Details of the Target

General Information of Target

Target ID LDTP00907
Target Name Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D)
Gene Name PDE6D
Gene ID 5147
Synonyms
PDED; Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; GMP-PDE delta; Protein p17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV
Target Bioclass
Enzyme
Family
PDE6D/unc-119 family
Subcellular location
Cytoplasm, cytosol
Function
Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
Uniprot ID
O43924
Ensemble ID
ENST00000287600.9
HGNC ID
HGNC:8788
ChEMBL ID
CHEMBL3860

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 87 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C044
 Probe Info  		12.13  LDD1743  [1]
C049
 Probe Info  		6.54  LDD1747  [1]
C055
 Probe Info  		26.17  LDD1752  [1]
C063
 Probe Info  		17.63  LDD1760  [1]
C064
 Probe Info  		13.18  LDD1761  [1]
C067
 Probe Info  		7.31  LDD1763  [1]
C070
 Probe Info  		11.55  LDD1766  [1]
C071
 Probe Info  		15.14  LDD1767  [1]
C072
 Probe Info  		36.50  LDD1768  [1]
C085
 Probe Info  		14.52  LDD1777  [1]
C087
 Probe Info  		10.56  LDD1779  [1]
C095
 Probe Info  		5.58  LDD1786  [1]
C099
 Probe Info  		8.69  LDD1788  [1]
C112
 Probe Info  		61.39  LDD1799  [1]
C115
 Probe Info  		7.21  LDD1802  [1]
C130
 Probe Info  		18.25  LDD1812  [1]
C153
 Probe Info  		48.50  LDD1834  [1]
C156
 Probe Info  		9.38  LDD1836  [1]
C158
 Probe Info  		46.85  LDD1838  [1]
C159
 Probe Info  		10.34  LDD1839  [1]
C160
 Probe Info  		16.00  LDD1840  [1]
C161
 Probe Info  		30.27  LDD1841  [1]
C163
 Probe Info  		9.32  LDD1843  [1]
C164
 Probe Info  		13.00  LDD1844  [1]
C165
 Probe Info  		26.54  LDD1845  [1]
C166
 Probe Info  		15.24  LDD1846  [1]
C167
 Probe Info  		10.34  LDD1847  [1]
C183
 Probe Info  		7.01  LDD1861  [1]
C187
 Probe Info  		15.78  LDD1865  [1]
C218
 Probe Info  		14.12  LDD1892  [1]
C219
 Probe Info  		16.34  LDD1893  [1]
C220
 Probe Info  		21.71  LDD1894  [1]
C229
 Probe Info  		15.67  LDD1902  [1]
C231
 Probe Info  		23.43  LDD1904  [1]
C232
 Probe Info  		33.36  LDD1905  [1]
C233
 Probe Info  		70.52  LDD1906  [1]
C234
 Probe Info  		34.54  LDD1907  [1]
C235
 Probe Info  		39.67  LDD1908  [1]
C240
 Probe Info  		8.63  LDD1913  [1]
C241
 Probe Info  		9.65  LDD1914  [1]
C243
 Probe Info  		14.32  LDD1916  [1]
C244
 Probe Info  		14.72  LDD1917  [1]
C246
 Probe Info  		14.83  LDD1919  [1]
C249
 Probe Info  		26.91  LDD1922  [1]
C272
 Probe Info  		5.21  LDD1942  [1]
C277
 Probe Info  		33.36  LDD1947  [1]
C288
 Probe Info  		6.92  LDD1958  [1]
C293
 Probe Info  		23.26  LDD1963  [1]
C297
 Probe Info  		9.25  LDD1967  [1]
C299
 Probe Info  		6.15  LDD1968  [1]
C301
 Probe Info  		6.68  LDD1970  [1]
C303
 Probe Info  		7.62  LDD1972  [1]
C304
 Probe Info  		13.45  LDD1973  [1]
C305
 Probe Info  		9.65  LDD1974  [1]
C307
 Probe Info  		16.91  LDD1975  [1]
C322
 Probe Info  		20.82  LDD1988  [1]
C326
 Probe Info  		19.16  LDD1990  [1]
C327
 Probe Info  		7.01  LDD1991  [1]
C333
 Probe Info  		14.22  LDD1996  [1]
C343
 Probe Info  		19.56  LDD2005  [1]
C347
 Probe Info  		10.20  LDD2008  [1]
C348
 Probe Info  		13.74  LDD2009  [1]
C349
 Probe Info  		41.93  LDD2010  [1]
C350
 Probe Info  		23.10  LDD2011  [1]
C354
 Probe Info  		8.28  LDD2015  [1]
C364
 Probe Info  		27.67  LDD2025  [1]
C366
 Probe Info  		8.06  LDD2027  [1]
C367
 Probe Info  		29.24  LDD2028  [1]
C373
 Probe Info  		13.74  LDD2033  [1]
C374
 Probe Info  		6.41  LDD2034  [1]
C376
 Probe Info  		26.91  LDD2036  [1]
C378
 Probe Info  		10.34  LDD2037  [1]
C380
 Probe Info  		33.59  LDD2039  [1]
C382
 Probe Info  		21.71  LDD2041  [1]
C385
 Probe Info  		9.92  LDD2044  [1]
C386
 Probe Info  		8.11  LDD2045  [1]
C387
 Probe Info  		15.24  LDD2046  [1]
C388
 Probe Info  		83.87  LDD2047  [1]
C390
 Probe Info  		62.68  LDD2049  [1]
C407
 Probe Info  		11.47  LDD2064  [1]
C419
 Probe Info  		30.91  LDD2074  [1]
C426
 Probe Info  		56.89  LDD2081  [1]
C428
 Probe Info  		5.82  LDD2083  [1]
C429
 Probe Info  		22.78  LDD2084  [1]
C433
 Probe Info  		16.80  LDD2088  [1]
DFG-out-3
 Probe Info  		10.50  LDD0074  [2]
DFG-out-4
 Probe Info  		0.00  LDD0075  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0017  DFG-out-2 A431 0.00  LDD0075  [2]
 LDCM0016  Ranjitkar_cp1 A431 10.50  LDD0074  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 15 (ARL15) Arf family Q9NXU5
ADP-ribosylation factor-like protein 16 (ARL16) Arf family Q0P5N6
ADP-ribosylation factor-like protein 2 (ARL2) Arf family P36404
ADP-ribosylation factor-like protein 3 (ARL3) Arf family P36405
Ras-related protein Rab-13 (RAB13) Rab family P51153
X-linked retinitis pigmentosa GTPase regulator (RPGR) . Q92834
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein orthopedia (OTP) Paired homeobox family Q5XKR4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
2 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.