General Information of Experiment

Probe Name Dasatinib-CA-3PAP  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Dasatinib  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cell lysate (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 4.9
 LDTP03703  Trypsin-3 (PRSS3) 4.5
 LDTP04689  Adenosine kinase (ADK) 4.4
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 4.3
 LDTP02560  Breakpoint cluster region protein (BCR) .
 LDTP04631  Ephrin type-B receptor 4 (EPHB4) .
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) .
 LDTP06547  Mitogen-activated protein kinase 14 (MAPK14) .
 LDTP02638  Proto-oncogene tyrosine-protein kinase Src (SRC) .
 LDTP00751  Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) .
 LDTP01784  Tyrosine-protein kinase ABL1 (ABL1) .
 LDTP03991  Tyrosine-protein kinase ABL2 (ABL2) .
 LDTP05478  Tyrosine-protein kinase BTK (BTK) .
 LDTP02139  Tyrosine-protein kinase Fyn (FYN) .
 LDTP02232  Tyrosine-protein kinase Lyn (LYN) .
 LDTP02231  Tyrosine-protein kinase Yes (YES1) .
Other
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04107  Large ribosomal subunit protein eL21 (RPL21) 6.5
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6) 5.0
 LDTP06055  Eukaryotic translation initiation factor 3 subunit A (EIF3A) 4.5
 LDTP02292  U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) 4.0

References

1 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.