Details of the Target

General Information of Target

Target ID LDTP05378
Target Name Large ribosomal subunit protein eL6 (RPL6)
Gene Name RPL6
Gene ID 6128
Synonyms
TXREB1; Large ribosomal subunit protein eL6; 60S ribosomal protein L6; Neoplasm-related protein C140; Tax-responsive enhancer element-binding protein 107; TaxREB107
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRS
AMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTED
VPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLV
LNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKY
EITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL6 family
Subcellular location
Cytoplasm, cytosol
Function
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.; (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
Uniprot ID
Q02878
Ensemble ID
ENST00000202773.14
HGNC ID
HGNC:10362

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.24  LDD0402  [1]
P3
 Probe Info  		1.69  LDD0450  [2]
A-EBA
 Probe Info  		4.00  LDD0215  [3]
TH211
 Probe Info  		Y282(20.00); Y216(7.79)  LDD0260  [4]
C-Sul
 Probe Info  		4.02  LDD0066  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
BTD
 Probe Info  		C44(6.71)  LDD1699  [7]
ONAyne
 Probe Info  		K20(0.00); K94(0.00); K207(0.00); K237(0.00)  LDD0273  [8]
Probe 1
 Probe Info  		Y115(28.47); Y116(14.16); Y270(12.98)  LDD3495  [9]
AZ-9
 Probe Info  		10.00  LDD2154  [10]
HHS-482
 Probe Info  		Y115(20.00)  LDD0285  [11]
DBIA
 Probe Info  		C44(1.64)  LDD0547  [12]
AMP probe
 Probe Info  		N.A.  LDD0200  [13]
ATP probe
 Probe Info  		K87(0.00); K207(0.00); K237(0.00); K210(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
IPM
 Probe Info  		N.A.  LDD0147  [16]
NHS
 Probe Info  		K260(0.00); K87(0.00); K5(0.00); K251(0.00)  LDD0010  [15]
OSF
 Probe Info  		Y115(0.00); H128(0.00)  LDD0029  [17]
SF
 Probe Info  		Y240(0.00); K5(0.00); K260(0.00); Y282(0.00)  LDD0028  [17]
STPyne
 Probe Info  		K207(0.00); K251(0.00)  LDD0009  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
1c-yne
 Probe Info  		K237(0.00); K192(0.00); K251(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		H227(0.00); H211(0.00); H128(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		H227(0.00); H211(0.00); H136(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		C44(0.00); H136(0.00)  LDD0218  [20]
AOyne
 Probe Info  		5.50  LDD0443  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [22]
HHS-475
 Probe Info  		Y115(0.93)  LDD2238  [23]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		10.46  LDD0138  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]
Dasatinib-CA-3PAP
 Probe Info  		5.00  LDD0365  [26]
Diazir
 Probe Info  		N.A.  LDD0011  [15]
DA-2
 Probe Info  		N.A.  LDD0071  [27]
STS-1
 Probe Info  		N.A.  LDD0069  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C44(0.84)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C44(1.05)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C44(0.67)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C44(0.81)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C44(1.09)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C44(1.40)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C44(0.55)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C44(1.78)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C44(0.53)  LDD2131  [7]
 LDCM0214  AC1 HEK-293T C44(1.20)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C44(1.08)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C44(1.23)  LDD1509  [29]
 LDCM0230  AC113 HCT 116 C44(1.64)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C44(1.05)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C44(1.09)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C44(1.01)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C44(1.02)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C44(1.12)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C44(0.95)  LDD0553  [12]
 LDCM0237  AC12 HEK-293T C44(0.97)  LDD1510  [29]
 LDCM0238  AC120 HCT 116 C44(0.97)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C44(0.84)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C44(0.97)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C44(1.04)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C44(0.94)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C44(0.91)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C44(1.01)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C44(0.99)  LDD0562  [12]
 LDCM0259  AC14 HEK-293T C44(0.99)  LDD1512  [29]
 LDCM0263  AC143 HEK-293T C44(1.08)  LDD0861  [12]
 LDCM0264  AC144 HEK-293T C44(1.06)  LDD0862  [12]
 LDCM0265  AC145 HEK-293T C44(1.66)  LDD0863  [12]
 LDCM0266  AC146 HEK-293T C44(1.71)  LDD0864  [12]
 LDCM0267  AC147 HEK-293T C44(1.01)  LDD0865  [12]
 LDCM0268  AC148 HEK-293T C44(1.92)  LDD0866  [12]
 LDCM0269  AC149 HEK-293T C44(0.94)  LDD0867  [12]
 LDCM0270  AC15 HEK-293T C44(1.02)  LDD1513  [29]
 LDCM0271  AC150 HEK-293T C44(1.23)  LDD0869  [12]
 LDCM0272  AC151 HEK-293T C44(0.95)  LDD0870  [12]
 LDCM0273  AC152 HEK-293T C44(0.44)  LDD0871  [12]
 LDCM0274  AC153 HEK-293T C44(0.55)  LDD0872  [12]
 LDCM0621  AC154 HEK-293T C44(0.59)  LDD2162  [12]
 LDCM0622  AC155 HEK-293T C44(0.84)  LDD2163  [12]
 LDCM0623  AC156 HEK-293T C44(0.64)  LDD2164  [12]
 LDCM0624  AC157 HEK-293T C44(0.48)  LDD2165  [12]
 LDCM0276  AC17 HCT 116 C44(0.78)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C44(0.83)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C44(0.70)  LDD0595  [12]
 LDCM0279  AC2 HEK-293T C44(1.04)  LDD1518  [29]
 LDCM0280  AC20 HCT 116 C44(0.81)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C44(0.70)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C44(0.69)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C44(0.73)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C44(0.76)  LDD0601  [12]
 LDCM0285  AC25 HEK-293T C44(0.90)  LDD0883  [12]
 LDCM0286  AC26 HEK-293T C44(0.96)  LDD0884  [12]
 LDCM0287  AC27 HEK-293T C44(1.16)  LDD0885  [12]
 LDCM0288  AC28 HEK-293T C44(1.27)  LDD0886  [12]
 LDCM0289  AC29 HEK-293T C44(1.10)  LDD0887  [12]
 LDCM0290  AC3 HEK-293T C44(1.23)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C44(1.03)  LDD0889  [12]
 LDCM0292  AC31 HEK-293T C44(0.92)  LDD0890  [12]
 LDCM0293  AC32 HEK-293T C44(0.97)  LDD0891  [12]
 LDCM0294  AC33 HEK-293T C44(1.21)  LDD0892  [12]
 LDCM0295  AC34 HEK-293T C44(1.00)  LDD0893  [12]
 LDCM0296  AC35 HCT 116 C44(0.95)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C44(1.03)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C44(0.82)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C44(1.29)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C44(1.13)  LDD0617  [12]
 LDCM0301  AC4 HEK-293T C44(1.00)  LDD1540  [29]
 LDCM0302  AC40 HCT 116 C44(1.10)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C44(0.73)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C44(0.86)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C44(0.43)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C44(0.72)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C44(0.67)  LDD0624  [12]
 LDCM0308  AC46 HEK-293T C44(0.99)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C44(0.99)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C44(0.88)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C44(1.09)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C44(1.03)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C44(1.09)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C44(1.09)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C44(0.97)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C44(0.97)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C44(0.99)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C44(1.02)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C44(0.99)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C44(1.07)  LDD0918  [12]
 LDCM0321  AC58 HEK-293T C44(1.13)  LDD0919  [12]
 LDCM0322  AC59 HEK-293T C44(1.32)  LDD0920  [12]
 LDCM0323  AC6 HEK-293T C44(1.07)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C44(5.59)  LDD0922  [12]
 LDCM0325  AC61 HEK-293T C44(1.57)  LDD0923  [12]
 LDCM0326  AC62 HEK-293T C44(1.14)  LDD0924  [12]
 LDCM0327  AC63 HEK-293T C44(1.39)  LDD0925  [12]
 LDCM0328  AC64 HEK-293T C44(1.17)  LDD0926  [12]
 LDCM0329  AC65 HEK-293T C44(1.33)  LDD0927  [12]
 LDCM0330  AC66 HEK-293T C44(1.02)  LDD0928  [12]
 LDCM0331  AC67 HEK-293T C44(1.34)  LDD0929  [12]
 LDCM0332  AC68 HEK-293T C44(1.01)  LDD0930  [12]
 LDCM0333  AC69 HEK-293T C44(1.14)  LDD0931  [12]
 LDCM0334  AC7 HEK-293T C44(1.00)  LDD1568  [29]
 LDCM0335  AC70 HEK-293T C44(1.18)  LDD0933  [12]
 LDCM0336  AC71 HEK-293T C44(1.11)  LDD0934  [12]
 LDCM0337  AC72 HEK-293T C44(1.25)  LDD0935  [12]
 LDCM0338  AC73 HEK-293T C44(1.24)  LDD0936  [12]
 LDCM0339  AC74 HEK-293T C44(1.18)  LDD0937  [12]
 LDCM0340  AC75 HEK-293T C44(1.02)  LDD0938  [12]
 LDCM0341  AC76 HEK-293T C44(0.87)  LDD0939  [12]
 LDCM0342  AC77 HEK-293T C44(1.04)  LDD0940  [12]
 LDCM0343  AC78 HEK-293T C44(1.10)  LDD0941  [12]
 LDCM0344  AC79 HEK-293T C44(1.07)  LDD0942  [12]
 LDCM0345  AC8 HEK-293T C44(1.06)  LDD1569  [29]
 LDCM0346  AC80 HEK-293T C44(1.20)  LDD0944  [12]
 LDCM0347  AC81 HEK-293T C44(1.04)  LDD0945  [12]
 LDCM0348  AC82 HEK-293T C44(1.42)  LDD0946  [12]
 LDCM0349  AC83 HEK-293T C44(0.79)  LDD0947  [12]
 LDCM0350  AC84 HEK-293T C44(1.22)  LDD0948  [12]
 LDCM0351  AC85 HEK-293T C44(1.00)  LDD0949  [12]
 LDCM0352  AC86 HEK-293T C44(1.31)  LDD0950  [12]
 LDCM0353  AC87 HEK-293T C44(0.99)  LDD0951  [12]
 LDCM0354  AC88 HEK-293T C44(1.25)  LDD0952  [12]
 LDCM0355  AC89 HEK-293T C44(1.49)  LDD0953  [12]
 LDCM0357  AC90 HEK-293T C44(1.27)  LDD0955  [12]
 LDCM0358  AC91 HEK-293T C44(0.82)  LDD0956  [12]
 LDCM0359  AC92 HEK-293T C44(0.85)  LDD0957  [12]
 LDCM0360  AC93 HEK-293T C44(0.83)  LDD0958  [12]
 LDCM0361  AC94 HEK-293T C44(0.99)  LDD0959  [12]
 LDCM0362  AC95 HEK-293T C44(0.90)  LDD0960  [12]
 LDCM0363  AC96 HEK-293T C44(0.85)  LDD0961  [12]
 LDCM0364  AC97 HEK-293T C44(1.32)  LDD0962  [12]
 LDCM0545  Acetamide MDA-MB-231 C44(0.34)  LDD2138  [7]
 LDCM0248  AKOS034007472 HEK-293T C44(0.97)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C44(1.12)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C44(0.99)  LDD1514  [29]
 LDCM0156  Aniline NCI-H1299 11.43  LDD0403  [1]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [10]
 LDCM0498  BS-3668 MDA-MB-231 C44(0.40)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa H227(0.00); H136(0.00); H128(0.00); H211(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C44(2.72); C44(0.80)  LDD2227  [22]
 LDCM0367  CL1 HEK-293T C44(0.85)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C44(0.89)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C44(1.16)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C44(0.99)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C44(0.97)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C44(0.99)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C44(1.04)  LDD1577  [29]
 LDCM0374  CL105 HCT 116 C44(0.74)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C44(0.60)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C44(0.78)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C44(0.76)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C44(0.73)  LDD0695  [12]
 LDCM0379  CL11 HEK-293T C44(0.79)  LDD1583  [29]
 LDCM0380  CL110 HCT 116 C44(0.57)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C44(0.64)  LDD0698  [12]
 LDCM0382  CL112 HEK-293T C44(1.38)  LDD0980  [12]
 LDCM0383  CL113 HEK-293T C44(0.92)  LDD0981  [12]
 LDCM0384  CL114 HEK-293T C44(1.39)  LDD0982  [12]
 LDCM0385  CL115 HEK-293T C44(1.21)  LDD0983  [12]
 LDCM0386  CL116 HEK-293T C44(1.30)  LDD0984  [12]
 LDCM0387  CL117 HCT 116 C44(1.00)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C44(0.89)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C44(0.77)  LDD0706  [12]
 LDCM0390  CL12 HEK-293T C44(0.69)  LDD1594  [29]
 LDCM0391  CL120 HCT 116 C44(0.68)  LDD0708  [12]
 LDCM0392  CL121 HEK-293T C44(0.99)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C44(0.96)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C44(0.94)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C44(1.03)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C44(1.08)  LDD0994  [12]
 LDCM0397  CL126 HEK-293T C44(1.26)  LDD0995  [12]
 LDCM0398  CL127 HEK-293T C44(1.01)  LDD0996  [12]
 LDCM0399  CL128 HEK-293T C44(0.90)  LDD0997  [12]
 LDCM0400  CL13 HEK-293T C44(0.91)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C44(0.98)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C44(0.91)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C44(1.02)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C44(0.92)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C44(0.86)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C44(0.69)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C44(0.94)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C44(0.88)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C44(0.89)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C44(0.72)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C44(0.77)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C44(0.76)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C44(0.89)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C44(1.06)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C44(1.08)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C44(1.07)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C44(1.06)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C44(0.89)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C44(1.02)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C44(0.95)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C44(0.93)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C44(0.93)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C44(0.74)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C44(0.80)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C44(0.87)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C44(0.90)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C44(1.12)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C44(0.98)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C44(1.05)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C44(1.04)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C44(0.92)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C44(0.86)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C44(0.96)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C44(0.99)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C44(0.78)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C44(0.80)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C44(0.89)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C44(0.94)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C44(0.96)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C44(1.10)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C44(1.12)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C44(1.01)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C44(0.87)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C44(0.92)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C44(1.07)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C44(1.04)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C44(0.76)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C44(0.83)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C44(0.82)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C44(0.85)  LDD1655  [29]
 LDCM0453  CL61 HCT 116 C44(0.96)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C44(0.60)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C44(0.95)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C44(0.77)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C44(1.07)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C44(0.83)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C44(1.03)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C44(1.16)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C44(0.92)  LDD0778  [12]
 LDCM0462  CL7 HEK-293T C44(0.88)  LDD1665  [29]
 LDCM0463  CL70 HCT 116 C44(0.83)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C44(0.59)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C44(0.88)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C44(1.02)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C44(0.85)  LDD0784  [12]
 LDCM0469  CL76 HEK-293T C44(1.12)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C44(1.12)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C44(1.03)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C44(0.96)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C44(0.71)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C44(1.01)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C44(0.98)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C44(0.86)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C44(0.87)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C44(0.80)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C44(0.74)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C44(0.76)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C44(0.86)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C44(0.97)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C44(0.97)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C44(0.90)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C44(0.90)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C44(0.93)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C44(0.82)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C44(0.86)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C44(0.80)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C44(0.80)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C44(0.61)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C44(0.97)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C44(1.11)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C44(1.06)  LDD1697  [29]
 LDCM0097  Dasatinib K562 5.00  LDD0365  [26]
 LDCM0495  E2913 HEK-293T C44(1.12)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C44(1.14)  LDD1702  [7]
 LDCM0625  F8 Ramos C44(1.47)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C44(0.23)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C44(0.05)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C44(0.33)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C44(0.18)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C44(0.17)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C44(0.46)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C44(0.35)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C44(0.27)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C44(0.59)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C44(0.63)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C44(0.34)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C44(0.48)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C44(0.39)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C44(0.60)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C44(0.41)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C44(0.40)  LDD2184  [30]
 LDCM0427  Fragment51 HEK-293T C44(1.23)  LDD1631  [29]
 LDCM0610  Fragment52 Ramos C44(0.74)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C44(0.16)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C44(0.34)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C44(0.13)  LDD2188  [30]
 LDCM0107  IAA HeLa H227(0.00); H136(0.00); H211(0.00); H128(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y115(20.00)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y282(0.35)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y282(0.90)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y115(6.43); Y282(4.62)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y115(3.12); Y282(1.33)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y282(0.55)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y282(0.36)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y282(0.57)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C44(0.99)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C44(0.96)  LDD1497  [29]
 LDCM0024  KB05 SK-MEL-28 C44(2.16)  LDD3427  [31]
 LDCM0109  NEM HeLa H227(0.00); H136(0.00); H211(0.00); H284(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C44(0.49)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C44(1.05)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C44(0.57)  LDD2092  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C44(1.10)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C44(0.62)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C44(1.85)  LDD2098  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C44(0.99)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C44(1.15)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C44(0.90)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C44(1.23)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C44(0.74)  LDD2106  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C44(1.05)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C44(1.23)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C44(1.07)  LDD2110  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C44(0.65)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C44(0.66)  LDD2118  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C44(0.64)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C44(0.83)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C44(1.01)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C44(0.77)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C44(0.96)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C44(0.98)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C44(1.11)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C44(0.60)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C44(0.55)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C44(0.27)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C44(1.04)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C44(0.57)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C44(1.38)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C44(1.02)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C44(1.38)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C44(1.39)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C44(0.83)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C44(2.04)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C44(11.57)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C44(1.02)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C44(2.30)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C44(0.42)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C44(0.89)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C44(0.35)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C44(0.67)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C44(1.98)  LDD2153  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) STE Ser/Thr protein kinase family Q99558

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
27 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
28 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840