Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name WP  Probe Info 
Probe concentration 8 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name WA  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lung
Disease Model Lung adenocarcinoma [ICD-11:2C25]
Model Name Human lung adenocarcinoma cells (NCI-H1975)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03510  Peroxiredoxin-6 (PRDX6) 2.9
 LDTP03229  Ribosomal protein S6 kinase beta-1 (RPS6KB1) 2.7
 LDTP10137  Cytochrome c oxidase assembly factor 7 (COA7) 2.7
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 2.6
 LDTP03944  Tyrosine-protein kinase CSK (CSK) 2.5
 LDTP05573  Peptidyl-prolyl cis-trans isomerase D (PPID) 2.5
 LDTP03607  RAC-alpha serine/threonine-protein kinase (AKT1) 2.4
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10033  WW domain-binding protein 2 (WBP2) 2.8
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 2.3

References

1 Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biol. 2021 Oct;46:102130. doi: 10.1016/j.redox.2021.102130. Epub 2021 Sep 9.