Details of the Target

General Information of Target

Target ID LDTP02724
Target Name Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2)
Gene Name COX7A2
Gene ID 1347
Synonyms
COX7AL; Cytochrome c oxidase subunit 7A2, mitochondrial; Cytochrome c oxidase subunit VIIa-liver/heart; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIaL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMI
LTVGGTAYAIYELAVASFPKKQE
Target Bioclass
Transporter and channel
Family
Cytochrome c oxidase VIIa family
Subcellular location
Mitochondrion inner membrane
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Uniprot ID
P14406
Ensemble ID
ENST00000684430.2
HGNC ID
HGNC:2288

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		30.84  LDD0318  [1]
TH211
 Probe Info  		Y44(8.56)  LDD0260  [2]
C-Sul
 Probe Info  		4.05  LDD0066  [3]
STPyne
 Probe Info  		K25(10.00); K27(6.75); K31(4.55)  LDD0277  [4]
P11
 Probe Info  		11.80  LDD0201  [5]
HPAP
 Probe Info  		3.31  LDD0064  [6]
AOyne
 Probe Info  		13.50  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 160 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.90  LDD1711  [8]
C002
 Probe Info  		6.59  LDD1712  [8]
C004
 Probe Info  		10.70  LDD1714  [8]
C006
 Probe Info  		5.35  LDD1715  [8]
C007
 Probe Info  		15.35  LDD1716  [8]
C010
 Probe Info  		8.57  LDD1719  [8]
C011
 Probe Info  		5.74  LDD1720  [8]
C017
 Probe Info  		13.18  LDD1725  [8]
C022
 Probe Info  		39.95  LDD1728  [8]
C026
 Probe Info  		20.53  LDD1732  [8]
C038
 Probe Info  		5.13  LDD1738  [8]
C039
 Probe Info  		32.22  LDD1739  [8]
C040
 Probe Info  		99.73  LDD1740  [8]
C041
 Probe Info  		25.28  LDD1741  [8]
C044
 Probe Info  		30.91  LDD1743  [8]
C049
 Probe Info  		30.06  LDD1747  [8]
C051
 Probe Info  		11.88  LDD1749  [8]
C052
 Probe Info  		8.51  LDD1750  [8]
C053
 Probe Info  		15.45  LDD1751  [8]
C055
 Probe Info  		99.73  LDD1752  [8]
C056
 Probe Info  		72.00  LDD1753  [8]
C060
 Probe Info  		7.89  LDD1757  [8]
C063
 Probe Info  		99.04  LDD1760  [8]
C065
 Probe Info  		8.40  LDD1762  [8]
C067
 Probe Info  		8.75  LDD1763  [8]
C070
 Probe Info  		20.25  LDD1766  [8]
C071
 Probe Info  		14.22  LDD1767  [8]
C072
 Probe Info  		45.89  LDD1768  [8]
C082
 Probe Info  		22.94  LDD1774  [8]
C085
 Probe Info  		12.73  LDD1777  [8]
C087
 Probe Info  		17.39  LDD1779  [8]
C095
 Probe Info  		29.04  LDD1786  [8]
C100
 Probe Info  		19.03  LDD1789  [8]
C106
 Probe Info  		38.32  LDD1793  [8]
C107
 Probe Info  		21.86  LDD1794  [8]
C108
 Probe Info  		12.13  LDD1795  [8]
C112
 Probe Info  		99.73  LDD1799  [8]
C122
 Probe Info  		7.46  LDD1808  [8]
C129
 Probe Info  		15.67  LDD1811  [8]
C130
 Probe Info  		19.03  LDD1812  [8]
C134
 Probe Info  		47.50  LDD1816  [8]
C139
 Probe Info  		34.06  LDD1821  [8]
C140
 Probe Info  		14.83  LDD1822  [8]
C141
 Probe Info  		20.11  LDD1823  [8]
C143
 Probe Info  		58.49  LDD1825  [8]
C147
 Probe Info  		8.00  LDD1829  [8]
C153
 Probe Info  		28.64  LDD1834  [8]
C159
 Probe Info  		20.53  LDD1839  [8]
C160
 Probe Info  		40.50  LDD1840  [8]
C161
 Probe Info  		99.73  LDD1841  [8]
C165
 Probe Info  		33.36  LDD1845  [8]
C177
 Probe Info  		14.42  LDD1856  [8]
C178
 Probe Info  		22.47  LDD1857  [8]
C183
 Probe Info  		6.68  LDD1861  [8]
C186
 Probe Info  		37.01  LDD1864  [8]
C187
 Probe Info  		77.71  LDD1865  [8]
C191
 Probe Info  		20.68  LDD1868  [8]
C193
 Probe Info  		14.03  LDD1869  [8]
C194
 Probe Info  		8.51  LDD1870  [8]
C196
 Probe Info  		72.00  LDD1872  [8]
C197
 Probe Info  		7.16  LDD1873  [8]
C201
 Probe Info  		99.73  LDD1877  [8]
C204
 Probe Info  		8.46  LDD1879  [8]
C206
 Probe Info  		79.34  LDD1881  [8]
C207
 Probe Info  		41.93  LDD1882  [8]
C210
 Probe Info  		99.73  LDD1884  [8]
C211
 Probe Info  		98.36  LDD1885  [8]
C213
 Probe Info  		72.00  LDD1887  [8]
C214
 Probe Info  		28.84  LDD1888  [8]
C218
 Probe Info  		30.27  LDD1892  [8]
C219
 Probe Info  		29.04  LDD1893  [8]
C220
 Probe Info  		93.70  LDD1894  [8]
C225
 Probe Info  		16.34  LDD1898  [8]
C226
 Probe Info  		17.03  LDD1899  [8]
C228
 Probe Info  		99.73  LDD1901  [8]
C229
 Probe Info  		18.51  LDD1902  [8]
C231
 Probe Info  		99.73  LDD1904  [8]
C232
 Probe Info  		86.82  LDD1905  [8]
C233
 Probe Info  		72.50  LDD1906  [8]
C234
 Probe Info  		14.72  LDD1907  [8]
C235
 Probe Info  		65.80  LDD1908  [8]
C238
 Probe Info  		78.25  LDD1911  [8]
C240
 Probe Info  		46.85  LDD1913  [8]
C242
 Probe Info  		6.41  LDD1915  [8]
C243
 Probe Info  		54.95  LDD1916  [8]
C244
 Probe Info  		45.25  LDD1917  [8]
C245
 Probe Info  		9.06  LDD1918  [8]
C246
 Probe Info  		64.45  LDD1919  [8]
C252
 Probe Info  		19.84  LDD1925  [8]
C260
 Probe Info  		5.06  LDD1932  [8]
C264
 Probe Info  		40.79  LDD1935  [8]
C265
 Probe Info  		50.56  LDD1936  [8]
C270
 Probe Info  		28.05  LDD1940  [8]
C273
 Probe Info  		17.39  LDD1943  [8]
C277
 Probe Info  		17.39  LDD1947  [8]
C278
 Probe Info  		99.73  LDD1948  [8]
C280
 Probe Info  		11.24  LDD1950  [8]
C282
 Probe Info  		99.73  LDD1952  [8]
C285
 Probe Info  		99.73  LDD1955  [8]
C287
 Probe Info  		11.88  LDD1957  [8]
C288
 Probe Info  		8.28  LDD1958  [8]
C289
 Probe Info  		99.73  LDD1959  [8]
C290
 Probe Info  		5.39  LDD1960  [8]
C292
 Probe Info  		6.73  LDD1962  [8]
C293
 Probe Info  		70.03  LDD1963  [8]
C296
 Probe Info  		24.25  LDD1966  [8]
C299
 Probe Info  		15.14  LDD1968  [8]
C301
 Probe Info  		6.45  LDD1970  [8]
C303
 Probe Info  		5.94  LDD1972  [8]
C304
 Probe Info  		6.45  LDD1973  [8]
C305
 Probe Info  		13.74  LDD1974  [8]
C310
 Probe Info  		49.52  LDD1977  [8]
C313
 Probe Info  		40.79  LDD1980  [8]
C314
 Probe Info  		16.80  LDD1981  [8]
C317
 Probe Info  		8.17  LDD1983  [8]
C322
 Probe Info  		16.22  LDD1988  [8]
C333
 Probe Info  		15.67  LDD1996  [8]
C337
 Probe Info  		10.78  LDD2000  [8]
C338
 Probe Info  		36.50  LDD2001  [8]
C339
 Probe Info  		18.77  LDD2002  [8]
C342
 Probe Info  		5.98  LDD2004  [8]
C343
 Probe Info  		31.56  LDD2005  [8]
C346
 Probe Info  		10.56  LDD2007  [8]
C347
 Probe Info  		10.13  LDD2008  [8]
C348
 Probe Info  		22.94  LDD2009  [8]
C349
 Probe Info  		79.89  LDD2010  [8]
C350
 Probe Info  		99.73  LDD2011  [8]
C353
 Probe Info  		16.11  LDD2014  [8]
C355
 Probe Info  		74.54  LDD2016  [8]
C356
 Probe Info  		57.28  LDD2017  [8]
C357
 Probe Info  		28.25  LDD2018  [8]
C361
 Probe Info  		20.25  LDD2022  [8]
C362
 Probe Info  		99.73  LDD2023  [8]
C363
 Probe Info  		30.91  LDD2024  [8]
C364
 Probe Info  		41.64  LDD2025  [8]
C366
 Probe Info  		70.52  LDD2027  [8]
C367
 Probe Info  		23.26  LDD2028  [8]
C373
 Probe Info  		6.36  LDD2033  [8]
C376
 Probe Info  		8.82  LDD2036  [8]
C378
 Probe Info  		6.02  LDD2037  [8]
C380
 Probe Info  		15.03  LDD2039  [8]
C382
 Probe Info  		37.79  LDD2041  [8]
C388
 Probe Info  		99.73  LDD2047  [8]
C390
 Probe Info  		99.73  LDD2049  [8]
C391
 Probe Info  		40.22  LDD2050  [8]
C396
 Probe Info  		5.94  LDD2055  [8]
C399
 Probe Info  		14.32  LDD2058  [8]
C403
 Probe Info  		72.50  LDD2061  [8]
C407
 Probe Info  		99.73  LDD2064  [8]
C409
 Probe Info  		19.84  LDD2066  [8]
C413
 Probe Info  		17.27  LDD2069  [8]
C419
 Probe Info  		53.82  LDD2074  [8]
C423
 Probe Info  		99.73  LDD2078  [8]
C424
 Probe Info  		18.13  LDD2079  [8]
C426
 Probe Info  		44.63  LDD2081  [8]
C429
 Probe Info  		99.73  LDD2084  [8]
C431
 Probe Info  		24.76  LDD2086  [8]
BD-F
 Probe Info  		Y68(0.00); E72(0.00); L73(0.00); G65(0.00)  LDD0024  [9]
LD-F
 Probe Info  		G64(0.00); Y71(0.00); E72(0.00); A74(0.00)  LDD0015  [9]
TM-F
 Probe Info  		G65(0.00); Y71(0.00)  LDD0020  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0088  C45 HEK-293T 11.80  LDD0201  [5]
 LDCM0014  Panhematin hPBMC 3.31  LDD0064  [6]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652