Details of the Target

General Information of Target

Target ID LDTP19689
Target Name Transmembrane protein 256 (TMEM256)
Gene Name TMEM256
Gene ID 254863
Synonyms
C17orf61; Transmembrane protein 256
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPWKKHKFELLAEAPPRQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKK
LHITSEDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRM
VHAEERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEK
AQAMALLLYQTSANALAEFKRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHGPCCYKPP
VERSRSAPKLGSITEDLLGEQLEQELQEEEEEEQPEGCPEEEENRAAEGDPAEEEAEAQR
ALVVAMHFECGDLLDTLENGRGEALGGGGGSLGPGAGPPPLLLGSASDMKAELSQLISDL
GELSFGNDVRTLQADLRVTRLLSGDSTGSESSIEGGGPDATSATAGDSSRQADGASADEP
HSG
Target Bioclass
Other
Family
TMEM256 family
Subcellular location
Membrane
Uniprot ID
Q8N2U0
Ensemble ID
ENST00000302422.4
HGNC ID
HGNC:28618

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y36(8.49); Y25(6.05)  LDD0260  [1]
C-Sul
 Probe Info  		3.00  LDD0066  [2]
DBIA
 Probe Info  		C61(1.13)  LDD1492  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BD-F
 Probe Info  		Q31(0.00); A27(0.00); Y25(0.00); S24(0.00)  LDD0024  [6]
LD-F
 Probe Info  		F32(0.00); Q31(0.00); A27(0.00); S24(0.00)  LDD0015  [6]
TM-F
 Probe Info  		N.A.  LDD0020  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C61(1.13)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C61(0.94)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C61(1.10)  LDD1502  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652