Details of the Target

General Information of Target

Target ID LDTP03703
Target Name Trypsin-3 (PRSS3)
Gene Name PRSS3
Gene ID 5646
Synonyms
PRSS4; TRY3; TRY4; Trypsin-3; EC 3.4.21.4; Brain trypsinogen; Mesotrypsin; Mesotrypsinogen; Serine protease 3; Serine protease 4; Trypsin III; Trypsin IV
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAAR
DADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH
CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV
STISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM
FCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTI
AANS
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.
Uniprot ID
P35030
Ensemble ID
ENST00000379405.4
HGNC ID
HGNC:9486
ChEMBL ID
CHEMBL4551

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C217(0.94); C228(0.94)  LDD0531  [1]
N1
 Probe Info  		D159(0.00); H153(0.00); Y156(0.00); N157(0.00)  LDD0245  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Dasatinib-CA-3PAP
 Probe Info  		4.50  LDD0365  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C217(0.94); C228(0.94)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C217(1.19); C228(1.54)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C217(0.98); C228(0.98)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C217(0.94); C228(0.94)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C217(0.93); C228(0.93)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C217(1.10); C228(1.10)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C217(1.04); C228(1.04)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C217(1.24); C228(1.24)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C217(1.19); C228(1.19)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C217(1.05); C228(0.82)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C217(0.76); C228(0.80)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C217(0.90); C228(2.42)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C217(1.45); C228(1.80)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C217(0.89); C228(1.82)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C217(0.95); C228(1.45)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C217(1.02); C228(1.11)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C217(0.87); C228(0.87)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C217(1.25); C228(1.05)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C217(1.43); C228(1.11)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C217(1.34); C228(1.18)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C217(1.04); C228(0.83)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C217(1.12); C228(1.18)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C217(1.37); C228(0.93)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C217(0.93); C228(1.14)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C217(1.18); C228(1.29)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C217(0.95); C228(0.99)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C217(0.95); C228(1.07)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C217(0.99); C228(0.84)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C217(1.14); C228(1.04)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C217(1.31); C228(1.10)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C217(1.42); C228(1.11)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C217(0.97); C228(1.17)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C217(0.72); C228(0.72)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C217(0.64); C228(0.64)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C217(0.69); C228(0.69)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C217(0.76); C228(0.76)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C217(0.77); C228(0.77)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C217(0.75); C228(0.75)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C217(0.85); C228(0.85)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C217(0.70); C228(0.70)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C217(0.84); C228(0.84)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C217(0.68); C228(0.68)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C217(0.69); C228(0.69)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C217(0.83); C228(0.83)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C217(1.23); C228(1.60)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C217(0.74); C228(0.74)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C217(0.79); C228(0.79)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C217(0.98); C228(0.98)  LDD0579  [1]
 LDCM0270  AC15 HCT 116 C217(1.20); C228(1.55)  LDD0587  [1]
 LDCM0279  AC2 HCT 116 C217(1.20); C228(1.20)  LDD0596  [1]
 LDCM0290  AC3 HCT 116 C217(1.01); C228(1.01)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C217(0.98); C228(0.98)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C217(1.01); C228(1.01)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C217(1.21); C228(1.21)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C217(1.39); C228(1.39)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C217(1.20); C228(1.20)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C217(1.32); C228(1.59)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C217(1.32); C228(1.32)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C217(1.20); C228(1.20)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C217(1.32); C228(1.32)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C217(1.17); C228(1.17)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C217(1.51); C228(1.51)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C217(1.47); C228(1.47)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C217(1.28); C228(1.28)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C217(1.42); C228(1.42)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C217(0.76); C228(0.76)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C217(0.70); C228(0.70)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C217(0.97); C228(1.18)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C217(0.91); C228(0.91)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C217(0.85); C228(0.85)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C217(1.02); C228(1.02)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C217(1.01); C228(1.01)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C217(0.92); C228(0.92)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C217(0.86); C228(0.86)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C217(0.85); C228(0.85)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C217(0.91); C228(0.91)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C217(0.84); C228(0.84)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C217(0.86); C228(0.86)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C217(1.29); C228(1.63)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C217(1.08); C228(1.08)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C217(0.87); C228(0.87)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C217(0.92); C228(0.92)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C217(1.42); C228(1.42)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C217(1.58); C228(1.58)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C217(1.38); C228(1.38)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C217(1.26); C228(1.26)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C217(1.00); C228(1.00)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C217(1.00); C228(1.00)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C217(1.20); C228(1.20)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C217(1.06); C228(1.06)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C217(1.50); C228(1.50)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C217(1.21); C228(1.21)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C217(1.01); C228(1.01)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C217(1.05); C228(1.05)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C217(0.97); C228(0.97)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C217(1.26); C228(1.26)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C217(1.30); C228(1.30)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C217(1.19); C228(1.19)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C217(0.99); C228(0.99)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C217(1.28); C228(1.67)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C217(1.16); C228(1.36)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C217(1.37); C228(1.88)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C217(1.02); C228(1.02)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C217(1.48); C228(1.48)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C217(0.87); C228(0.87)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C217(1.48); C228(2.09)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C217(1.12); C228(1.45)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C217(1.47); C228(2.13)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C217(1.10); C228(1.51)  LDD0690  [1]
 LDCM0379  CL11 HCT 116 C217(1.21); C228(1.21)  LDD0696  [1]
 LDCM0390  CL12 HCT 116 C217(1.37); C228(1.37)  LDD0707  [1]
 LDCM0396  CL125 HCT 116 C217(1.19); C228(1.19)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C217(1.41); C228(1.41)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C217(1.15); C228(1.15)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C217(1.30); C228(1.30)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C217(1.07); C228(1.07)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C217(1.42); C228(1.42)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C217(1.47); C228(1.47)  LDD0719  [1]
 LDCM0404  CL17 HCT 116 C217(1.13); C228(1.13)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C217(1.08); C228(1.08)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C217(1.03); C228(1.03)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C217(0.97); C228(0.97)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C217(1.13); C228(1.13)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C217(1.57); C228(1.57)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C217(1.09); C228(1.09)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C217(0.73); C228(0.73)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C217(1.06); C228(1.06)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C217(1.18); C228(1.18)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C217(1.02); C228(1.02)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C217(1.15); C228(1.15)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C217(1.41); C228(1.41)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C217(1.16); C228(1.16)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C217(1.10); C228(1.10)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C217(1.01); C228(1.01)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C217(1.00); C228(1.00)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C217(0.91); C228(0.91)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C217(1.75); C228(1.75)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C217(1.66); C228(1.66)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C217(0.85); C228(0.85)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C217(1.13); C228(1.13)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C217(1.94); C228(1.94)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C217(1.19); C228(1.19)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C217(1.08); C228(1.08)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C217(1.05); C228(1.05)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C217(0.90); C228(0.90)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C217(1.70); C228(1.70)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C217(1.20); C228(1.20)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C217(1.10); C228(1.10)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C217(1.79); C228(1.79)  LDD0752  [1]
 LDCM0440  CL5 HCT 116 C217(1.09); C228(1.09)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C217(1.57); C228(1.57)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C217(1.12); C228(1.12)  LDD0779  [1]
 LDCM0473  CL8 HCT 116 C217(1.52); C228(1.52)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C217(1.04); C228(1.04)  LDD0801  [1]
 LDCM0486  CL91 HCT 116 C217(1.09); C228(1.09)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C217(0.85); C228(0.85)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C217(0.92); C228(0.92)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C217(1.07); C228(1.07)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C217(1.07); C228(1.07)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C217(0.92); C228(0.92)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C217(1.34); C228(1.34)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C217(1.15); C228(1.15)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C217(1.07); C228(1.07)  LDD0811  [1]
 LDCM0097  Dasatinib K562 4.50  LDD0365  [3]
 LDCM0427  Fragment51 HCT 116 C217(1.44); C228(1.44)  LDD0744  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzamidine Small molecular drug DB03127
132-dioxaborolan-2-ol . DB04369
4-(132-dioxaborolan-2-yloxy)Butan-1-aminium . DB02308
4-(Hydroxymethyl)Benzamidine . DB02585
4-hydroxybutan-1-aminium . DB02541
Diamino-n-[3-(132-dioxaborolan-2-yloxy)Propyl]Methaniminium . DB03129
Guanidine-3-propanol . DB03637
[4-(132-dioxaborolan-2-yloxy)Methyl]Benzamidine . DB04109

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.