Details of the Target

General Information of Target

Target ID LDTP01704
Target Name Phosphatidylserine lipase ABHD16A (ABHD16A)
Gene Name ABHD16A
Gene ID 7920
Synonyms
BAT5; G5; NG26; Phosphatidylserine lipase ABHD16A; EC 3.1.-.-; Alpha/beta hydrolase domain-containing protein 16A; Abhydrolase domain-containing protein 16A; HLA-B-associated transcript 5; hBAT5; Monoacylglycerol lipase ABHD16A; EC 3.1.1.23; Protein G5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSI
LALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWT
NPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGV
ALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQG
QARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTP
LEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFT
ATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQG
PVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQL
EEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFE
ATHCTPLPAQNFQMPWHL
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, ABHD16 family
Subcellular location
Membrane
Function
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes. Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G).
Uniprot ID
O95870
Ensemble ID
ENST00000395952.8
HGNC ID
HGNC:13921
ChEMBL ID
CHEMBL6168

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.D45G DBIA    Probe Info 
COLO678 SNV: p.D45G .
HEP3B217 SNV: p.N142S .
JURKAT SNV: p.L196P; p.Q479Ter; p.R501H Compound 10    Probe Info 
MCC13 SNV: p.P509L DBIA    Probe Info 
MCC26 SNV: p.S477F DBIA    Probe Info 
MFE296 Insertion: p.Q123PfsTer30 DBIA    Probe Info 
MFE319 SNV: p.I349T DBIA    Probe Info 
MOLT4 SNV: p.V8I; p.A108V; p.D152N IA-alkyne    Probe Info 
NCIH661 SNV: p.T129N .
REH SNV: p.T134I DBIA    Probe Info 
SKN SNV: p.P175S .
WM2664 Insertion: p.Q277PfsTer10 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		4.42  LDD0197  [1]
BTD
 Probe Info  		C416(1.71)  LDD2144  [2]
Johansson_61
 Probe Info  		_(4.13)  LDD1485  [3]
YY4-yne
 Probe Info  		3.87  LDD0400  [4]
AHL-Pu-1
 Probe Info  		C205(6.40)  LDD0171  [5]
DBIA
 Probe Info  		C248(0.78); C416(0.75)  LDD0531  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C248(0.00); C416(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		C248(0.00); C7(0.00)  LDD0148  [8]
AOyne
 Probe Info  		8.60  LDD0443  [11]
NAIA_5
 Probe Info  		C205(0.00); C258(0.00); C7(0.00); C248(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C348
 Probe Info  		10.34  LDD2009  [13]
C349
 Probe Info  		14.42  LDD2010  [13]
C350
 Probe Info  		25.11  LDD2011  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		16.07  LDD0476  [14]
FFF probe3
 Probe Info  		20.00  LDD0465  [14]
Photocelecoxib
 Probe Info  		T195(0.00); R199(0.00)  LDD0019  [15]
OEA-DA
 Probe Info  		3.75  LDD0046  [16]
Probe 12
 Probe Info  		N.A.  LDD0420  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C205(6.40)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C248(0.78); C416(0.75)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C248(0.90); C416(0.56); C7(0.43)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C248(0.89)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C248(0.77)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C248(0.84)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C248(0.98)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C248(0.73)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C248(0.68)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C248(0.65)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C248(0.87)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C248(0.90)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C248(0.85)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C248(0.80); C416(0.47); C7(0.45)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C248(0.65)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C248(0.88)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C248(0.75)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C248(1.16); C416(0.90); C7(1.13)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C248(0.79); C416(0.84); C7(0.80)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C248(0.66); C416(0.93); C7(0.98)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C248(0.86); C416(0.82); C7(1.04)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C248(0.99); C416(0.77); C7(0.86)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C248(0.99); C416(0.72); C7(0.95)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C248(0.89); C416(0.73); C7(0.89)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C248(0.99); C416(0.66); C7(0.49)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C248(0.88); C416(0.92); C7(1.05)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C248(1.10); C416(1.25); C7(1.10)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C248(1.00); C416(0.76); C7(0.92)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C248(1.48); C416(0.95); C7(0.70)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C248(1.10); C416(1.04); C7(0.90)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C248(0.84); C416(1.04); C7(0.92)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C248(0.87); C416(1.01); C7(1.05)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C248(0.77); C416(0.75); C7(0.90)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C248(0.90); C416(0.99)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C248(1.03); C416(1.15)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C248(0.86); C416(0.91)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C248(1.11); C416(1.23)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C248(1.24); C416(1.50)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C248(1.17); C416(0.95)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C248(1.01); C416(0.95)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C248(1.04); C416(0.82)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C248(1.16); C416(0.94)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C248(1.27); C416(1.05)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C248(0.94); C416(1.07)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C248(1.09); C416(1.14)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C248(0.96); C416(0.62); C7(0.33)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C248(1.10); C416(1.02)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C248(1.16); C416(0.88)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C248(1.57); C416(1.25)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C7(1.07)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C7(1.01)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C7(0.86)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C7(0.86)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C7(1.07)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C7(0.88)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C7(0.91)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C7(0.45); C416(0.51); C248(0.86)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C7(0.95)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C7(0.91)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C7(0.95)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C7(0.77)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C7(1.02)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C7(0.96)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C7(0.93)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C7(0.87)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C416(0.73); C248(1.05); C7(1.25)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C416(0.42); C7(0.99); C248(1.08)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C416(0.58); C248(1.06); C7(1.50)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C416(0.80); C248(0.89)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C416(0.59); C248(1.07); C7(1.35)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C416(0.48); C248(0.90); C7(1.06)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C416(0.94); C248(0.95); C7(1.06)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C416(0.74); C248(1.34); C7(1.36)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C416(0.85); C248(0.88); C7(1.14)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C416(0.78)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C416(0.61)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C416(0.55)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C416(0.67)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C416(0.57)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C416(0.92); C248(0.93)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C416(0.53)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C416(0.53)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C416(0.49)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C416(0.58)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C416(0.55)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C248(0.83); C416(1.43)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C248(0.74); C416(1.62)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C248(0.98); C416(1.32)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C248(0.76); C416(1.05)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C248(0.78); C416(0.99)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C416(0.77); C248(0.80)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C248(0.79); C416(1.03)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C248(0.83); C416(1.21)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C248(0.71); C416(1.15)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C248(0.80); C416(1.15)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C248(0.89); C416(1.24)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C248(0.76); C416(1.00)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C7(0.85); C248(1.08); C416(1.13)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C7(0.80); C248(0.90); C416(1.03)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C416(0.89); C7(0.93); C248(0.99)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C7(0.93); C416(0.95); C248(1.31)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C416(0.81); C248(1.10)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C416(0.82); C7(0.84); C248(0.85)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C248(1.01); C7(1.06); C416(1.24)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C7(0.80); C248(0.97); C416(0.99)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C7(0.80); C416(0.95); C248(1.59)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C7(0.81); C416(1.02); C248(1.48)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C7(0.88); C416(0.97); C248(1.16)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C416(0.87); C7(1.07); C248(1.32)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C7(0.61); C248(1.05)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C7(0.54); C248(1.09)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C7(0.57); C248(0.92)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C7(0.43); C416(0.50); C248(0.74)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C7(0.63); C248(0.79)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C7(0.65); C248(1.00)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C7(0.58); C248(0.88)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C7(0.61); C248(1.28)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C7(0.71); C248(0.93)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C7(0.72); C248(1.15)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C7(0.70); C248(0.96)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C7(0.58); C248(1.01)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C248(0.95); C7(1.25)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C248(0.84); C7(1.02)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C7(0.50); C416(0.79); C248(0.92)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C248(0.87); C7(1.63)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C7(0.84); C248(1.06)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C248(0.80); C7(0.97)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C248(0.98); C7(1.10)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C7(0.95); C248(1.06)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C7(0.85); C248(1.07)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C248(0.80); C7(0.97)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C7(0.92); C248(0.96)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C248(0.97); C7(1.11)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C248(1.01); C7(1.05)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C416(0.55); C7(0.62); C248(0.94)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C248(0.90); C7(1.03)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C248(1.22); C7(1.27)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C248(1.11); C7(1.51)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C416(0.48); C7(0.70)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C416(0.55); C7(0.63)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C416(0.62); C7(0.73)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C416(0.63); C7(0.83)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C416(0.65); C7(0.88)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C7(0.57); C416(0.59)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C416(0.54); C7(0.56)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C7(1.37); C416(1.63)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C416(0.40); C7(0.84)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C416(0.47); C7(0.48)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C416(0.54); C7(0.93)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C416(0.68); C7(0.74)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C416(0.71); C7(1.32)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C416(0.54); C7(0.57)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C416(0.49); C7(0.62)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C248(1.18)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C248(1.16)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C248(1.32); C416(0.84); C7(0.59)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C7(0.46); C416(0.60); C248(0.96)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C416(0.38); C7(0.39); C248(0.81)  LDD0592  [6]
 LDCM0367  CL1 HCT 116 C248(0.93); C416(1.38); C7(1.46)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C7(1.05); C248(1.13); C416(1.15)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C248(0.80); C416(0.82)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C7(0.46); C416(0.49); C248(0.85)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C7(0.66); C416(0.84); C248(0.93)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C7(0.66); C416(0.75); C248(0.91)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C7(0.37); C416(0.69); C248(1.02)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C416(0.45); C7(1.09); C248(1.17)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C416(0.36); C7(1.04); C248(1.11)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C416(0.39); C248(1.15); C7(1.21)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C416(0.38); C7(0.99); C248(1.02)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C416(0.48); C7(0.99); C248(1.09)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C248(0.99); C7(1.10); C416(1.33)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C416(0.43); C248(1.08); C7(1.12)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C416(0.61); C7(1.14); C248(1.17)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C416(0.76)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C416(0.61)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C416(0.60)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C416(0.65)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C416(0.66)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C248(0.91); C416(1.02)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C248(0.83); C416(1.11)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C248(0.78); C416(0.97)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C248(1.19); C7(1.30); C416(1.33)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C248(0.75); C416(1.16)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C7(0.56); C416(0.81); C248(0.99)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C7(0.74); C416(0.97); C248(0.99)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C7(0.70); C416(0.92); C248(1.01)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C7(0.78); C248(0.87); C416(0.94)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C7(0.96); C248(1.03)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C7(0.85); C248(0.99)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C7(0.78); C248(1.01)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C7(0.67); C248(0.84)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C7(1.04); C248(1.15); C416(1.39)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C248(1.16); C7(1.21); C416(1.40)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C7(1.10); C248(1.14); C416(1.35)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C7(0.84); C248(1.44)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C248(0.62); C7(0.74)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C7(0.67); C248(0.70)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C7(0.61); C248(0.83)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C248(1.12); C416(1.31); C7(1.39)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C7(0.69); C248(0.71)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C248(0.63); C7(0.64)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C7(0.78); C248(0.84)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C7(0.69); C248(0.86)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C248(0.61); C7(0.70)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C248(0.62); C7(0.71)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C248(0.60); C7(0.65)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C248(0.75); C7(0.73)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C248(0.66); C7(0.58)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C248(0.71); C7(0.69)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C248(1.12); C416(1.17); C7(1.25)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C248(0.82); C7(0.74)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C248(0.84); C416(0.79); C7(1.23)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C248(0.90); C416(0.94); C7(1.03)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C248(1.00); C416(0.95); C7(1.02)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C248(0.59); C416(0.94); C7(0.93)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C248(0.68); C416(0.94); C7(0.99)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C248(0.84); C416(1.14); C7(1.08)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C248(0.95); C416(0.94); C7(1.11)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C248(0.84); C416(0.86); C7(1.22)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C248(0.93); C416(1.37); C7(1.05)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C248(0.88); C416(0.97); C7(1.15)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C248(0.93); C416(0.99); C7(1.07)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C248(1.04); C416(0.76); C7(1.05)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C248(0.88); C416(0.92); C7(1.12)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C248(0.77); C416(0.96); C7(1.28)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C248(1.07); C416(0.93); C7(1.18)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C248(1.08); C7(0.82)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C248(1.04); C7(1.00)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C248(1.31); C7(0.88)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C248(1.82); C7(1.17)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C248(1.10); C416(1.13); C7(1.22)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C248(1.57); C7(1.04)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C248(1.39); C7(0.94)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C248(1.16); C7(0.75)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C248(0.99); C7(1.29)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C248(1.66); C7(1.03)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C248(1.13); C7(1.20)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C248(1.38); C7(1.48)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C248(1.04); C7(1.21)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C248(1.17); C7(1.11)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C248(1.63); C7(1.04)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C248(1.04); C416(1.26); C7(1.27)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C248(1.73); C7(1.00)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C248(1.53); C416(0.81)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C248(1.12); C416(0.61)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C248(0.76); C416(1.19)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C248(1.44); C416(0.74)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C248(2.18); C416(0.89)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C248(1.14); C416(0.56)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C248(1.04); C416(0.59)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C248(1.14); C416(0.54)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C248(1.41); C416(0.45)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C248(1.22); C416(1.20); C7(1.09)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C248(1.18); C416(0.47)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C248(0.98); C416(0.45)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C248(1.08); C416(0.45)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C248(1.58); C416(0.76)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C248(1.02); C416(0.53)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C248(0.89); C416(0.81)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C248(0.83); C416(0.70)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C248(0.76); C416(0.77)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C248(0.78); C416(0.72)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C248(0.94); C416(1.38); C7(1.22)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C248(0.87); C416(0.66)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C248(0.90); C416(0.95)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C248(0.76); C416(1.16)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C248(0.77); C416(0.78)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C248(0.80); C416(0.56)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C248(0.86); C416(0.58)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C248(1.02); C416(0.64)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C248(0.89); C416(0.60)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C248(0.77); C416(0.51)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C248(0.90); C416(0.57)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C248(1.04); C416(1.73); C7(1.01)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C248(1.13); C416(0.97)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C248(0.88); C416(0.88)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C248(1.07); C416(1.10)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C248(0.98); C416(1.00)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C248(0.77); C416(0.76)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C248(0.78); C416(0.75)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C248(0.81); C416(0.80)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C248(0.95); C416(0.75)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C248(0.89); C416(0.74)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C248(0.87); C416(0.72)  LDD0811  [6]
 LDCM0165  Compound 9 HL-60 N.A.  LDD0420  [17]
 LDCM0495  E2913 HEK-293T C258(1.19); C7(1.24)  LDD1698  [18]
 LDCM0625  F8 Ramos C7(1.19)  LDD2187  [19]
 LDCM0573  Fragment11 Ramos C7(0.71)  LDD2190  [19]
 LDCM0468  Fragment33 HCT 116 C248(0.97); C416(0.41)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C248(0.96); C416(0.81); C7(1.38)  LDD0744  [6]
 LDCM0616  Fragment61 Jurkat _(12.12)  LDD1489  [3]
 LDCM0617  Fragment63-S Jurkat _(13.89)  LDD1490  [3]
 LDCM0569  Fragment7 Jurkat _(4.13)  LDD1485  [3]
 LDCM0022  KB02 HEK-293T C7(0.92); C258(1.03)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C7(0.86); C258(1.14)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C7(3.72); C416(1.81)  LDD3310  [20]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C416(1.71)  LDD2144  [2]
 LDCM0154  YY4 T cell 3.87  LDD0400  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ7
Cytochrome P450 1A2 (CYP1A2) Cytochrome P450 family P05177
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
DNA polymerase epsilon catalytic subunit A (POLE) DNA polymerase type-B family Q07864
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Farnesyl pyrophosphate synthase (FDPS) FPP/GGPP synthase family P14324
Vesicle transport protein GOT1A (GOLT1A) GOT1 family Q6ZVE7
Rhomboid-related protein 1 (RHBDL1) Peptidase S54 family O75783
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Proton-coupled zinc antiporter SLC30A2 (SLC30A2) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q9BRI3
Interferon-induced transmembrane protein 3 (IFITM3) CD225/Dispanin family Q01628
Gap junction alpha-5 protein (GJA5) Connexin family P36382
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
PRA1 family protein 2 (PRAF2) PRA1 family O60831
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
BOS complex subunit TMEM147 (TMEM147) TMEM147 family Q9BVK8
p53 apoptosis effector related to PMP-22 (PERP) TMEM47 family Q96FX8
Transmembrane protein 139 (TMEM139) . Q8IV31
Transmembrane protein 65 (TMEM65) . Q6PI78
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lymphotoxin-alpha (LTA) Tumor necrosis factor family P01374
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane protein BRI3 (BRI3) BRI3 family O95415
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Glycophorin-C (GYPC) Glycophorin-C family P04921
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Small EDRK-rich factor 1 (SERF1A; SERF1B) SERF family O75920
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Syntaxin-1B (STX1B) Syntaxin family P61266
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) VMA21 family Q3ZAQ7
Sperm-associated antigen 4 protein (SPAG4) . Q9NPE6
Transmembrane protein 143 (TMEM143) . Q96AN5
WW domain binding protein 1-like (WBP1L) . Q9NX94

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family. Angew Chem Int Ed Engl. 2019 Nov 25;58(48):17322-17327. doi: 10.1002/anie.201906321. Epub 2019 Oct 31.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840