Details of the Target

General Information of Target

Target ID LDTP11009
Target Name Opiorphin prepropeptide (OPRPN)
Gene Name OPRPN
Gene ID 58503
Synonyms
BPLP; PROL1; Opiorphin prepropeptide; Basic proline-rich lacrimal protein; Proline-rich protein 1; PRL1) [Cleaved into: Opiorphin]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQRGGARRPRGDRERLGSRLRALRPGREPRQSEPPAQRGPPPSGRPPARSTASGHDRPT
RGAAAGARRPRMKKKTRRRSTRSEELTRSEELTLSEEATWSEEATQSEEATQGEEMNRSQ
EVTRDEESTRSEEVTREEMAAAGLTVTVTHSNEKHDLHVTSQQGSSEPVVQDLAQVVEEV
IGVPQSFQKLIFKGKSLKEMETPLSALGIQDGCRVMLIGKKNSPQEEVELKKLKHLEKSV
EKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPEN
FKDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE
Target Bioclass
Other
Family
PROL1/PROL3 family
Subcellular location
Secreted
Function
Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.
Uniprot ID
Q99935
Ensemble ID
ENST00000399575.7
HGNC ID
HGNC:17279

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C218
 Probe Info  		34.54  LDD1892  [1]
C221
 Probe Info  		15.67  LDD1895  [1]

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587