Details of the Target
General Information of Target
| Target ID | LDTP02453 | |||||
|---|---|---|---|---|---|---|
| Target Name | Tubulin alpha-3D chain (TUBA3D) | |||||
| Gene Name | TUBA3D | |||||
| Gene ID | 113457 | |||||
| Synonyms |
Tubulin alpha-3D chain; EC 3.6.5.-; Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] |
|||||
| 3D Structure | ||||||
| Sequence |
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDLAALEKDYEEVGVDSVEAEAEEGEEY |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Tubulin family
|
|||||
| Subcellular location |
Cytoplasm, cytoskeleton
|
|||||
| Function |
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IA-alkyne Probe Info |
 |
C347(0.85); C347(0.74) | LDD2206 | [1] | |
|
Acrolein Probe Info |
 |
H393(0.00); H88(0.00) | LDD0217 | [2] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
BD-F Probe Info |
 |
N356(0.00); I355(0.00); F255(0.00); Q256(0.00) | LDD0024 | [3] | |
|
LD-F Probe Info |
 |
C295(0.00); E297(0.00); I355(0.00); V375(0.00) | LDD0015 | [3] | |
|
TM-F Probe Info |
 |
Q256(0.00); E254(0.00); T253(0.00) | LDD0020 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0108 | Chloroacetamide | HeLa | H393(0.00); H88(0.00) | LDD0222 | [2] |
| LDCM0107 | IAA | HeLa | N.A. | LDD0221 | [2] |
| LDCM0109 | NEM | HeLa | H393(0.00); H88(0.00) | LDD0223 | [2] |
| LDCM0627 | NUDT7-COV-1 | HEK-293T | C347(0.85); C347(0.74) | LDD2206 | [1] |
| LDCM0628 | OTUB2-COV-1 | HEK-293T | C20(15.00); C25(15.00); C20(1.06); C347(0.84) | LDD2207 | [1] |
References