probe Info	100.00	LDD0445	[3]
P11 Probe Info	20.00	LDD0201	[4]
Alkylaryl probe 3 Probe Info	5.41	LDD0384	[1]
FBPP2 Probe Info	2.80	LDD0054	[5]
HPAP Probe Info	5.46	LDD0062	[6]
HHS-482 Probe Info	Y508(0.99)	LDD0285	[7]
IA-alkyne Probe Info	C365(10.48)	LDD1705	[8]
Acrolein Probe Info	H253(0.00); H511(0.00)	LDD0221	[9]
DBIA Probe Info	C365(1.75)	LDD0080	[10]
5E-2FA Probe Info	N.A.	LDD2235	[11]
m-APA Probe Info	N.A.	LDD2231	[11]
Crotonaldehyde Probe Info	H253(0.00); H511(0.00)	LDD0219	[9]
AOyne Probe Info	9.70	LDD0443	[12]
MPP-AC Probe Info	N.A.	LDD0428	[13]
TER-AC Probe Info	N.A.	LDD0426	[13]
TPP-AC Probe Info	N.A.	LDD0427	[13]

PAL-AfBPP Probe

Click To Hide/Show 130 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
DR-1 Probe Info	4.85	LDD0398	[14]
C004 Probe Info	7.11	LDD1714	[15]
C011 Probe Info	7.11	LDD1720	[15]
C017 Probe Info	14.03	LDD1725	[15]
C022 Probe Info	12.21	LDD1728	[15]
C027 Probe Info	8.11	LDD1733	[15]
C040 Probe Info	10.20	LDD1740	[15]
C041 Probe Info	11.88	LDD1741	[15]
C045 Probe Info	11.24	LDD1744	[15]
C053 Probe Info	8.94	LDD1751	[15]
C063 Probe Info	19.16	LDD1760	[15]
C064 Probe Info	6.11	LDD1761	[15]
C070 Probe Info	19.56	LDD1766	[15]
C071 Probe Info	8.63	LDD1767	[15]
C072 Probe Info	9.58	LDD1768	[15]
C073 Probe Info	9.00	LDD1769	[15]
C087 Probe Info	9.32	LDD1779	[15]
C091 Probe Info	17.03	LDD1782	[15]
C092 Probe Info	39.67	LDD1783	[15]
C100 Probe Info	5.74	LDD1789	[15]
C106 Probe Info	47.84	LDD1793	[15]
C107 Probe Info	13.55	LDD1794	[15]
C108 Probe Info	19.56	LDD1795	[15]
C112 Probe Info	63.12	LDD1799	[15]
C115 Probe Info	18.38	LDD1802	[15]
C117 Probe Info	6.77	LDD1804	[15]
C125 Probe Info	7.89	LDD1809	[15]
C129 Probe Info	5.24	LDD1811	[15]
C130 Probe Info	10.70	LDD1812	[15]
C134 Probe Info	44.63	LDD1816	[15]
C135 Probe Info	13.64	LDD1817	[15]
C139 Probe Info	14.52	LDD1821	[15]
C140 Probe Info	13.74	LDD1822	[15]
C141 Probe Info	10.78	LDD1823	[15]
C143 Probe Info	18.25	LDD1825	[15]
C149 Probe Info	17.63	LDD1830	[15]
C153 Probe Info	33.13	LDD1834	[15]
C159 Probe Info	16.91	LDD1839	[15]
C160 Probe Info	13.74	LDD1840	[15]
C161 Probe Info	26.54	LDD1841	[15]
C163 Probe Info	6.36	LDD1843	[15]
C164 Probe Info	9.65	LDD1844	[15]
C169 Probe Info	31.34	LDD1849	[15]
C170 Probe Info	94.35	LDD1850	[15]
C171 Probe Info	25.99	LDD1851	[15]
C178 Probe Info	22.47	LDD1857	[15]
C183 Probe Info	7.94	LDD1861	[15]
C184 Probe Info	6.36	LDD1862	[15]
C186 Probe Info	45.89	LDD1864	[15]
C187 Probe Info	44.02	LDD1865	[15]
C193 Probe Info	5.98	LDD1869	[15]
C194 Probe Info	9.19	LDD1870	[15]
C197 Probe Info	9.25	LDD1873	[15]
C208 Probe Info	22.01	LDD1883	[15]
C211 Probe Info	16.11	LDD1885	[15]
C213 Probe Info	20.53	LDD1887	[15]
C219 Probe Info	6.11	LDD1893	[15]
C220 Probe Info	20.97	LDD1894	[15]
C221 Probe Info	12.73	LDD1895	[15]
C223 Probe Info	19.84	LDD1897	[15]
C225 Probe Info	9.25	LDD1898	[15]
C226 Probe Info	8.75	LDD1899	[15]
C228 Probe Info	19.70	LDD1901	[15]
C229 Probe Info	8.88	LDD1902	[15]
C231 Probe Info	25.81	LDD1904	[15]
C232 Probe Info	68.12	LDD1905	[15]
C233 Probe Info	14.22	LDD1906	[15]
C235 Probe Info	20.39	LDD1908	[15]
C237 Probe Info	16.00	LDD1910	[15]
C239 Probe Info	6.68	LDD1912	[15]
C240 Probe Info	13.74	LDD1913	[15]
C243 Probe Info	16.11	LDD1916	[15]
C245 Probe Info	4.92	LDD1918	[15]
C246 Probe Info	29.04	LDD1919	[15]
C249 Probe Info	31.56	LDD1922	[15]
C264 Probe Info	29.24	LDD1935	[15]
C265 Probe Info	16.56	LDD1936	[15]
C270 Probe Info	7.46	LDD1940	[15]
C277 Probe Info	11.71	LDD1947	[15]
C280 Probe Info	8.75	LDD1950	[15]
C281 Probe Info	10.93	LDD1951	[15]
C282 Probe Info	19.29	LDD1952	[15]
C284 Probe Info	27.10	LDD1954	[15]
C287 Probe Info	10.63	LDD1957	[15]
C288 Probe Info	7.67	LDD1958	[15]
C293 Probe Info	19.29	LDD1963	[15]
C296 Probe Info	11.79	LDD1966	[15]
C302 Probe Info	6.11	LDD1971	[15]
C310 Probe Info	18.90	LDD1977	[15]
C314 Probe Info	21.71	LDD1981	[15]
C326 Probe Info	14.12	LDD1990	[15]
C343 Probe Info	14.52	LDD2005	[15]
C346 Probe Info	12.04	LDD2007	[15]
C348 Probe Info	14.32	LDD2009	[15]
C349 Probe Info	12.55	LDD2010	[15]
C350 Probe Info	56.49	LDD2011	[15]
C355 Probe Info	30.06	LDD2016	[15]
C356 Probe Info	7.94	LDD2017	[15]
C362 Probe Info	45.57	LDD2023	[15]
C363 Probe Info	20.97	LDD2024	[15]
C364 Probe Info	18.25	LDD2025	[15]
C376 Probe Info	6.87	LDD2036	[15]
C383 Probe Info	18.13	LDD2042	[15]
C386 Probe Info	9.85	LDD2045	[15]
C387 Probe Info	9.00	LDD2046	[15]
C388 Probe Info	66.72	LDD2047	[15]
C390 Probe Info	99.73	LDD2049	[15]
C391 Probe Info	14.93	LDD2050	[15]
C396 Probe Info	4.96	LDD2055	[15]
C399 Probe Info	20.53	LDD2058	[15]
C403 Probe Info	35.02	LDD2061	[15]
C419 Probe Info	10.27	LDD2074	[15]
C420 Probe Info	13.64	LDD2075	[15]
C425 Probe Info	31.34	LDD2080	[15]
C426 Probe Info	13.36	LDD2081	[15]
C429 Probe Info	29.04	LDD2084	[15]
C431 Probe Info	43.11	LDD2086	[15]
C433 Probe Info	7.41	LDD2088	[15]
FFF probe11 Probe Info	20.00	LDD0471	[16]
FFF probe12 Probe Info	20.00	LDD0473	[16]
FFF probe13 Probe Info	20.00	LDD0475	[16]
FFF probe14 Probe Info	20.00	LDD0477	[16]
FFF probe15 Probe Info	10.47	LDD0478	[16]
FFF probe2 Probe Info	12.87	LDD0463	[16]
FFF probe4 Probe Info	14.54	LDD0466	[16]
FFF probe9 Probe Info	20.00	LDD0470	[16]
JN0003 Probe Info	20.00	LDD0469	[16]
BD-F Probe Info	E524(0.00); D543(0.00); S525(0.00)	LDD0024	[17]
LD-F Probe Info	E524(0.00); S525(0.00); W542(0.00); Q534(0.00)	LDD0015	[17]
OEA-DA Probe Info	20.00	LDD0046	[18]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HCT 116	C365(0.66)	LDD0531	[10]
LDCM0215	AC10	PaTu 8988t	C365(0.59)	LDD1094	[10]
LDCM0226	AC11	PaTu 8988t	C365(0.45)	LDD1105	[10]
LDCM0230	AC113	HCT 116	C365(0.99)	LDD0547	[10]
LDCM0231	AC114	HCT 116	C365(0.55)	LDD0548	[10]
LDCM0232	AC115	HCT 116	C365(0.30)	LDD0549	[10]
LDCM0233	AC116	HCT 116	C365(0.31)	LDD0550	[10]
LDCM0234	AC117	HCT 116	C365(0.56)	LDD0551	[10]
LDCM0235	AC118	HCT 116	C365(0.82)	LDD0552	[10]
LDCM0236	AC119	HCT 116	C365(0.56)	LDD0553	[10]
LDCM0237	AC12	PaTu 8988t	C365(0.47)	LDD1116	[10]
LDCM0238	AC120	HCT 116	C365(0.50)	LDD0555	[10]
LDCM0239	AC121	HCT 116	C365(1.30)	LDD0556	[10]
LDCM0240	AC122	HCT 116	C365(0.87)	LDD0557	[10]
LDCM0241	AC123	HCT 116	C365(0.75)	LDD0558	[10]
LDCM0242	AC124	HCT 116	C365(1.07)	LDD0559	[10]
LDCM0243	AC125	HCT 116	C365(0.66)	LDD0560	[10]
LDCM0244	AC126	HCT 116	C365(0.58)	LDD0561	[10]
LDCM0245	AC127	HCT 116	C365(0.50)	LDD0562	[10]
LDCM0246	AC128	PaTu 8988t	C365(0.73)	LDD1125	[10]
LDCM0247	AC129	PaTu 8988t	C365(0.52)	LDD1126	[10]
LDCM0249	AC130	PaTu 8988t	C365(0.67)	LDD1128	[10]
LDCM0250	AC131	PaTu 8988t	C365(0.59)	LDD1129	[10]
LDCM0251	AC132	PaTu 8988t	C365(0.78)	LDD1130	[10]
LDCM0252	AC133	PaTu 8988t	C365(0.61)	LDD1131	[10]
LDCM0253	AC134	PaTu 8988t	C365(0.62)	LDD1132	[10]
LDCM0254	AC135	PaTu 8988t	C365(0.60)	LDD1133	[10]
LDCM0255	AC136	PaTu 8988t	C365(0.52)	LDD1134	[10]
LDCM0256	AC137	PaTu 8988t	C365(0.54)	LDD1135	[10]
LDCM0257	AC138	PaTu 8988t	C365(0.62)	LDD1136	[10]
LDCM0258	AC139	PaTu 8988t	C365(0.55)	LDD1137	[10]
LDCM0259	AC14	PaTu 8988t	C365(0.40)	LDD1138	[10]
LDCM0260	AC140	PaTu 8988t	C365(0.64)	LDD1139	[10]
LDCM0261	AC141	PaTu 8988t	C365(0.64)	LDD1140	[10]
LDCM0262	AC142	PaTu 8988t	C365(0.57)	LDD1141	[10]
LDCM0263	AC143	HCT 116	C365(1.05)	LDD0580	[10]
LDCM0264	AC144	HCT 116	C365(0.87)	LDD0581	[10]
LDCM0265	AC145	HCT 116	C365(1.05)	LDD0582	[10]
LDCM0266	AC146	HCT 116	C365(1.22)	LDD0583	[10]
LDCM0267	AC147	HCT 116	C365(0.67)	LDD0584	[10]
LDCM0268	AC148	HCT 116	C365(0.57)	LDD0585	[10]
LDCM0269	AC149	HCT 116	C365(0.74)	LDD0586	[10]
LDCM0270	AC15	PaTu 8988t	C365(0.54)	LDD1149	[10]
LDCM0271	AC150	HCT 116	C365(1.48)	LDD0588	[10]
LDCM0272	AC151	HCT 116	C365(1.80)	LDD0589	[10]
LDCM0273	AC152	HCT 116	C365(0.61)	LDD0590	[10]
LDCM0274	AC153	HCT 116	C365(0.72)	LDD0591	[10]
LDCM0621	AC154	HCT 116	C365(0.72)	LDD2158	[10]
LDCM0622	AC155	HCT 116	C365(0.50)	LDD2159	[10]
LDCM0623	AC156	HCT 116	C365(1.29)	LDD2160	[10]
LDCM0624	AC157	HCT 116	C365(1.52)	LDD2161	[10]
LDCM0276	AC17	PaTu 8988t	C365(0.72)	LDD1155	[10]
LDCM0277	AC18	PaTu 8988t	C365(0.38)	LDD1156	[10]
LDCM0278	AC19	PaTu 8988t	C365(0.64)	LDD1157	[10]
LDCM0279	AC2	HCT 116	C365(0.48)	LDD0596	[10]
LDCM0280	AC20	PaTu 8988t	C365(0.46)	LDD1159	[10]
LDCM0281	AC21	PaTu 8988t	C365(0.67)	LDD1160	[10]
LDCM0282	AC22	PaTu 8988t	C365(0.44)	LDD1161	[10]
LDCM0283	AC23	PaTu 8988t	C365(0.33)	LDD1162	[10]
LDCM0284	AC24	PaTu 8988t	C365(0.61)	LDD1163	[10]
LDCM0285	AC25	HCT 116	C365(0.77)	LDD0602	[10]
LDCM0286	AC26	HCT 116	C365(0.49)	LDD0603	[10]
LDCM0287	AC27	HCT 116	C365(0.44)	LDD0604	[10]
LDCM0288	AC28	HCT 116	C365(0.52)	LDD0605	[10]
LDCM0289	AC29	HCT 116	C365(0.59)	LDD0606	[10]
LDCM0290	AC3	HCT 116	C365(0.57)	LDD0607	[10]
LDCM0291	AC30	HCT 116	C365(0.44)	LDD0608	[10]
LDCM0292	AC31	HCT 116	C365(0.59)	LDD0609	[10]
LDCM0293	AC32	HCT 116	C365(0.35)	LDD0610	[10]
LDCM0294	AC33	HCT 116	C365(0.40)	LDD0611	[10]
LDCM0295	AC34	HCT 116	C365(0.38)	LDD0612	[10]
LDCM0296	AC35	HCT 116	C365(1.32)	LDD0613	[10]
LDCM0297	AC36	HCT 116	C365(1.08)	LDD0614	[10]
LDCM0298	AC37	HCT 116	C365(0.99)	LDD0615	[10]
LDCM0299	AC38	HCT 116	C365(1.09)	LDD0616	[10]
LDCM0300	AC39	HCT 116	C365(0.74)	LDD0617	[10]
LDCM0301	AC4	HCT 116	C365(0.47)	LDD0618	[10]
LDCM0302	AC40	HCT 116	C365(0.81)	LDD0619	[10]
LDCM0303	AC41	HCT 116	C365(0.77)	LDD0620	[10]
LDCM0304	AC42	HCT 116	C365(0.81)	LDD0621	[10]
LDCM0305	AC43	HCT 116	C365(0.97)	LDD0622	[10]
LDCM0306	AC44	HCT 116	C365(0.85)	LDD0623	[10]
LDCM0307	AC45	HCT 116	C365(0.73)	LDD0624	[10]
LDCM0308	AC46	HCT 116	C365(1.35)	LDD0625	[10]
LDCM0309	AC47	HCT 116	C365(1.03)	LDD0626	[10]
LDCM0310	AC48	HCT 116	C365(2.86)	LDD0627	[10]
LDCM0311	AC49	HCT 116	C365(0.95)	LDD0628	[10]
LDCM0312	AC5	HCT 116	C365(0.39)	LDD0629	[10]
LDCM0313	AC50	HCT 116	C365(0.85)	LDD0630	[10]
LDCM0314	AC51	HCT 116	C365(2.93)	LDD0631	[10]
LDCM0315	AC52	HCT 116	C365(0.97)	LDD0632	[10]
LDCM0316	AC53	HCT 116	C365(0.82)	LDD0633	[10]
LDCM0317	AC54	HCT 116	C365(0.80)	LDD0634	[10]
LDCM0318	AC55	HCT 116	C365(0.94)	LDD0635	[10]
LDCM0319	AC56	HCT 116	C365(1.08)	LDD0636	[10]
LDCM0320	AC57	HCT 116	C365(0.29)	LDD0637	[10]
LDCM0321	AC58	HCT 116	C365(0.34)	LDD0638	[10]
LDCM0322	AC59	HCT 116	C365(0.28)	LDD0639	[10]
LDCM0323	AC6	PaTu 8988t	C365(0.68)	LDD1202	[10]
LDCM0324	AC60	HCT 116	C365(0.50)	LDD0641	[10]
LDCM0325	AC61	HCT 116	C365(0.81)	LDD0642	[10]
LDCM0326	AC62	HCT 116	C365(0.28)	LDD0643	[10]
LDCM0327	AC63	HCT 116	C365(0.38)	LDD0644	[10]
LDCM0328	AC64	HCT 116	C365(0.27)	LDD0645	[10]
LDCM0329	AC65	HCT 116	C365(0.31)	LDD0646	[10]
LDCM0330	AC66	HCT 116	C365(0.35)	LDD0647	[10]
LDCM0331	AC67	HCT 116	C365(0.22)	LDD0648	[10]
LDCM0332	AC68	HCT 116	C365(0.84)	LDD0649	[10]
LDCM0333	AC69	HCT 116	C365(0.75)	LDD0650	[10]
LDCM0334	AC7	PaTu 8988t	C365(1.24)	LDD1213	[10]
LDCM0335	AC70	HCT 116	C365(0.53)	LDD0652	[10]
LDCM0336	AC71	HCT 116	C365(1.27)	LDD0653	[10]
LDCM0337	AC72	HCT 116	C365(0.74)	LDD0654	[10]
LDCM0338	AC73	HCT 116	C365(0.65)	LDD0655	[10]
LDCM0339	AC74	HCT 116	C365(0.74)	LDD0656	[10]
LDCM0340	AC75	HCT 116	C365(0.62)	LDD0657	[10]
LDCM0341	AC76	HCT 116	C365(0.59)	LDD0658	[10]
LDCM0342	AC77	HCT 116	C365(0.60)	LDD0659	[10]
LDCM0343	AC78	HCT 116	C365(1.33)	LDD0660	[10]
LDCM0344	AC79	HCT 116	C365(0.81)	LDD0661	[10]
LDCM0345	AC8	PaTu 8988t	C365(1.47)	LDD1224	[10]
LDCM0346	AC80	HCT 116	C365(0.73)	LDD0663	[10]
LDCM0347	AC81	HCT 116	C365(1.09)	LDD0664	[10]
LDCM0348	AC82	HCT 116	C365(0.55)	LDD0665	[10]
LDCM0349	AC83	PaTu 8988t	C365(0.95)	LDD1228	[10]
LDCM0350	AC84	PaTu 8988t	C365(1.01)	LDD1229	[10]
LDCM0351	AC85	PaTu 8988t	C365(1.04)	LDD1230	[10]
LDCM0352	AC86	PaTu 8988t	C365(1.17)	LDD1231	[10]
LDCM0353	AC87	PaTu 8988t	C365(1.40)	LDD1232	[10]
LDCM0354	AC88	PaTu 8988t	C365(1.67)	LDD1233	[10]
LDCM0355	AC89	PaTu 8988t	C365(1.13)	LDD1234	[10]
LDCM0357	AC90	PaTu 8988t	C365(1.53)	LDD1236	[10]
LDCM0358	AC91	PaTu 8988t	C365(1.70)	LDD1237	[10]
LDCM0359	AC92	PaTu 8988t	C365(1.19)	LDD1238	[10]
LDCM0360	AC93	PaTu 8988t	C365(2.07)	LDD1239	[10]
LDCM0361	AC94	PaTu 8988t	C365(1.27)	LDD1240	[10]
LDCM0362	AC95	PaTu 8988t	C365(1.33)	LDD1241	[10]
LDCM0363	AC96	PaTu 8988t	C365(2.70)	LDD1242	[10]
LDCM0364	AC97	PaTu 8988t	C365(1.84)	LDD1243	[10]
LDCM0248	AKOS034007472	PaTu 8988t	C365(0.43)	LDD1127	[10]
LDCM0356	AKOS034007680	PaTu 8988t	C365(0.62)	LDD1235	[10]
LDCM0275	AKOS034007705	PaTu 8988t	C365(0.85)	LDD1154	[10]
LDCM0088	C45	HEK-293T	20.00	LDD0201	[4]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[9]
LDCM0367	CL1	HCT 116	C365(1.77)	LDD0684	[10]
LDCM0368	CL10	HCT 116	C365(0.72)	LDD0685	[10]
LDCM0369	CL100	HCT 116	C365(0.39)	LDD0686	[10]
LDCM0370	CL101	PaTu 8988t	C365(0.85)	LDD1249	[10]
LDCM0371	CL102	PaTu 8988t	C365(0.65)	LDD1250	[10]
LDCM0372	CL103	PaTu 8988t	C365(0.44)	LDD1251	[10]
LDCM0373	CL104	PaTu 8988t	C365(0.46)	LDD1252	[10]
LDCM0374	CL105	PaTu 8988t	C365(0.67)	LDD1253	[10]
LDCM0375	CL106	PaTu 8988t	C365(0.62)	LDD1254	[10]
LDCM0376	CL107	PaTu 8988t	C365(0.59)	LDD1255	[10]
LDCM0377	CL108	PaTu 8988t	C365(0.69)	LDD1256	[10]
LDCM0378	CL109	PaTu 8988t	C365(0.56)	LDD1257	[10]
LDCM0379	CL11	HCT 116	C365(0.69)	LDD0696	[10]
LDCM0380	CL110	PaTu 8988t	C365(0.40)	LDD1259	[10]
LDCM0381	CL111	PaTu 8988t	C365(0.29)	LDD1260	[10]
LDCM0382	CL112	HCT 116	C365(1.07)	LDD0699	[10]
LDCM0383	CL113	HCT 116	C365(0.38)	LDD0700	[10]
LDCM0384	CL114	HCT 116	C365(0.71)	LDD0701	[10]
LDCM0385	CL115	HCT 116	C365(0.60)	LDD0702	[10]
LDCM0386	CL116	HCT 116	C365(0.59)	LDD0703	[10]
LDCM0387	CL117	HCT 116	C365(0.69)	LDD0704	[10]
LDCM0388	CL118	HCT 116	C365(0.74)	LDD0705	[10]
LDCM0389	CL119	HCT 116	C365(0.81)	LDD0706	[10]
LDCM0390	CL12	HCT 116	C365(0.71)	LDD0707	[10]
LDCM0391	CL120	HCT 116	C365(0.88)	LDD0708	[10]
LDCM0392	CL121	HCT 116	C365(1.51)	LDD0709	[10]
LDCM0393	CL122	HCT 116	C365(1.14)	LDD0710	[10]
LDCM0394	CL123	HCT 116	C365(0.76)	LDD0711	[10]
LDCM0395	CL124	HCT 116	C365(0.96)	LDD0712	[10]
LDCM0396	CL125	HCT 116	C365(0.63)	LDD0713	[10]
LDCM0397	CL126	HCT 116	C365(3.33)	LDD0714	[10]
LDCM0398	CL127	HCT 116	C365(0.49)	LDD0715	[10]
LDCM0399	CL128	HCT 116	C365(0.24)	LDD0716	[10]
LDCM0400	CL13	HCT 116	C365(0.91)	LDD0717	[10]
LDCM0401	CL14	HCT 116	C365(0.95)	LDD0718	[10]
LDCM0402	CL15	HCT 116	C365(1.39)	LDD0719	[10]
LDCM0403	CL16	PaTu 8988t	C365(0.29)	LDD1282	[10]
LDCM0404	CL17	PaTu 8988t	C365(0.23)	LDD1283	[10]
LDCM0405	CL18	PaTu 8988t	C365(0.26)	LDD1284	[10]
LDCM0406	CL19	PaTu 8988t	C365(0.26)	LDD1285	[10]
LDCM0407	CL2	HCT 116	C365(1.69)	LDD0724	[10]
LDCM0408	CL20	PaTu 8988t	C365(0.21)	LDD1287	[10]
LDCM0409	CL21	PaTu 8988t	C365(0.23)	LDD1288	[10]
LDCM0410	CL22	PaTu 8988t	C365(0.28)	LDD1289	[10]
LDCM0411	CL23	PaTu 8988t	C365(0.25)	LDD1290	[10]
LDCM0412	CL24	PaTu 8988t	C365(0.26)	LDD1291	[10]
LDCM0413	CL25	PaTu 8988t	C365(0.38)	LDD1292	[10]
LDCM0414	CL26	PaTu 8988t	C365(0.22)	LDD1293	[10]
LDCM0415	CL27	PaTu 8988t	C365(0.24)	LDD1294	[10]
LDCM0416	CL28	PaTu 8988t	C365(0.25)	LDD1295	[10]
LDCM0417	CL29	PaTu 8988t	C365(0.26)	LDD1296	[10]
LDCM0418	CL3	HCT 116	C365(0.88)	LDD0735	[10]
LDCM0419	CL30	PaTu 8988t	C365(0.41)	LDD1298	[10]
LDCM0420	CL31	HCT 116	C365(0.86)	LDD0737	[10]
LDCM0421	CL32	HCT 116	C365(1.51)	LDD0738	[10]
LDCM0422	CL33	HCT 116	C365(1.66)	LDD0739	[10]
LDCM0423	CL34	HCT 116	C365(0.61)	LDD0740	[10]
LDCM0424	CL35	HCT 116	C365(0.67)	LDD0741	[10]
LDCM0425	CL36	HCT 116	C365(0.67)	LDD0742	[10]
LDCM0426	CL37	HCT 116	C365(0.71)	LDD0743	[10]
LDCM0428	CL39	HCT 116	C365(0.69)	LDD0745	[10]
LDCM0429	CL4	HCT 116	C365(0.92)	LDD0746	[10]
LDCM0430	CL40	HCT 116	C365(0.70)	LDD0747	[10]
LDCM0431	CL41	HCT 116	C365(0.66)	LDD0748	[10]
LDCM0432	CL42	HCT 116	C365(0.59)	LDD0749	[10]
LDCM0433	CL43	HCT 116	C365(0.94)	LDD0750	[10]
LDCM0434	CL44	HCT 116	C365(0.69)	LDD0751	[10]
LDCM0435	CL45	HCT 116	C365(0.87)	LDD0752	[10]
LDCM0436	CL46	HCT 116	C365(1.59)	LDD0753	[10]
LDCM0437	CL47	HCT 116	C365(1.71)	LDD0754	[10]
LDCM0438	CL48	HCT 116	C365(1.30)	LDD0755	[10]
LDCM0439	CL49	HCT 116	C365(1.09)	LDD0756	[10]
LDCM0440	CL5	HCT 116	C365(0.92)	LDD0757	[10]
LDCM0441	CL50	HCT 116	C365(1.75)	LDD0758	[10]
LDCM0442	CL51	HCT 116	C365(1.17)	LDD0759	[10]
LDCM0443	CL52	HCT 116	C365(1.21)	LDD0760	[10]
LDCM0444	CL53	HCT 116	C365(1.75)	LDD0761	[10]
LDCM0445	CL54	HCT 116	C365(1.52)	LDD0762	[10]
LDCM0446	CL55	HCT 116	C365(2.15)	LDD0763	[10]
LDCM0447	CL56	HCT 116	C365(0.80)	LDD0764	[10]
LDCM0448	CL57	HCT 116	C365(1.51)	LDD0765	[10]
LDCM0449	CL58	HCT 116	C365(1.33)	LDD0766	[10]
LDCM0450	CL59	HCT 116	C365(1.00)	LDD0767	[10]
LDCM0451	CL6	HCT 116	C365(1.79)	LDD0768	[10]
LDCM0452	CL60	HCT 116	C365(1.48)	LDD0769	[10]
LDCM0453	CL61	HCT 116	C365(0.98)	LDD0770	[10]
LDCM0454	CL62	HCT 116	C365(0.80)	LDD0771	[10]
LDCM0455	CL63	HCT 116	C365(0.57)	LDD0772	[10]
LDCM0456	CL64	HCT 116	C365(0.57)	LDD0773	[10]
LDCM0457	CL65	HCT 116	C365(0.65)	LDD0774	[10]
LDCM0458	CL66	HCT 116	C365(0.39)	LDD0775	[10]
LDCM0459	CL67	HCT 116	C365(0.44)	LDD0776	[10]
LDCM0460	CL68	HCT 116	C365(0.60)	LDD0777	[10]
LDCM0461	CL69	HCT 116	C365(1.25)	LDD0778	[10]
LDCM0462	CL7	HCT 116	C365(1.10)	LDD0779	[10]
LDCM0463	CL70	HCT 116	C365(0.83)	LDD0780	[10]
LDCM0464	CL71	HCT 116	C365(0.43)	LDD0781	[10]
LDCM0465	CL72	HCT 116	C365(0.92)	LDD0782	[10]
LDCM0466	CL73	HCT 116	C365(0.68)	LDD0783	[10]
LDCM0467	CL74	HCT 116	C365(0.52)	LDD0784	[10]
LDCM0469	CL76	PaTu 8988t	C365(1.05)	LDD1348	[10]
LDCM0470	CL77	PaTu 8988t	C365(0.85)	LDD1349	[10]
LDCM0471	CL78	PaTu 8988t	C365(0.44)	LDD1350	[10]
LDCM0472	CL79	PaTu 8988t	C365(0.50)	LDD1351	[10]
LDCM0473	CL8	HCT 116	C365(0.66)	LDD0790	[10]
LDCM0474	CL80	PaTu 8988t	C365(1.29)	LDD1353	[10]
LDCM0475	CL81	PaTu 8988t	C365(0.38)	LDD1354	[10]
LDCM0476	CL82	PaTu 8988t	C365(0.58)	LDD1355	[10]
LDCM0477	CL83	PaTu 8988t	C365(0.51)	LDD1356	[10]
LDCM0478	CL84	PaTu 8988t	C365(0.54)	LDD1357	[10]
LDCM0479	CL85	PaTu 8988t	C365(0.56)	LDD1358	[10]
LDCM0480	CL86	PaTu 8988t	C365(0.65)	LDD1359	[10]
LDCM0481	CL87	PaTu 8988t	C365(0.50)	LDD1360	[10]
LDCM0482	CL88	PaTu 8988t	C365(0.40)	LDD1361	[10]
LDCM0483	CL89	PaTu 8988t	C365(0.52)	LDD1362	[10]
LDCM0484	CL9	HCT 116	C365(1.02)	LDD0801	[10]
LDCM0485	CL90	PaTu 8988t	C365(0.38)	LDD1364	[10]
LDCM0486	CL91	HCT 116	C365(0.29)	LDD0803	[10]
LDCM0487	CL92	HCT 116	C365(0.34)	LDD0804	[10]
LDCM0488	CL93	HCT 116	C365(0.41)	LDD0805	[10]
LDCM0489	CL94	HCT 116	C365(0.21)	LDD0806	[10]
LDCM0490	CL95	HCT 116	C365(0.20)	LDD0807	[10]
LDCM0491	CL96	HCT 116	C365(0.22)	LDD0808	[10]
LDCM0492	CL97	HCT 116	C365(0.39)	LDD0809	[10]
LDCM0493	CL98	HCT 116	C365(0.34)	LDD0810	[10]
LDCM0494	CL99	HCT 116	C365(0.39)	LDD0811	[10]
LDCM0185	Compound 17	HEK-293T	6.58	LDD0512	[16]
LDCM0495	E2913	HEK-293T	C365(1.15)	LDD1698	[19]
LDCM0468	Fragment33	HCT 116	C365(0.52)	LDD0785	[10]
LDCM0427	Fragment51	HCT 116	C365(0.73)	LDD0744	[10]
LDCM0107	IAA	HeLa	H253(0.00); H511(0.00)	LDD0221	[9]
LDCM0123	JWB131	DM93	Y508(0.99)	LDD0285	[7]
LDCM0124	JWB142	DM93	Y508(1.34)	LDD0286	[7]
LDCM0125	JWB146	DM93	Y508(1.24)	LDD0287	[7]
LDCM0126	JWB150	DM93	Y508(6.65)	LDD0288	[7]
LDCM0127	JWB152	DM93	Y508(3.51)	LDD0289	[7]
LDCM0128	JWB198	DM93	Y508(0.33)	LDD0290	[7]
LDCM0129	JWB202	DM93	Y508(1.29)	LDD0291	[7]
LDCM0130	JWB211	DM93	Y508(0.94)	LDD0292	[7]
LDCM0022	KB02	HCT 116	C365(1.75)	LDD0080	[10]
LDCM0023	KB03	HCT 116	C365(2.33)	LDD0081	[10]
LDCM0024	KB05	HCT 116	C365(2.57)	LDD0082	[10]
LDCM0109	NEM	HeLa	H253(0.00); H511(0.00)	LDD0223	[9]
LDCM0014	Panhematin	HEK-293T	5.46	LDD0062	[6]
LDCM0099	Phenelzine	MDA-MB-231	5.41	LDD0384	[1]
LDCM0008	Tranylcypromine	SH-SY5Y	2.80	LDD0054	[5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 5 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Ubiquitin thioesterase OTUB1 (OTUB1)	Peptidase C65 family	Q96FW1
Telomerase reverse transcriptase (TERT)	Reverse transcriptase family	O14746
TNF receptor-associated factor 4 (TRAF4)	TNF receptor-associated factor family	Q9BUZ4
E3 ubiquitin-protein ligase RNF183 (RNF183)	.	Q96D59
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2)	.	O00308

Transcription factor

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Zinc finger and BTB domain-containing protein 38 (ZBTB38)				.	Q8NAP3

Other

Click To Hide/Show 5 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
CST complex subunit STN1 (STN1)	STN1 family	Q9H668
Centrosomal protein of 55 kDa (CEP55)	.	Q53EZ4
Cytokine-inducible SH2-containing protein (CISH)	.	Q9NSE2
F-box only protein 42 (FBXO42)	.	Q6P3S6
F-box/LRR-repeat protein 4 (FBXL4)	.	Q9UKA2

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Cerliponase Alfa				Recombinant protein	D06CAS

References

1	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
6	A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12. Mass spectrometry data entry: PXD034651
7	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8	An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
9	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
12	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13	Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
14	Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
15	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
16	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
18	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
19	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402

Details of the Target

Citation

Visitor Map

Correspondence

Prof. Feng Zhu

Prof. Feng Ni