Details of the Target

General Information of Target

Target ID LDTP08881
Target Name Transmembrane protein 199 (TMEM199)
Gene Name TMEM199
Gene ID 147007
Synonyms
C17orf32; Transmembrane protein 199
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASSLLAGERLVRALGPGGELEPERLPRKLRAELEAALGKKHKGGDSSSGPQRLVSFRLI
RDLHQHLRERDSKLYLHELLEGSEIYLPEVVKPPRNPELVARLEKIKIQLANEEYKRITR
NVTCQDTRHGGTLSDLGKQVRSLKALVITIFNFIVTVVAAFVCTYLGSQYIFTEMASRVL
AALIVASVVGLAELYVMVRAMEGELGEL
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasmic vesicle, COPI-coated vesicle membrane
Function
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis. Binds 20(S)-hydroxycholesterol (20(S)-OHC).
Uniprot ID
Q8N511
Ensemble ID
ENST00000292114.8
HGNC ID
HGNC:18085

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.86  LDD0402  [1]
FBPP2
 Probe Info  		29.96  LDD0318  [2]
BTD
 Probe Info  		C124(0.29)  LDD2108  [3]
DA-P3
 Probe Info  		7.97  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C124(2.09)  LDD0171  [5]
DBIA
 Probe Info  		C124(2.49)  LDD0080  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 176 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.62  LDD1711  [13]
C003
 Probe Info  		13.36  LDD1713  [13]
C004
 Probe Info  		16.45  LDD1714  [13]
C007
 Probe Info  		9.06  LDD1716  [13]
C010
 Probe Info  		5.35  LDD1719  [13]
C011
 Probe Info  		6.19  LDD1720  [13]
C017
 Probe Info  		18.90  LDD1725  [13]
C022
 Probe Info  		11.63  LDD1728  [13]
C026
 Probe Info  		9.32  LDD1732  [13]
C039
 Probe Info  		7.21  LDD1739  [13]
C040
 Probe Info  		37.79  LDD1740  [13]
C041
 Probe Info  		20.25  LDD1741  [13]
C044
 Probe Info  		5.31  LDD1743  [13]
C049
 Probe Info  		7.06  LDD1747  [13]
C051
 Probe Info  		8.63  LDD1749  [13]
C052
 Probe Info  		10.93  LDD1750  [13]
C053
 Probe Info  		9.38  LDD1751  [13]
C055
 Probe Info  		46.85  LDD1752  [13]
C056
 Probe Info  		44.94  LDD1753  [13]
C059
 Probe Info  		6.96  LDD1756  [13]
C063
 Probe Info  		17.03  LDD1760  [13]
C064
 Probe Info  		10.34  LDD1761  [13]
C067
 Probe Info  		8.11  LDD1763  [13]
C070
 Probe Info  		33.36  LDD1766  [13]
C071
 Probe Info  		9.00  LDD1767  [13]
C072
 Probe Info  		17.88  LDD1768  [13]
C082
 Probe Info  		19.97  LDD1774  [13]
C083
 Probe Info  		5.06  LDD1775  [13]
C085
 Probe Info  		10.41  LDD1777  [13]
C087
 Probe Info  		20.82  LDD1779  [13]
C091
 Probe Info  		55.33  LDD1782  [13]
C092
 Probe Info  		60.13  LDD1783  [13]
C093
 Probe Info  		4.92  LDD1784  [13]
C094
 Probe Info  		69.07  LDD1785  [13]
C106
 Probe Info  		62.68  LDD1793  [13]
C107
 Probe Info  		31.34  LDD1794  [13]
C108
 Probe Info  		48.50  LDD1795  [13]
C112
 Probe Info  		36.25  LDD1799  [13]
C129
 Probe Info  		14.12  LDD1811  [13]
C130
 Probe Info  		23.59  LDD1812  [13]
C134
 Probe Info  		62.68  LDD1816  [13]
C135
 Probe Info  		40.50  LDD1817  [13]
C139
 Probe Info  		25.99  LDD1821  [13]
C140
 Probe Info  		20.68  LDD1822  [13]
C141
 Probe Info  		40.22  LDD1823  [13]
C143
 Probe Info  		46.85  LDD1825  [13]
C145
 Probe Info  		9.51  LDD1827  [13]
C147
 Probe Info  		12.64  LDD1829  [13]
C153
 Probe Info  		56.49  LDD1834  [13]
C156
 Probe Info  		16.00  LDD1836  [13]
C159
 Probe Info  		27.67  LDD1839  [13]
C160
 Probe Info  		26.17  LDD1840  [13]
C161
 Probe Info  		38.59  LDD1841  [13]
C163
 Probe Info  		14.03  LDD1843  [13]
C165
 Probe Info  		15.45  LDD1845  [13]
C166
 Probe Info  		10.27  LDD1846  [13]
C169
 Probe Info  		48.17  LDD1849  [13]
C170
 Probe Info  		8.06  LDD1850  [13]
C173
 Probe Info  		5.98  LDD1853  [13]
C174
 Probe Info  		5.90  LDD1854  [13]
C177
 Probe Info  		17.27  LDD1856  [13]
C178
 Probe Info  		68.12  LDD1857  [13]
C183
 Probe Info  		13.45  LDD1861  [13]
C185
 Probe Info  		6.23  LDD1863  [13]
C186
 Probe Info  		28.25  LDD1864  [13]
C194
 Probe Info  		22.63  LDD1870  [13]
C196
 Probe Info  		20.11  LDD1872  [13]
C197
 Probe Info  		7.11  LDD1873  [13]
C198
 Probe Info  		25.11  LDD1874  [13]
C199
 Probe Info  		5.06  LDD1875  [13]
C201
 Probe Info  		53.45  LDD1877  [13]
C206
 Probe Info  		41.64  LDD1881  [13]
C207
 Probe Info  		22.94  LDD1882  [13]
C210
 Probe Info  		70.03  LDD1884  [13]
C211
 Probe Info  		20.11  LDD1885  [13]
C213
 Probe Info  		28.64  LDD1887  [13]
C214
 Probe Info  		6.63  LDD1888  [13]
C215
 Probe Info  		5.06  LDD1889  [13]
C216
 Probe Info  		11.31  LDD1890  [13]
C217
 Probe Info  		7.67  LDD1891  [13]
C218
 Probe Info  		71.01  LDD1892  [13]
C219
 Probe Info  		46.85  LDD1893  [13]
C220
 Probe Info  		73.52  LDD1894  [13]
C225
 Probe Info  		11.63  LDD1898  [13]
C226
 Probe Info  		13.00  LDD1899  [13]
C228
 Probe Info  		30.70  LDD1901  [13]
C229
 Probe Info  		14.42  LDD1902  [13]
C231
 Probe Info  		32.67  LDD1904  [13]
C232
 Probe Info  		45.57  LDD1905  [13]
C233
 Probe Info  		25.81  LDD1906  [13]
C234
 Probe Info  		24.59  LDD1907  [13]
C235
 Probe Info  		47.50  LDD1908  [13]
C238
 Probe Info  		50.21  LDD1911  [13]
C239
 Probe Info  		6.87  LDD1912  [13]
C240
 Probe Info  		36.25  LDD1913  [13]
C243
 Probe Info  		40.22  LDD1916  [13]
C244
 Probe Info  		27.86  LDD1917  [13]
C245
 Probe Info  		23.59  LDD1918  [13]
C246
 Probe Info  		36.00  LDD1919  [13]
C249
 Probe Info  		34.30  LDD1922  [13]
C258
 Probe Info  		5.35  LDD1931  [13]
C264
 Probe Info  		99.73  LDD1935  [13]
C265
 Probe Info  		88.03  LDD1936  [13]
C266
 Probe Info  		21.56  LDD1937  [13]
C269
 Probe Info  		25.11  LDD1939  [13]
C270
 Probe Info  		79.34  LDD1940  [13]
C271
 Probe Info  		5.62  LDD1941  [13]
C273
 Probe Info  		12.91  LDD1943  [13]
C277
 Probe Info  		21.56  LDD1947  [13]
C285
 Probe Info  		34.30  LDD1955  [13]
C286
 Probe Info  		6.82  LDD1956  [13]
C287
 Probe Info  		34.06  LDD1957  [13]
C288
 Probe Info  		17.75  LDD1958  [13]
C289
 Probe Info  		53.45  LDD1959  [13]
C290
 Probe Info  		8.82  LDD1960  [13]
C293
 Probe Info  		22.01  LDD1963  [13]
C296
 Probe Info  		19.43  LDD1966  [13]
C299
 Probe Info  		27.28  LDD1968  [13]
C301
 Probe Info  		9.13  LDD1970  [13]
C303
 Probe Info  		8.63  LDD1972  [13]
C304
 Probe Info  		13.18  LDD1973  [13]
C305
 Probe Info  		46.21  LDD1974  [13]
C307
 Probe Info  		7.16  LDD1975  [13]
C310
 Probe Info  		10.56  LDD1977  [13]
C313
 Probe Info  		16.34  LDD1980  [13]
C314
 Probe Info  		26.17  LDD1981  [13]
C317
 Probe Info  		6.92  LDD1983  [13]
C320
 Probe Info  		6.63  LDD1986  [13]
C322
 Probe Info  		13.27  LDD1988  [13]
C326
 Probe Info  		45.57  LDD1990  [13]
C327
 Probe Info  		5.90  LDD1991  [13]
C333
 Probe Info  		18.13  LDD1996  [13]
C348
 Probe Info  		29.45  LDD2009  [13]
C349
 Probe Info  		34.54  LDD2010  [13]
C350
 Probe Info  		66.72  LDD2011  [13]
C351
 Probe Info  		5.86  LDD2012  [13]
C353
 Probe Info  		7.21  LDD2014  [13]
C354
 Probe Info  		15.78  LDD2015  [13]
C355
 Probe Info  		28.05  LDD2016  [13]
C356
 Probe Info  		15.67  LDD2017  [13]
C357
 Probe Info  		9.85  LDD2018  [13]
C362
 Probe Info  		49.52  LDD2023  [13]
C363
 Probe Info  		28.44  LDD2024  [13]
C364
 Probe Info  		28.84  LDD2025  [13]
C366
 Probe Info  		17.88  LDD2027  [13]
C367
 Probe Info  		4.92  LDD2028  [13]
C373
 Probe Info  		13.55  LDD2033  [13]
C376
 Probe Info  		15.03  LDD2036  [13]
C378
 Probe Info  		9.71  LDD2037  [13]
C380
 Probe Info  		7.89  LDD2039  [13]
C382
 Probe Info  		23.26  LDD2041  [13]
C383
 Probe Info  		19.43  LDD2042  [13]
C386
 Probe Info  		13.27  LDD2045  [13]
C387
 Probe Info  		7.21  LDD2046  [13]
C388
 Probe Info  		90.51  LDD2047  [13]
C399
 Probe Info  		17.75  LDD2058  [13]
C403
 Probe Info  		29.86  LDD2061  [13]
C405
 Probe Info  		10.85  LDD2063  [13]
C407
 Probe Info  		56.89  LDD2064  [13]
C408
 Probe Info  		9.32  LDD2065  [13]
C409
 Probe Info  		22.16  LDD2066  [13]
C413
 Probe Info  		42.22  LDD2069  [13]
C414
 Probe Info  		9.51  LDD2070  [13]
C416
 Probe Info  		10.56  LDD2071  [13]
C424
 Probe Info  		26.72  LDD2079  [13]
C426
 Probe Info  		61.39  LDD2081  [13]
C428
 Probe Info  		5.17  LDD2083  [13]
C429
 Probe Info  		52.71  LDD2084  [13]
C430
 Probe Info  		5.06  LDD2085  [13]
C431
 Probe Info  		70.03  LDD2086  [13]
C433
 Probe Info  		13.18  LDD2088  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
A-DA
 Probe Info  		2.48  LDD0145  [15]
OEA-DA
 Probe Info  		20.00  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C124(2.09)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C124(0.99)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C124(0.92)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C124(1.20)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C124(1.23)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C124(1.25)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C124(1.25)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C124(1.14)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C124(1.16)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C124(1.40)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C124(1.20)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C124(1.21)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C124(1.14)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C124(1.01)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C124(1.23)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C124(1.21)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C124(1.25)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C124(1.05)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C124(0.96)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C124(0.90)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C124(1.12)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C124(1.10)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C124(1.09)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C124(1.01)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C124(0.93)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C124(0.96)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C124(1.15)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C124(0.97)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C124(0.92)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C124(0.95)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C124(0.89)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C124(0.84)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C124(0.96)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C124(1.25)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C124(1.10)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C124(1.42)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C124(1.05)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C124(1.00)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C124(1.20)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C124(1.84)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C124(1.45)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C124(1.02)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C124(1.00)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C124(1.35)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C124(1.72)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C124(0.87)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C124(1.39)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C124(1.28)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C124(1.05)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C124(1.16)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C124(0.89)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C124(1.04)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C124(0.90)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C124(1.19)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C124(0.97)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C124(0.98)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C124(0.87)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C124(1.12)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C124(1.08)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C124(0.87)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C124(0.89)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C124(0.87)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C124(0.83)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C124(1.09)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C124(0.88)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C124(0.93)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C124(1.03)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C124(1.12)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C124(1.01)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C124(1.04)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C124(1.01)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C124(1.08)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C124(0.99)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C124(0.90)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C124(0.96)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C124(1.24)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C124(1.31)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C124(1.28)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C124(1.36)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C124(0.95)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C124(1.22)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C124(1.11)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C124(1.36)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C124(1.30)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C124(1.34)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C124(0.89)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C124(1.01)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C124(0.90)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C124(0.89)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C124(1.04)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C124(1.05)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C124(0.89)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C124(1.19)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C124(1.14)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C124(1.12)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C124(1.16)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C124(1.01)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C124(1.27)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C124(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C124(1.13)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C124(1.21)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C124(0.97)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C124(1.27)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C124(1.18)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C124(1.13)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C124(1.14)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C124(1.09)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C124(1.14)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C124(1.12)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C124(1.03)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C124(1.24)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C124(1.31)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C124(0.98)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C124(1.20)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C124(1.08)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C124(1.17)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C124(1.31)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C124(1.03)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C124(1.04)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C124(1.08)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C124(1.21)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C124(0.82)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C124(0.94)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C124(1.00)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C124(1.25)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C124(0.95)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C124(1.32)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C124(1.32)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C124(1.00)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C124(1.06)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C124(1.12)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C124(0.75)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C124(1.01)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C124(1.00)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C124(1.03)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C124(0.87)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C124(0.92)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C124(0.95)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C124(1.25)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C124(1.25)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C124(1.33)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C124(1.30)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C124(1.18)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C124(1.40)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C124(1.30)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C124(1.37)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C124(1.21)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C124(1.31)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C124(1.19)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C124(1.21)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C124(1.34)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C124(1.18)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C124(1.38)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C124(1.43)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C124(1.23)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C124(0.93)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C124(1.07)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C124(1.12)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 9.49  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C124(1.11)  LDD2171  [6]
 LDCM0367  CL1 HCT 116 C124(0.99)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C124(1.11)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C124(1.01)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C124(0.91)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C124(1.23)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C124(0.98)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C124(0.96)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C124(0.93)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C124(0.94)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C124(0.92)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C124(1.10)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C124(1.08)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C124(0.94)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C124(1.10)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C124(1.13)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C124(1.06)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C124(1.25)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C124(1.28)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C124(1.22)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C124(1.13)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C124(1.06)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C124(1.20)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C124(1.02)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C124(0.95)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C124(1.20)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C124(0.99)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C124(1.15)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C124(1.30)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C124(1.18)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C124(1.19)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C124(1.31)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C124(1.19)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C124(1.00)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C124(1.03)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C124(1.02)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C124(0.99)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C124(1.14)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C124(1.17)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C124(1.25)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C124(1.10)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C124(0.99)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C124(1.26)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C124(1.24)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C124(1.01)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C124(0.95)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C124(1.23)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C124(1.27)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C124(1.20)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C124(1.11)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C124(1.24)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C124(1.18)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C124(1.01)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C124(1.16)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C124(1.06)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C124(1.11)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C124(1.29)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C124(0.96)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C124(1.11)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C124(1.11)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C124(1.13)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C124(1.10)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C124(1.24)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C124(1.31)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C124(1.04)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C124(0.97)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C124(1.07)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C124(1.18)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C124(1.16)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C124(1.03)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C124(1.01)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C124(0.86)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C124(1.11)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C124(0.87)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C124(1.21)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C124(1.49)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C124(1.32)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C124(1.07)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C124(1.02)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C124(1.16)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C124(1.08)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C124(1.09)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C124(1.18)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C124(1.05)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C124(0.96)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C124(1.02)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C124(1.33)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C124(1.08)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C124(1.42)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C124(1.34)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C124(1.37)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C124(1.58)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C124(1.12)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C124(1.27)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C124(1.14)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C124(0.95)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C124(1.27)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C124(1.29)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C124(1.16)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C124(1.18)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C124(1.19)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C124(0.89)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C124(1.01)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C124(1.04)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C124(0.98)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C124(1.21)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C124(0.93)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C124(1.10)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C124(0.94)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C124(1.13)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C124(1.23)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C124(1.05)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C124(0.97)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C124(1.16)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C124(1.02)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C124(1.11)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C124(1.12)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C124(1.17)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C124(1.09)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C124(0.97)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C124(1.17)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C124(0.91)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C124(1.17)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C124(1.05)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C124(1.04)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C124(1.06)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C124(0.96)  LDD0811  [6]
 LDCM0028  Dobutamine HEK-293T 11.91  LDD0180  [4]
 LDCM0027  Dopamine HEK-293T 7.97  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C124(1.06)  LDD1698  [17]
 LDCM0625  F8 Ramos C124(1.54)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C124(6.78)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C124(0.54)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C124(1.89)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C124(1.23)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C124(1.84)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C124(2.51)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C124(1.11)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C124(1.03)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C124(1.05)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C124(0.78)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C124(1.64)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C124(0.95)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C124(5.83)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C124(1.46)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C124(1.17)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C124(1.38)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C124(1.69)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C124(1.58)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C124(1.69)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C124(1.92)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C124(2.88)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C124(2.49)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C124(2.60)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C124(3.83)  LDD0082  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C124(0.29)  LDD2108  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C124(0.92)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C124(0.85)  LDD2207  [19]
 LDCM0029  Quercetin HEK-293T 7.53  LDD0181  [4]
 LDCM0084  Ro 48-8071 A-549 2.48  LDD0145  [15]
 LDCM0021  THZ1 HCT 116 C124(1.11)  LDD2173  [6]
 LDCM0111  W14 Hep-G2 C124(5.32)  LDD0238  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Erlin-1 (ERLIN1) Band 7/mec-2 family O75477
Sodium/bile acid cotransporter 4 (SLC10A4) Bile acid:sodium symporter (BASS) family Q96EP9
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CMRF35-like molecule 8 (CD300A) CD300 family Q9UGN4
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Bcl-2-interacting killer (BIK) . Q13323
Protein KASH5 (KASH5) . Q8N6L0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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