Details of the Target

General Information of Target

Target ID LDTP02824
Target Name Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2)
Gene Name NQO2
Gene ID 4835
Synonyms
NMOR2; Ribosyldihydronicotinamide dehydrogenase [quinone]; EC 1.10.5.1; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Quinone reductase 2; QR2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
Target Type
Successful
Target Bioclass
Enzyme
Family
NAD(P)H dehydrogenase (quinone) family
Subcellular location
Cytoplasm
Function
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
TTD ID
T75498
Uniprot ID
P16083
DrugMap ID
TTJLP0R
Ensemble ID
ENST00000338130.7
HGNC ID
HGNC:7856
ChEMBL ID
CHEMBL3959

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 3
 Probe Info  		5.03  LDD0282  [1]
THZ1-DTB
 Probe Info  		C223(1.23)  LDD0460  [2]
DBIA
 Probe Info  		C223(1.01)  LDD0532  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		H73(0.00); H226(0.00)  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C223(0.00); C122(0.00); C180(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C223(0.00); C180(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C223(0.00); C122(0.00); C180(0.00)  LDD0037  [5]
AOyne
 Probe Info  		13.10  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Dasatinib-CA-8PAP
 Probe Info  		8.00  LDD0364  [7]
Staurosporine capture compound
 Probe Info  		23.00  LDD0083  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C180(0.72); C122(0.90)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C223(1.01)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C223(1.16)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C223(1.20)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C223(1.23)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C223(1.35)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C223(0.98)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C223(1.22)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C223(1.31)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C223(1.22)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C223(1.19)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C223(0.96)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C223(1.23)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C223(1.32)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C223(1.23)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C223(1.19)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C223(0.94)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C223(1.57)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C223(1.16)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C223(1.59)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C223(1.25)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C223(1.63)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C223(1.80)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C223(0.95)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C223(1.84)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C223(0.93)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C223(1.95)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C223(0.77)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C223(1.91)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C223(1.68)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C223(0.95)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C223(1.39)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C223(1.13)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C223(0.95)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C223(0.99)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C223(1.20)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C223(1.03)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C223(0.96)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C223(1.34)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C223(1.09)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C223(1.20)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C223(1.00)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C223(1.36)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C223(1.28)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C223(1.34)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C223(1.44)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C223(1.24)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C223(1.19)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C223(1.06)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C223(1.09)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C223(0.82)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C223(0.93)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C223(0.99)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C223(1.05)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C223(1.09)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C223(1.05)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C223(0.89)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C223(1.16)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C223(0.99)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C223(0.90)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C223(0.80)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C223(0.87)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C223(0.88)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C223(0.78)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C180(0.96); C122(0.90)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C180(0.59); C122(0.98)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C180(0.78); C122(0.74)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C180(1.14); C122(0.78)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C180(0.80); C122(0.85)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C180(0.83); C122(0.91)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C180(0.89); C122(0.90)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C180(0.73); C122(0.85)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C180(0.99); C122(0.97)  LDD1523  [9]
 LDCM0285  AC25 HCT 116 C223(0.78)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C223(0.82)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C223(0.94)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C223(0.73)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C223(0.94)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C180(0.84); C122(1.18)  LDD1529  [9]
 LDCM0291  AC30 HCT 116 C223(1.08)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C223(0.88)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C223(1.07)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C223(0.85)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C223(1.23)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C223(1.06)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C223(1.19)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C223(1.06)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C223(1.29)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C223(1.05)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C180(0.94); C122(0.77)  LDD1540  [9]
 LDCM0302  AC40 HCT 116 C223(1.21)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C223(1.36)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C223(1.25)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C223(1.21)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C223(1.17)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C223(1.12)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C223(0.85)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C223(0.72)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C223(0.75)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C223(0.93)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C180(0.88); C122(1.07)  LDD1551  [9]
 LDCM0313  AC50 HCT 116 C223(1.08)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C223(1.04)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C223(0.75)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C223(0.84)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C223(0.74)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C223(0.68)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C223(0.72)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C223(0.88)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C223(1.04)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C223(1.13)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C223(0.93)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C223(1.08)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C223(0.86)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C223(0.95)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C223(1.16)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C223(1.23)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C223(1.02)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C223(1.22)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C223(1.21)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C223(1.13)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C223(0.95)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C223(0.95)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C223(1.09)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C223(1.07)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C223(0.90)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C223(0.96)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C223(1.07)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C223(1.07)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C223(1.23)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C223(0.89)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C223(0.87)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C223(1.28)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C223(0.78)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C223(1.02)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C223(0.86)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C223(1.18)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C223(1.20)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C223(1.10)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C223(1.13)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C223(1.20)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C223(1.12)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C223(0.93)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C223(1.26)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C223(1.10)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C180(0.91); C122(1.04)  LDD1573  [9]
 LDCM0370  CL101 HCT 116 C223(1.39)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C223(2.26)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C223(1.53)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C223(1.51)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C180(0.88); C122(0.85)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C180(0.93); C122(0.94)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C180(0.86); C122(0.82)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C180(0.79); C122(0.84)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C180(0.95); C122(0.77)  LDD1582  [9]
 LDCM0379  CL11 HCT 116 C223(1.24)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C180(0.70); C122(0.82)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C180(0.80); C122(0.95)  LDD1585  [9]
 LDCM0382  CL112 HCT 116 C223(0.89)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C223(1.02)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C223(1.25)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C223(1.15)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C223(1.05)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C223(1.41)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C223(1.00)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C223(1.02)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C223(1.42)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C223(1.09)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C223(0.75)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C223(0.75)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C223(0.60)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C223(0.62)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C223(0.93)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C223(1.18)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C223(1.10)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C223(0.85)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C223(1.21)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C223(1.17)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C223(1.17)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C180(0.71); C122(1.04)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C180(0.48); C122(0.94)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C180(0.89); C122(0.93)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C180(0.78); C122(1.08)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C223(1.12)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C180(0.70); C122(1.09)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C180(0.79); C122(0.83)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C180(0.92); C122(1.52)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C180(0.89); C122(0.87)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C180(1.07); C122(1.16)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C180(0.68); C122(0.80)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C180(0.92); C122(0.91)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C180(0.88); C122(0.70)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C180(1.04); C122(0.88)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C180(0.72); C122(0.87)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C223(1.19)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C180(0.78); C122(1.46)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C180(0.91); C122(0.92)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C180(0.78); C122(0.88)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C180(0.65); C122(0.82)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C180(0.87); C122(1.05)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C180(0.76); C122(0.82)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C180(1.02); C122(1.05)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C180(0.70); C122(0.80)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C180(0.89); C122(0.75)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C223(1.83)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C180(1.08); C122(0.89)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C180(0.70); C122(0.80)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C180(0.66); C122(1.01)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C180(1.02); C122(1.06)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C180(0.85); C122(0.93)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C180(0.72); C122(1.01)  LDD1639  [9]
 LDCM0436  CL46 HCT 116 C223(1.09)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C223(0.81)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C223(1.11)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C223(1.04)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C223(1.03)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C223(0.97)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C223(0.93)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C223(1.50)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C223(1.27)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C223(1.09)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C223(1.07)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C223(1.02)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C223(0.98)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C223(1.34)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C223(1.00)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C223(0.89)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C223(0.97)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C180(0.73); C122(1.00)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C180(1.08); C122(0.94)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C180(1.00); C122(0.69)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C180(0.72); C122(0.87)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C180(0.83); C122(0.78)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C180(0.80); C122(1.09)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C180(0.90); C122(1.20)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C180(0.80); C122(0.80)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C180(0.72); C122(0.97)  LDD1664  [9]
 LDCM0462  CL7 HCT 116 C223(0.99)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C180(0.79); C122(1.14)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C180(0.63); C122(0.94)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C180(1.04); C122(1.34)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C180(0.69); C122(0.86)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C180(0.93); C122(0.93)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C180(1.01); C122(0.98)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C180(0.75); C122(0.90)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C180(0.77); C122(1.02)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C180(0.95); C122(1.21)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C223(1.14)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C180(0.92); C122(1.09)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C180(0.87); C122(0.93)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C180(1.06); C122(1.26)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C180(0.90); C122(0.88)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C180(0.58); C122(1.30)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C180(0.45); C122(0.92)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C180(0.55); C122(1.09)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C180(0.71); C122(0.93)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C180(0.66); C122(1.07)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C180(0.61); C122(0.99)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C223(1.23)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C180(0.09); C122(0.92)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C180(0.71); C122(1.16)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C180(0.64); C122(0.81)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C180(0.68); C122(0.96)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C180(0.76); C122(0.95)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C180(0.55); C122(0.83)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C180(0.51); C122(0.95)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C180(0.87); C122(0.75)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C180(0.89); C122(0.88)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C180(0.98); C122(0.71)  LDD1697  [9]
 LDCM0097  Dasatinib K562 8.00  LDD0364  [7]
 LDCM0495  E2913 HEK-293T C180(1.04); C122(0.62)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C180(0.89); C122(0.75)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C180(1.00); C122(0.88)  LDD1631  [9]
 LDCM0022  KB02 A204 C223(1.31)  LDD2252  [10]
 LDCM0023  KB03 A204 C223(1.95); C122(1.42)  LDD2669  [10]
 LDCM0024  KB05 MKN-1 C122(1.97)  LDD3331  [10]
 LDCM0099  Phenelzine HEK-293T 5.03  LDD0282  [1]
 LDCM0019  Staurosporine Hep-G2 23.00  LDD0083  [8]
 LDCM0021  THZ1 HeLa S3 C223(1.23)  LDD0460  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Iron-sulfur cluster co-chaperone protein HscB (HSCB) HscB family Q8IWL3
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dabigatran Etexilate Small molecular drug DB06695
Flavin Adenine Dinucleotide Small molecular drug DB03147
Melatonin Small molecular drug D0AN7B
Menadione Small molecular drug DB00170
Nadh Small molecular drug DB00157
Primaquine Small molecular drug DB01087
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nsc-645809 Small molecular drug D07JTD
Prolarix Small molecular drug D0C6VV
Investigative
Click To Hide/Show 73 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,4-dimethylquinolin-2(1h)-one Small molecular drug D04LWL
10-propargyl-5,8-dideazafolic Acid Small molecular drug D0PG5D
10-propargyl-58-dideazafolic Acid Small molecular drug DB03541
2-iodo-melatonin Small molecular drug D0H6YF
3,4,5-trimethoxy-4'-amino-trans-stilbene Small molecular drug D09MQF
3,5-dimethoxy-4'-amino-trans-stilbene Small molecular drug D0Q8UZ
5,6,8-trimethoxy-1,4-dimethylquinolin-2(1h)-one Small molecular drug D0T5NO
5,6,8-trimethoxy-4-methylquinolin-2(1h)-one Small molecular drug D06UQR
5,8-dimethoxy-1,4-dimethylquinolin-2(1h)-one Small molecular drug D0C8KC
5,8-dimethoxy-4-methylquinolin-2(1h)-one Small molecular drug D0S1AY
58-dimethoxy-14-dimethylquinolin-2(1h)-one Small molecular drug DB08228
6,7,8-trimethoxy-1,4-dimethylquinolin-2(1h)-one Small molecular drug D08FHU
6,7,8-trimethoxy-4-methylquinolin-2(1h)-one Small molecular drug D05YCI
6,8-dimethoxy-1,4-dimethylquinolin-2(1h)-one Small molecular drug D09DRS
6,8-dimethoxy-4-methylquinolin-2(1h)-one Small molecular drug D08ISK
6-methyl-[1,3]Dioxolo[4,5-h]Quinolin-8(9h)-one Small molecular drug D0O4YS
7,8-dimethoxy-1,4-dimethylquinolin-2(1h)-one Small molecular drug D0XQ6T
8-methoxy-1,4-dimethylquinolin-2(1h)-one Small molecular drug D0L3AJ
Decynium 22 Small molecular drug D0I5YK
Flavin-adenine Dinucleotide Small molecular drug D00IMW
N-[2-(2-iodo-5-methoxy-1h-indol-3-yl)Ethyl]Acetamide Small molecular drug DB08190
Nsc-106080 Small molecular drug D0J3RB
Nsc-115890 Small molecular drug D04PMX
Nsc-180969 Small molecular drug D0W8VX
Nsc-204996 Small molecular drug D01DYZ
Nsc-238146 Small molecular drug D00GIU
Nsc-300853 Small molecular drug D01WRT
Nsc-306843 Small molecular drug D09XVU
Nsc-356819 Small molecular drug D0WW2D
Nsc-356820 Small molecular drug D0OT1Z
Nsc-359466 Small molecular drug D0Z9MG
Nsc-381864 Small molecular drug D00OTC
Nsc-637991 Small molecular drug D02NED
Nsc-637992 Small molecular drug D0O6NU
Nsc-637993 Small molecular drug D0Q8JE
Nsc-637994 Small molecular drug D0A0DN
Nsc-640353 Small molecular drug D02GDG
Nsc-640558 Small molecular drug D0M7RM
Nsc-640559 Small molecular drug D00DSW
Nsc-640566 Small molecular drug D08WKQ
Nsc-640583 Small molecular drug D06GRP
Nsc-640584 Small molecular drug D0UB3V
Nsc-645808 Small molecular drug D0E0DQ
Nsc-645811 Small molecular drug D0TT3K
Nsc-645812 Small molecular drug D03QRT
Nsc-645831 Small molecular drug D05GDD
Nsc-645833 Small molecular drug D00SNO
Nsc-645834 Small molecular drug D04KTJ
Nsc-645835 Small molecular drug D04UGI
Nsc-645836 Small molecular drug D01ZKN
Nsc-649091 Small molecular drug D0I3PD
Nsc-660838 Small molecular drug D03SBI
Nsc-660839 Small molecular drug D08NCP
Nsc-660840 Small molecular drug D08NWU
Nsc-660841 Small molecular drug D01JID
Nsc-665126 Small molecular drug D00GUG
Nsc-669977 Small molecular drug D03GWA
Nsc-676468 Small molecular drug D0G8VF
Nsc-677939 Small molecular drug D02DOX
Nsc-693571 Small molecular drug D05TZK
Nsc-720622 Small molecular drug D0W9ZH
Nsc-77833 Small molecular drug D06CHV
Nsc-78017 Small molecular drug D0K0TO
Nsc-78021 Small molecular drug D07OAH
Nsc-86715 Small molecular drug D0H3LU
Nsc-99495 Small molecular drug D0S6RL
Nsc-99528 Small molecular drug D0M0WT
Quercetin Small molecular drug DB04216
Resveratrol Small molecular drug DB02709
Tretazicar Small molecular drug DB04253
(3s)-3-hydroxy-1-methyl-23-dihydro-1h-indole-56-dione . DB07339
Casimiroin . DB08744
Nsc-640556 . D0G7MJ
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cb1954 Small molecular drug D07ZHV

References

1 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
8 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840