Details of the Target

General Information of Target

Target ID LDTP02139
Target Name Tyrosine-protein kinase Fyn (FYN)
Gene Name FYN
Gene ID 2534
Synonyms
Tyrosine-protein kinase Fyn; EC 2.7.10.2; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
Subcellular location
Cytoplasm
Function
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling.
TTD ID
T17980
Uniprot ID
P06241
DrugMap ID
TT2B9KF
Ensemble ID
ENST00000229471.8
HGNC ID
HGNC:4037
ChEMBL ID
CHEMBL1841

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.K505RfsTer53 .
HCT15 SNV: p.E521K .
HEC1 SNV: p.T15M; p.R392Q .
HEC1B SNV: p.T15M; p.R392Q .
HT115 SNV: p.R161Ter .
IPC298 SNV: p.R206C .
KMCH1 SNV: p.L187H .
RH41 Deletion: p.E419TfsTer51 .
SG231 SNV: p.P134A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K427(10.00)  LDD0275  [1]
DBIA
 Probe Info  		C246(0.95); C487(1.00)  LDD1492  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
TFBX
 Probe Info  		C240(0.00); C404(0.00); C246(0.00); C239(0.00)  LDD0148  [6]
Ox-W18
 Probe Info  		N.A.  LDD2175  [7]
AOyne
 Probe Info  		11.30  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Dasatinib-CA-3PAP
 Probe Info  		N.A.  LDD0365  [9]
Dasatinib-CA-8PAP
 Probe Info  		N.A.  LDD0364  [9]
DA-2
 Probe Info  		N.A.  LDD0072  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C246(0.87); C239(0.94)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C246(0.99); C239(0.90); C491(1.03)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C246(0.99); C404(0.95); C239(0.85)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C246(0.95); C404(0.95); C487(0.98); C239(1.06)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C246(0.98); C404(0.95); C487(1.24); C239(0.97)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C246(1.02); C404(0.89); C239(0.96)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C246(0.79); C239(1.01)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C246(1.00); C239(0.93); C491(0.93)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C246(0.90); C404(0.90); C239(0.81)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C246(1.02); C239(1.00); C491(0.98)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C246(0.93); C404(0.92); C487(1.08); C239(0.96)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C246(1.04); C239(1.00)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C246(0.98); C404(1.08); C487(1.20); C239(0.91)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C246(0.98); C404(0.93); C239(0.96)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C246(0.97); C487(1.12); C239(0.98)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C246(0.75); C239(0.95)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C246(0.97); C239(0.93); C491(1.04)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C246(0.99); C404(1.05); C239(0.88)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C246(0.99); C404(0.93); C487(1.07); C239(0.98)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C246(1.00); C239(1.07)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C246(0.93); C404(1.00); C239(0.89)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C246(1.02); C404(0.93); C487(1.21); C239(1.01)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C246(1.13); C404(0.94); C239(0.94)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C246(0.99); C487(1.06); C239(0.98)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C246(0.91); C239(0.90)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C246(1.02); C239(0.96); C491(0.98)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C246(1.00); C404(0.95); C239(0.95)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C246(0.99); C404(0.99); C487(1.02); C239(1.02)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C246(1.08); C239(1.07)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C246(0.94); C404(1.09); C487(1.30); C239(1.00)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C246(1.13); C404(0.95); C239(0.85)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C246(0.94); C404(0.95); C487(1.03); C239(0.94)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C246(0.95); C487(1.12); C239(0.93)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C246(0.89); C239(0.90)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C246(0.99); C239(0.91); C491(1.01)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C246(1.07); C404(0.96); C239(0.95)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C246(0.98); C404(0.96); C487(1.18); C239(0.95)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C246(1.05); C239(1.02)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C246(0.99); C404(0.95); C487(1.18); C239(0.99)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C246(1.13); C404(0.88); C239(0.90)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C246(1.00); C487(1.06); C239(0.89)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C246(0.85); C239(0.89)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C246(1.03); C239(1.03)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C246(1.02); C239(0.88); C491(1.04)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C246(0.87); C404(0.99); C239(0.86)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C246(0.93); C404(0.92); C487(1.00); C239(0.97)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C246(1.05); C239(1.00)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C246(0.98); C404(0.96); C487(1.04); C239(0.87)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C246(1.06); C404(0.98); C239(0.88)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C246(1.00); C487(1.07); C239(0.89)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C246(0.85); C239(0.97)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C246(1.05); C239(0.96); C491(1.01)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C246(0.88); C404(1.00); C239(0.93)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C246(0.90); C404(0.95); C487(1.05); C239(0.96)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C246(0.96); C404(0.98); C487(1.02); C239(1.00)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C246(1.05); C239(0.99)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C246(0.92); C404(0.95); C487(1.05); C239(0.99)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C246(1.06); C404(0.91); C239(0.95)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C246(1.03); C487(1.12); C239(0.99)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C246(1.06); C404(0.91); C239(0.94)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C246(0.99); C487(1.06); C239(0.98)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C246(1.05); C239(1.05)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C246(0.79); C239(0.94)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C246(0.95); C487(1.25); C239(0.94)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C246(0.97); C487(1.14); C239(0.98)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C246(1.20); C404(1.10); C487(1.18); C239(0.83)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C246(1.00); C404(1.01); C487(0.92); C239(0.91)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C246(0.93); C487(1.09); C239(0.99)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C246(0.96); C404(1.17); C239(0.93); C491(1.04)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C246(1.02); C404(0.95); C487(0.96); C239(0.88)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C246(1.04); C404(0.98); C487(1.02); C239(0.96)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C246(0.95); C487(1.21); C239(0.91)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C246(0.93); C404(1.05); C239(0.96); C491(0.94)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C246(0.97); C404(0.88); C487(1.01); C239(0.90)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C246(0.98); C404(1.07); C487(1.22); C239(0.98)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C246(0.95); C487(1.13); C239(1.02)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C246(1.17); C404(0.97); C239(0.93)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C246(0.94); C404(1.13); C239(0.91); C491(1.03)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C246(0.97); C404(0.91); C487(1.18); C239(0.86)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C246(1.02); C404(1.09); C487(0.90); C239(0.88)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C246(0.99); C487(1.10); C239(1.00)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C246(0.99); C404(1.20); C239(0.96); C491(1.15)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C246(1.09); C404(0.79); C487(1.02); C239(0.94)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C246(1.04); C404(0.99); C487(0.95); C239(0.90)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C246(0.98); C487(1.08); C239(1.02)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C246(0.94); C404(0.96); C239(0.96); C491(1.03)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C246(1.05); C404(0.99); C487(0.90); C239(0.92)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C246(1.00); C487(1.10); C239(0.97)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C246(1.02); C404(1.06); C487(1.13); C239(0.89)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C246(0.99); C487(1.16); C239(0.90)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C246(0.99); C404(1.09); C239(0.88); C491(0.99)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C246(1.06); C404(1.01); C487(1.00); C239(0.85)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C246(1.05); C404(1.00); C487(0.97); C239(0.79)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C246(0.99); C487(1.28); C239(0.95)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C246(1.03); C404(1.15); C239(0.93); C491(0.89)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C246(1.02); C404(0.95); C487(0.92); C239(0.94)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C246(0.98); C404(1.02); C487(0.95); C239(0.97)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C246(0.89); C487(1.18); C239(0.87)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C246(1.02); C404(1.05); C239(0.96); C491(1.12)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C246(1.07); C404(0.90); C487(0.90); C239(0.79)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C246(1.06); C404(1.04); C487(0.93); C239(0.91)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C246(0.88); C239(0.90)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C246(1.03); C239(0.94); C491(1.06)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C246(0.87); C404(1.02); C239(0.90)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C246(0.97); C404(1.13); C239(0.93); C491(0.92)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C246(1.02); C404(1.03); C487(0.89); C239(1.00)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C246(1.07); C239(0.93)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C246(1.08); C404(0.93); C487(1.12); C239(0.99)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C246(1.19); C404(0.89); C239(0.85)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C246(1.04); C487(1.22); C239(1.00)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C246(0.96); C487(1.04); C239(0.93)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C246(0.92); C404(0.95); C239(0.99); C491(1.06)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C246(1.02); C404(0.91); C487(1.04); C239(0.93)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C246(0.94); C404(0.96); C487(1.03); C239(0.96)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C246(0.86); C239(0.93)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C246(1.10); C404(0.87); C487(1.00); C239(0.89)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C246(1.04); C239(1.01); C491(1.00)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C246(1.22); C404(0.94); C239(0.91)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C246(1.00); C404(1.00); C487(0.95); C239(1.07)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C246(1.12); C239(0.86)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C246(1.10); C404(0.95); C487(1.15); C239(1.07)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C246(1.13); C404(0.87); C239(0.96)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C246(1.06); C487(1.18); C239(0.94)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C246(0.94); C487(1.21); C239(1.00)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C246(1.01); C404(0.76); C487(1.00); C239(0.89)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C246(1.04); C404(1.08); C487(0.86); C239(0.87)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C246(0.98); C404(1.04); C487(0.80); C239(0.92)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C246(0.81); C239(0.96)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C246(1.04); C239(1.00); C491(0.95)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C246(1.30); C404(1.02); C239(1.01)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C246(1.04); C404(0.93); C487(1.07); C239(1.05)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C246(1.09); C239(1.01)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C246(1.14); C404(1.03); C487(0.95); C239(1.06)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C246(1.23); C404(0.89); C239(0.99)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C246(1.04); C487(0.98); C239(0.99)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C246(1.01); C487(1.29); C239(0.94)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C246(1.07); C239(0.91)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C246(0.96); C404(1.01); C239(0.89); C491(1.09)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C246(0.99); C404(0.99); C487(0.96); C239(0.97)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C246(0.80); C239(0.91)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C246(0.97); C239(0.91); C491(1.00)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C246(1.03); C404(1.03); C239(0.97)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C246(1.04); C404(0.95); C487(1.16); C239(1.12)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C246(1.07); C239(1.04)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C246(1.02); C404(0.84); C487(1.07); C239(1.01)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C246(1.17); C404(0.85); C239(1.00)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C246(0.97); C239(0.88); C491(0.99)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C246(1.09); C487(1.03); C239(0.98)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C246(0.94); C487(1.08); C239(1.05)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C246(1.00); C404(1.02); C239(0.91); C491(1.05)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C246(1.05); C404(0.95); C487(1.02); C239(0.94)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C246(1.03); C404(1.01); C487(0.81); C239(0.89)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C246(0.91); C239(0.97)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C246(1.00); C239(0.96); C491(1.09)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C246(1.07); C404(1.11); C239(0.96)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C246(1.02); C404(0.93); C487(1.01); C239(1.05)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C246(1.12); C239(1.00)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C246(0.94); C404(1.00); C239(0.90)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C246(1.04); C404(0.88); C487(1.02); C239(1.01)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C246(1.14); C404(0.83); C239(0.97)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C246(1.02); C487(1.10); C239(0.98)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C246(1.02); C487(1.27); C239(0.98)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C246(0.95); C404(1.09); C239(0.96); C491(0.97)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C246(0.97); C404(1.04); C487(1.00); C239(0.97)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C246(0.85); C239(0.89)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C246(1.01); C239(0.98); C491(1.02)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C246(1.01); C404(0.96); C239(0.95)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C246(0.94); C404(1.58); C487(1.01); C239(0.76)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C246(1.04); C404(0.94); C487(0.97); C239(1.05)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C246(1.11); C239(1.04)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C246(1.07); C404(0.91); C487(0.98); C239(1.06)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C246(1.12); C404(0.93); C239(0.97)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C246(1.04); C487(1.18); C239(0.92)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C246(0.95); C487(1.18); C239(0.94)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C246(1.05); C404(1.12); C239(0.93); C491(1.00)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C246(1.06); C404(0.89); C487(0.94); C239(0.92)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C246(1.05); C404(1.02); C487(0.86); C239(0.95)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C246(0.83); C239(0.98)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C246(1.13); C239(0.97)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C246(1.02); C239(0.83); C491(1.03)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C246(1.15); C404(1.04); C239(1.00)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C246(0.93); C404(1.00); C487(0.95); C239(0.98)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C246(1.13); C239(1.03)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C246(1.03); C404(0.92); C487(1.05); C239(1.02)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C246(1.13); C404(1.11); C239(0.89)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C246(1.11); C487(1.12); C239(1.01)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C246(0.93); C487(1.22); C239(0.98)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C246(0.97); C404(1.04); C239(0.99); C491(0.95)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C246(1.07); C404(0.86); C487(1.05); C239(0.88)  LDD1697  [2]
 LDCM0097  Dasatinib K562 N.A.  LDD0364  [9]
 LDCM0495  E2913 HEK-293T C246(1.07); C404(0.79); C487(1.02); C239(0.91)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C246(1.00); C404(0.97); C487(1.06); C239(0.93)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C246(0.96); C404(0.99); C239(1.01); C491(0.95)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C246(0.95); C487(1.00)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C246(0.98); C487(1.31)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C246(1.01); C487(1.08)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
Purine nucleoside phosphorylase (PNP) PNP/MTAP phosphorylase family P00491
Protein kinase C delta type (PRKCD) AGC Ser/Thr protein kinase family Q05655
Protein kinase C theta type (PRKCQ) AGC Ser/Thr protein kinase family Q04759
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) STE Ser/Thr protein kinase family Q92918
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Receptor-type tyrosine-protein kinase FLT3 (FLT3) Tyr protein kinase family P36888
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Protein-tyrosine kinase 2-beta (PTK2B) Tyr protein kinase family Q14289
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Cytochrome b-c1 complex subunit 7 (UQCRB) UQCRB/QCR7 family P14927
Ataxin-3 (ATXN3) . P54252
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) . O14672
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) . Q13444
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-secretase subunit APH-1A (APH1A) APH-1 family Q96BI3
Amyloid-beta precursor protein (APP) APP family P05067
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Cytochrome c (CYCS) Cytochrome c family P99999
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Rho GTPase-activating protein 33 (ARHGAP33) PX domain-containing GAP family O14559
Alpha-synuclein (SNCA) Synuclein family P37840
CD2-associated protein (CD2AP) . Q9Y5K6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxytryptamine receptor 6 (HTR6) G-protein coupled receptor 1 family P50406
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet glycoprotein VI (GP6) . Q9HCN6
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Embryonal Fyn-associated substrate (EFS) CAS family O43281
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) KHDRBS family Q07666
Mediator of RNA polymerase II transcription subunit 28 (MED28) Mediator complex subunit 28 family Q9H204
ERBB receptor feedback inhibitor 1 (ERRFI1) MIG6 family Q9UJM3
Negative elongation factor B (NELFB) NELF-B family Q8WX92
Gamma-secretase subunit PEN-2 (PSENEN) PEN-2 family Q9NZ42
Prickle planar cell polarity protein 3 (PRICKLE3) Prickle / espinas / testin family O43900
Rho GTPase-activating protein 32 (ARHGAP32) PX domain-containing GAP family A7KAX9
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) . Q9ULH1
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Chromobox protein homolog 1 (CBX1) . P83916
FYN-binding protein 1 (FYB1) . O15117
Microtubule-associated protein tau (MAPT) . P10636
NCK-interacting protein with SH3 domain (NCKIPSD) . Q9NZQ3
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) . Q9NWQ8
Programmed cell death 6-interacting protein (PDCD6IP) . Q8WUM4
Rap guanine nucleotide exchange factor 1 (RAPGEF1) . Q13905
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
WW domain-binding protein 11 (WBP11) . Q9Y2W2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dasatinib Small molecular drug D0E6XR
Fostamatinib Small molecular drug DB12010
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Jnj-26483327 . D0U3XL
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-methoxy-2-[2-(2-methoxy-ethoxy]-ethane Small molecular drug D0OD8N
Cep-5104 Small molecular drug D09QBA
Cep-6331 Small molecular drug D07IHM
Jnj-10198409 Small molecular drug D0YZ7H
Pmid15546730c2 Small molecular drug D08RZB
Ro-4396686 Small molecular drug D09XIL
Triglyme Small molecular drug DB02078
Zotiraciclib . DB16656

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
10 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.