Details of the Target

General Information of Target

Target ID LDTP15000
Target Name Solute carrier family 35 member F1 (SLC35F1)
Gene Name SLC35F1
Gene ID 222553
Synonyms
C6orf169; Solute carrier family 35 member F1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTEASSPAQALPPQYQSII
VRQGIQNTALSPDCSLGDTQHGEKLRRNCTIYRPWFSPYSYFVCADKESQLEAYDFPEVQ
QDEGKWDNCLSEDMAENICSSSSSPENTCPREATKKSRHGLDSITSQDILMASRWHPAQQ
NGYKCVACCRMYPTLDFLKSHIKRGFREGFSCKVYYRKLKALWSKEQKARLGDRLSSGSC
QAFNSPAEHLRQIGGEAYLCL
Target Bioclass
Transporter and channel
Family
SLC35F solute transporter family
Subcellular location
Membrane
Function Putative solute transporter.
Uniprot ID
Q5T1Q4
Ensemble ID
ENST00000360388.9
HGNC ID
HGNC:21483

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ECC2 SNV: p.A17S .
HCC1143 Deletion: p.S336FfsTer23 .
LN229 Deletion: p.Y230WfsTer4 .
LS123 SNV: p.V386L .
MCC13 SNV: p.R127Q .
NCIH358 SNV: p.W278R .
NCIH82 SNV: p.V200L .
T98G Substitution: p.P16H .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C194
 Probe Info  		8.51  LDD1870  [1]
C197
 Probe Info  		7.06  LDD1873  [1]
C198
 Probe Info  		9.71  LDD1874  [1]
C199
 Probe Info  		6.23  LDD1875  [1]
C229
 Probe Info  		19.97  LDD1902  [1]
C231
 Probe Info  		19.03  LDD1904  [1]
C232
 Probe Info  		36.00  LDD1905  [1]
C233
 Probe Info  		23.92  LDD1906  [1]
C235
 Probe Info  		34.54  LDD1908  [1]
C273
 Probe Info  		5.74  LDD1943  [1]
C277
 Probe Info  		9.99  LDD1947  [1]
C327
 Probe Info  		6.06  LDD1991  [1]
C328
 Probe Info  		8.34  LDD1992  [1]
C331
 Probe Info  		4.96  LDD1994  [1]
C333
 Probe Info  		8.63  LDD1996  [1]
C386
 Probe Info  		6.92  LDD2045  [1]
C389
 Probe Info  		5.86  LDD2048  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction alpha-5 protein (GJA5) Connexin family P36382
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587