Details of the Target

General Information of Target

Target ID LDTP02030
Target Name Keratin, type II cytoskeletal 6B (KRT6B)
Gene Name KRT6B
Gene ID 3854
Synonyms
K6B; KRTL1; Keratin, type II cytoskeletal 6B; Cytokeratin-6B; CK-6B; Keratin-6B; K6B; Type-II keratin Kb10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRS
LYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAG
GFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDK
VRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDSELR
NMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRA
LYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKY
EELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMAL
KDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEG
VGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSSGRATGGGLS
SVGGGSSTIKYTTTSSSSRKSYKH
Target Bioclass
Other
Family
Intermediate filament family
Uniprot ID
P04259
Ensemble ID
ENST00000252252.4
HGNC ID
HGNC:6444

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
AZ-9
 Probe Info  		E450(0.95); D179(0.99); E447(0.95); E185(0.98)  LDD2208  [2]
DBIA
 Probe Info  		C77(1.17)  LDD3323  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		C402(0.00); C474(0.00); C77(0.00); C51(0.00)  LDD0162  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
HHS-465
 Probe Info  		N.A.  LDD2240  [7]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		1.03  LDD0136  [8]
STS-2
 Probe Info  		N.A.  LDD0138  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]
Dasatinib-CA-8PAP
 Probe Info  		4.91  LDD0364  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0097  Dasatinib K562 4.91  LDD0364  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 A431 C51(3.63); C77(4.80)  LDD2258  [3]
 LDCM0023  KB03 A431 C51(3.39); C77(5.01)  LDD2675  [3]
 LDCM0024  KB05 SKMEL24 C77(1.17)  LDD3323  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 13 (KRT13) Intermediate filament family P13646
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 25 (KRT25) Intermediate filament family Q7Z3Z0
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 28 (KRT28) Intermediate filament family Q7Z3Y7
Keratin, type I cytoskeletal 39 (KRT39) Intermediate filament family Q6A163
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Protein Mis18-beta (OIP5) Mis18 family O43482
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.