Details of the Target

General Information of Target

Target ID LDTP06901
Target Name Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12)
Gene Name HSD17B12
Gene ID 51144
Synonyms
SDR12C1; Very-long-chain 3-oxoacyl-CoA reductase; EC 1.1.1.330; 17-beta-hydroxysteroid dehydrogenase 12; 17-beta-HSD 12; 3-ketoacyl-CoA reductase; KAR; Estradiol 17-beta-dehydrogenase 12; EC 1.1.1.62; Short chain dehydrogenase/reductase family 12C member 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTD
GIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKT
GLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERS
KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLA
KIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKS
TRAHYLKKTKKN
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Uniprot ID
Q53GQ0
Ensemble ID
ENST00000278353.10
HGNC ID
HGNC:18646
ChEMBL ID
CHEMBL5998

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.L145F DBIA    Probe Info 
CCK81 SNV: p.E101A DBIA    Probe Info 
HT29 SNV: p.S164P DBIA    Probe Info 
NCIH2172 SNV: p.A4S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.99  LDD0402  [1]
HDSF-alk
 Probe Info  		4.34  LDD0197  [2]
CHEMBL5175495
 Probe Info  		6.23  LDD0196  [3]
CY4
 Probe Info  		100.00  LDD0244  [4]
C-Sul
 Probe Info  		6.12  LDD0066  [5]
FBP2
 Probe Info  		2.14  LDD0317  [6]
TH211
 Probe Info  		Y233(11.38)  LDD0257  [7]
ONAyne
 Probe Info  		K72(6.67)  LDD0275  [8]
OPA-S-S-alkyne
 Probe Info  		K261(1.88)  LDD3494  [9]
HPAP
 Probe Info  		3.41  LDD0062  [10]
EA-probe
 Probe Info  		C166(1.35); C166(1.76); C215(1.03)  LDD2210  [11]
DBIA
 Probe Info  		C166(0.99)  LDD0078  [12]
ATP probe
 Probe Info  		K84(0.00); K86(0.00); K72(0.00); K76(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C166(0.00); C215(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C215(0.00); C166(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C166(0.00); C215(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		C166(0.00); C215(0.00)  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
IPM
 Probe Info  		C215(0.00); C166(0.00)  LDD0005  [20]
NHS
 Probe Info  		K117(0.00); K249(0.00); K261(0.00); K244(0.00)  LDD0010  [20]
STPyne
 Probe Info  		K249(0.00); K244(0.00); K72(0.00)  LDD0009  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
1d-yne
 Probe Info  		N.A.  LDD0357  [22]
Acrolein
 Probe Info  		C215(0.00); C166(0.00)  LDD0217  [23]
AOyne
 Probe Info  		15.00  LDD0443  [24]
NAIA_5
 Probe Info  		C166(0.00); C215(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 74 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.66  LDD1714  [25]
C022
 Probe Info  		7.62  LDD1728  [25]
C040
 Probe Info  		10.13  LDD1740  [25]
C041
 Probe Info  		6.50  LDD1741  [25]
C055
 Probe Info  		13.00  LDD1752  [25]
C056
 Probe Info  		21.56  LDD1753  [25]
C063
 Probe Info  		11.31  LDD1760  [25]
C070
 Probe Info  		9.51  LDD1766  [25]
C072
 Probe Info  		7.31  LDD1768  [25]
C091
 Probe Info  		11.71  LDD1782  [25]
C092
 Probe Info  		27.47  LDD1783  [25]
C094
 Probe Info  		47.18  LDD1785  [25]
C100
 Probe Info  		5.46  LDD1789  [25]
C106
 Probe Info  		16.00  LDD1793  [25]
C107
 Probe Info  		7.26  LDD1794  [25]
C112
 Probe Info  		19.84  LDD1799  [25]
C134
 Probe Info  		22.78  LDD1816  [25]
C143
 Probe Info  		28.25  LDD1825  [25]
C153
 Probe Info  		20.25  LDD1834  [25]
C160
 Probe Info  		8.22  LDD1840  [25]
C161
 Probe Info  		14.93  LDD1841  [25]
C169
 Probe Info  		20.97  LDD1849  [25]
C177
 Probe Info  		7.67  LDD1856  [25]
C178
 Probe Info  		15.45  LDD1857  [25]
C194
 Probe Info  		11.63  LDD1870  [25]
C198
 Probe Info  		19.29  LDD1874  [25]
C201
 Probe Info  		26.91  LDD1877  [25]
C218
 Probe Info  		16.45  LDD1892  [25]
C219
 Probe Info  		7.01  LDD1893  [25]
C220
 Probe Info  		16.91  LDD1894  [25]
C225
 Probe Info  		6.36  LDD1898  [25]
C228
 Probe Info  		18.51  LDD1901  [25]
C231
 Probe Info  		20.39  LDD1904  [25]
C232
 Probe Info  		43.71  LDD1905  [25]
C233
 Probe Info  		39.67  LDD1906  [25]
C235
 Probe Info  		37.01  LDD1908  [25]
C246
 Probe Info  		13.55  LDD1919  [25]
C264
 Probe Info  		16.34  LDD1935  [25]
C265
 Probe Info  		14.42  LDD1936  [25]
C277
 Probe Info  		8.06  LDD1947  [25]
C287
 Probe Info  		8.69  LDD1957  [25]
C288
 Probe Info  		9.00  LDD1958  [25]
C289
 Probe Info  		43.71  LDD1959  [25]
C293
 Probe Info  		17.75  LDD1963  [25]
C296
 Probe Info  		11.71  LDD1966  [25]
C299
 Probe Info  		7.73  LDD1968  [25]
C322
 Probe Info  		7.89  LDD1988  [25]
C339
 Probe Info  		6.68  LDD2002  [25]
C349
 Probe Info  		9.19  LDD2010  [25]
C350
 Probe Info  		25.81  LDD2011  [25]
C355
 Probe Info  		25.28  LDD2016  [25]
C356
 Probe Info  		8.34  LDD2017  [25]
C362
 Probe Info  		46.85  LDD2023  [25]
C363
 Probe Info  		20.68  LDD2024  [25]
C382
 Probe Info  		8.82  LDD2041  [25]
C388
 Probe Info  		49.18  LDD2047  [25]
C390
 Probe Info  		28.25  LDD2049  [25]
FFF probe11
 Probe Info  		20.00  LDD0471  [26]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe14
 Probe Info  		20.00  LDD0477  [26]
FFF probe15
 Probe Info  		10.06  LDD0478  [26]
FFF probe2
 Probe Info  		20.00  LDD0463  [26]
FFF probe3
 Probe Info  		20.00  LDD0464  [26]
FFF probe4
 Probe Info  		13.36  LDD0466  [26]
FFF probe7
 Probe Info  		15.99  LDD0483  [26]
FFF probe9
 Probe Info  		5.16  LDD0470  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]
A-DA
 Probe Info  		2.97  LDD0145  [28]
BD-F
 Probe Info  		L49(0.00); V45(0.00); E42(0.00); G50(0.00)  LDD0024  [29]
LD-F
 Probe Info  		G46(0.00); V39(0.00); E42(0.00); V36(0.00)  LDD0015  [29]
TM-F
 Probe Info  		G38(0.00); W37(0.00); G50(0.00)  LDD0020  [29]
OEA-DA
 Probe Info  		16.17  LDD0046  [30]
STS-1
 Probe Info  		N.A.  LDD0068  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C166(0.94); C215(0.85)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C166(0.72); C215(0.85)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C166(0.58); C215(0.84)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C166(0.65); C215(0.97)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C166(0.54); C215(0.93)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C166(0.48); C215(0.90)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C166(0.42); C215(1.10)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C166(0.58); C215(0.77)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C166(0.53); C215(0.82)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C166(0.81); C215(0.84)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C166(0.78); C215(0.83)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C166(0.71); C215(0.97)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C166(0.78); C215(0.81)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C166(0.70); C215(0.92)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C166(0.71); C215(0.75)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C166(0.75); C215(0.89)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C166(0.99); C215(0.94)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C166(0.88); C215(0.76)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C166(0.75); C215(0.77)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C166(0.79); C215(0.72)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C166(0.87); C215(0.78)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C166(0.99); C215(0.92)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C166(0.92); C215(0.82)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C166(0.96); C215(0.89)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C166(0.97); C215(0.80)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C166(0.99); C215(0.87)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C166(0.98); C215(0.80)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C166(1.04); C215(0.91)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C166(0.98); C215(0.93)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C166(1.06); C215(0.77)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C166(0.82); C215(0.68)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C166(0.84); C215(0.69)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C166(1.08); C215(0.88)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C166(1.16); C215(0.83)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C166(1.04); C215(0.79)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C166(1.12); C215(0.79)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C166(1.35); C215(1.20)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C166(1.13); C215(0.91)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C166(1.13); C215(0.85)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C166(1.10); C215(0.93)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C166(1.17); C215(1.02)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C166(1.26); C215(1.22)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C166(1.42); C215(1.00)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C166(1.21); C215(0.94)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C166(0.82); C215(1.01)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C166(1.30); C215(0.87)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C166(1.30); C215(0.97)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C166(1.45); C215(1.13)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C166(0.90); C215(0.98)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C215(0.50); C166(0.69)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C215(0.62); C166(0.86)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C215(0.57); C166(0.79)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C215(0.53); C166(0.73)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C215(0.50); C166(0.69)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C215(0.51); C166(0.68)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C166(0.72); C215(0.87)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C215(0.74); C166(0.91)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C215(0.78); C166(0.82)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C215(0.54); C166(0.65)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C215(0.48); C166(0.68)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C166(0.67); C215(0.54)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C166(0.66); C215(0.46)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C166(0.84); C215(0.70)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C166(0.72); C215(0.65)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C215(0.83); C166(0.93)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C166(0.69); C215(0.77)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C166(0.73); C215(0.78)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C215(0.91); C166(0.95)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C166(0.76); C215(0.83)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C166(0.67); C215(0.80)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C215(0.87); C166(0.88)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C166(0.81); C215(0.86)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C215(0.81); C166(0.86)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C215(0.64); C166(0.73)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C166(0.65); C215(0.66)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C166(0.65); C215(0.68)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C166(0.64); C215(0.64)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C215(0.61); C166(0.68)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C215(0.95); C166(1.00)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C166(0.70); C215(0.72)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C166(0.64); C215(0.67)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C166(0.58); C215(0.58)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C166(0.59); C215(0.60)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C166(0.60); C215(0.68)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C215(1.13); C166(1.34)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C215(0.99); C166(1.11)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C215(0.96); C166(1.12)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C166(1.02); C215(1.04)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C215(0.99); C166(1.17)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C215(0.83); C166(0.92)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C166(0.93); C215(1.00)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C215(0.97); C166(1.03)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C166(0.88); C215(0.92)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C166(0.94); C215(1.02)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C166(0.90); C215(0.98)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C166(0.90); C215(1.00)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C215(0.80); C166(0.93)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C215(0.83); C166(0.94)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C215(0.87); C166(0.90)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C215(0.86); C166(0.90)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C215(0.89); C166(0.94)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C215(0.75); C166(0.82)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C215(0.92); C166(1.10)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C215(0.87); C166(0.94)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C215(0.73); C166(0.83)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C215(0.94); C166(1.00)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C215(0.75); C166(0.89)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C215(0.84); C166(0.97)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C215(0.95); C166(1.01)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C215(0.85); C166(0.91)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C166(1.03); C215(1.12)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C166(0.71); C215(0.83)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C166(0.98); C215(1.08)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C166(0.97); C215(1.01)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C215(0.94); C166(1.03)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C215(1.00); C166(1.06)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C215(1.07); C166(1.10)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C166(1.06); C215(1.10)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C166(1.05); C215(1.10)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C215(1.01); C166(1.02)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C215(0.76); C166(0.94)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C215(0.86); C166(0.90)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C215(0.95); C166(0.99)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C215(0.67); C166(0.80)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C215(0.89); C166(1.04)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C215(0.77); C166(0.93)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C215(0.93); C166(0.97)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C215(0.95); C166(1.09)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C215(0.82); C166(1.05)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C215(0.83); C166(0.90)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C215(0.73); C166(0.89)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C215(0.77); C166(0.92)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C166(0.95); C215(1.03)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C166(0.78); C215(0.96)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C215(0.82); C166(1.02)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C166(1.01); C215(1.02)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C215(0.97); C166(1.10)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C215(0.70); C166(0.89)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C215(0.73); C166(0.81)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C215(0.70); C166(0.87)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C166(0.89); C215(0.92)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C166(0.87); C215(0.94)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C166(0.80); C215(0.95)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C215(0.80); C166(0.84)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C215(0.83); C166(0.93)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C166(0.86); C215(0.95)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C215(0.70); C166(0.84)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C215(0.76); C166(0.84)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C215(0.82); C166(0.89)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C215(0.75); C166(0.78)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C166(0.84); C215(0.89)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C166(0.80); C215(0.83)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C166(0.53); C215(0.88)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C166(0.78); C215(0.94)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C166(0.93); C215(0.91)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C166(0.85); C215(0.90)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C166(0.63); C215(0.79)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C166(0.99)  LDD0078  [12]
 LDCM0108  Chloroacetamide HeLa C215(0.00); C166(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C215(0.26)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C166(1.04); C215(1.27)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C215(0.85); C166(0.92)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C215(0.79); C166(0.90)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C166(0.71); C215(0.84)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C215(0.88); C166(1.01)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C166(0.84); C215(0.86)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C166(0.81); C215(0.87)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C166(0.65); C215(0.86)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C166(0.54); C215(0.84)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C166(0.60); C215(0.87)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C166(0.65); C215(0.84)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C166(0.62); C215(0.74)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C215(0.87); C166(0.91)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C166(0.53); C215(0.74)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C166(0.71); C215(0.87)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C215(0.80); C166(0.88)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C166(0.60); C215(0.61)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C166(0.74); C215(0.78)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C166(0.67); C215(0.76)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C215(0.75); C166(0.76)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C166(1.00); C215(1.13)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C215(0.97); C166(1.13)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C215(0.99); C166(1.11)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C166(0.84); C215(0.87)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C215(1.03); C166(1.09)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C166(0.75); C215(1.03)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C215(0.85); C166(0.94)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C166(0.81); C215(0.82)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C215(0.79); C166(0.89)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C166(1.17); C215(1.17)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C166(1.02); C215(1.16)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C166(1.04); C215(1.04)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C215(0.97); C166(0.98)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C166(0.88); C215(0.98)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C166(0.94); C215(1.07)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C166(0.98); C215(1.03)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C215(1.00); C166(1.05)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C215(0.83); C166(0.88)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C215(0.72); C166(0.75)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C166(0.77); C215(0.82)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C166(1.08); C215(1.13)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C215(0.68); C166(0.73)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C166(0.66); C215(0.69)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C215(0.79); C166(0.84)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C166(0.77); C215(0.77)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C166(0.75); C215(0.76)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C166(0.74); C215(0.75)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C166(0.86); C215(0.80)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C166(0.71); C215(0.76)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C166(0.69); C215(0.74)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C166(0.69); C215(0.71)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C166(1.02); C215(1.07)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C166(0.87); C215(0.95)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C166(0.70); C215(0.77)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C166(0.65); C215(0.73)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C166(0.58); C215(0.68)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C166(0.60); C215(0.70)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C166(0.62); C215(0.76)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C166(0.61); C215(0.67)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C166(0.59); C215(0.79)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C166(0.61); C215(0.71)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C166(0.91); C215(1.08)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C166(0.62); C215(0.68)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C166(0.59); C215(0.71)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C166(0.72); C215(0.73)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C166(0.63); C215(0.64)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C166(0.58); C215(0.61)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C166(0.61); C215(0.76)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C166(1.13); C215(0.99)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C166(1.19); C215(1.08)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C166(1.17); C215(0.93)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C166(0.99); C215(0.90)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C166(0.95); C215(1.02)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C166(0.99); C215(0.97)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C166(1.03); C215(0.89)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C166(1.03); C215(0.82)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C166(1.04); C215(0.92)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C166(0.98); C215(0.93)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C166(1.01); C215(0.89)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C166(1.02); C215(0.91)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C166(1.04); C215(0.97)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C166(1.12); C215(0.97)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C166(1.04); C215(0.87)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C166(1.06); C215(0.89)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C166(1.95); C215(0.96)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C166(0.79); C215(0.89)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C166(0.80); C215(0.83)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C166(0.61); C215(0.81)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C166(0.59); C215(0.71)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C166(0.73); C215(0.84)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C166(0.67); C215(0.74)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C166(0.66); C215(0.82)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C166(0.68); C215(0.85)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C166(0.64); C215(0.70)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C166(0.96); C215(1.00)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C166(0.69); C215(0.82)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C166(0.67); C215(0.75)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C166(0.81); C215(0.90)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C166(0.62); C215(0.82)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C166(0.69); C215(0.79)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C166(0.75); C215(0.88)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C166(0.87); C215(0.89)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C166(0.78); C215(0.80)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C166(0.67); C215(0.72)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C166(0.85); C215(0.78)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C166(1.16); C215(0.99)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C166(0.76); C215(0.78)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C166(0.70); C215(0.85)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C166(0.74); C215(0.85)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C166(0.82); C215(0.79)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C166(0.79); C215(0.86)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C166(1.10); C215(0.89)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C166(0.76); C215(0.76)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C166(0.69); C215(0.74)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C166(0.90); C215(1.10)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C166(0.89); C215(0.92)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C166(1.14); C215(0.96)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C166(0.95); C215(0.85)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C166(1.01); C215(0.90)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C166(0.96); C215(0.93)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C166(0.86); C215(0.76)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C166(0.90); C215(0.79)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C166(0.89); C215(0.83)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C166(0.90); C215(0.89)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C166(0.86); C215(0.79)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C166(0.90); C215(0.84)  LDD0811  [12]
 LDCM0189  Compound 16 HEK-293T 29.55  LDD0492  [26]
 LDCM0185  Compound 17 HEK-293T 8.06  LDD0504  [26]
 LDCM0184  Compound 20 HEK-293T 10.95  LDD0503  [26]
 LDCM0191  Compound 21 HEK-293T 6.19  LDD0493  [26]
 LDCM0186  Compound 31 HEK-293T 4.90  LDD0506  [26]
 LDCM0187  Compound 32 HEK-293T 43.55  LDD0507  [26]
 LDCM0188  Compound 33 HEK-293T 4.19  LDD0505  [26]
 LDCM0190  Compound 34 HEK-293T 13.53  LDD0497  [26]
 LDCM0192  Compound 35 HEK-293T 9.05  LDD0491  [26]
 LDCM0193  Compound 36 HEK-293T 8.88  LDD0494  [26]
 LDCM0194  Compound 37 HEK-293T 9.40  LDD0498  [26]
 LDCM0195  Compound 38 HEK-293T 10.13  LDD0499  [26]
 LDCM0196  Compound 39 HEK-293T 7.17  LDD0496  [26]
 LDCM0197  Compound 40 HEK-293T 8.62  LDD0495  [26]
 LDCM0495  E2913 HEK-293T C215(0.90); C166(0.87)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C215(6.36)  LDD1702  [33]
 LDCM0175  Ethacrynic acid HeLa C166(1.35); C166(1.76); C215(1.03)  LDD2210  [11]
 LDCM0625  F8 Ramos C166(0.53); C215(0.55)  LDD2187  [34]
 LDCM0572  Fragment10 Ramos C166(2.70); C215(1.18)  LDD2189  [34]
 LDCM0573  Fragment11 Ramos C166(0.08); C215(0.44)  LDD2190  [34]
 LDCM0574  Fragment12 Ramos C166(4.82); C215(0.94)  LDD2191  [34]
 LDCM0575  Fragment13 Ramos C166(0.62); C215(0.39)  LDD2192  [34]
 LDCM0576  Fragment14 Ramos C166(20.00); C215(10.10)  LDD2193  [34]
 LDCM0580  Fragment21 Ramos C166(0.80)  LDD2195  [34]
 LDCM0582  Fragment23 Ramos C166(0.55)  LDD2196  [34]
 LDCM0578  Fragment27 Ramos C166(0.50); C215(0.39)  LDD2197  [34]
 LDCM0586  Fragment28 Ramos C166(3.44); C215(1.39)  LDD2198  [34]
 LDCM0588  Fragment30 Ramos C166(0.36); C215(0.26)  LDD2199  [34]
 LDCM0589  Fragment31 Ramos C166(1.20); C215(0.54)  LDD2200  [34]
 LDCM0590  Fragment32 Ramos C166(2.41)  LDD2201  [34]
 LDCM0468  Fragment33 HCT 116 C166(0.73); C215(0.82)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C166(2.24); C215(1.23)  LDD2203  [34]
 LDCM0566  Fragment4 Ramos C166(9.61); C215(1.78)  LDD2184  [34]
 LDCM0427  Fragment51 HCT 116 C166(0.64); C215(0.84)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C166(0.78); C215(0.38)  LDD2204  [34]
 LDCM0614  Fragment56 Ramos C166(0.32); C215(0.37)  LDD2205  [34]
 LDCM0569  Fragment7 Ramos C166(9.67)  LDD2186  [34]
 LDCM0015  HNE MDA-MB-231 C166(1.19); C215(1.12)  LDD0346  [34]
 LDCM0107  IAA HeLa N.A.  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C166(2.70)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C166(5.18)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C166(3.57)  LDD0082  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C215(1.10); C166(0.92); C166(0.31)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C215(0.89); C166(0.74); C166(0.71)  LDD2207  [35]
 LDCM0014  Panhematin HEK-293T 3.41  LDD0062  [10]
 LDCM0131  RA190 MM1.R C166(1.85)  LDD0304  [36]
 LDCM0084  Ro 48-8071 A-549 2.97  LDD0145  [28]
 LDCM0021  THZ1 HCT 116 C166(0.99)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
29 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
36 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.