Details of the Target

General Information of Target

Target ID LDTP10282
Target Name DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3)
Gene Name DNAJA3
Gene ID 9093
Synonyms
HCA57; TID1; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; hTid-1; Hepatocellular carcinoma-associated antigen 57; Tumorous imaginal discs protein Tid56 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRW
ETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVI
RELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAY
GRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSG
EVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQG
IGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPL
KCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY
SMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQ
DESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAA
Target Bioclass
Other
Subcellular location
Mitochondrion matrix
Function
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Uniprot ID
Q96EY1
Ensemble ID
ENST00000262375.11
HGNC ID
HGNC:11808

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DEL SNV: p.G279S .
HCC1395 SNV: p.E462Ter .
HUCCT1 SNV: p.Q153E DBIA    Probe Info 
LS123 SNV: p.S40G .
MCC13 Substitution: p.P268F .
SBC5 SNV: p.R58Ter .
SNU1 Deletion: p.L471QfsTer3
SNV: p.V12L		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y120(9.80); Y399(5.16)  LDD0260  [1]
OPA-S-S-alkyne
 Probe Info  		K391(1.50)  LDD3494  [2]
Probe 1
 Probe Info  		Y113(44.39); Y120(23.83)  LDD3495  [3]
Acrolein
 Probe Info  		C236(0.00); C292(0.00); H171(0.00)  LDD0227  [4]
DBIA
 Probe Info  		C289(0.59); C292(0.59)  LDD0532  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
m-APA
 Probe Info  		N.A.  LDD2234  [7]
1d-yne
 Probe Info  		N.A.  LDD0358  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		C289(0.00); C236(0.00)  LDD0162  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
1c-yne
 Probe Info  		K152(0.00); K226(0.00); K134(0.00)  LDD0228  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		19.63  LDD0472  [14]
FFF probe13
 Probe Info  		13.73  LDD0475  [14]
FFF probe2
 Probe Info  		13.27  LDD0463  [14]
STS-2
 Probe Info  		N.A.  LDD0139  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]
Dasatinib-CA-8PAP
 Probe Info  		4.50  LDD0364  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C289(0.76); C292(0.76)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C289(0.59); C292(0.59)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C289(0.78); C292(0.78)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C289(0.84); C292(0.84)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C289(0.89); C292(0.89)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C289(0.84); C292(0.84)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C289(1.05); C292(1.05)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C289(0.83); C292(0.83)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C289(0.92); C292(0.92)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C289(0.82); C292(0.82)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C289(0.77); C292(0.77)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C289(1.05); C292(1.05)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C289(0.54); C292(0.54)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C289(0.85); C292(0.85)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C289(0.93); C292(0.93)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C289(0.76); C292(0.76)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C289(0.73); C292(0.73)  LDD0554  [5]
 LDCM0246  AC128 HCT 116 C289(0.81); C292(0.81)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C289(0.90); C292(0.90)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C289(0.94); C292(0.94)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C289(1.02); C292(1.02)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C289(1.11); C292(1.11)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C289(0.92); C292(0.92)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C289(0.87); C292(0.87)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C289(0.83); C292(0.83)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C289(0.94); C292(0.94)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C289(0.97); C292(0.97)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C289(0.82); C292(0.82)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C289(0.84); C292(0.84)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C289(0.71); C292(0.71)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C289(0.84); C292(0.84)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C289(0.98); C292(0.98)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C289(1.25); C292(1.25)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C289(1.05); C292(1.05)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C289(0.86); C292(0.86)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C289(1.00); C292(1.00)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C289(0.92); C292(0.92)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C289(1.08); C292(1.08)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C289(0.96); C292(0.96)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C289(0.97); C292(0.97)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C289(0.60); C292(0.60)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C289(0.84); C292(0.84)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C289(0.87); C292(0.87)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C289(0.89); C292(0.89)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C289(1.06); C292(1.06)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C289(1.13); C292(1.13)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C289(1.10); C292(1.10)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C289(0.97); C292(0.97)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C289(1.10); C292(1.10)  LDD2161  [5]
 LDCM0279  AC2 HEK-293T C289(0.99); C292(0.99)  LDD0877  [5]
 LDCM0290  AC3 HEK-293T C289(0.98); C292(0.98)  LDD0888  [5]
 LDCM0296  AC35 HCT 116 C292(0.90)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C292(0.87)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C292(0.94)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C292(0.86)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C292(0.93)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C289(0.89); C292(0.89)  LDD0899  [5]
 LDCM0302  AC40 HCT 116 C292(1.02)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C292(0.85)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C292(1.10)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C292(0.73)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C292(0.95)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C292(0.87)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C289(1.04); C292(1.04)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C289(0.86); C292(0.86)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C289(1.47); C292(1.47)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C289(0.75); C292(0.75)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C289(0.91); C292(0.91)  LDD0910  [5]
 LDCM0313  AC50 HCT 116 C289(0.76); C292(0.76)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C289(1.51); C292(1.51)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C289(0.91); C292(0.91)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C289(0.81); C292(0.81)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C289(0.98); C292(0.98)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C289(0.89); C292(0.89)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C289(0.72); C292(0.72)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C289(0.50); C292(0.50)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C289(0.54); C292(0.54)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C289(0.41); C292(0.41)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C289(0.62); C292(0.62)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C289(0.52); C292(0.52)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C289(0.69); C292(0.69)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C289(0.43); C292(0.43)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C289(0.52); C292(0.52)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C289(0.46); C292(0.46)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C289(0.45); C292(0.45)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C289(0.49); C292(0.49)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C289(0.29); C292(0.29)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C289(0.82); C292(0.82)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C289(0.70); C292(0.70)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C289(0.79); C292(0.79)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C289(0.37); C292(0.37)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C289(0.87); C292(0.87)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C289(0.66); C292(0.66)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C289(0.46); C292(0.46)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C289(0.49); C292(0.49)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C289(0.44); C292(0.44)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C289(0.58); C292(0.58)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C289(0.57); C292(0.57)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C289(0.88); C292(0.88)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C289(0.59); C292(0.59)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C289(0.65); C292(0.65)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C289(0.58); C292(0.58)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C289(0.80); C292(0.80)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C289(0.29); C292(0.29)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C289(0.44); C292(0.44)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C289(0.47); C292(0.47)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C289(0.64); C292(0.64)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C289(0.55); C292(0.55)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C289(0.85); C292(0.85)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C289(0.63); C292(0.63)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C289(0.54); C292(0.54)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C289(1.13); C292(1.13)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C289(0.45); C292(0.45)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C289(0.52); C292(0.52)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C289(0.64); C292(0.64)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C289(0.76); C292(0.76)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C289(1.08); C292(1.08)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C289(0.60); C292(0.60)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C289(0.51); C292(0.51)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C289(0.87); C292(0.87)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C289(0.84); C292(0.84)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C289(0.93); C292(0.93)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C289(0.75); C292(0.75)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C289(0.52); C292(0.52)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C289(1.22); C292(1.22)  LDD2171  [5]
 LDCM0367  CL1 HEK-293T C289(0.99); C292(0.99)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C289(0.80); C292(0.80)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C289(0.89); C292(0.89)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C289(0.62); C292(0.62)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C289(0.80); C292(0.80)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C289(0.86); C292(0.86)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C289(0.79); C292(0.79)  LDD0690  [5]
 LDCM0379  CL11 HEK-293T C289(0.93); C292(0.93)  LDD0977  [5]
 LDCM0387  CL117 HCT 116 C292(1.03)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C292(0.91)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C292(0.91)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C289(0.91); C292(0.91)  LDD0988  [5]
 LDCM0391  CL120 HCT 116 C292(0.90)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C289(2.38); C292(2.38)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C289(0.96); C292(0.96)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C289(0.75); C292(0.75)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C289(0.76); C292(0.76)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C289(0.71); C292(0.71)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C289(0.55); C292(0.55)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C289(0.57); C292(0.57)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C289(0.56); C292(0.56)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C289(0.82); C292(0.82)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C289(0.91); C292(0.91)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C289(0.94); C292(0.94)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C289(1.13); C292(1.13)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C289(0.94); C292(0.94)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C289(1.14); C292(1.14)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C289(1.18); C292(1.18)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C289(1.14); C292(1.14)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C289(1.16); C292(1.16)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C289(1.24); C292(1.24)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C289(1.03); C292(1.03)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C289(1.26); C292(1.26)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C289(1.31); C292(1.31)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C289(1.11); C292(1.11)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C289(1.12); C292(1.12)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C289(1.40); C292(1.40)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C289(1.15); C292(1.15)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C289(1.24); C292(1.24)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C289(1.00); C292(1.00)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C289(1.27); C292(1.27)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C289(0.93); C292(0.93)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C289(1.16); C292(1.16)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C289(1.15); C292(1.15)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C289(1.05); C292(1.05)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C289(0.92); C292(0.92)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C289(1.05); C292(1.05)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C289(1.01); C292(1.01)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C289(0.92); C292(0.92)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C289(1.00); C292(1.00)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C289(1.44); C292(1.44)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C289(1.15); C292(1.15)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C289(0.88); C292(0.88)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C289(1.03); C292(1.03)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C289(1.46); C292(1.46)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C289(0.90); C292(0.90)  LDD1033  [5]
 LDCM0436  CL46 HCT 116 C289(1.61); C292(1.61)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C289(1.44); C292(1.44)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C289(1.27); C292(1.27)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C289(1.07); C292(1.07)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C289(1.08); C292(1.08)  LDD1038  [5]
 LDCM0441  CL50 HCT 116 C289(1.10); C292(1.10)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C289(1.15); C292(1.15)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C289(1.20); C292(1.20)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C289(1.38); C292(1.38)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C289(1.54); C292(1.54)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C289(1.39); C292(1.39)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C289(1.17); C292(1.17)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C289(1.18); C292(1.18)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C289(1.44); C292(1.44)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C289(1.23); C292(1.23)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C289(0.91); C292(0.91)  LDD1049  [5]
 LDCM0452  CL60 HCT 116 C289(1.02); C292(1.02)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C289(1.24); C292(1.24)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C289(1.00); C292(1.00)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C289(1.22); C292(1.22)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C289(0.88); C292(0.88)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C289(1.18); C292(1.18)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C289(0.93); C292(0.93)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C289(0.95); C292(0.95)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C289(1.16); C292(1.16)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C289(1.15); C292(1.15)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C289(0.98); C292(0.98)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C289(1.22); C292(1.22)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C289(1.21); C292(1.21)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C289(0.91); C292(0.91)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C289(0.99); C292(0.99)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C289(0.95); C292(0.95)  LDD1065  [5]
 LDCM0469  CL76 HCT 116 C289(0.86); C292(0.86)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C289(0.73); C292(0.73)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C289(0.62); C292(0.62)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C289(0.56); C292(0.56)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C289(0.87); C292(1.17)  LDD1071  [5]
 LDCM0474  CL80 HCT 116 C289(0.83); C292(0.83)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C289(0.64); C292(0.64)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C289(0.54); C292(0.54)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C289(0.48); C292(0.48)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C289(0.44); C292(0.44)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C289(0.55); C292(0.55)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C289(0.77); C292(0.77)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C289(0.66); C292(0.66)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C289(0.65); C292(0.65)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C289(0.47); C292(0.47)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C289(1.07); C292(1.10)  LDD1082  [5]
 LDCM0485  CL90 HCT 116 C289(0.76); C292(0.76)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C289(0.86); C292(0.86)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C289(1.10); C292(1.10)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C289(0.91); C292(0.91)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C289(1.00); C292(1.00)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C289(0.74); C292(0.74)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C289(0.90); C292(0.90)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C289(1.33); C292(1.33)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C289(0.90); C292(0.90)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C289(0.77); C292(0.77)  LDD1092  [5]
 LDCM0097  Dasatinib K562 4.50  LDD0364  [17]
 LDCM0468  Fragment33 HEK-293T C289(0.97); C292(0.97)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C289(0.98); C292(0.98)  LDD1025  [5]
 LDCM0022  KB02 8305C C83(1.09)  LDD2248  [18]
 LDCM0023  KB03 8505C C83(1.25)  LDD2666  [18]
 LDCM0024  KB05 HMCB C83(1.02)  LDD3312  [18]
 LDCM0109  NEM HeLa C236(0.00); C292(0.00); H171(0.00)  LDD0227  [4]
 LDCM0021  THZ1 HCT 116 C289(1.22); C292(1.22)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-arginine methyltransferase CARM1 (CARM1) Protein arginine N-methyltransferase family Q86X55
Protein arginine N-methyltransferase 6 (PRMT6) Protein arginine N-methyltransferase family Q96LA8
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
Caspase-6 (CASP6) Peptidase C14A family P55212
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fos-related antigen 2 (FOSL2) BZIP family P15408
Signal transducer and activator of transcription 5B (STAT5B) Transcription factor STAT family P51692
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Ataxin-1 (ATXN1) ATXN1 family P54253
Nucleolar complex protein 4 homolog (NOC4L) CBF/MAK21 family Q9BVI4
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OKL38 family Q9UJX0
Gelsolin (GSN) Villin/gelsolin family P06396
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
FERM domain-containing protein 6 (FRMD6) . Q96NE9
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
TAR DNA-binding protein 43 (TARDBP) . Q13148
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840