Details of the Target

General Information of Target

Target ID LDTP07831
Target Name Transmembrane protein with metallophosphoesterase domain (TMPPE)
Gene Name TMPPE
Gene ID 643853
Synonyms
Transmembrane protein with metallophosphoesterase domain; EC 3.1.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAIFRQLSLGAKATLAAVTVFVSMIASRSYLAESLELRAWRWLLRLQLALFVNSLLLIGS
LYIWRSTVSNLCHSPAAESTCFQLWKVVVLAFLALAHSSFFTMFFLVAEEPYLFSLAAYS
CLGAYIIMLFFLFILSGMEQAYQLLAWRSGRVVGSLEKTRKLVLRPALAVGVTAVLSVAG
ILNAAQPPAVKTVEVPIHQLPASMNNLKIVLLSDIHLGPTVGRTKMEMFVRMVNVLEPDI
TVIVGDLSDSEASVLRTAVAPLGQLHSHLGAYFVTGNHEYYTSDVSNWFALLESLHVQPL
HNENVKISATRAQRGGGGSGSGSEDEDWICLAGVDDIEADILHYSGHGMDLDKALEGCSP
DHTIILLAHQPLAAKRALQARPDINLILSGHTHAGQIFPLNVAAYLLNPFFAGLYQVAQA
TFVYVSPGTAYYGIPMRLGSRAEITELILQRSP
Target Bioclass
Enzyme
Family
Metallophosphoesterase superfamily, LOC643853 family
Subcellular location
Membrane
Uniprot ID
Q6ZT21
Ensemble ID
ENST00000342462.5
HGNC ID
HGNC:33865

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.F130V .
IGROV1 SNV: p.A309D .
KYSE510 SNV: p.P219S .
MIAPACA2 SNV: p.A117G .
PC9 SNV: p.P75Q .
RKO SNV: p.T192A; p.E279D .
SNGM SNV: p.S136N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.95  LDD0197  [1]
STPyne
 Probe Info  		K225(2.48)  LDD0277  [2]
IPM
 Probe Info  		C358(0.88)  LDD1701  [3]
PAL-AfBPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		14.12  LDD1740  [4]
C041
 Probe Info  		8.88  LDD1741  [4]
C059
 Probe Info  		10.27  LDD1756  [4]
C082
 Probe Info  		9.45  LDD1774  [4]
C085
 Probe Info  		7.62  LDD1777  [4]
C087
 Probe Info  		8.51  LDD1779  [4]
C112
 Probe Info  		22.63  LDD1799  [4]
C130
 Probe Info  		6.87  LDD1812  [4]
C152
 Probe Info  		8.28  LDD1833  [4]
C153
 Probe Info  		24.59  LDD1834  [4]
C156
 Probe Info  		5.50  LDD1836  [4]
C158
 Probe Info  		13.83  LDD1838  [4]
C159
 Probe Info  		16.34  LDD1839  [4]
C160
 Probe Info  		12.30  LDD1840  [4]
C161
 Probe Info  		16.11  LDD1841  [4]
C169
 Probe Info  		35.02  LDD1849  [4]
C170
 Probe Info  		11.79  LDD1850  [4]
C194
 Probe Info  		9.99  LDD1870  [4]
C198
 Probe Info  		12.13  LDD1874  [4]
C199
 Probe Info  		6.82  LDD1875  [4]
C201
 Probe Info  		30.48  LDD1877  [4]
C206
 Probe Info  		27.10  LDD1881  [4]
C211
 Probe Info  		10.27  LDD1885  [4]
C216
 Probe Info  		7.01  LDD1890  [4]
C217
 Probe Info  		11.16  LDD1891  [4]
C218
 Probe Info  		74.03  LDD1892  [4]
C219
 Probe Info  		9.65  LDD1893  [4]
C220
 Probe Info  		41.36  LDD1894  [4]
C232
 Probe Info  		40.50  LDD1905  [4]
C235
 Probe Info  		79.34  LDD1908  [4]
C243
 Probe Info  		39.12  LDD1916  [4]
C244
 Probe Info  		23.59  LDD1917  [4]
C245
 Probe Info  		11.79  LDD1918  [4]
C246
 Probe Info  		36.50  LDD1919  [4]
C249
 Probe Info  		20.39  LDD1922  [4]
C369
 Probe Info  		5.43  LDD2030  [4]
C373
 Probe Info  		62.68  LDD2033  [4]
C376
 Probe Info  		16.11  LDD2036  [4]
C378
 Probe Info  		7.41  LDD2037  [4]
C380
 Probe Info  		6.11  LDD2039  [4]
C382
 Probe Info  		15.03  LDD2041  [4]
C424
 Probe Info  		15.14  LDD2079  [4]
C426
 Probe Info  		13.83  LDD2081  [4]
LD-F
 Probe Info  		D239(0.00); V254(0.00); S250(0.00); D246(0.00)  LDD0015  [5]
OEA-DA
 Probe Info  		19.94  LDD0046  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0023  KB03 MDA-MB-231 C358(0.88)  LDD1701  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
Phospholipid phosphatase-related protein type 1 (PLPPR1) PA-phosphatase related phosphoesterase family Q8TBJ4
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid symporter 1 (SLC38A1) Amino acid/polyamine transporter 2 family Q9H2H9
Clarin-1 (CLRN1) Clarin family P58418
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
B-lymphocyte antigen CD20 (MS4A1) MS4A family P11836
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-3 (STX3) Syntaxin family Q13277
Protein YIPF1 (YIPF1) YIP1 family Q9Y548
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cannabinoid receptor 2 (CNR2) G-protein coupled receptor 1 family P34972
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
SLAM family member 6 (SLAMF6) . Q96DU3
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Mitochondrial fission 1 protein (FIS1) FIS1 family Q9Y3D6
Plasmolipin (PLLP) MAL family Q9Y342
Claudin domain-containing protein 2 (CLDND2) PMP-22/EMP/MP20 family Q8NHS1
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Sideroflexin-5 (SFXN5) Sideroflexin family Q8TD22
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
LEM domain-containing protein 1 (LEMD1) . Q68G75
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
6 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570