Details of the Target

General Information of Target

Target ID LDTP00589
Target Name Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3)
Gene Name ACOX3
Gene ID 8310
Synonyms
BRCOX; PRCOX; Peroxisomal acyl-coenzyme A oxidase 3; EC 1.3.3.6; Branched-chain acyl-CoA oxidase; BRCACox; Pristanoyl-CoA oxidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPL
FARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAK
YLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPAT
EEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMP
GVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGAS
LGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYL
AAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQ
ECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFR
SPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSG
SSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSL
SRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADG
ELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL
Target Bioclass
Enzyme
Family
Acyl-CoA oxidase family
Subcellular location
Peroxisome
Function Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
Uniprot ID
O15254
Ensemble ID
ENST00000356406.10
HGNC ID
HGNC:121
ChEMBL ID
CHEMBL4105817

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.G694E DBIA    Probe Info 
DAOY SNV: p.F686L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.L347I; p.A425V DBIA    Probe Info 
OVCAR5 SNV: p.V568L DBIA    Probe Info 
SW1573 SNV: p.K48Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.70  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0391  [2]
STPyne
 Probe Info  		K49(0.32); K537(1.05)  LDD0277  [3]
Jackson_14
 Probe Info  		2.94  LDD0123  [4]
DBIA
 Probe Info  		C214(0.92); C220(0.92)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C422(0.00); C109(0.00); C478(0.00); C448(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C426(0.00); C523(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C523(0.00); C426(0.00); C478(0.00); C448(0.00)  LDD0037  [6]
NAIA_5
 Probe Info  		C426(0.00); C422(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.46  LDD1714  [8]
C040
 Probe Info  		6.68  LDD1740  [8]
C041
 Probe Info  		5.70  LDD1741  [8]
C053
 Probe Info  		5.28  LDD1751  [8]
C063
 Probe Info  		14.32  LDD1760  [8]
C087
 Probe Info  		9.65  LDD1779  [8]
C092
 Probe Info  		18.38  LDD1783  [8]
C094
 Probe Info  		23.43  LDD1785  [8]
C112
 Probe Info  		25.46  LDD1799  [8]
C139
 Probe Info  		10.78  LDD1821  [8]
C140
 Probe Info  		8.82  LDD1822  [8]
C153
 Probe Info  		15.67  LDD1834  [8]
C158
 Probe Info  		38.85  LDD1838  [8]
C159
 Probe Info  		8.57  LDD1839  [8]
C160
 Probe Info  		7.67  LDD1840  [8]
C161
 Probe Info  		30.48  LDD1841  [8]
C166
 Probe Info  		9.58  LDD1846  [8]
C169
 Probe Info  		26.91  LDD1849  [8]
C177
 Probe Info  		8.17  LDD1856  [8]
C199
 Probe Info  		6.15  LDD1875  [8]
C201
 Probe Info  		31.56  LDD1877  [8]
C206
 Probe Info  		20.39  LDD1881  [8]
C218
 Probe Info  		14.42  LDD1892  [8]
C220
 Probe Info  		11.55  LDD1894  [8]
C235
 Probe Info  		20.53  LDD1908  [8]
C269
 Probe Info  		5.82  LDD1939  [8]
C285
 Probe Info  		22.47  LDD1955  [8]
C287
 Probe Info  		11.39  LDD1957  [8]
C288
 Probe Info  		7.89  LDD1958  [8]
C289
 Probe Info  		30.48  LDD1959  [8]
C293
 Probe Info  		18.90  LDD1963  [8]
C296
 Probe Info  		18.77  LDD1966  [8]
C299
 Probe Info  		6.06  LDD1968  [8]
C305
 Probe Info  		10.85  LDD1974  [8]
C313
 Probe Info  		14.72  LDD1980  [8]
C314
 Probe Info  		31.56  LDD1981  [8]
C322
 Probe Info  		7.26  LDD1988  [8]
C326
 Probe Info  		8.28  LDD1990  [8]
C378
 Probe Info  		7.62  LDD2037  [8]
C380
 Probe Info  		6.23  LDD2039  [8]
C382
 Probe Info  		16.80  LDD2041  [8]
C420
 Probe Info  		33.13  LDD2075  [8]
C424
 Probe Info  		10.20  LDD2079  [8]
C426
 Probe Info  		16.56  LDD2081  [8]
C429
 Probe Info  		11.16  LDD2084  [8]
C432
 Probe Info  		4.99  LDD2087  [8]
C433
 Probe Info  		8.17  LDD2088  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C478(1.14)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C214(0.97); C220(0.97)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C214(0.68); C220(0.68)  LDD0543  [5]
 LDCM0237  AC12 HCT 116 C214(0.76); C220(0.76)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C214(0.84); C220(0.84)  LDD0576  [5]
 LDCM0270  AC15 HCT 116 C214(1.17); C220(1.17)  LDD0587  [5]
 LDCM0276  AC17 HCT 116 C214(1.04); C220(1.04)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C214(1.25); C220(1.25)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C214(1.08); C220(1.08)  LDD0595  [5]
 LDCM0280  AC20 HCT 116 C214(1.23); C220(1.23)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C214(1.12); C220(1.12)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C214(1.14); C220(1.14)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C214(1.25); C220(1.25)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C214(1.20); C220(1.20)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C220(0.77)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C220(0.95)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C220(0.99)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C220(0.94)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C220(1.26)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C478(0.77)  LDD1529  [9]
 LDCM0291  AC30 HCT 116 C220(1.20)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C220(0.92)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C220(1.12)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C220(1.31)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C220(1.49)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C214(0.87); C220(0.87)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C214(0.98); C220(0.98)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C214(1.15); C220(1.15)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C214(1.17); C220(1.17)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C214(1.36); C220(1.36)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C109(0.80)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C214(1.05); C220(1.05)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C214(0.77); C220(0.77)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C214(0.80); C220(0.80)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C214(1.12); C220(1.12)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C214(0.95); C220(0.95)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C214(1.05); C220(1.05)  LDD0905  [5]
 LDCM0308  AC46 HCT 116 C214(0.95); C220(0.95)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C214(0.94); C220(0.94)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C214(1.18); C220(1.18)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C214(0.98); C220(0.98)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C109(0.96); C478(0.94)  LDD1551  [9]
 LDCM0313  AC50 HCT 116 C214(1.22); C220(1.22)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C214(0.85); C220(0.85)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C214(1.04); C220(1.04)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C214(0.93); C220(0.93)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C214(0.93); C220(0.93)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C214(0.88); C220(0.88)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C214(0.95); C220(0.95)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C214(1.00); C220(1.00)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C214(1.59); C220(1.59)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C214(1.24); C220(1.24)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C214(1.30); C220(1.30)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C214(1.48); C220(1.48)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C214(1.04); C220(1.04)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C214(1.16); C220(1.16)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C214(1.03); C220(1.03)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C214(1.11); C220(1.11)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C214(1.13); C220(1.13)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C214(1.03); C220(1.03)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C214(1.35); C220(1.35)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C214(0.98); C220(0.98)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C214(0.87); C220(0.87)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C214(1.05); C220(1.05)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C214(0.92); C220(0.92)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C214(0.89); C220(0.89)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C214(0.99); C220(0.99)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C214(0.99); C220(0.99)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C214(0.97); C220(0.97)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C214(0.90); C220(0.90)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C214(0.86); C220(0.86)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C214(1.09); C220(1.09)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C214(1.06); C220(1.06)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C214(0.97); C220(0.97)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C214(1.18); C220(1.18)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C214(0.95); C220(0.95)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C214(0.97); C220(0.97)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C214(0.93); C220(0.93)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C214(0.93); C220(0.93)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C214(0.88); C220(0.88)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C214(0.90); C220(0.90)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C214(1.06); C220(1.06)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C214(0.95); C220(0.95)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C214(0.98); C220(0.98)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C214(0.87); C220(0.87)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C214(0.94); C220(0.94)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C214(0.82); C220(0.82)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C214(0.85); C220(0.85)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C214(0.93); C220(0.93)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C214(0.88); C220(0.88)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C214(0.96); C220(0.96)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C214(0.98); C220(0.98)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C214(0.99); C220(0.99)  LDD0681  [5]
 LDCM0248  AKOS034007472 HCT 116 C214(0.78); C220(0.78)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C214(0.96); C220(0.96)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C214(1.17); C220(1.17)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C214(0.92); C220(0.92)  LDD0078  [5]
 LDCM0367  CL1 HEK-293T C550(1.04); C478(0.83)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C550(1.72); C109(0.27); C523(0.69); C478(1.17)  LDD1572  [9]
 LDCM0370  CL101 HCT 116 C214(1.24); C220(1.24)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C214(1.05); C220(1.05)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C214(0.78); C220(0.78)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C214(1.06); C220(1.06)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C214(1.32); C220(1.32)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C214(1.20); C220(1.20)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C214(1.19); C220(1.19)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C214(1.10); C220(1.10)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C214(1.27); C220(1.27)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C478(1.14)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C214(1.23); C220(1.23)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C214(1.21); C220(1.21)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C220(1.23)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C220(1.44)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C220(1.87)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C220(1.46)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C220(1.19)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C214(1.23); C220(1.23)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C214(1.01); C220(1.01)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C214(0.90); C220(0.90)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C550(1.50); C478(0.81)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C214(1.16); C220(1.16)  LDD0989  [5]
 LDCM0392  CL121 HCT 116 C214(0.86); C220(0.86)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C214(0.90); C220(0.90)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C214(0.83); C220(0.83)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C214(0.92); C220(0.92)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C214(1.35); C220(1.35)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C214(2.19); C220(2.19)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C214(1.72); C220(1.72)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C214(1.02); C220(1.02)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C550(1.09); C478(0.89)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C550(1.05)  LDD1605  [9]
 LDCM0404  CL17 HEK-293T C478(1.07)  LDD1608  [9]
 LDCM0406  CL19 HEK-293T C478(1.30)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C550(1.05)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C109(1.25)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C109(0.81); C478(1.40)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C550(1.64); C109(1.02); C523(0.68); C478(1.70)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C478(1.16)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C550(1.67); C478(0.94)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C550(1.01); C478(0.80)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C550(0.97)  LDD1618  [9]
 LDCM0417  CL29 HEK-293T C478(1.28)  LDD1621  [9]
 LDCM0420  CL31 HEK-293T C478(0.98)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C109(1.06)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C109(0.90); C478(0.90)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C550(1.50); C109(1.21); C523(0.70); C478(1.84)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C478(0.89)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C550(1.51); C478(1.11)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C550(1.04); C478(0.90)  LDD1630  [9]
 LDCM0431  CL41 HEK-293T C478(0.96)  LDD1635  [9]
 LDCM0433  CL43 HEK-293T C478(0.95)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C109(1.11)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C109(1.09); C478(0.79)  LDD1639  [9]
 LDCM0436  CL46 HCT 116 C214(1.36); C220(1.36)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C214(1.25); C220(1.25)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C214(1.41); C220(1.41)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C214(0.97); C220(0.97)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C478(0.92)  LDD1644  [9]
 LDCM0441  CL50 HCT 116 C214(1.03); C220(1.03)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C214(1.09); C220(1.09)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C214(1.28); C220(1.28)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C214(1.41); C220(1.41)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C214(1.23); C220(1.23)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C214(1.08); C220(1.08)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C214(1.32); C220(1.32)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C214(1.48); C220(1.48)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C214(1.14); C220(1.14)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C214(0.93); C220(0.93)  LDD0767  [5]
 LDCM0452  CL60 HCT 116 C214(1.13); C220(1.13)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C214(1.14); C220(1.14)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C214(1.31); C220(1.31)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C214(1.11); C220(1.11)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C214(1.12); C220(1.12)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C214(1.30); C220(1.30)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C214(1.63); C220(1.63)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C214(1.00); C220(1.00)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C214(1.81); C220(1.81)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C214(1.50); C220(1.50)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C478(1.27)  LDD1665  [9]
 LDCM0463  CL70 HCT 116 C214(1.12); C220(1.12)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C214(1.03); C220(1.03)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C214(1.24); C220(1.24)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C214(1.35); C220(1.35)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C214(1.22); C220(1.22)  LDD0784  [5]
 LDCM0470  CL77 HEK-293T C478(0.95)  LDD1673  [9]
 LDCM0472  CL79 HEK-293T C478(1.13)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C109(0.91)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C109(1.06)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C109(1.05); C478(1.11)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C550(1.45); C109(1.03); C523(0.84); C478(1.69)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C478(0.93)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C550(1.40); C478(0.81)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C550(1.03); C478(0.89)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C550(1.00)  LDD1683  [9]
 LDCM0483  CL89 HEK-293T C478(1.24)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C109(1.07); C478(1.08)  LDD1687  [9]
 LDCM0486  CL91 HEK-293T C478(0.92)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C109(0.95)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C109(0.92); C478(0.83)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C550(1.23); C109(1.03); C523(0.82); C478(1.54)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C478(1.25)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C550(1.26); C478(0.91)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C550(0.99); C478(0.78)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C550(0.96)  LDD1696  [9]
 LDCM0468  Fragment33 HCT 116 C214(1.54); C220(1.54)  LDD0785  [5]
 LDCM0427  Fragment51 HEK-293T C550(0.95)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C478(0.91)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C478(0.92)  LDD1497  [9]
 LDCM0024  KB05 COLO792 C426(1.57)  LDD3310  [10]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.94  LDD0123  [4]
 LDCM0021  THZ1 HCT 116 C214(1.12); C220(1.12)  LDD2173  [5]

References

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2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840