Details of the Target

General Information of Target

Target ID LDTP02609
Target Name ADP/ATP translocase 3 (SLC25A6)
Gene Name SLC25A6
Gene ID 293
Synonyms
AAC3; ANT3; ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR
IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASG
GAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVS
VQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMM
QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it.
Uniprot ID
P12236
Ensemble ID
ENST00000381401.11
HGNC ID
HGNC:10992
ChEMBL ID
CHEMBL4105854

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.96  LDD0402  [2]
CHEMBL5175495
 Probe Info  		9.55  LDD0196  [3]
N1
 Probe Info  		13.69  LDD0242  [4]
W1
 Probe Info  		10.65  LDD0235  [5]
TH211
 Probe Info  		Y251(17.65); Y112(7.74)  LDD0260  [6]
C-Sul
 Probe Info  		4.60  LDD0066  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
BTD
 Probe Info  		C160(2.11); C57(1.93)  LDD1700  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
Acrolein
 Probe Info  		H106(0.00); C57(0.00)  LDD0221  [11]
DBIA
 Probe Info  		C160(2.64); C257(2.39)  LDD0080  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K96(0.00); K105(0.00); K43(0.00); K166(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C257(0.00); C57(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C257(0.00); C129(0.00); C160(0.00)  LDD0032  [16]
ATP probe
 Probe Info  		K105(0.00); K272(0.00); K163(0.00); K94(0.00)  LDD0035  [17]
IPM
 Probe Info  		C129(0.00); C160(0.00)  LDD0025  [18]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		C57(0.00); C129(0.00); C257(0.00)  LDD2226  [19]
TFBX
 Probe Info  		C57(0.00); C257(0.00); C129(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C257(0.00); C160(0.00)  LDD0021  [20]
WYneO
 Probe Info  		C257(0.00); C160(0.00)  LDD0022  [20]
Compound 10
 Probe Info  		C160(0.00); C57(0.00)  LDD2216  [21]
NHS
 Probe Info  		K63(0.00); K92(0.00); K272(0.00); K147(0.00)  LDD0010  [20]
PF-06672131
 Probe Info  		N.A.  LDD0152  [22]
SF
 Probe Info  		K33(0.00); Y81(0.00)  LDD0028  [23]
STPyne
 Probe Info  		K94(0.00); K63(0.00); K163(0.00); K92(0.00)  LDD0009  [20]
VSF
 Probe Info  		C160(0.00); C257(0.00)  LDD0007  [20]
Phosphinate-6
 Probe Info  		C129(0.00); C160(0.00); C257(0.00)  LDD0018  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
MPP-AC
 Probe Info  		N.A.  LDD0428  [26]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [26]
PAL-AfBPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IMP2070
 Probe Info  		1.56  LDD0367  [27]
C022
 Probe Info  		10.63  LDD1728  [28]
C040
 Probe Info  		10.20  LDD1740  [28]
C056
 Probe Info  		18.00  LDD1753  [28]
C091
 Probe Info  		11.39  LDD1782  [28]
C092
 Probe Info  		16.45  LDD1783  [28]
C094
 Probe Info  		25.63  LDD1785  [28]
C106
 Probe Info  		20.53  LDD1793  [28]
C112
 Probe Info  		17.15  LDD1799  [28]
C134
 Probe Info  		26.35  LDD1816  [28]
C143
 Probe Info  		16.91  LDD1825  [28]
C153
 Probe Info  		15.03  LDD1834  [28]
C160
 Probe Info  		7.67  LDD1840  [28]
C161
 Probe Info  		12.55  LDD1841  [28]
C163
 Probe Info  		6.63  LDD1843  [28]
C178
 Probe Info  		14.62  LDD1857  [28]
C196
 Probe Info  		12.04  LDD1872  [28]
C201
 Probe Info  		26.17  LDD1877  [28]
C218
 Probe Info  		11.24  LDD1892  [28]
C219
 Probe Info  		5.10  LDD1893  [28]
C220
 Probe Info  		20.11  LDD1894  [28]
C225
 Probe Info  		5.39  LDD1898  [28]
C228
 Probe Info  		26.91  LDD1901  [28]
C231
 Probe Info  		16.34  LDD1904  [28]
C235
 Probe Info  		17.63  LDD1908  [28]
C246
 Probe Info  		12.64  LDD1919  [28]
C277
 Probe Info  		11.39  LDD1947  [28]
C285
 Probe Info  		22.78  LDD1955  [28]
C287
 Probe Info  		8.75  LDD1957  [28]
C289
 Probe Info  		35.02  LDD1959  [28]
C293
 Probe Info  		27.28  LDD1963  [28]
C296
 Probe Info  		12.21  LDD1966  [28]
C310
 Probe Info  		19.29  LDD1977  [28]
C339
 Probe Info  		5.82  LDD2002  [28]
C349
 Probe Info  		17.51  LDD2010  [28]
C350
 Probe Info  		66.72  LDD2011  [28]
C362
 Probe Info  		29.04  LDD2023  [28]
C366
 Probe Info  		7.26  LDD2027  [28]
C388
 Probe Info  		45.57  LDD2047  [28]
C403
 Probe Info  		13.74  LDD2061  [28]
FFF probe11
 Probe Info  		14.81  LDD0471  [29]
FFF probe13
 Probe Info  		16.20  LDD0475  [29]
FFF probe14
 Probe Info  		14.61  LDD0477  [29]
FFF probe2
 Probe Info  		15.88  LDD0463  [29]
FFF probe3
 Probe Info  		12.04  LDD0464  [29]
FFF probe4
 Probe Info  		8.93  LDD0466  [29]
JN0003
 Probe Info  		15.29  LDD0469  [29]
BD-F
 Probe Info  		D292(0.00); K295(0.00); L294(0.00); E293(0.00)  LDD0024  [30]
TM-F
 Probe Info  		G120(0.00); S119(0.00); G124(0.00)  LDD0020  [30]
DA-2
 Probe Info  		N.A.  LDD0071  [31]
OEA-DA
 Probe Info  		3.84  LDD0046  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C57(0.67); C160(0.74)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C57(1.08); C160(0.95)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C57(0.65)  LDD2095  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C57(1.09); C160(1.24)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C160(0.91)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C57(0.88)  LDD2131  [9]
 LDCM0214  AC1 HCT 116 C129(0.73); C160(1.11); C257(1.05)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C160(1.20); C257(1.13)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C160(1.53); C257(2.23)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C160(0.97); C257(1.43)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C160(1.18); C257(1.41)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C160(1.22); C257(1.64)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C160(1.33); C257(2.14)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C160(1.33); C257(1.67)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C160(1.48); C257(2.40)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C160(1.15); C257(2.43)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C160(1.50); C257(1.47)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C160(1.21); C257(1.83)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C160(0.82); C257(0.87)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C160(1.21); C257(1.57)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C160(1.04); C257(1.73)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C160(1.26); C257(1.86)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C129(0.81); C160(0.82); C257(0.87)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C129(1.05); C160(0.89); C257(0.93)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C129(1.26); C160(0.90); C257(0.90)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C129(1.10); C160(0.73); C257(0.73)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C129(1.09); C160(0.90); C257(0.82)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C129(1.22); C160(0.93); C257(0.95)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C129(0.97); C160(0.77); C257(0.78)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C160(1.22); C257(1.12)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C129(1.67); C160(0.73); C257(0.77)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C129(1.51); C160(1.30); C257(1.29)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C129(0.98); C160(1.03); C257(0.91)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C129(1.90); C160(1.32); C257(1.14)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C129(1.55); C160(1.08); C257(1.00)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C129(1.03); C160(0.91); C257(0.87)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C129(1.42); C160(1.08); C257(1.08)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C129(0.76); C160(1.08); C257(0.95)  LDD0562  [12]
 LDCM0246  AC128 HEK-293T C160(0.69); C257(0.86); C57(0.90)  LDD0844  [12]
 LDCM0247  AC129 HEK-293T C160(0.63); C257(0.71); C57(1.32)  LDD0845  [12]
 LDCM0249  AC130 HEK-293T C160(0.75); C257(0.68); C57(1.22)  LDD0847  [12]
 LDCM0250  AC131 HEK-293T C160(0.96); C257(0.67); C57(0.99)  LDD0848  [12]
 LDCM0251  AC132 HEK-293T C160(0.60); C257(0.53); C57(1.10)  LDD0849  [12]
 LDCM0252  AC133 HEK-293T C160(0.89); C257(0.67); C57(1.35)  LDD0850  [12]
 LDCM0253  AC134 HEK-293T C160(0.83); C257(0.93); C57(1.38)  LDD0851  [12]
 LDCM0254  AC135 HEK-293T C160(0.97); C257(0.96); C57(1.24)  LDD0852  [12]
 LDCM0255  AC136 HEK-293T C160(1.14); C257(0.70); C57(1.57)  LDD0853  [12]
 LDCM0256  AC137 HEK-293T C160(0.74); C257(0.75); C57(1.61)  LDD0854  [12]
 LDCM0257  AC138 HEK-293T C160(0.86); C257(0.85); C57(1.86)  LDD0855  [12]
 LDCM0258  AC139 HEK-293T C160(0.60); C257(0.75); C57(1.62)  LDD0856  [12]
 LDCM0259  AC14 HCT 116 C160(0.80); C257(0.83)  LDD0576  [12]
 LDCM0260  AC140 HEK-293T C160(0.97); C257(0.79); C57(1.48)  LDD0858  [12]
 LDCM0261  AC141 HEK-293T C160(0.88); C257(0.85); C57(1.55)  LDD0859  [12]
 LDCM0262  AC142 HEK-293T C160(0.84); C257(0.86); C57(1.34)  LDD0860  [12]
 LDCM0263  AC143 HCT 116 C257(1.34)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C257(1.00)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C257(2.03)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C257(1.19)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C257(1.35)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C257(1.40)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C257(1.19)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C160(1.10); C257(1.16)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C257(1.66)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C257(0.86)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C257(1.19)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C257(1.49)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C257(1.72)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C257(1.26)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C257(1.09)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C257(1.43)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C257(1.34); C160(1.39)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C160(1.02); C257(1.18)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C160(1.00); C257(1.04)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C160(0.98); C257(1.01); C129(1.15)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C257(1.28); C160(1.30)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C257(1.24); C160(1.31)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C257(1.26); C160(1.28)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C257(1.31); C160(1.51)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C160(1.40); C257(1.40)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C257(0.75); C160(0.78)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C160(0.79); C257(0.82)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C160(0.70); C257(0.74)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C257(0.78); C160(0.85)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C160(0.69); C257(0.79)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C129(0.88); C257(0.94); C160(0.95)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C160(0.74); C257(0.86)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C257(0.94); C160(0.95)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C257(0.66); C160(0.67)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C257(0.62); C160(0.62)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C160(0.67); C257(0.67)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C257(1.26); C129(1.65); C160(1.67)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C129(0.99); C160(1.04); C257(1.11)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C160(0.75); C257(0.89); C129(0.99)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C160(0.82); C257(0.98); C129(1.13)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C160(1.10); C129(1.12); C257(1.35)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C129(1.16); C257(1.20); C160(1.22)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C160(0.90); C129(0.96); C257(0.99)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C257(0.89); C129(0.91); C160(0.92)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C129(0.82); C160(0.94); C257(1.03)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C160(0.73); C257(0.83); C129(1.22)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C129(0.82); C160(0.83); C257(0.86)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C129(0.72); C160(0.72); C257(0.86)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C257(0.87); C160(0.95); C129(1.04)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C257(1.02); C160(1.13); C129(1.47)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C129(1.00); C257(1.18); C160(1.43)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C160(0.90); C129(0.91); C257(0.93)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C257(0.99); C129(1.04); C160(1.08)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C160(0.91); C257(0.96); C129(1.07)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C160(1.04); C257(1.09); C129(1.21)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C257(0.95); C129(0.97); C160(1.23)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C129(0.82); C257(0.87); C160(0.92)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C129(1.23); C257(1.30); C160(1.39)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C257(0.85); C129(0.94); C160(0.96)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C257(0.96); C129(1.02); C160(1.05)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C160(1.13); C257(1.25)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C160(1.25); C257(1.36)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C160(0.80); C257(0.90)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C160(1.00); C257(1.02)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C160(0.76); C257(1.04)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C257(1.12); C160(1.14)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C160(0.84); C257(0.96)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C257(0.91); C160(0.94)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C160(0.83); C257(0.98)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C160(0.93); C257(1.01)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C160(1.06); C257(1.26)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C257(0.83); C160(0.84)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C257(1.07); C160(1.24)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C257(1.41); C160(1.57)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C160(0.95); C257(1.04)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C257(1.19); C160(1.24)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C257(1.32); C160(1.64)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C257(1.08); C160(1.23)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C257(1.05); C160(1.13)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C257(1.27); C160(1.48)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C257(1.07); C160(1.22)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C257(1.33); C160(1.52)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C257(1.00); C160(1.36)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C257(0.97); C160(1.18)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C257(1.04); C160(1.26)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C160(0.88); C257(0.94)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C257(0.96); C160(1.18)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C257(1.30); C160(1.69)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C257(0.98); C160(1.33)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C160(0.63); C257(0.66); C129(0.96)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C160(0.58); C129(0.64); C257(0.72)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C160(0.65); C257(0.72); C129(0.73)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C160(0.62); C257(0.72); C129(0.80)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C129(0.81); C257(0.98); C160(1.03)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C160(0.93); C129(1.01); C257(1.02)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C160(0.65); C257(0.74); C129(0.76)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C129(0.76); C160(0.83); C257(0.90)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C160(0.69); C129(0.70); C257(0.77)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C129(0.74); C257(0.79); C160(0.81)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C129(0.64); C257(0.76); C160(0.82)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C129(0.59); C160(0.64); C257(0.67)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C129(0.74); C160(0.92); C257(0.93)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C160(0.72); C129(0.74); C257(0.76)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C160(0.61); C257(0.66); C129(0.68)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C160(0.97); C257(0.99)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C257(0.91); C160(1.19)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C160(1.02); C257(1.00)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C160(0.79); C257(0.91)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C160(1.03); C257(1.09)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 12.09  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C160(1.15)  LDD2171  [12]
 LDCM0498  BS-3668 MDA-MB-231 C57(1.00)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C57(0.00); H106(0.00)  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C129(0.71); C160(0.89); C257(0.92)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C257(0.80); C160(0.86); C129(0.87)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C129(0.89); C257(0.95); C160(0.97)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C160(0.80); C257(0.84)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C160(0.83); C257(0.93)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C160(0.72); C257(0.82)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C160(0.74); C257(0.85)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C257(1.10); C160(1.29)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C257(1.23); C160(1.56)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C257(1.06); C160(1.23)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C257(1.23); C160(1.29)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C257(0.91); C160(0.96)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C129(0.85); C257(0.90); C160(1.23)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C257(1.27); C160(1.41)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C257(1.02); C160(1.08)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C160(0.96); C257(0.96)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C257(0.82); C160(0.87)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C257(0.69); C160(0.81)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C257(0.67); C160(0.69)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C160(0.61); C257(0.61)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C257(1.14); C160(1.52); C129(1.75)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C160(0.89); C257(0.97); C129(1.35)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C129(0.80); C257(0.90); C160(0.93)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C160(0.91); C129(0.97); C257(1.05)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C160(0.85); C257(0.90); C129(0.91)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C160(0.76); C257(0.80); C129(0.86)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C129(0.78); C257(0.91); C160(0.93)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C257(1.01); C129(1.04); C160(1.26)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C129(0.89); C257(0.97); C160(1.04)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C160(0.89); C257(1.03)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C160(0.95); C257(1.06)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C160(0.84); C257(0.98)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C160(1.10); C257(1.10)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C160(0.94); C129(0.98); C257(1.19)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C257(0.52); C160(0.79); C129(0.98)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C160(0.86); C257(0.96); C129(1.34)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C160(0.86); C257(0.91)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C129(0.81); C257(0.94); C160(1.06)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C257(1.00); C160(1.00); C129(1.35)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C160(0.94); C129(1.00); C257(1.12)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C129(0.70); C160(0.91); C257(0.92)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C160(0.83); C129(0.88); C257(0.91)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C129(0.64); C160(1.01); C257(1.03)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C160(0.81); C129(0.91); C257(1.01)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C129(0.75); C257(0.89); C160(0.91)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C129(1.03); C160(1.02); C257(0.95)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C129(1.08); C160(1.06); C257(0.90)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C129(1.17); C160(0.97); C257(0.92)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C129(0.74); C160(0.99); C257(0.90)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C129(0.79); C160(0.93); C257(0.86)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C129(0.81); C160(0.83); C257(0.74)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C129(0.69); C160(0.87); C257(0.95)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C129(1.23); C160(1.20); C257(0.63)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C129(1.08); C160(1.06); C257(1.00)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C160(0.92); C257(0.90)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C160(0.92); C257(0.93)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C160(0.92); C257(0.97)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C160(1.06); C257(0.92)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C160(1.11); C257(1.26)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C160(1.20); C257(1.19)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C160(0.99); C257(0.99)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C129(0.75); C160(0.89); C257(0.95)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C160(1.00); C257(0.90)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C160(0.81); C257(0.89)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C160(1.30); C257(1.19)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C160(0.91); C257(0.88)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C160(1.01); C257(0.86)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C160(1.08); C257(0.93)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C129(1.32); C160(1.01); C257(0.92)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C129(1.61); C160(1.22); C257(1.01)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C129(1.57); C160(1.02); C257(0.96)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C129(1.67); C160(1.11); C257(1.09)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C129(1.16); C160(0.98); C257(1.00)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C129(1.76); C160(1.05); C257(0.96)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C129(1.87); C160(1.20); C257(1.10)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C129(1.44); C160(1.02); C257(0.93)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C129(1.43); C160(1.08); C257(1.02)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C129(0.96); C160(1.09); C257(0.89)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C129(1.11); C160(1.38); C257(1.04)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C129(1.17); C160(1.28); C257(1.08)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C129(1.52); C160(1.37); C257(1.03)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C129(1.22); C160(1.03); C257(0.87)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C129(1.28); C160(1.16); C257(1.04)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C129(0.64); C160(0.75); C257(0.85)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C129(1.69); C160(1.16); C257(0.92)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C257(1.32)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C257(0.87)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C257(0.88)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C257(1.15)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C257(1.01)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C257(0.95)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C257(1.08)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C257(1.30)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C257(0.89)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C129(0.79); C160(1.01); C257(1.02)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C257(0.98)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C257(0.95)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C257(1.07)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C257(1.14)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C257(0.91)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C160(1.22); C257(1.11)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C160(1.18); C257(1.04)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C160(1.12); C257(1.01)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C160(1.05); C257(1.25)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C129(0.62); C160(0.79); C257(0.97)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C160(1.04); C257(1.06)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C160(1.52); C257(1.42)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C160(1.73); C257(1.42)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C160(1.45); C257(1.38)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C160(1.05); C257(1.12)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C160(1.15); C257(1.10)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C160(1.25); C257(1.21)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C160(1.55); C257(1.43)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C160(1.65); C257(1.59)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C160(1.10); C257(1.03)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C129(1.48); C160(0.88); C257(0.96)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C160(1.40); C257(1.39)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C129(1.47); C160(1.09); C257(1.11)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C129(1.10); C160(1.27); C257(1.25)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C129(1.02); C160(1.74); C257(1.50)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C129(1.09); C160(0.81); C257(0.79)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C129(0.88); C160(1.27); C257(1.22)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C129(0.98); C160(0.98); C257(1.03)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C129(1.46); C160(0.91); C257(0.93)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C129(1.05); C160(1.08); C257(1.02)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C129(0.99); C160(1.12); C257(1.15)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C257(1.04); C129(0.89)  LDD1698  [33]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0625  F8 Ramos C57(0.91)  LDD2187  [34]
 LDCM0573  Fragment11 Ramos C57(0.67)  LDD2190  [34]
 LDCM0586  Fragment28 Ramos C57(0.52)  LDD2198  [34]
 LDCM0468  Fragment33 HCT 116 C257(1.43)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C160(1.25); C257(1.27)  LDD0744  [12]
 LDCM0569  Fragment7 Ramos C57(1.94)  LDD2186  [34]
 LDCM0015  HNE MDA-MB-231 C57(1.25)  LDD0346  [34]
 LDCM0107  IAA HeLa H106(0.00); C57(0.00)  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C160(2.64); C257(2.39)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C160(2.52); C257(1.00)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C160(2.20); C257(1.41)  LDD0082  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C160(0.89)  LDD2121  [9]
 LDCM0109  NEM HeLa N.A.  LDD0224  [11]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C57(0.39)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C57(1.56)  LDD2090  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C57(1.22)  LDD2093  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C57(1.46)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C57(0.57)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C160(0.85)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C57(0.59); C160(0.70)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C57(0.94)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C57(0.59); C160(0.69)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C57(1.18)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C57(1.01); C160(0.72)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C57(0.86)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C57(0.99)  LDD2110  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C57(1.02)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C160(0.63)  LDD2115  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C57(1.19); C160(1.32)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C57(1.12); C160(1.90)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C57(0.77); C160(0.65)  LDD2120  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C57(1.15)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C57(0.94)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C57(0.94)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C57(1.31)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C57(1.55); C160(1.16)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C57(0.67); C160(0.87)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C57(0.59); C160(0.64)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C57(1.87); C160(1.34)  LDD2135  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C57(1.00)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C160(2.11); C57(1.93)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C57(0.88)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C57(1.02)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C57(0.89); C160(0.70)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C57(1.89); C160(1.99)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C160(6.35)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C57(1.46)  LDD2146  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C160(0.55)  LDD2150  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C57(0.74); C57(0.62)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C57(0.88); C57(0.77)  LDD2207  [35]
 LDCM0021  THZ1 HCT 116 C160(1.15)  LDD2173  [12]
 LDCM0110  W12 Hep-G2 C160(0.75)  LDD0237  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Voltage-dependent anion-selective channel protein 1 (VDAC1) Eukaryotic mitochondrial porin family P21796
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Tektin-4 (TEKT4) Tektin family Q8WW24
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
TNF receptor-associated factor 1 (TRAF1) . Q13077

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Clodronic Acid Small molecular drug DB00720
Etidronic Acid Small molecular drug DB01077

References

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Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
31 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
32 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.