Details of the Target

General Information of Target

Target ID LDTP07908
Target Name Histone H2A.V (H2AZ2)
Gene Name H2AZ2
Gene ID 94239
Synonyms
H2AFV; H2AV; Histone H2A.V; H2A.F/Z; H2A.Z variant histone 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILE
YLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIG
KKGQQKTA
Target Bioclass
Other
Family
Histone H2A family
Subcellular location
Nucleus
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Uniprot ID
Q71UI9
Ensemble ID
ENST00000222690.10
HGNC ID
HGNC:20664

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K8(1.64)  LDD0274  [2]
STPyne
 Probe Info  		K16(6.67)  LDD0277  [2]
W1
 Probe Info  		H86(1.01)  LDD0239  [3]
NHS
 Probe Info  		N.A.  LDD0010  [4]
OSF
 Probe Info  		N.A.  LDD0029  [5]
SF
 Probe Info  		K116(0.00); K8(0.00)  LDD0028  [5]
Acrolein
 Probe Info  		H113(0.00); H115(0.00)  LDD0217  [6]
Crotonaldehyde
 Probe Info  		H113(0.00); H115(0.00)  LDD0219  [6]
Methacrolein
 Probe Info  		H113(0.00); H115(0.00)  LDD0218  [6]
HHS-465
 Probe Info  		N.A.  LDD2240  [7]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BD-F
 Probe Info  		E68(0.00); Y61(0.00); A64(0.00); I58(0.00)  LDD0024  [8]
LD-F
 Probe Info  		E60(0.00); E65(0.00); T63(0.00); L59(0.00)  LDD0015  [8]
TM-F
 Probe Info  		L59(0.00); L67(0.00); A56(0.00); V66(0.00)  LDD0020  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H115(0.00); H113(0.00)  LDD0222  [6]
 LDCM0107  IAA HeLa H113(0.00); H115(0.00)  LDD0221  [6]
 LDCM0109  NEM HeLa H113(0.00); H115(0.00); H86(0.00)  LDD0223  [6]
 LDCM0112  W16 Hep-G2 H86(1.01)  LDD0239  [3]
 LDCM0113  W17 Hep-G2 H86(0.93)  LDD0240  [3]

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652