Details of the Target

General Information of Target

Target ID LDTP14075
Target Name AFG3-like protein 2 (AFG3L2)
Gene Name AFG3L2
Gene ID 10939
Synonyms
AFG3-like protein 2; EC 3.4.24.-; Paraplegin-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWESGAGPGLGSQGMDLVWSAWYGKCVKGKGSLPLSAHGIVVAWLSRAEWDQVTVYLFC
DDHKLQRYALNRITVWRSRSGNELPLAVASTADLIRCKLLDVTGGLGTDELRLLYGMALV
RFVNLISERKTKFAKVPLKCLAQEVNIPDWIVDLRHELTHKKMPHINDCRRGCYFVLDWL
QKTYWCRQLENSLRETWELEEFREGIEEEDQEEDKNIVVDDITEQKPEPQDDGKSTESDV
KADGDSKGSEEVDSHCKKALSHKELYERARELLVSYEEEQFTVLEKFRYLPKAIKAWNNP
SPRVECVLAELKGVTCENREAVLDAFLDDGFLVPTFEQLAALQIEYEDGQTEVQRGEGTD
PKSHKNVDLNDVLVPKPFSQFWQPLLRGLHSQNFTQALLERMLSELPALGISGIRPTYIL
RWTVELIVANTKTGRNARRFSAGQWEARRGWRLFNCSASLDWPRMVESCLGSPCWASPQL
LRIIFKAMGQGLPDEEQEKLLRICSIYTQSGENSLVQEGSEASPIGKSPYTLDSLYWSVK
PASSSFGSEAKAQQQEEQGSVNDVKEEEKEEKEVLPDQVEEEEENDDQEEEEEDEDDEDD
EEEDRMEVGPFSTGQESPTAENARLLAQKRGALQGSAWQVSSEDVRWDTFPLGRMPGQTE
DPAELMLENYDTMYLLDQPVLEQRLEPSTCKTDTLGLSCGVGSGNCSNSSSSNFEGLLWS
QGQLHGLKTGLQLF
Target Bioclass
Enzyme
Family
AAA ATPase family; Peptidase M41 family
Subcellular location
Mitochondrion
Function
ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Required for paraplegin (SPG7) maturation. After its cleavage by mitochondrial-processing peptidase (MPP), it converts paraplegin into a proteolytically active mature form. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Involved in the regulation of OMA1-dependent processing of OPA1. Contributes to the proteolytic degradation of GHITM upon hyperpolarization of mitochondria. Progressive GHITM degradation upon persistent hyperpolarization leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2.
Uniprot ID
Q9Y4W6
Ensemble ID
ENST00000269143.8
HGNC ID
HGNC:315
ChEMBL ID
CHEMBL4802020

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		8.94  LDD0196  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y689(16.09); Y605(6.16)  LDD0260  [3]
Probe 1
 Probe Info  		Y614(44.91)  LDD3495  [4]
m-APA
 Probe Info  		12.52  LDD0403  [5]
BTD
 Probe Info  		C626(0.97)  LDD2091  [6]
AHL-Pu-1
 Probe Info  		C402(10.26)  LDD0170  [7]
DBIA
 Probe Info  		C313(1.01)  LDD0078  [8]
ATP probe
 Probe Info  		K543(0.00); K559(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C525(0.00); C313(0.00); C402(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		C525(0.00); C402(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C402(0.00); C626(0.00); C525(0.00); C313(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
1d-yne
 Probe Info  		N.A.  LDD0356  [14]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		C14(0.00); C402(0.00); C313(0.00)  LDD0005  [15]
SF
 Probe Info  		N.A.  LDD0028  [16]
STPyne
 Probe Info  		K543(0.00); K308(0.00)  LDD0009  [15]
TFBX
 Probe Info  		C66(0.00); C402(0.00); C525(0.00)  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		C313(0.00); C402(0.00); C14(0.00)  LDD0018  [17]
Ox-W18
 Probe Info  		N.A.  LDD2175  [18]
Acrolein
 Probe Info  		C402(0.00); C313(0.00); H535(0.00); C525(0.00)  LDD0217  [19]
Crotonaldehyde
 Probe Info  		C313(0.00); H535(0.00)  LDD0219  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
W1
 Probe Info  		N.A.  LDD0236  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		C313(0.00); C402(0.00); C525(0.00)  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		19.29  LDD1799  [23]
C187
 Probe Info  		15.67  LDD1865  [23]
C191
 Probe Info  		10.85  LDD1868  [23]
C391
 Probe Info  		13.18  LDD2050  [23]
FFF probe11
 Probe Info  		20.00  LDD0471  [24]
FFF probe13
 Probe Info  		19.58  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
STS-1
 Probe Info  		N.A.  LDD0137  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
Dasatinib-CA-8PAP
 Probe Info  		6.00  LDD0364  [27]
OEA-DA
 Probe Info  		20.00  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C14(0.95)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C626(0.71)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C626(0.53)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C626(1.20)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C14(0.80)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C626(1.08)  LDD2152  [6]
 LDCM0025  4SU-RNA DM93 C402(10.26)  LDD0170  [7]
 LDCM0214  AC1 HCT 116 C313(1.27); C626(1.05)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C313(1.99); C626(0.93)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C313(1.11)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C313(1.01)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C313(0.98)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C313(1.11)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C313(1.02)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C313(0.98)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C313(1.32)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C313(1.25)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C313(1.02)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C313(0.93)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C313(1.34); C626(1.05)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C313(1.02)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C313(1.01)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C313(1.06)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C313(1.00); C626(0.97)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C313(1.36); C626(1.06)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C313(1.59); C626(0.99)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C313(1.05); C626(1.10)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C313(1.06); C626(0.92)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C313(1.38); C626(0.98)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C313(1.42); C626(0.89)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C313(1.37); C626(0.93)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C313(3.04); C626(0.93)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C313(1.02); C626(0.78)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C313(1.34); C626(0.87)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C313(1.15); C626(0.77)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C313(1.26); C626(0.81)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C313(1.91); C626(0.86)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C313(1.25); C626(0.89)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C313(1.88); C626(0.79)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C313(0.86); C626(0.56)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C313(1.01); C626(1.37)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C313(1.14); C626(0.82)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C313(0.92); C626(1.29)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C313(0.99); C626(1.17)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C313(0.90); C626(0.92)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C313(1.47); C626(0.84)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C313(1.06); C626(0.83)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C313(0.98); C626(0.88)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C313(1.13); C626(1.02)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C313(0.88); C626(1.01)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C313(0.89); C626(0.94)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C313(1.44); C626(0.83)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C313(1.11); C626(0.92)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C313(1.11); C626(1.02)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C313(0.95); C626(1.09)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C313(1.27)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C313(1.50)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C313(1.23)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C313(1.20)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C313(1.27)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C313(1.69)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C313(1.44)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C626(0.74); C313(1.30)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C313(1.18)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C313(1.38)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C313(1.37)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C313(1.81)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C313(1.20)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C313(1.20)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C313(0.97)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C313(1.09)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C626(0.94); C313(1.04)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C626(0.86); C313(1.15)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C626(1.01); C313(1.07)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C626(1.10); C313(1.17)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C626(0.78); C313(1.04)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C626(0.89); C313(0.95)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C626(0.87); C313(0.92)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C626(0.85); C313(0.92)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C313(0.92); C626(1.65)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C402(0.98); C626(1.21); C313(1.36)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C402(0.70); C626(0.98); C313(1.68)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C402(0.67); C626(1.02); C313(1.68)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C402(0.59); C626(0.88); C313(1.57)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C402(0.77); C626(0.81); C313(1.71)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C313(1.21); C626(1.25)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C402(0.59); C626(0.93); C313(1.65)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C402(0.61); C626(1.01); C313(1.46)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C402(0.49); C626(0.79); C313(2.01)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C402(0.53); C626(1.00); C313(1.66)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C402(0.40); C626(0.74); C313(1.72)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C313(1.11); C402(1.18); C626(1.19)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C313(1.04); C402(1.27); C626(1.33)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C313(1.12); C626(1.24); C402(1.32)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C313(0.97); C626(1.06); C402(1.34)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C402(1.00); C626(1.07); C313(1.12)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C626(1.24); C313(1.33)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C402(0.94); C626(0.97); C313(1.36)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C626(1.08); C313(1.13); C402(1.16)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C626(1.00); C402(1.03); C313(1.07)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C402(1.03); C626(1.18); C313(1.25)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C402(1.01); C626(1.16); C313(1.51)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C402(0.90); C626(0.94); C313(1.25)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C626(1.11); C313(1.12); C402(1.50)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C626(0.96); C402(1.00); C313(1.18)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C626(1.15); C313(1.34); C402(1.57)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C402(0.76); C626(1.06); C313(1.29)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C626(1.23); C313(1.44)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C402(0.92); C626(1.07); C313(1.38)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C313(1.00); C626(1.22); C402(2.12)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C626(1.02); C402(1.19); C313(1.28)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C402(0.90); C313(1.08); C626(1.10)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C402(0.74); C626(0.99); C313(1.20)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C402(0.81); C626(1.11); C313(1.22)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C402(0.93); C626(1.04); C313(1.45)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C313(0.87); C402(1.04)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C402(0.65); C313(0.92)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C402(0.86); C313(0.87)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C626(0.80); C313(1.33)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C402(0.82); C313(0.84)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C402(0.91); C313(1.11)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C313(0.95); C402(1.06)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C402(0.51); C313(1.00)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C402(0.77); C313(0.90)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C402(1.04); C313(1.15)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C402(0.89); C313(1.12)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C402(0.75); C313(0.85)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C626(0.50); C313(1.08)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C626(0.56); C313(1.10)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C626(0.78); C313(1.35)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C626(0.51); C313(1.14)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C626(0.71); C313(0.95)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C626(0.82); C313(1.12)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C626(0.61); C313(1.37)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C626(0.55); C313(1.30)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C626(0.53); C313(1.40)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C626(0.43); C313(1.33)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C626(0.55); C313(1.23)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C626(0.75); C313(1.20)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C626(0.60); C313(1.22)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C626(0.71); C313(1.79)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C626(0.52); C313(1.28)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C626(0.55); C313(1.04)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C626(0.47); C313(1.41)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C626(0.82); C402(0.94); C313(1.45)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C402(0.79); C626(0.88); C313(1.31)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C402(0.86); C626(1.05); C313(1.25)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C626(0.77); C402(1.06); C313(1.15)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C626(0.80); C313(1.13); C402(1.14)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C626(0.80); C402(0.93); C313(1.18)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C626(0.62); C402(0.86); C313(1.26)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C626(0.78); C313(1.18); C402(1.31)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C626(0.56); C402(0.84); C313(1.42)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C626(0.55); C402(0.86); C313(1.44)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C626(0.61); C402(0.81); C313(1.21)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C626(0.69); C402(0.85); C313(1.07)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C626(0.76); C313(1.16); C402(1.21)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C626(0.56); C402(0.92); C313(1.27)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C626(0.62); C402(0.87); C313(1.31)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C313(1.30)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C313(0.94)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C626(1.13)  LDD2138  [6]
 LDCM0248  AKOS034007472 HCT 116 C313(1.14); C626(1.04)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C626(0.99); C313(1.35)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C626(0.66); C313(2.32)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.52  LDD0403  [5]
 LDCM0020  ARS-1620 HCC44 C313(1.01)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C626(0.97)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C525(0.00); C402(0.00); C313(0.00); H544(0.00)  LDD0222  [19]
 LDCM0367  CL1 HCT 116 C626(0.89); C313(1.05); C402(1.34)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C626(0.72); C402(0.82); C313(1.03)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C626(1.16); C313(1.30)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C626(0.85); C313(1.35)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C626(1.00); C313(1.88)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C626(0.74); C313(1.05)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C626(0.84); C313(1.41)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C626(0.82); C313(1.26)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C626(0.75); C313(1.45)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C626(0.78); C313(1.34)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C626(0.81); C313(1.35)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C626(0.83); C313(1.01)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C626(0.66); C402(0.70); C313(1.02)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C626(0.77); C313(1.10)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C626(0.88); C313(1.00)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C402(0.86); C626(1.06); C313(1.13)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C402(0.43); C626(0.75); C313(1.47)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C402(0.72); C626(0.75); C313(1.49)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C402(0.57); C626(0.85); C313(1.30)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C402(0.82); C626(0.95); C313(1.44)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C402(0.87); C626(0.98); C313(1.25)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C626(0.98); C402(1.01); C313(1.03)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C402(0.84); C626(0.94); C313(1.23)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C626(0.59); C402(0.80); C313(1.00)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C626(1.05); C313(1.19); C402(1.25)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C313(0.90); C626(0.96); C402(1.12)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C626(1.11); C402(1.12); C313(1.17)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C402(0.87); C626(1.04); C313(1.10)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C402(0.81); C626(0.95); C313(1.14)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C313(1.08); C402(1.19)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C313(0.99); C402(1.77)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C402(0.86); C313(1.06)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C402(0.54); C313(0.87)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C626(0.72); C402(0.81); C313(1.05)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C626(0.74); C313(1.00); C402(1.07)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C626(0.68); C402(0.81); C313(1.08)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C402(0.62); C313(1.10); C626(1.16)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C402(0.81); C313(1.02); C626(1.06)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C402(0.78); C626(1.04); C313(1.09)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C402(0.63); C313(0.93); C626(0.95)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C313(1.09); C626(1.13); C402(1.35)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C402(0.64); C626(0.97); C313(1.12)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C402(0.70); C626(0.90); C313(1.03)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C626(0.65); C402(0.71); C313(0.96)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C402(0.64); C626(0.84); C313(0.94)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C402(0.57); C626(0.89); C313(1.24)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C313(1.32); C402(0.58); C626(0.78)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C313(1.15); C402(0.63); C626(0.93)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C313(1.14); C402(0.72); C626(0.84)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C313(1.15); C402(0.60); C626(0.83)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C313(1.13); C402(0.69); C626(0.91)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C313(1.01); C402(0.95); C626(1.01)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C313(1.27); C402(0.65); C626(0.81)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C313(1.04); C626(0.68)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C313(1.28); C626(0.83)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C313(1.16); C626(0.98)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C313(1.26); C626(0.75)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C313(1.28); C626(0.60)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C313(1.28); C626(0.78)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C313(1.42); C626(0.79)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C313(1.32); C626(0.69)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C313(1.01); C402(1.01); C626(0.84)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C313(1.26); C626(0.63)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C313(1.20); C626(0.69)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C313(1.59); C626(0.56)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C313(1.35); C626(0.77)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C313(1.26); C626(0.63)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C313(1.41); C626(0.68)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C313(1.05); C402(1.92); C626(1.24)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C313(1.01); C402(1.56); C626(1.30)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C313(1.06); C402(1.67); C626(1.17)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C313(1.06); C402(1.18); C626(0.94)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C313(1.03); C402(1.02); C626(0.89)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C313(0.96); C402(1.70); C626(1.10)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C313(1.01); C402(1.90); C626(1.09)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C313(0.99); C402(1.83); C626(1.12)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C313(0.90); C402(1.63); C626(0.98)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C313(0.93); C402(1.93); C626(1.01)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C313(0.96); C402(1.88); C626(1.10)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C313(0.98); C402(1.11); C626(1.04)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C313(0.93); C402(1.80); C626(0.91)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C313(1.02); C402(1.70); C626(1.15)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C313(0.98); C402(1.31); C626(1.17)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C313(1.11); C402(0.87); C626(1.03)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C313(1.05); C402(1.19); C626(1.12)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C313(1.10); C402(1.07); C626(0.92)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C313(1.16); C402(0.74); C626(1.18)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C313(1.30); C402(0.77); C626(0.88)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C313(1.31); C402(0.62); C626(0.98)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C313(1.21); C402(0.74); C626(1.11)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C313(1.34); C402(0.42); C626(1.03)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C313(1.27); C402(0.47); C626(0.85)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C313(1.22); C402(0.70); C626(0.72)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C313(1.14); C402(0.76); C626(1.05)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C313(1.02); C402(0.74); C626(0.72)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C313(1.26); C402(0.78); C626(1.06)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C313(1.33); C402(0.55); C626(0.89)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C313(1.20); C402(0.91); C626(1.06)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C313(1.18); C402(0.69); C626(0.99)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C313(1.22); C402(0.70); C626(0.90)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C313(0.88); C626(0.78)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C313(0.93); C626(0.63)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C313(1.02); C626(0.77)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C313(1.00); C626(0.73)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C313(1.04); C402(0.69); C626(0.70)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C313(0.91); C626(0.92)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C313(1.01); C626(0.86)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C313(0.93); C626(0.92)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C313(0.86); C626(0.83)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C313(0.89); C626(0.59)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C313(0.97); C626(0.76)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C313(0.96); C626(0.93)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C313(0.89); C626(0.85)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C313(0.92); C626(0.94)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C313(0.94); C626(0.90)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C313(1.14); C402(0.72); C626(0.67)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C313(0.89); C626(0.65)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C313(1.14); C626(1.16)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C313(1.02); C626(0.91)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C313(1.16); C626(1.02)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C313(1.07); C626(1.26)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C313(1.13); C626(0.93)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C313(1.12); C626(1.06)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C313(1.14); C626(1.26)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C313(1.25); C626(1.11)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C313(1.30); C626(1.08)  LDD0811  [8]
 LDCM0097  Dasatinib K562 6.00  LDD0364  [27]
 LDCM0495  E2913 HEK-293T C313(0.97); C626(1.04); C402(1.20); C525(1.08)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C626(2.85); C525(2.31); C14(0.94)  LDD1702  [6]
 LDCM0625  F8 Ramos C626(0.53); C402(1.02); C525(0.72)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C626(0.58); C525(1.30)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C626(1.67); C402(0.71)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C626(0.95); C525(1.43)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C626(0.74); C525(1.88)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C626(1.05); C402(1.26); C525(0.86)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C626(1.25); C525(1.18)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C626(0.70); C525(1.64)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C626(1.23); C525(0.76)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C626(0.76); C525(0.63)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C626(0.72); C402(0.48); C525(0.86)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C626(0.90); C525(0.67)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C626(0.95); C525(1.04)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C626(1.78); C525(1.07)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C313(1.15); C402(0.57); C626(0.88)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C626(1.06); C525(0.92)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C402(0.33); C525(0.70)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C313(1.44); C626(0.88)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C626(0.87); C525(0.32)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C626(0.86); C525(0.94)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C626(0.59); C402(0.57); C525(0.43)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C626(0.91); C525(1.31)  LDD2188  [30]
 LDCM0107  IAA HeLa H535(0.00); C402(0.00); H544(0.00)  LDD0221  [19]
 LDCM0022  KB02 HCT 116 C313(1.57)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C313(1.86)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C313(1.46)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C14(0.89)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C626(1.25); C14(1.19)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C626(0.62)  LDD2100  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C14(1.14)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C14(0.81)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C626(0.72)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C626(0.80)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C626(0.98)  LDD2111  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C626(1.43)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C626(1.10)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C626(1.06)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C626(0.90)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C626(1.15); C14(0.85)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C626(1.36)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C14(0.92)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C14(1.53)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C14(0.70)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C626(1.04)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C626(1.42); C14(0.81)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C626(1.37)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C626(1.01)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C626(0.71); C14(0.85)  LDD2143  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C626(0.77)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C626(2.06); C402(1.14); C313(0.75)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C313(0.19)  LDD2207  [31]
 LDCM0021  THZ1 HCT 116 C313(1.06)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD001377 , PXD005252
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD027578
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