Details of the Target

General Information of Target

Target ID LDTP04720
Target Name IgG receptor FcRn large subunit p51 (FCGRT)
Gene Name FCGRT
Gene ID 2217
Synonyms
FCRN; IgG receptor FcRn large subunit p51; FcRn; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLS
YNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCE
LGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLF
SCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGL
AAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLV
VGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNV
IPATA
Target Type
Successful
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily
Subcellular location
Cell membrane
Function
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.; (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
TTD ID
T06020
Uniprot ID
P55899
DrugMap ID
TTKLPHO
Ensemble ID
ENST00000221466.10
HGNC ID
HGNC:3621
ChEMBL ID
CHEMBL5966

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C182(2.17)  LDD3368  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.63  LDD1714  [3]
C011
 Probe Info  		12.91  LDD1720  [3]
C073
 Probe Info  		9.71  LDD1769  [3]
C106
 Probe Info  		51.98  LDD1793  [3]
C107
 Probe Info  		13.00  LDD1794  [3]
C108
 Probe Info  		34.30  LDD1795  [3]
C149
 Probe Info  		21.11  LDD1830  [3]
C153
 Probe Info  		16.00  LDD1834  [3]
C170
 Probe Info  		31.34  LDD1850  [3]
C171
 Probe Info  		7.89  LDD1851  [3]
C178
 Probe Info  		91.14  LDD1857  [3]
C197
 Probe Info  		7.57  LDD1873  [3]
C216
 Probe Info  		5.10  LDD1890  [3]
C221
 Probe Info  		10.93  LDD1895  [3]
C222
 Probe Info  		7.78  LDD1896  [3]
C223
 Probe Info  		16.34  LDD1897  [3]
C228
 Probe Info  		20.11  LDD1901  [3]
C237
 Probe Info  		14.62  LDD1910  [3]
C348
 Probe Info  		17.39  LDD2009  [3]
C349
 Probe Info  		21.86  LDD2010  [3]
C350
 Probe Info  		44.94  LDD2011  [3]
C353
 Probe Info  		8.11  LDD2014  [3]
C354
 Probe Info  		12.64  LDD2015  [3]
C386
 Probe Info  		6.77  LDD2045  [3]
C387
 Probe Info  		4.99  LDD2046  [3]
C388
 Probe Info  		42.81  LDD2047  [3]
C425
 Probe Info  		18.51  LDD2080  [3]
C429
 Probe Info  		15.67  LDD2084  [3]
C431
 Probe Info  		15.03  LDD2086  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C71(0.67)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C71(0.55)  LDD1105  [4]
 LDCM0237  AC12 PaTu 8988t C71(0.41)  LDD1116  [4]
 LDCM0259  AC14 PaTu 8988t C71(0.70)  LDD1138  [4]
 LDCM0270  AC15 PaTu 8988t C71(0.77)  LDD1149  [4]
 LDCM0276  AC17 PaTu 8988t C71(0.96)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C71(0.88)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C71(1.22)  LDD1157  [4]
 LDCM0280  AC20 PaTu 8988t C71(1.70)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C71(0.85)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C71(1.12)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C71(0.91)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C71(0.65)  LDD1163  [4]
 LDCM0289  AC29 HEK-293T C71(0.97)  LDD1528  [5]
 LDCM0291  AC30 HEK-293T C119(0.93)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C71(0.89)  LDD1531  [5]
 LDCM0296  AC35 PaTu 8988t C71(1.53)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C71(0.88)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C71(0.65)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C71(0.70)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C71(0.68)  LDD1179  [4]
 LDCM0302  AC40 PaTu 8988t C71(0.91)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C71(1.00)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C71(0.65)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C71(0.64)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C71(0.60)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C71(0.69)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C71(1.11)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C71(1.20)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C71(0.81)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C71(0.89)  LDD1190  [4]
 LDCM0312  AC5 HEK-293T C71(1.04)  LDD1551  [5]
 LDCM0313  AC50 PaTu 8988t C71(0.98)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C71(0.36)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C71(0.81)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C71(1.07)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C71(1.05)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C71(0.75)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C71(1.14)  LDD1198  [4]
 LDCM0323  AC6 PaTu 8988t C71(0.52)  LDD1202  [4]
 LDCM0325  AC61 HEK-293T C71(1.01)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C119(0.94)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C71(0.98)  LDD1566  [5]
 LDCM0334  AC7 PaTu 8988t C71(0.59)  LDD1213  [4]
 LDCM0345  AC8 PaTu 8988t C71(0.88)  LDD1224  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C71(0.58)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C71(0.55)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C71(0.64)  LDD1154  [4]
 LDCM0367  CL1 PaTu 8988t C71(0.94)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C71(0.61)  LDD1247  [4]
 LDCM0370  CL101 PaTu 8988t C71(0.60)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C71(0.61)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C71(0.50)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C71(0.84)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C71(1.35)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C71(1.77)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C71(1.08)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C71(1.41)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C71(1.99)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C71(0.85)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C71(2.14)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C71(0.58)  LDD1260  [4]
 LDCM0385  CL115 HEK-293T C71(1.07)  LDD1589  [5]
 LDCM0387  CL117 PaTu 8988t C71(1.51)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C71(0.75)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C71(0.59)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C71(0.93)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C71(1.35)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C71(2.01)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C71(1.00)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C71(1.24)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C71(0.89)  LDD1274  [4]
 LDCM0398  CL127 HEK-293T C71(1.13)  LDD1602  [5]
 LDCM0400  CL13 PaTu 8988t C71(0.63)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C71(0.60)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C71(0.83)  LDD1281  [4]
 LDCM0407  CL2 PaTu 8988t C71(1.02)  LDD1286  [4]
 LDCM0409  CL21 HEK-293T C71(1.02)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C119(0.86)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C71(1.16)  LDD1615  [5]
 LDCM0415  CL27 HEK-293T C71(0.98)  LDD1619  [5]
 LDCM0418  CL3 PaTu 8988t C71(0.54)  LDD1297  [4]
 LDCM0420  CL31 PaTu 8988t C71(0.58)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C71(0.48)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C71(0.42)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C71(0.44)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C71(0.56)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C71(0.40)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C71(0.41)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C71(0.42)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C71(0.70)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C71(0.46)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C71(0.43)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C71(0.53)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C71(0.36)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C71(0.54)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C71(0.47)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C71(0.81)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C71(0.72)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C71(0.93)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C71(0.83)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C71(0.71)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C71(0.65)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C71(0.74)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C71(0.95)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C71(0.75)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C71(0.49)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C71(0.51)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C71(0.29)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C71(0.40)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C71(0.73)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C71(0.41)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C71(0.81)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C71(0.52)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C71(0.99)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C71(0.63)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C71(0.79)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C71(0.81)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C71(0.82)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C71(0.92)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C71(0.95)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C71(0.82)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C71(0.81)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C71(0.70)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C71(0.89)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C71(0.68)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C71(1.09)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C71(0.65)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C71(0.73)  LDD1346  [4]
 LDCM0473  CL8 PaTu 8988t C71(0.64)  LDD1352  [4]
 LDCM0475  CL81 HEK-293T C71(1.05)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C119(0.91)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C71(0.84)  LDD1680  [5]
 LDCM0481  CL87 HEK-293T C71(1.45)  LDD1684  [5]
 LDCM0484  CL9 PaTu 8988t C71(0.75)  LDD1363  [4]
 LDCM0488  CL93 HEK-293T C71(0.23)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C119(0.82)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C71(0.86)  LDD1693  [5]
 LDCM0494  CL99 HEK-293T C71(1.11)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C71(1.30)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C71(0.82)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C71(0.38)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C182(0.95)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C182(1.02)  LDD1497  [5]
 LDCM0024  KB05 OAW-28 C182(2.17)  LDD3368  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Uroplakin-2 (UPK2) Uroplakin-2 family O00526
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM3C (FAM3C) FAM3 family Q92520
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Efgartigimod Alfa . DB15270
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Argx-113 Small molecular drug DZA98D
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Syn-1327 . D0QR7C

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402