Details of the Target

General Information of Target

Target ID LDTP03952
Target Name Reduced folate transporter (SLC19A1)
Gene Name SLC19A1
Gene ID 6573
Synonyms
FLOT1; RFC1; Reduced folate transporter; FOLT; Cyclic dinucleotide:anion antiporter SLC19A1; Folate:anion antiporter SLC19A1; Intestinal folate carrier 1; IFC-1; Placental folate transporter; Reduced folate carrier protein; RFC; hRFC; Reduced folate transporter 1; RFT-1; Solute carrier family 19 member 1; hSLC19A1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Subcellular location
Cell membrane
Function
Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity.
TTD ID
T35465
Uniprot ID
P41440
DrugMap ID
TT09I7D
Ensemble ID
ENST00000311124.9
HGNC ID
HGNC:10937
ChEMBL ID
CHEMBL4833

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.T65M .
CAL51 SNV: p.S127N .
CCK81 SNV: p.V8M; p.A302V .
ETK1 SNV: p.A407V .
HT3 SNV: p.G449A .
IPC298 SNV: p.V350G .
JURKAT SNV: p.M122I; p.V175I Compound 10    Probe Info 
MOLT4 SNV: p.R91H; p.V144L IA-alkyne    Probe Info 
NCIH358 SNV: p.A340S .
RKO SNV: p.R253W .
SKMEL24 Substitution: p.R23W .
SSP25 SNV: p.A407V .
TOV21G SNV: p.A318T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C246(5.57)  LDD0169  [1]
Alkyne-RA190
 Probe Info  		2.30  LDD0300  [2]
DBIA
 Probe Info  		C220(0.97); C246(0.85)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
TFBX
 Probe Info  		C580(0.00); C246(0.00); C220(0.00)  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
IPM
 Probe Info  		C580(0.00); C220(0.00)  LDD0147  [6]
VSF
 Probe Info  		N.A.  LDD0007  [7]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.54  LDD1725  [9]
C040
 Probe Info  		7.16  LDD1740  [9]
C058
 Probe Info  		5.43  LDD1755  [9]
C082
 Probe Info  		4.99  LDD1774  [9]
C091
 Probe Info  		13.83  LDD1782  [9]
C092
 Probe Info  		20.39  LDD1783  [9]
C094
 Probe Info  		23.59  LDD1785  [9]
C136
 Probe Info  		5.06  LDD1818  [9]
C138
 Probe Info  		5.31  LDD1820  [9]
C161
 Probe Info  		11.00  LDD1841  [9]
C170
 Probe Info  		7.84  LDD1850  [9]
C173
 Probe Info  		6.87  LDD1853  [9]
C176
 Probe Info  		5.06  LDD1855  [9]
C177
 Probe Info  		8.69  LDD1856  [9]
C191
 Probe Info  		10.27  LDD1868  [9]
C229
 Probe Info  		7.11  LDD1902  [9]
C234
 Probe Info  		11.16  LDD1907  [9]
C275
 Probe Info  		6.50  LDD1945  [9]
C280
 Probe Info  		10.63  LDD1950  [9]
C322
 Probe Info  		5.94  LDD1988  [9]
C342
 Probe Info  		6.02  LDD2004  [9]
C347
 Probe Info  		5.54  LDD2008  [9]
C429
 Probe Info  		11.08  LDD2084  [9]
C432
 Probe Info  		5.66  LDD2087  [9]
C433
 Probe Info  		8.57  LDD2088  [9]
FFF probe11
 Probe Info  		20.00  LDD0471  [10]
FFF probe12
 Probe Info  		15.91  LDD0473  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]
OEA-DA
 Probe Info  		10.28  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C246(5.57)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C246(1.13); C580(1.09)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C246(1.09)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C220(2.02); C246(1.18)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C220(1.74); C246(1.14)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C220(1.45); C246(1.23)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C220(1.45); C246(1.74)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C220(1.07); C246(1.32)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C220(1.36); C246(1.23)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C220(2.04); C246(1.46)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C220(1.39); C246(1.54)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C220(1.26); C246(1.06)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C220(1.41); C246(1.09)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C246(1.13)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C220(2.38); C246(1.30)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C220(1.73); C246(1.17)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C220(1.68); C246(1.30)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C246(0.89)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C246(1.10)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C246(1.18)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C246(1.18)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C246(1.10)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C246(1.02)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C246(1.08)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C246(1.07)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C246(1.18)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C246(0.92)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C246(1.00)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C246(0.91)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C246(0.89)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C246(0.91)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C246(1.05)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C246(1.06)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C220(1.55); C246(0.74)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C220(1.02); C246(0.85)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C220(1.66); C246(0.93)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C220(1.29); C246(0.90)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C220(1.26); C246(1.21)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C220(1.48); C246(1.07)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C220(1.96); C246(0.94)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C220(2.12); C246(1.08)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C220(1.14); C246(1.44)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C220(0.87); C246(0.96)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C220(1.48); C246(1.16)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C220(1.73); C246(1.41)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C246(1.17)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C220(1.68); C246(1.48)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C220(1.34); C246(1.47)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C220(1.71); C246(1.23)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C220(0.88); C246(1.13)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C246(0.98); C220(1.26)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C246(1.00); C220(1.15)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C246(1.08); C220(1.18)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C246(0.95); C220(1.46)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C246(1.04); C220(1.65)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C246(1.09); C220(1.71)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C246(1.24)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C246(0.95); C220(1.20)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C246(1.32); C220(1.41)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C246(1.07); C220(1.11)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C246(1.16); C220(1.84)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C220(1.16); C246(1.00)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C220(1.15); C246(1.11)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C220(1.20); C246(1.04)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C220(1.18); C246(1.03)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C580(1.03); C246(1.05)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C246(0.82); C580(1.11)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C246(0.94); C580(1.17)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C246(1.04); C580(1.22)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C246(1.01); C580(1.17)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C580(0.98); C246(1.23)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C246(0.96); C580(1.03)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C246(0.92); C580(0.98)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C580(0.89); C246(1.01)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C246(1.15); C580(1.18)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C246(1.30); C580(1.36)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C246(1.27); C580(1.37)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C580(1.24); C246(1.50)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C246(1.23); C580(1.31)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C580(1.12); C246(1.19)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C580(1.25); C246(1.61)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C246(1.47); C580(1.91)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C246(1.56); C580(1.86)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C246(1.53); C580(1.88)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C246(1.40); C580(1.75)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C246(0.87); C220(0.95)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C246(0.84); C220(1.32)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C246(0.77); C220(1.00)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C246(0.97); C220(1.31)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C246(0.98); C220(1.28)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C580(1.06); C246(1.07)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C246(0.93); C220(1.36)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C246(0.94); C220(1.12)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C246(0.92); C220(1.42)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C246(1.03); C220(1.48)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C246(0.91); C220(1.31)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C246(1.13); C220(1.20)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C246(1.17)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C246(1.38)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C246(1.54)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C246(1.16)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C580(0.98); C246(1.05)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C246(1.27)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C246(1.22)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C246(1.10)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C246(0.96)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C246(1.11)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C246(1.06)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C246(1.02)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C246(1.10); C580(1.60)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C246(0.92); C580(1.53)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C246(0.96); C580(1.03)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C246(1.24)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C246(1.08); C580(1.52)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C246(1.05); C580(1.28)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C580(1.11); C246(1.22)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C246(1.22); C580(1.32)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C246(1.05); C580(1.34)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C246(1.11); C580(1.32)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C246(0.79); C580(1.39)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C246(1.09); C580(1.30)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C220(0.78); C246(1.19)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C220(0.86); C246(1.19)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C246(1.15)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C246(0.89); C220(0.90)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C220(0.80); C246(0.92)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C246(0.90); C220(0.93)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C220(1.09); C246(1.14)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C246(0.65); C220(1.12)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C246(0.92); C220(1.24)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C246(0.81); C220(1.05)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C246(0.84); C220(1.16)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C246(0.74); C220(1.02)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C220(0.84); C246(0.95)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C246(1.17)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C246(0.79); C220(0.88)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C220(0.61); C246(0.88)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C246(0.74); C220(1.13)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C580(1.30); C246(1.65); C220(1.73)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C580(1.00); C220(1.45); C246(1.93)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C580(0.97); C220(1.13); C246(1.53)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C580(1.04); C220(1.34); C246(1.40)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C220(0.76); C580(1.02); C246(1.26)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C220(1.00); C246(1.44); C580(1.59)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C580(1.38); C246(1.71); C220(1.86)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C580(1.16); C246(1.24); C220(1.55)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C580(1.10); C246(1.76); C220(1.87)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C580(0.93); C246(1.59); C220(1.97)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C220(0.85); C580(0.95); C246(1.50)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C220(0.73); C580(0.87); C246(1.41)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C220(0.89); C580(1.03); C246(1.19)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C580(0.81); C246(1.18); C220(1.41)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C220(1.25); C580(1.29); C246(1.42)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C220(1.57); C246(1.83)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C246(1.19); C220(1.31)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C246(1.14)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C246(1.10)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C246(1.42)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C220(0.97); C246(0.85)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C246(0.91); C580(0.96); C220(1.07)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C246(0.95); C580(1.12); C220(1.14)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C246(0.98); C580(1.23)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C246(1.00)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C246(0.84)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C246(0.95)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C246(1.00)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C246(0.95); C580(1.10)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C580(0.98); C246(1.01)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C246(0.94); C580(1.14)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C246(0.94); C580(0.98)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C246(1.09); C580(1.14)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C220(0.90); C580(0.93); C246(0.96)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C246(0.91); C580(1.01)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C580(0.96); C246(1.16)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C580(1.06); C246(1.19)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C580(1.37); C246(1.56)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C580(1.27); C246(1.33)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C246(1.40); C580(1.52)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C246(1.23); C580(1.72)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C246(1.36); C220(1.43)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C246(0.95); C220(1.16)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C246(1.05); C220(1.46)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C220(1.02); C246(1.19); C580(1.40)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C246(1.03); C220(1.16)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C246(1.22)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C246(1.07)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C246(1.31)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C246(1.09)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C246(1.10); C580(1.18)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C246(0.91); C580(1.19)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C246(1.06); C580(1.18)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C246(0.99); C580(1.29)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C580(0.96); C246(1.03); C220(1.17)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C246(0.82); C580(1.04); C220(1.15)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C246(0.79); C580(0.96); C220(1.12)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C246(1.39)  LDD1001  [3]
 LDCM0404  CL17 HCT 116 C246(1.03)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C246(1.09)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C246(0.96)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C246(0.77); C220(0.85); C580(1.07)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C246(1.15)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C246(2.06)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C246(0.96)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C246(0.97)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C246(1.07)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C246(1.02)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C246(1.09)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C246(0.99)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C246(0.92)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C246(1.00)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C220(1.09); C246(0.89); C580(0.95)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C246(0.98)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C220(0.96); C246(1.33); C580(0.91)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C220(1.14); C246(1.13); C580(1.11)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C220(1.29); C246(1.08); C580(1.21)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C220(1.53); C246(1.42); C580(1.14)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C220(0.91); C246(1.34); C580(0.96)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C220(1.31); C246(1.57); C580(1.17)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C220(0.85); C246(1.11); C580(1.31)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C220(0.96); C246(1.32); C580(1.26)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C220(1.14); C246(2.03); C580(0.94)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C220(0.99); C246(1.81); C580(1.10)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C220(1.04); C246(1.37); C580(1.44)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C220(1.02); C246(1.45); C580(1.05)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C220(1.23); C246(1.46); C580(1.26)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C220(1.11); C246(1.42); C580(1.15)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C220(1.45); C246(1.64); C580(1.11)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C220(0.42); C246(0.97)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C220(0.60); C246(1.09)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C220(0.64); C246(1.06)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C220(0.55); C246(0.97)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C220(1.00); C246(0.95); C580(1.04)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C220(0.58); C246(0.93)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C220(0.90); C246(1.01)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C220(0.80); C246(1.16)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C220(0.69); C246(1.32)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C220(0.59); C246(1.14)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C220(0.49); C246(1.00)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C220(0.69); C246(1.01)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C220(0.47); C246(0.98)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C220(0.71); C246(1.01)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C220(0.58); C246(1.06)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C220(0.96); C246(1.07); C580(1.08)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C220(0.56); C246(1.07)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C220(1.25); C246(1.28)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C220(1.19); C246(1.29)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C220(1.51); C246(1.40)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C220(0.97); C246(1.35)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C220(0.99); C246(1.14)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C220(1.29); C246(1.46)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C220(0.76); C246(1.27)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C220(0.99); C246(1.10)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C220(1.02); C246(1.21)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C220(1.13); C246(0.97); C580(1.18)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C220(0.82); C246(1.20)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C220(1.09); C246(0.95)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C220(1.22); C246(1.09)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C220(1.21); C246(1.08)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C220(1.13); C246(1.02)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C220(0.70); C246(0.99)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C220(1.07); C246(0.92)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C220(0.77); C246(1.00)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C220(0.94); C246(1.22)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C220(1.10); C246(1.02); C580(0.85)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C220(0.77); C246(0.91)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C220(1.04); C246(1.11)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C220(1.02); C246(1.32)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C220(0.85); C246(1.18)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C220(0.86); C246(1.43)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C220(0.70); C246(0.99)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C220(0.89); C246(1.07)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C220(0.80); C246(0.99)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C220(0.84); C246(1.25)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C220(1.00); C246(1.70)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C220(1.28); C246(1.01); C580(0.93)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C220(1.00); C246(0.95)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C246(1.06); C580(0.89)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C246(1.01); C580(0.91)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C246(0.89); C580(1.08)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C246(0.86); C580(1.10)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C246(0.87); C580(0.88)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C246(1.07); C580(1.05)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C246(1.20); C580(1.02)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C246(1.10); C580(1.11)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C246(1.07); C580(0.89)  LDD0811  [3]
 LDCM0634  CY-0357 Hep-G2 C580(0.30)  LDD2228  [5]
 LDCM0495  E2913 HEK-293T C220(0.93); C246(0.89)  LDD1698  [13]
 LDCM0625  F8 Ramos C246(1.62); C220(1.33)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C246(0.25); C220(3.07)  LDD2190  [14]
 LDCM0575  Fragment13 Ramos C220(0.80)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C220(0.62)  LDD2193  [14]
 LDCM0580  Fragment21 Ramos C220(1.15)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C220(1.11)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C220(0.79)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C246(0.96); C220(0.95)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C220(1.26)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C220(0.85)  LDD2200  [14]
 LDCM0468  Fragment33 HCT 116 C220(1.07); C246(1.39)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C220(1.36); C246(2.10); C580(1.60)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C220(1.85)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C220(0.79)  LDD2205  [14]
 LDCM0022  KB02 HCT 116 C220(3.46)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C220(1.91)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C220(3.67)  LDD0082  [3]
 LDCM0131  RA190 MM1.R 2.30  LDD0300  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 26 (KRT26) Intermediate filament family Q7Z3Y9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Folic Acid Small molecular drug D0Z0DW
Methotrexate Small molecular drug D0SV8E
Pemetrexed Small molecular drug DB00642
Pralatrexate Small molecular drug DB06813
Trimetrexate Small molecular drug DB01157

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578