Details of the Target

General Information of Target

Target ID LDTP10137
Target Name Cytochrome c oxidase assembly factor 7 (COA7)
Gene Name COA7
Gene ID 65260
Synonyms
C1orf163; RESA1; SELRC1; Cytochrome c oxidase assembly factor 7; Beta-lactamase hcp-like protein; Respiratory chain assembly factor 1; Sel1 repeat-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
AFVGFSYAPPSEDLFL
Target Bioclass
Enzyme
Family
Hcp beta-lactamase family
Subcellular location
Mitochondrion intermembrane space
Function Required for assembly of mitochondrial respiratory chain complex I and complex IV.
Uniprot ID
Q96BR5
Ensemble ID
ENST00000371538.5
HGNC ID
HGNC:25716

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		C172(0.00); C28(0.00); C24(0.00)  LDD0241  [2]
SAHA-CA-4PAP
 Probe Info  		4.00  LDD0360  [3]
BTD
 Probe Info  		C172(0.40)  LDD2100  [4]
WP
 Probe Info  		2.70  LDD0192  [5]
HHS-482
 Probe Info  		Y72(0.80)  LDD0285  [6]
HHS-475
 Probe Info  		Y72(1.34)  LDD0264  [7]
DBIA
 Probe Info  		C62(9.82); C71(9.82); C37(3.83); C172(3.65)  LDD0080  [8]
5E-2FA
 Probe Info  		H218(0.00); H67(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K106(0.00); K82(0.00); K90(0.00); K195(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		C179(0.00); C172(0.00); C111(0.00)  LDD0162  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
NHS
 Probe Info  		N.A.  LDD0010  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [13]
Phosphinate-6
 Probe Info  		C111(0.00); C24(0.00)  LDD0018  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [17]
Acrolein
 Probe Info  		C62(0.00); C71(0.00); C172(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		C62(0.00); C71(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [2]
NAIA_5
 Probe Info  		C172(0.00); C111(0.00); C100(0.00); C95(0.00)  LDD2223  [14]
HHS-465
 Probe Info  		K73(0.00); Y72(0.00)  LDD2240  [19]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		24.08  LDD1865  [20]
C191
 Probe Info  		16.22  LDD1868  [20]
C193
 Probe Info  		6.45  LDD1869  [20]
C232
 Probe Info  		36.76  LDD1905  [20]
C275
 Probe Info  		7.36  LDD1945  [20]
C293
 Probe Info  		15.89  LDD1963  [20]
C296
 Probe Info  		12.38  LDD1966  [20]
C338
 Probe Info  		13.09  LDD2001  [20]
C350
 Probe Info  		28.05  LDD2011  [20]
C407
 Probe Info  		13.27  LDD2064  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C172(0.35)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C172(0.70)  LDD2112  [4]
 LDCM0214  AC1 HCT 116 C179(0.79); C187(0.79); C37(0.93); C62(1.02)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C179(1.04); C187(1.04); C37(0.78); C62(0.94)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C179(0.84); C187(0.84); C37(0.88); C62(0.88)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C179(0.86); C187(0.86); C37(0.94); C62(1.09)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C179(0.74); C187(0.74); C37(0.86); C62(1.23)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C179(0.72); C187(0.72); C37(0.91); C62(1.03)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C179(0.93); C187(0.93); C37(0.86); C62(1.33)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C179(0.86); C187(0.86); C37(0.85); C62(1.10)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C179(0.59); C187(0.59); C37(0.97); C62(0.97)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C179(0.66); C187(0.66); C37(0.90); C62(1.01)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C179(0.90); C187(0.90); C37(0.97); C62(0.95)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C179(0.79); C187(0.79); C37(0.87); C62(0.87)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C179(0.84); C187(0.84); C37(0.98); C62(1.07)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C179(0.83); C187(0.83); C37(0.94); C62(1.11)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C179(0.76); C187(0.76); C37(0.94); C62(0.91)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C179(0.77); C187(0.77); C37(1.06); C62(0.98)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C172(1.00); C179(1.16); C187(1.16); C37(1.08)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C172(0.98); C179(1.10); C187(1.10); C37(1.02)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C172(1.03); C179(1.30); C187(1.30); C37(1.10)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C172(0.87); C179(1.11); C187(1.11); C37(1.24)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C172(0.96); C179(1.18); C187(1.18); C37(1.26)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C172(1.03); C179(0.99); C187(0.99); C37(1.13)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C172(0.94); C179(1.05); C187(1.05); C37(1.34)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C179(1.10); C187(1.10); C37(1.27); C62(1.11)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C172(1.03); C179(1.17); C187(1.17); C37(1.07)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C172(0.99); C179(0.95); C187(0.95); C37(0.82)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C172(0.81); C179(0.95); C187(0.95); C37(1.08)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C172(0.82); C179(0.84); C187(0.84); C37(1.02)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C172(0.87); C179(1.30); C187(1.30); C37(0.92)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C172(0.99); C179(1.03); C187(1.03); C37(1.08)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C172(1.51); C179(1.26); C187(1.26); C37(0.98)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C172(1.19); C179(1.23); C187(1.23); C37(1.16)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C179(0.88); C187(0.88); C62(0.72); C71(0.72)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C179(0.83); C187(0.83); C62(1.08); C71(1.08)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C179(0.79); C187(0.79); C62(0.66); C71(0.66)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C179(0.75); C187(0.75); C62(0.73); C71(0.73)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C179(0.64); C187(0.64); C62(0.58); C71(0.58)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C179(0.65); C187(0.65); C62(0.47); C71(0.47)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C179(1.02); C187(1.02); C62(0.64); C71(0.64)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C179(0.80); C187(0.80); C62(0.66); C71(0.66)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C179(0.64); C187(0.64); C62(0.47); C71(0.47)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C179(0.81); C187(0.81); C62(0.95); C71(0.95)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C179(0.89); C187(0.89); C62(0.53); C71(0.53)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C179(0.97); C187(0.97); C62(0.73); C71(0.73)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C179(1.25); C187(1.25); C37(1.07); C62(1.08)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C179(0.87); C187(0.87); C62(0.54); C71(0.54)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C179(0.84); C187(0.84); C62(0.71); C71(0.71)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C179(0.62); C187(0.62); C62(0.72); C71(0.72)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C95(0.93); C100(0.93); C172(0.95); C37(0.95)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C95(0.82); C100(0.82); C172(1.04); C62(1.08)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C95(0.81); C100(0.81); C62(0.95); C71(0.95)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C62(0.86); C71(0.86); C95(0.92); C100(0.92)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C95(0.92); C100(0.92); C62(0.96); C71(0.96)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C95(0.86); C100(0.86); C179(0.96); C187(0.96)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C179(1.14); C187(1.14); C95(1.17); C100(1.17)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C37(0.97); C62(0.99); C71(0.99); C179(1.09)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C62(1.05); C71(1.05); C172(1.08); C95(1.08)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C95(0.84); C100(0.84); C37(1.07); C179(1.13)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C95(0.94); C100(0.94); C62(0.99); C71(0.99)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C179(0.79); C187(0.79); C95(0.93); C100(0.93)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C95(0.95); C100(0.95); C172(1.32); C179(1.34)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C95(0.90); C100(0.90); C172(1.42); C179(1.41)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C95(0.97); C100(0.97); C172(1.28); C179(1.06)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C95(0.93); C100(0.93); C172(1.33); C179(1.35)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C37(1.03)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C37(1.01)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C37(1.07)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C37(1.00); C179(1.01); C187(1.01); C62(1.07)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C37(1.03)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C37(0.99)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C37(1.06)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C37(1.16)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C37(1.00)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C172(0.82); C62(0.92); C71(0.92); C37(1.08)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C172(0.79); C62(0.88); C71(0.88); C37(1.15)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C172(0.88); C62(0.88); C71(0.88); C37(1.03)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C172(0.86); C62(1.01); C71(1.01); C37(1.13)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C62(1.03); C71(1.03); C172(1.04); C37(1.42)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C37(0.93); C179(1.05); C187(1.05); C62(1.09)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C172(1.08); C62(1.20); C71(1.20); C37(1.75)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C172(0.82); C62(0.95); C71(0.95); C37(1.28)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C62(0.99); C71(0.99); C172(1.10); C37(1.48)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C172(0.82); C62(0.88); C71(0.88); C37(1.24)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C172(0.87); C37(1.10); C62(1.22); C71(1.22)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C62(0.99); C71(0.99); C37(1.18)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C62(0.97); C71(0.97); C37(1.28)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C37(1.01); C62(1.55); C71(1.55)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C62(1.08); C71(1.08); C37(1.52)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C62(1.06); C71(1.06); C37(1.31)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C62(0.89); C71(0.89); C37(0.93); C179(1.07)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C62(1.03); C71(1.03); C37(1.41)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C62(1.17); C71(1.17); C37(1.25)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C62(1.11); C71(1.11); C37(1.35)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C37(1.30); C62(1.61); C71(1.61)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C37(1.15); C62(1.29); C71(1.29)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C62(1.20); C71(1.20); C37(1.21)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C37(0.97); C179(1.02); C187(1.02)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C37(0.79); C179(0.90); C187(0.90)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C179(0.81); C187(0.81); C37(0.93)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C179(0.84); C187(0.84); C37(0.96)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C179(0.84); C187(0.84); C37(0.93); C62(1.07)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C37(0.73); C179(1.16); C187(1.16)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C37(0.89); C179(0.92); C187(0.92)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C37(0.69); C179(1.01); C187(1.01)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C37(0.76); C179(0.94); C187(0.94)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C37(0.78); C179(0.94); C187(0.94)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C37(1.20); C179(1.23); C187(1.23)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C179(0.99); C187(0.99); C37(1.33)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C37(1.10)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C37(1.47)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C37(1.26)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C37(0.80); C62(1.02); C71(1.02); C179(1.07)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C37(0.96)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C37(1.03)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C37(1.16)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C37(0.92)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C37(0.75)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C37(1.15)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C37(1.48)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C37(1.03)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C187(0.89); C179(0.95); C95(0.98); C62(1.00)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C172(0.89); C95(0.96); C187(1.02); C62(1.07)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C37(0.83); C62(1.08); C71(1.08); C179(1.08)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C187(0.87); C172(0.89); C62(0.92); C71(0.92)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C62(0.91); C71(0.91); C187(0.93); C95(0.95)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C95(0.95); C100(0.96); C187(1.04); C172(1.08)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C187(0.88); C179(0.92); C62(0.94); C71(0.94)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C187(0.87); C179(0.88); C62(0.93); C71(0.93)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C187(0.77); C179(0.83); C172(0.92); C95(0.92)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C95(0.84); C172(0.90); C100(0.91); C187(0.96)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C187(0.87); C100(0.94); C95(0.95); C62(0.97)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C172(0.89); C95(0.92); C187(0.92); C100(0.96)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C172(0.95); C187(0.97); C62(1.00); C71(1.00)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C62(0.92); C71(0.92); C37(0.96); C179(1.09)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C95(0.89); C172(1.01); C100(1.03); C187(1.11)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C179(0.92); C187(0.93); C62(0.96); C71(0.96)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C187(0.74); C62(0.77); C71(0.77); C179(0.78)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C62(0.82); C71(0.82); C179(1.03); C187(1.03)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C62(0.82); C71(0.82); C179(1.04); C187(1.04)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C62(0.79); C71(0.79); C179(1.31); C187(1.31)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C62(1.03); C71(1.03); C179(1.04); C187(1.04)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C37(1.08); C179(1.08); C187(1.08); C62(1.10)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C37(0.96); C62(1.06); C71(1.06); C179(1.60)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C62(1.08); C71(1.08); C37(1.15); C179(1.27)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C62(0.87); C71(0.87); C179(1.15); C187(1.15)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C62(1.00); C71(1.00); C179(1.28); C187(1.28)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C62(0.98); C71(0.98); C37(1.29); C179(1.35)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C62(1.07); C71(1.07); C179(1.15); C187(1.15)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C62(0.97); C71(0.97); C37(1.18); C179(1.46)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C62(0.93); C71(0.93); C37(1.08); C179(1.31)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C62(1.15); C71(1.15); C37(1.38); C179(1.47)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C37(1.19); C62(1.26); C71(1.26); C179(1.58)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C179(0.30); C187(0.30); C37(0.95); C62(1.05)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C179(0.70); C187(0.70); C37(0.91); C62(0.92)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C179(0.98); C187(0.98); C37(1.01); C62(1.06)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C37(0.89); C62(0.92); C71(0.92); C179(0.97)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C62(0.84); C71(0.84); C37(0.95); C179(1.03)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 13.89  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C37(1.08); C179(1.30); C187(1.30)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa C172(0.00); C62(0.00); C71(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C37(1.79); C95(1.91); C100(1.91)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C37(1.43); C95(1.64); C100(1.64)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C37(0.96); C62(1.02); C71(1.02); C179(1.04)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C37(1.03); C179(1.27); C187(1.27); C62(1.31)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C37(1.02); C179(1.61); C187(1.61); C62(2.12)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C37(1.04); C62(1.19); C71(1.19); C179(1.24)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C37(1.00); C179(1.09); C187(1.09); C62(1.21)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C37(1.03)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C37(1.01)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C37(1.04)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C37(1.03)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C37(1.07)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C95(1.44); C100(1.44); C37(1.58)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C37(1.01)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C37(1.15)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C172(0.80); C37(1.13); C62(1.30); C71(1.30)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C62(0.94); C71(0.94); C172(0.95); C37(1.48)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C172(0.92); C62(1.31); C71(1.31); C37(1.38)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C172(1.14); C62(1.16); C71(1.16); C37(1.42)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C172(1.00); C62(1.05); C71(1.05); C37(1.18)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C62(0.84); C71(0.84); C37(1.54)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C37(1.23); C62(1.33); C71(1.33)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C62(1.28); C71(1.28); C37(1.29)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C37(1.35); C95(1.57); C100(1.57)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C37(1.11); C62(1.17); C71(1.17)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C37(0.83); C179(1.04); C187(1.04)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C37(1.02); C179(1.30); C187(1.30)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C37(1.34); C179(1.60); C187(1.60)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C37(0.75); C179(1.24); C187(1.24)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C37(1.34)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C37(1.15)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C37(1.16)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C37(1.09)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C95(1.19); C100(1.19); C37(1.35)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C95(1.35); C100(1.35); C37(1.40)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C37(1.06); C95(1.36); C100(1.36)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C179(0.83); C187(0.83); C37(1.20)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C37(0.92)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C37(0.96)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C37(0.93)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C37(1.28); C95(1.36); C100(1.36)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C37(1.06)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C37(0.92)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C37(1.11)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C37(1.08)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C37(1.09)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C37(1.12)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C37(1.01)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C37(1.12)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C37(1.11)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C37(1.15)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C95(1.28); C100(1.28); C37(1.13)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C37(1.17)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C179(0.97); C187(0.97); C37(1.16)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C179(0.90); C187(0.90); C37(1.31)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C179(1.06); C187(1.06); C37(1.17)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C179(1.04); C187(1.04); C37(1.11)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C179(0.76); C187(0.76); C37(0.99)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C179(1.05); C187(1.05); C37(1.09)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C179(0.98); C187(0.98); C37(1.08)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C179(0.97); C187(0.97); C37(1.17)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C95(1.24); C100(1.24); C37(0.92)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C179(0.91); C187(0.91); C37(1.33)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C179(1.13); C187(1.13); C37(0.98)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C179(1.07); C187(1.07); C37(1.30)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C179(0.98); C187(0.98); C37(1.37)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C179(0.83); C187(0.83); C37(1.31)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C179(0.83); C187(0.83); C37(1.02)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C95(1.14); C100(1.54); C62(2.22); C71(2.22)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C95(1.41); C100(1.64); C62(1.86); C71(1.86)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C95(1.15); C100(1.44); C62(1.68); C71(1.68)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C95(0.87); C100(1.09); C62(1.20); C71(1.20)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C95(1.09); C100(1.09); C37(1.13)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C95(1.01); C100(1.13); C62(1.50); C71(1.50)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C95(1.16); C100(1.21); C62(1.32); C71(1.32)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C95(1.12); C100(1.46); C62(1.49); C71(1.49)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C95(2.41); C100(1.03); C62(1.59); C71(1.59)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C95(1.28); C100(1.29); C62(2.46); C71(2.46)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C95(1.22); C100(1.59); C62(1.73); C71(1.73)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C95(1.21); C100(1.05); C62(1.58); C71(1.58)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C95(1.83); C100(1.64); C62(1.61); C71(1.61)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C95(1.24); C100(1.70); C62(1.79); C71(1.79)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C95(0.93); C100(0.90); C62(1.25); C71(1.25)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C95(1.40); C100(1.40); C37(1.08)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C95(1.04); C100(1.12); C62(1.56); C71(1.56)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C95(1.27); C179(0.71); C187(0.71); C62(0.82)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C95(1.17); C179(0.84); C187(0.84); C62(1.21)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C95(3.17); C179(1.05); C187(1.05); C62(1.08)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C95(1.19); C179(0.84); C187(0.84); C62(0.79)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C95(1.25); C179(0.67); C187(0.67); C62(0.80)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C95(1.50); C179(0.91); C187(0.91); C62(1.10)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C95(1.70); C179(0.90); C187(0.90); C62(0.70)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C95(2.46); C179(1.20); C187(1.20); C62(0.90)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C95(2.33); C179(1.21); C187(1.21); C62(1.21)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C95(1.18); C100(1.18); C37(0.99)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C95(1.73); C179(0.92); C187(0.92); C62(0.67)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C95(1.98); C179(1.15); C187(1.15); C62(0.93)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C95(1.62); C179(1.01); C187(1.01); C62(0.63)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C95(3.48); C179(0.96); C187(0.96); C62(0.81)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C95(2.01); C179(1.05); C187(1.05); C62(0.87)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C95(1.81); C179(1.02); C187(1.02); C62(0.71)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C95(3.59); C179(1.51); C187(1.51); C62(0.46)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C95(1.35); C179(1.16); C187(1.16); C62(1.04)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C95(1.40); C179(1.01); C187(1.01); C62(0.92)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C95(1.71); C100(1.71); C37(1.23)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C95(1.11); C179(1.17); C187(1.17); C62(0.49)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C95(1.23); C179(1.26); C187(1.26); C62(0.45)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C95(1.33); C179(1.17); C187(1.17); C62(0.65)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C95(2.14); C179(1.21); C187(1.21); C62(1.00)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C95(1.41); C179(1.36); C187(1.36); C62(1.20)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C95(1.69); C179(1.02); C187(1.02); C62(0.44)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C95(2.04); C179(1.42); C187(1.42); C62(0.51)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C95(1.66); C179(1.19); C187(1.19); C62(0.68)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C95(1.84); C179(1.35); C187(1.35); C62(0.78)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C95(1.31); C179(1.25); C187(1.25); C62(0.47)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C95(1.02); C100(1.02); C37(1.17)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C95(8.42); C179(1.44); C187(1.44); C62(1.08)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C179(1.08); C187(1.08); C37(1.04); C62(1.10)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C179(1.19); C187(1.19); C37(1.24); C62(1.81)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C179(1.16); C187(1.16); C37(0.95); C62(1.30)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C179(1.03); C187(1.03); C37(1.14); C62(1.46)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C179(0.81); C187(0.81); C37(1.15); C62(1.87)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C179(1.01); C187(1.01); C37(1.03); C62(1.19)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C179(1.42); C187(1.42); C37(1.11); C62(1.59)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C179(1.30); C187(1.30); C37(1.15); C62(1.64)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C179(1.05); C187(1.05); C37(1.12); C62(1.27)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C111(0.95); C24(1.42)  LDD1698  [21]
 LDCM0468  Fragment33 HCT 116 C95(1.86); C179(0.93); C187(0.93); C62(1.29)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C179(1.01); C187(1.01); C37(1.00)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y72(1.34)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y72(1.81)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y72(0.48)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y72(10.56)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y72(0.93)  LDD0268  [7]
 LDCM0123  JWB131 DM93 Y72(0.80)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y72(0.68)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y72(0.88)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y72(2.74)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y72(1.77)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y72(1.03)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y72(0.36)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y72(1.00)  LDD0292  [6]
 LDCM0022  KB02 HCT 116 C62(9.82); C71(9.82); C37(3.83); C172(3.65)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C62(8.22); C71(8.22); C37(4.47); C172(3.30)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C62(19.27); C71(19.27); C37(5.76); C172(3.35)  LDD0082  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C172(0.40)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C172(0.43)  LDD2104  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C172(0.92)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C172(0.57)  LDD2141  [4]
 LDCM0096  SAHA K562 4.00  LDD0360  [3]
 LDCM0021  THZ1 HCT 116 C37(1.08); C179(1.30); C187(1.30)  LDD2173  [8]
 LDCM0085  WA NCI-H1975 2.70  LDD0192  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c (CYCS) Cytochrome c family P99999
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biol. 2021 Oct;46:102130. doi: 10.1016/j.redox.2021.102130. Epub 2021 Sep 9.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402