Details of the Target

General Information of Target

Target ID LDTP07899
Target Name Histone H3.2 (H3C15; H3C14; H3C13)
Gene Name H3C15; H3C14; H3C13
Gene ID 126961
Synonyms
HIST2H3A; H3F2; H3FM; HIST2H3C; HIST2H3D; Histone H3.2; H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; Histone H3/m; Histone H3/o
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA
Target Bioclass
Other
Family
Histone H3 family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q71DI3
Ensemble ID
ENST00000331491.2
HGNC ID
HGNC:25311
ChEMBL ID
CHEMBL4295875

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [2]
STPyne
 Probe Info  		K123(5.00); K80(7.79)  LDD0277  [3]
AZ-9
 Probe Info  		D78(0.98)  LDD2208  [4]
ONAyne
 Probe Info  		K123(0.00); K80(0.00)  LDD0273  [3]
AHL-Pu-1
 Probe Info  		C111(2.30)  LDD0170  [5]
DBIA
 Probe Info  		C111(0.91)  LDD0602  [6]
ATP probe
 Probe Info  		K80(0.00); K28(0.00); K123(0.00); K57(0.00)  LDD0199  [7]
N1
 Probe Info  		C111(0.00); D107(0.00); E106(0.00); H114(0.00)  LDD0245  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
W1
 Probe Info  		K80(0.00); K123(0.00); K57(0.00); Q77(0.00)  LDD0236  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [13]
STS-2
 Probe Info  		N.A.  LDD0138  [13]
BD-F
 Probe Info  		D107(0.00); F105(0.00)  LDD0024  [14]
LD-F
 Probe Info  		D107(0.00); F105(0.00); A99(0.00)  LDD0015  [14]
TM-F
 Probe Info  		E106(0.00); G103(0.00); D107(0.00)  LDD0020  [14]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C111(2.30)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C111(3.47)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C111(0.70)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C111(1.02)  LDD0813  [6]
 LDCM0216  AC100 PaTu 8988t C111(1.06)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C111(0.96)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C111(1.21)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C111(0.96)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C111(0.91)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C111(1.47)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C111(1.03)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C111(1.04)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C111(1.07)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C111(1.31)  LDD1104  [6]
 LDCM0226  AC11 HEK-293T C111(0.83)  LDD0824  [6]
 LDCM0227  AC110 PaTu 8988t C111(1.07)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C111(0.88)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C111(0.97)  LDD1108  [6]
 LDCM0237  AC12 HEK-293T C111(1.13)  LDD0835  [6]
 LDCM0246  AC128 PaTu 8988t C111(0.77)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C111(0.52)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C111(0.48)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C111(0.84)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C111(0.55)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C111(0.62)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C111(0.78)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C111(0.64)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C111(0.71)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C111(0.75)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C111(0.72)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C111(0.59)  LDD1137  [6]
 LDCM0259  AC14 HEK-293T C111(1.24)  LDD0857  [6]
 LDCM0260  AC140 PaTu 8988t C111(0.77)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C111(0.58)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C111(0.84)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C111(1.46)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C111(1.09)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C111(1.05)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C111(1.55)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C111(2.70)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C111(1.07)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C111(1.15)  LDD1148  [6]
 LDCM0270  AC15 HEK-293T C111(1.14)  LDD0868  [6]
 LDCM0271  AC150 PaTu 8988t C111(1.22)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C111(1.30)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C111(1.35)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C111(1.42)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C111(1.48)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C111(1.29)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C111(1.42)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C111(1.23)  LDD2169  [6]
 LDCM0277  AC18 HEK-293T C111(1.08)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C111(0.91)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C111(0.80)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C111(1.06)  LDD1519  [16]
 LDCM0283  AC23 HEK-293T C111(0.94)  LDD1522  [16]
 LDCM0285  AC25 HCT 116 C111(0.91)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C111(1.02)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C111(1.09)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C111(0.90)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C111(0.90)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C111(0.73)  LDD0888  [6]
 LDCM0291  AC30 HCT 116 C111(1.05)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C111(0.92)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C111(0.87)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C111(0.88)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C111(1.01)  LDD0612  [6]
 LDCM0296  AC35 PaTu 8988t C111(1.18)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C111(1.18)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C111(1.15)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C111(1.12)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C111(1.27)  LDD1179  [6]
 LDCM0301  AC4 HEK-293T C111(0.73)  LDD0899  [6]
 LDCM0302  AC40 PaTu 8988t C111(1.54)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C111(1.10)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C111(1.29)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C111(1.40)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C111(1.28)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C111(1.32)  LDD1186  [6]
 LDCM0308  AC46 HCT 116 C111(1.11)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C111(0.87)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C111(0.82)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C111(0.63)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C111(0.64)  LDD0910  [6]
 LDCM0313  AC50 HCT 116 C111(0.77)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C111(0.63)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C111(0.96)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C111(1.04)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C111(0.88)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C111(0.80)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C111(0.86)  LDD0636  [6]
 LDCM0320  AC57 PaTu 8988t C111(1.37)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C111(0.97)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C111(1.40)  LDD1201  [6]
 LDCM0323  AC6 HEK-293T C111(1.27)  LDD0921  [6]
 LDCM0324  AC60 PaTu 8988t C111(1.19)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C111(1.32)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C111(1.48)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C111(1.29)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C111(1.24)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C111(1.51)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C111(1.28)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C111(1.50)  LDD1210  [6]
 LDCM0332  AC68 HEK-293T C111(1.32)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C111(1.01)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C111(0.89)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C111(1.26)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C111(0.73)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C111(1.44)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C111(1.25)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C111(1.08)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C111(0.82)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C111(1.02)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C111(1.20)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C111(1.05)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C111(1.72)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C111(1.02)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C111(1.11)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C111(0.96)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C111(1.05)  LDD0946  [6]
 LDCM0349  AC83 PaTu 8988t C111(1.23)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C111(0.84)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C111(1.23)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C111(1.12)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C111(1.29)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C111(1.47)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C111(1.19)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C111(1.03)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C111(0.89)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C111(1.32)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C111(1.53)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C111(0.87)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C111(0.88)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C111(0.95)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C111(1.28)  LDD1243  [6]
 LDCM0365  AC98 PaTu 8988t C111(1.41)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C111(1.05)  LDD1245  [6]
 LDCM0248  AKOS034007472 HEK-293T C111(0.89)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C111(1.05)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C111(1.15)  LDD0873  [6]
 LDCM0630  CCW28-3 231MFP C111(1.26)  LDD2214  [17]
 LDCM0367  CL1 HEK-293T C111(1.67)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C111(0.73)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C111(0.77)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C111(1.01)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C111(1.17)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C111(1.25)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C111(1.15)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C111(0.95)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C111(0.87)  LDD1579  [16]
 LDCM0377  CL108 HEK-293T C111(0.90)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C111(0.92)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C111(1.34)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C111(0.89)  LDD1584  [16]
 LDCM0382  CL112 HCT 116 C111(1.01)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C111(0.88)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C111(0.84)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C111(0.97)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C111(0.94)  LDD0703  [6]
 LDCM0387  CL117 PaTu 8988t C111(1.05)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C111(1.20)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C111(1.22)  LDD1268  [6]
 LDCM0390  CL12 HEK-293T C111(1.42)  LDD0988  [6]
 LDCM0391  CL120 PaTu 8988t C111(1.12)  LDD1270  [6]
 LDCM0392  CL121 HCT 116 C111(0.37)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C111(0.76)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C111(0.94)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C111(0.79)  LDD0712  [6]
 LDCM0396  CL125 PaTu 8988t C111(1.26)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C111(1.26)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C111(1.32)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C111(1.54)  LDD1278  [6]
 LDCM0400  CL13 HEK-293T C111(2.42)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C111(1.44)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C111(1.37)  LDD1000  [6]
 LDCM0403  CL16 HCT 116 C111(0.87)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C111(1.18)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C111(1.37)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C111(1.05)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C111(2.72)  LDD1005  [6]
 LDCM0408  CL20 HCT 116 C111(0.64)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C111(0.61)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C111(0.44)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C111(0.68)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C111(0.59)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C111(0.72)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C111(0.86)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C111(0.70)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C111(0.91)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C111(0.80)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C111(1.25)  LDD1016  [6]
 LDCM0419  CL30 HCT 116 C111(0.81)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C111(0.89)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C111(0.78)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C111(0.85)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C111(1.03)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C111(0.87)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C111(1.39)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C111(0.99)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C111(0.82)  LDD0745  [6]
 LDCM0429  CL4 HEK-293T C111(1.73)  LDD1027  [6]
 LDCM0430  CL40 HCT 116 C111(0.85)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C111(0.84)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C111(0.79)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C111(0.97)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C111(0.86)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C111(0.96)  LDD0752  [6]
 LDCM0436  CL46 PaTu 8988t C111(0.82)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C111(1.17)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C111(1.24)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C111(1.32)  LDD1318  [6]
 LDCM0440  CL5 HEK-293T C111(1.13)  LDD1038  [6]
 LDCM0441  CL50 PaTu 8988t C111(1.12)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C111(0.92)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C111(0.98)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C111(1.02)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C111(0.93)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C111(1.35)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C111(0.43)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C111(1.20)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C111(1.04)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C111(1.22)  LDD1329  [6]
 LDCM0451  CL6 HEK-293T C111(1.10)  LDD1049  [6]
 LDCM0452  CL60 PaTu 8988t C111(1.31)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C111(2.03)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C111(1.03)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C111(0.97)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C111(0.95)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C111(1.13)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C111(0.94)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C111(1.63)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C111(0.74)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C111(1.54)  LDD1340  [6]
 LDCM0462  CL7 HEK-293T C111(1.93)  LDD1060  [6]
 LDCM0463  CL70 PaTu 8988t C111(1.26)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C111(1.28)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C111(0.50)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C111(1.10)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C111(0.74)  LDD1346  [6]
 LDCM0469  CL76 HCT 116 C111(20.00)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C111(1.29)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C111(0.66)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C111(0.57)  LDD0789  [6]
 LDCM0473  CL8 HEK-293T C111(0.84)  LDD1071  [6]
 LDCM0474  CL80 HCT 116 C111(1.37)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C111(0.74)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C111(0.42)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C111(0.81)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C111(0.44)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C111(0.86)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C111(1.13)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C111(0.51)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C111(0.57)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C111(0.45)  LDD0800  [6]
 LDCM0484  CL9 HEK-293T C111(0.94)  LDD1082  [6]
 LDCM0485  CL90 HCT 116 C111(1.14)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C111(0.60)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C111(0.43)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C111(0.84)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C111(0.83)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C111(0.58)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C111(0.64)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C111(0.92)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C111(0.85)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C111(0.69)  LDD1092  [6]
 LDCM0468  Fragment33 PaTu 8988t C111(0.93)  LDD1347  [6]
 LDCM0427  Fragment51 HCT 116 C111(0.88)  LDD0744  [6]
 LDCM0022  KB02 A101D C111(1.25)  LDD2250  [18]
 LDCM0023  KB03 A101D C111(1.89)  LDD2667  [18]
 LDCM0024  KB05 COLO792 C111(0.99)  LDD3310  [18]
 LDCM0110  W12 Hep-G2 K24(0.54); R84(0.60); K123(0.65); Q126(0.66)  LDD0237  [12]
 LDCM0111  W14 Hep-G2 K24(0.52); E74(0.98); K123(1.16); K80(1.17)  LDD0238  [12]
 LDCM0112  W16 Hep-G2 K80(0.83); Q126(0.87); Q77(0.89); Y42(0.92)  LDD0239  [12]
 LDCM0113  W17 Hep-G2 K24(0.56); K80(1.02); K123(1.06); Q126(1.08)  LDD0240  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Dopamine beta-hydroxylase (DBH) Copper type II ascorbate-dependent monooxygenase family P09172
Nitric oxide synthase 3 (NOS3) NOS family P29474
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Alpha-synuclein (SNCA) Synuclein family P37840
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Chromatin assembly factor 1 subunit A (CHAF1A) CHAF1A family Q13111
Histone H3.1t (H3-4) Histone H3 family Q16695
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Prelamin-A/C (LMNA) Intermediate filament family P02545

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
15 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840